ES2157975T3 - Soluciones farmaceuticas con solubilidad mejorada. - Google Patents
Soluciones farmaceuticas con solubilidad mejorada.Info
- Publication number
- ES2157975T3 ES2157975T3 ES94904489T ES94904489T ES2157975T3 ES 2157975 T3 ES2157975 T3 ES 2157975T3 ES 94904489 T ES94904489 T ES 94904489T ES 94904489 T ES94904489 T ES 94904489T ES 2157975 T3 ES2157975 T3 ES 2157975T3
- Authority
- ES
- Spain
- Prior art keywords
- improved solubility
- pharmaceutical solutions
- solutions
- pharmaceutical
- encapsulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Abstract
SE PRESENTAN SOLUCIONES FARMACEUTICAMENTE ACEPTABLES DE AGENTES FARMACEUTICOS ACIDICOS, BASICOS O ANFOTERICOS. ESTAS SOLUCIONES SON ADECUADAS PARA SU ENCAPSULACION EN CAPSULAS DE GELATINA PARA SU POSTERIOR ADMINISTRACION ORAL E INCLUYEN EL AGENTE FARMACEUTICO, UNA ESPECIE IONICA Y UN SISTEMA SOLVENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/993,305 US5376688A (en) | 1992-12-18 | 1992-12-18 | Enhanced solubility pharmaceutical solutions |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2157975T3 true ES2157975T3 (es) | 2001-09-01 |
Family
ID=25539370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94904489T Expired - Lifetime ES2157975T3 (es) | 1992-12-18 | 1993-12-15 | Soluciones farmaceuticas con solubilidad mejorada. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5376688A (es) |
EP (1) | EP0678019B1 (es) |
JP (1) | JP3739391B2 (es) |
AU (1) | AU692431B2 (es) |
CA (1) | CA2152062C (es) |
DE (1) | DE69330353T2 (es) |
ES (1) | ES2157975T3 (es) |
WO (1) | WO1994014423A1 (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3121080B2 (ja) * | 1991-12-19 | 2000-12-25 | アール・ピー・シーラー コーポレイション | カプセル封入用溶液 |
DE69435104D1 (de) | 1993-09-28 | 2008-07-31 | Scherer Gmbh R P | Herstellung von Weichgelatinekapseln |
US6312704B1 (en) * | 1993-09-30 | 2001-11-06 | Gattefosse, S.A. | Orally administrable composition capable of providing enhanced bioavailability when ingested |
US5468502A (en) * | 1994-12-20 | 1995-11-21 | American Home Products Corporation | Ibuprofen enhancing solvent system |
US5641512A (en) * | 1995-03-29 | 1997-06-24 | The Procter & Gamble Company | Soft gelatin capsule compositions |
IT1286778B1 (it) * | 1996-11-20 | 1998-07-17 | Alfa Wassermann Spa | Capsule contenenti diclofenac o suoi sali in soluzione |
WO1998038987A1 (en) * | 1997-03-03 | 1998-09-11 | Sanofi-Synthelabo | Pharmaceutical formulations containing poorly soluble drug substances |
SI0989851T1 (en) | 1997-07-29 | 2003-04-30 | Pharmacia & Upjohn Company | Self-emulsifying formulation for acidic lipophilic compounds |
GB2331458B (en) * | 1997-11-21 | 2002-07-31 | Gursharan Singh Moonga | Solubilising systems for difficult pharmaceutical actives for preparing concentrated stable solutions for encapsulation into soft gelatine |
US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
US6251426B1 (en) | 1999-09-02 | 2001-06-26 | Banner Pharmacaps, Inc. | Ibuprofen-containing softgels |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
WO2001078724A1 (en) * | 2000-04-18 | 2001-10-25 | Pharmacia Corporation | Rapid-onset formulation of a selective cyclooxigenase-2 |
PT1321140E (pt) * | 2000-08-25 | 2005-06-30 | Kowa Co | Solucoes de ibuprofeno para o enchimento de capsulas e preparacoes de capsula |
US6387400B1 (en) | 2000-08-29 | 2002-05-14 | R.P. Scherer Technologies, Inc. | Process for preparing pharmaceutical compositions for use with soft gelatin formulations |
WO2002069936A2 (en) * | 2001-03-02 | 2002-09-12 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical composition of ibuprofen |
US20030034458A1 (en) * | 2001-03-30 | 2003-02-20 | Fuji Photo Film Co., Ltd. | Radiation image storage panel |
EP1269994A3 (en) * | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
US6828301B2 (en) * | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
EP1344523A1 (en) | 2002-03-11 | 2003-09-17 | Warner-Lambert Company | Ibuprofen solution for hard gelatin capsules |
CN1655770A (zh) | 2002-04-25 | 2005-08-17 | 旗帜药物胶囊公司 | 可咀嚼的软胶囊 |
US20030232097A1 (en) * | 2002-06-17 | 2003-12-18 | Strides Inc. | Oily wax matrix suspension formulation comprising ibuprofen free acid and potassium salt of ibuprofen |
US20060241175A1 (en) * | 2002-09-27 | 2006-10-26 | Joseph Schwarz | Vehicle for topical delivery of anti-inflammatory compounds |
US7138394B2 (en) * | 2002-09-27 | 2006-11-21 | Alpharx Inc. | Vehicle for topical delivery of anti-inflammatory compounds |
US20040146537A1 (en) * | 2003-01-28 | 2004-07-29 | Ramachandran Radhakrishnan | Oily wax matrix suspension formulation comprising pharmacologically active agents |
US20090318558A1 (en) * | 2003-02-12 | 2009-12-24 | Jae-Hwan Kim | Solvent system of hardly soluble drug with improved dissolution rate |
JP2006514119A (ja) * | 2003-02-12 | 2006-04-27 | アール アンド ピー コリア カンパニー リミテッド | 溶解率が向上した難溶性薬剤の溶媒系 |
EP1684732A2 (en) * | 2003-11-12 | 2006-08-02 | Ranbaxy Laboratories Limited | Ibuprofen-containing soft gelatin capsules |
US20050137262A1 (en) * | 2003-12-22 | 2005-06-23 | Hu Patrick C. | Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses |
WO2005063219A2 (en) * | 2003-12-23 | 2005-07-14 | Ranbaxy Laboratories Limited | Ibuprofen-containing soft gelatin capsules |
US20050142185A1 (en) * | 2003-12-29 | 2005-06-30 | Beleno Alfredo B. | Softgel formulations of bisphosphonates bone resorption inhibitors |
US20050152968A1 (en) * | 2004-01-09 | 2005-07-14 | Brophy Kristine M. | Microemulsions for pharmaceutical compositions |
WO2005123133A1 (en) * | 2004-06-18 | 2005-12-29 | Ranbaxy Laboratories Limited | A process for preparing ibuprofen soft gelatin capsules |
WO2006034147A2 (en) * | 2004-09-16 | 2006-03-30 | Abraxis Bioscience, Inc. | Compositions and methods for the preparation and administration of poorly water soluble drugs |
US8231896B2 (en) | 2004-11-08 | 2012-07-31 | R.P. Scherer Technologies, Llc | Non-gelatin soft capsule system |
EP1926481A2 (en) * | 2005-09-19 | 2008-06-04 | Albermarle Corporation | Highly concentrated pourable aqueous solutions of potassium ibuprofen their preparation and their uses |
US7582679B2 (en) * | 2006-02-03 | 2009-09-01 | Pharmaceutics International Incorporated | Compositions containing solid ibuprofen concentrates and methods of making solid ibuprofen concentrates |
EP2099431B1 (en) * | 2006-11-28 | 2013-06-05 | Laboratorios Liconsa, S.A. | Stabilized solid pharmaceutical composition of candesartan cilexetil |
WO2009069139A1 (en) * | 2007-11-28 | 2009-06-04 | Alkem Laboratories Ltd. | Dosage form providing an ibuprofen-containing liquid fill |
US9629809B2 (en) | 2008-07-21 | 2017-04-25 | Si Group, Inc. | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms |
BRPI0916344A2 (pt) | 2008-07-21 | 2020-07-21 | Albemarle Corporation | grânulos com alto teor de ibuprofeno de sódio, preparação e utilização para preparação de formas de dosagem sólidas não efervescentes |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
JP2020503269A (ja) | 2016-11-28 | 2020-01-30 | リポカイン インコーポレーテッド | 経口ウンデカン酸テストステロン療法 |
WO2019224832A1 (en) | 2018-05-25 | 2019-11-28 | Strides Shasun Limited | Process for preparing pharmaceutical compositions resulting in reduction in overall fill volume for use with soft gelatin formulations |
GB2595453B (en) | 2020-05-21 | 2024-04-03 | Reckitt Benckiser Health Ltd | Novel Formulation |
GB2595300B (en) | 2020-05-21 | 2024-03-27 | Reckitt Benckiser Health Ltd | Novel Formulation |
GB2595301A (en) | 2020-05-21 | 2021-11-24 | Reckitt Benckiser Health Ltd | Novel formulation |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4188373A (en) * | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
DE3307353C2 (de) * | 1983-03-02 | 1985-01-31 | R.P. Scherer GmbH, 6930 Eberbach | Polyethylenglykolhaltige Weichgelatinekapsel und Verfahren zu ihrer Herstellung |
GB8305693D0 (en) * | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
DE3629386A1 (de) * | 1986-08-29 | 1988-03-03 | Scherer Gmbh R P | Gelatinekapseln und verfahren zu ihrer herstellung |
US5071643A (en) * | 1986-10-17 | 1991-12-10 | R. P. Scherer Corporation | Solvent system enhancing the solubility of pharmaceuticals for encapsulation |
US5141961A (en) * | 1991-06-27 | 1992-08-25 | Richrdson-Vicks Inc. | Process for solubilizing difficulty soluble pharmaceutical actives |
JPH0525037A (ja) * | 1991-07-01 | 1993-02-02 | Upjohn Co:The | 経口投与酵素感受性腸溶製剤 |
US5200191A (en) * | 1991-09-11 | 1993-04-06 | Banner Gelatin Products Corp. | Softgel manufacturing process |
-
1992
- 1992-12-18 US US07/993,305 patent/US5376688A/en not_active Expired - Lifetime
-
1993
- 1993-12-15 WO PCT/US1993/012346 patent/WO1994014423A1/en active IP Right Grant
- 1993-12-15 AU AU58518/94A patent/AU692431B2/en not_active Ceased
- 1993-12-15 ES ES94904489T patent/ES2157975T3/es not_active Expired - Lifetime
- 1993-12-15 JP JP51533194A patent/JP3739391B2/ja not_active Expired - Fee Related
- 1993-12-15 CA CA002152062A patent/CA2152062C/en not_active Expired - Fee Related
- 1993-12-15 EP EP94904489A patent/EP0678019B1/en not_active Expired - Lifetime
- 1993-12-15 DE DE69330353T patent/DE69330353T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU692431B2 (en) | 1998-06-11 |
WO1994014423A1 (en) | 1994-07-07 |
JPH08507494A (ja) | 1996-08-13 |
EP0678019B1 (en) | 2001-06-13 |
EP0678019A1 (en) | 1995-10-25 |
DE69330353T2 (de) | 2002-05-02 |
JP3739391B2 (ja) | 2006-01-25 |
AU5851894A (en) | 1994-07-19 |
DE69330353D1 (de) | 2001-07-19 |
CA2152062C (en) | 1999-01-05 |
CA2152062A1 (en) | 1994-07-07 |
US5376688A (en) | 1994-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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