DE69505697D1 - Biologisch abbaubare mikrosphären mit gesteuerter freigabe und verfahren zu deren herstellung - Google Patents
Biologisch abbaubare mikrosphären mit gesteuerter freigabe und verfahren zu deren herstellungInfo
- Publication number
- DE69505697D1 DE69505697D1 DE69505697T DE69505697T DE69505697D1 DE 69505697 D1 DE69505697 D1 DE 69505697D1 DE 69505697 T DE69505697 T DE 69505697T DE 69505697 T DE69505697 T DE 69505697T DE 69505697 D1 DE69505697 D1 DE 69505697D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- microspheres
- active ingredient
- date oct
- emulsifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9404511A FR2718642B1 (fr) | 1994-04-15 | 1994-04-15 | Microsphères biodégradables à libération contrôlée et leur procédé de préparation. |
PCT/FR1995/000485 WO1995028149A1 (fr) | 1994-04-15 | 1995-04-13 | Microspheres biodegradables a liberation controlee et leur procede de preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69505697D1 true DE69505697D1 (de) | 1998-12-03 |
DE69505697T2 DE69505697T2 (de) | 1999-06-10 |
Family
ID=9462140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69505697T Expired - Lifetime DE69505697T2 (de) | 1994-04-15 | 1995-04-13 | Biologisch abbaubare mikrosphären mit gesteuerter freigabe und verfahren zu deren herstellung |
Country Status (11)
Country | Link |
---|---|
US (1) | US5733567A (de) |
EP (1) | EP0804173B1 (de) |
JP (1) | JP4073478B2 (de) |
AT (1) | ATE172639T1 (de) |
AU (1) | AU698796B2 (de) |
CA (1) | CA2187898C (de) |
DE (1) | DE69505697T2 (de) |
DK (1) | DK0804173T3 (de) |
FR (1) | FR2718642B1 (de) |
NZ (1) | NZ284826A (de) |
WO (1) | WO1995028149A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
DE69705746T2 (de) | 1996-12-20 | 2001-10-31 | Alza Corp | Injizierbare depotgelzubereitung und herstellungsverfahren |
AU760034B2 (en) * | 1997-08-29 | 2003-05-08 | Corixa Corporation | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof |
KR19990085365A (ko) * | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
US20030211974A1 (en) * | 2000-03-21 | 2003-11-13 | Brodbeck Kevin J. | Gel composition and methods |
AR023940A1 (es) * | 2000-05-03 | 2002-09-04 | Eriochem Sa | Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua |
CN1189159C (zh) | 2000-05-05 | 2005-02-16 | 欧莱雅 | 含水溶性美容活性组分水性核的微胶囊及含其的组合物 |
US6565888B1 (en) | 2000-08-23 | 2003-05-20 | Alkermes Controlled Therapeutics, Inc. | Methods and compositions for the targeted delivery of biologically active agents |
EP1343480B2 (de) | 2000-12-21 | 2016-02-17 | Alrise Biosystems GmbH | Verfahren umfassend einen induzierten phasenübergang zur herstellung von hydrophobe wirkstoffe enthaltenden mikropartikeln |
JP2004535431A (ja) * | 2001-06-22 | 2004-11-25 | サザン バイオシステムズ, インコーポレイテッド | ゼロ次長期放出同軸インプラント |
ES2194590B2 (es) * | 2001-10-10 | 2006-02-16 | Pierre Fabre Iberica S.A. | Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion. |
BRPI0213226B1 (pt) * | 2001-10-10 | 2016-03-01 | Pf Medicament | processo de preparação de uma composição farmacêutica sob forma de microesferas com liberação prolongada de um princípio ativo hidrossolúvel, e, microesferas |
FR2830448B1 (fr) * | 2001-10-10 | 2004-03-19 | Pf Medicament | Microspheres biodegradables a liberation prolongee et leur procede de preparation |
US7235488B2 (en) * | 2002-08-28 | 2007-06-26 | Micron Technology, Inc. | In-situ chemical-mechanical planarization pad metrology using ultrasonic imaging |
WO2004022000A2 (en) * | 2002-09-05 | 2004-03-18 | Ambrose Catherine G | Antibiotic microspheres for treatment of infections and osteomyelitis |
US8986737B2 (en) * | 2002-09-05 | 2015-03-24 | Wm. Marsh Rice University | Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth |
CN1323096C (zh) * | 2005-05-26 | 2007-06-27 | 中国科学院长春应用化学研究所 | 生物可降解聚酯微粒及其制备方法和用途 |
US9693967B2 (en) * | 2005-09-07 | 2017-07-04 | Southwest Research Institute | Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates |
US20070106271A1 (en) * | 2005-11-09 | 2007-05-10 | Searete Llc, A Limited Liability Corporation | Remote control of substance delivery system |
ES2718612T3 (es) * | 2007-12-20 | 2019-07-03 | Evonik Corp | Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual |
WO2014106267A1 (en) * | 2012-12-31 | 2014-07-03 | Bacterin International, Inc. | Composition of d-alpha hydroxy acids and antimicrobials |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5389377A (en) * | 1989-12-22 | 1995-02-14 | Molecular Bioquest, Inc. | Solid care therapeutic compositions and methods for making same |
NO302481B1 (no) * | 1990-10-16 | 1998-03-09 | Takeda Chemical Industries Ltd | Polymer for et preparat med forlenget frigjöring, samt preparat med forlenget frigjöring |
WO1993000156A1 (en) * | 1991-06-29 | 1993-01-07 | Miyazaki-Ken | Monodisperse single and double emulsions and production thereof |
JP3051945B2 (ja) * | 1991-07-22 | 2000-06-12 | 大阪瓦斯株式会社 | 無機質均一微小球体、及びその製造方法 |
ES2181691T5 (es) * | 1992-06-11 | 2007-10-01 | Alkermes Controlled Therapeutics, Inc. | Sistema de distribucion de proteina eritropoyetina. |
FR2692147B1 (fr) * | 1992-06-15 | 1995-02-24 | Centre Nat Rech Scient | Microsphères en polymère biorésorbable exemptes de tensioactif, leur préparation et leur application comme médicament. |
-
1994
- 1994-04-15 FR FR9404511A patent/FR2718642B1/fr not_active Expired - Fee Related
-
1995
- 1995-04-13 US US08/722,159 patent/US5733567A/en not_active Expired - Lifetime
- 1995-04-13 AT AT95917394T patent/ATE172639T1/de active
- 1995-04-13 JP JP52676995A patent/JP4073478B2/ja not_active Expired - Lifetime
- 1995-04-13 NZ NZ284826A patent/NZ284826A/en not_active IP Right Cessation
- 1995-04-13 CA CA002187898A patent/CA2187898C/fr not_active Expired - Lifetime
- 1995-04-13 DK DK95917394T patent/DK0804173T3/da active
- 1995-04-13 WO PCT/FR1995/000485 patent/WO1995028149A1/fr active IP Right Grant
- 1995-04-13 DE DE69505697T patent/DE69505697T2/de not_active Expired - Lifetime
- 1995-04-13 EP EP95917394A patent/EP0804173B1/de not_active Expired - Lifetime
- 1995-04-13 AU AU23478/95A patent/AU698796B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPH09512002A (ja) | 1997-12-02 |
EP0804173A1 (de) | 1997-11-05 |
WO1995028149A1 (fr) | 1995-10-26 |
ATE172639T1 (de) | 1998-11-15 |
AU2347895A (en) | 1995-11-10 |
NZ284826A (en) | 1997-12-19 |
DE69505697T2 (de) | 1999-06-10 |
CA2187898A1 (fr) | 1995-10-26 |
AU698796B2 (en) | 1998-11-05 |
FR2718642A1 (fr) | 1995-10-20 |
DK0804173T3 (da) | 1999-07-12 |
FR2718642B1 (fr) | 1996-07-12 |
EP0804173B1 (de) | 1998-10-28 |
CA2187898C (fr) | 2005-08-23 |
US5733567A (en) | 1998-03-31 |
JP4073478B2 (ja) | 2008-04-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |