ATE90203T1 - Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen. - Google Patents

Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen.

Info

Publication number
ATE90203T1
ATE90203T1 AT90905065T AT90905065T ATE90203T1 AT E90203 T1 ATE90203 T1 AT E90203T1 AT 90905065 T AT90905065 T AT 90905065T AT 90905065 T AT90905065 T AT 90905065T AT E90203 T1 ATE90203 T1 AT E90203T1
Authority
AT
Austria
Prior art keywords
beadlets
macromolecular
macromolecular proteins
animal
water
Prior art date
Application number
AT90905065T
Other languages
English (en)
Inventor
Kallidaikuruc Sivaramakrishnan
Lindy F Miller
Original Assignee
Pitman Moore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pitman Moore Inc filed Critical Pitman Moore Inc
Application granted granted Critical
Publication of ATE90203T1 publication Critical patent/ATE90203T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT90905065T 1989-03-17 1990-03-13 Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen. ATE90203T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32474089A 1989-03-17 1989-03-17
PCT/US1990/001340 WO1990011070A1 (en) 1989-03-17 1990-03-13 Controlled release delivery device for macromolecular proteins

Publications (1)

Publication Number Publication Date
ATE90203T1 true ATE90203T1 (de) 1993-06-15

Family

ID=23264894

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90905065T ATE90203T1 (de) 1989-03-17 1990-03-13 Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen.

Country Status (9)

Country Link
EP (1) EP0463061B1 (de)
JP (1) JPH04504122A (de)
AT (1) ATE90203T1 (de)
AU (1) AU634529B2 (de)
DE (1) DE69001898T2 (de)
DK (1) DK0463061T3 (de)
ES (1) ES2042292T3 (de)
NO (1) NO913649L (de)
WO (1) WO1990011070A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ242065A (en) * 1991-03-26 1996-06-25 Csl Ltd Delayed release implant having a degradable or rupturable polymeric coating
ES2109362T3 (es) * 1991-06-21 1998-01-16 Univ Cincinnati Unas proteinas administrables oralmente y metodo para hacerlas.
US6613332B1 (en) 1991-06-21 2003-09-02 The University Of Cincinnati Oral administration of therapeutic proteins
AU3582893A (en) * 1992-01-13 1993-08-03 Pitman-Moore, Inc. Delayed release device for transition metal/protein complexes
US5260069A (en) * 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
CA2086631C (en) * 1992-12-22 1998-10-06 J. Gabriel Michael Oral administration of immunologically active biomolecules and other therapeutic proteins
KR100260632B1 (ko) * 1992-12-28 2000-07-01 성재갑 이식형 소마토트로핀 조성물
DE4342091A1 (de) * 1993-12-09 1995-06-14 Asta Medica Ag Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten
KR19990071255A (ko) 1998-02-28 1999-09-15 성재갑 소마토트로핀과 비타민의 합제 조성물
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
DE19820529A1 (de) 1998-05-08 1999-11-11 Lohmann Therapie Syst Lts Wirkstoff enthaltende orale und mucosale Zubereitung mit steuerbarer Wirkstofffreisetzung und ihre Verwendung
EP1064934A1 (de) * 1999-06-30 2001-01-03 Applied Research Systems ARS Holding N.V. Gefriergetrocknete GRF-enthaltende Arzneimittel
MXPA02001080A (es) * 1999-07-30 2002-08-20 Smithkline Beecham Plc Forma de dosificacion farmaceutica de componentes multiples.
JP2004513877A (ja) * 2000-06-28 2004-05-13 アンジオジェニックス，アイエヌシー． 放出制御アルギニン製剤
AUPR602501A0 (en) * 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release pharmaceutical composition
AUPR602401A0 (en) 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release delivery system
US20030050620A1 (en) * 2001-09-07 2003-03-13 Isa Odidi Combinatorial type controlled release drug delivery device
US8802139B2 (en) 2003-06-26 2014-08-12 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
DK1824460T3 (en) 2004-11-10 2015-01-19 Tolmar Therapeutics Inc Stabilized polymeric delivery system
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
BRPI0821359A2 (pt) * 2007-12-21 2015-06-16 Merck Patent Ges Mit Beschränkter Haftung Microcápsulas de lipídeos sólidas contendo hormônio de crescimento no núcleo sólido interno
AU2010246067B2 (en) 2009-05-04 2016-07-07 Eyepoint Pharmaceuticals Us, Inc. Porous silicon drug-eluting particles
CN104586742A (zh) 2010-11-01 2015-05-06 普西维达公司 用于递送治疗剂的可生物侵蚀的硅基装置
CN105025928A (zh) 2013-03-15 2015-11-04 普西维达公司 用于递送治疗剂的可生物蚀解的硅基组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738303A (en) * 1952-07-18 1956-03-13 Smith Kline French Lab Sympathomimetic preparation
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
US4590062A (en) * 1984-04-16 1986-05-20 Tech Trade Corp. Dry direct compression compositions for controlled release dosage forms
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
US4837381A (en) * 1986-08-11 1989-06-06 American Cyanamid Company Compositions for parenteral administration and their use
ATE106242T1 (de) * 1986-08-28 1994-06-15 Enzacor Pty Ltd Mikrogranuläre zubereitung zur verabreichung biologisch aktiver stoffe in den eingeweideregionen von tieren.
AU604052B2 (en) * 1986-08-28 1990-12-06 Enzacor Properties Limited Animal growth promotant
JP2792862B2 (ja) * 1988-07-30 1998-09-03 寛治 高田 経口腸溶製剤

Also Published As

Publication number Publication date
NO913649D0 (no) 1991-09-16
JPH04504122A (ja) 1992-07-23
AU634529B2 (en) 1993-02-25
NO913649L (no) 1991-09-16
WO1990011070A1 (en) 1990-10-04
ES2042292T3 (es) 1993-12-01
AU5279290A (en) 1990-10-22
DK0463061T3 (da) 1993-07-12
EP0463061A1 (de) 1992-01-02
DE69001898D1 (de) 1993-07-15
EP0463061B1 (de) 1993-06-09
DE69001898T2 (de) 1993-09-23

Similar Documents

Publication Publication Date Title
ATE90203T1 (de) Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen.
ATE90557T1 (de) Mikrokapsel mit verzoegerter freigabe fuer wasserloesliche arzneistoffe.
ATE211907T1 (de) Osmotisches arzneimittelfreisetzungssystem
KR900009106A (ko) 체계속으로의 유체의 잠입을 조절하는 수단을 포함하는 전달시스템
ES2157975T3 (es) Soluciones farmaceuticas con solubilidad mejorada.
IL86221A (en) Sustained release microencapsulated drugs and methods for the preparation thereof
FI883785A7 (fi) Kapseli lääkeaineen farmaseuttisesti vaikuttavaa inhalointiainetta varten.
DK163411C (da) Doseringsorgan med styret frigivelse af en aktiv ingrediens til blandt andet dyr
ES2051881T3 (es) Procedimiento de preparacion de un formulacion farmaceutica de liberacion prolongada.
DE60027608D1 (de) Mesalazine enthaltende pharmazeutische Zusammensetzungen mit gesteuerter Freisetzung
KR900007397A (ko) 서방성 제제
AU7465087A (en) Controlled release bioerodible drug delivery system
ATE65023T1 (de) Pharmazeutische mittel.
DK0841903T3 (da) Orale farmaceutiske præparater indeholdende antimikrobielt virksomme aktivstoffer og sustained release pantoprazol
EA199900734A1 (ru) Микрокапсулы, содержащие цис-платину
DE68909772D1 (de) Diclofenac-Natrium-Arzneizubereitung mit verlängerter Wirkstoffabgabe.
ATE66371T1 (de) Arzneimittelzubereitung mit verzoegerter freisetzung.
HUP0003840A2 (hu) Szabályozott hatóanyagleadású gyógyászati készítmények
NO972068D0 (no) Farmasöytisk sammensetning basert på stabiliserte lipofile matriser for kontrollert frigiving av aktive prinsipper
DE69725155D1 (de) Pharmazeutische zubereitungen enthaltend eine kombination aus isosorbid-nitrat und acetylsalicylsaeure
ECSP972004A (es) Absorcion programada de una substancia farmaceutica 2,6- dimetil 4-(2 nitrofenil) -1,4- dihidropiridin- 3,5- dicarboxilato de dimetilo ( nifedipina)
DE3688355D1 (de) Fester koerper mit ueberzogenem kern.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee