AR023940A1 - Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua - Google Patents

Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua

Info

Publication number
AR023940A1
AR023940A1 ARP000102102A ARP000102102A AR023940A1 AR 023940 A1 AR023940 A1 AR 023940A1 AR P000102102 A ARP000102102 A AR P000102102A AR P000102102 A ARP000102102 A AR P000102102A AR 023940 A1 AR023940 A1 AR 023940A1
Authority
AR
Argentina
Prior art keywords
water
microcapsules
fed
oil
continuously
Prior art date
Application number
ARP000102102A
Other languages
English (en)
Original Assignee
Eriochem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eriochem Sa filed Critical Eriochem Sa
Priority to ARP000102102A priority Critical patent/AR023940A1/es
Priority to DE60106666T priority patent/DE60106666T2/de
Priority to AT01201558T priority patent/ATE280573T1/de
Priority to EP01201558A priority patent/EP1151748B1/en
Priority to ES01201558T priority patent/ES2230231T3/es
Priority to US09/848,623 priority patent/US6534094B2/en
Publication of AR023940A1 publication Critical patent/AR023940A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Abstract

Un procedimiento para la produccion de microcápsulas de liberacion prolongada de péptidos solubles en agua, utilizables en preparaciones inyectables y conperíodos de liberacion regulables entre 1 y 18 semanas, que consiste en emulsionar, en forma continua, una solucion acuosa de un péptido activo, en unasolucion oleosa de un polímero biodegradable disuelto en un solvente orgánico muy poco soluble en agua, utilizándose para tal fin una primera cámara deagitacion intensa, cerrada al ambiente, alimentada mediante dosificadoras; esta primera emulsion agua/aceite, luego de ser enfriada, es alimentada mediante unadosificadora a una segunda cámara de agitacion intensa cerrada al ambiente, donde es emulsionada en forma continua en una fase acuosa vehículo conteniendo uncoloide hidrofílico protector, que se alimenta mediante una dosificadora continua; esta segunda emulsion compleja del tipo agua/aceite/agua se transporta enforma continua a un recipiente cerrado donde el solvente es evaporado por reduccion de la presion, produciéndose la consolidacion de las microcápsulas; luegoestas microcápsulas se someten a las siguientes operaciones en vía humeda: se tamizan en suspension; se centrifugan; se lavan con agua; y se fraccionan enrecipientesadecuados, dispersadas en un medio acuoso conteniendo un excipiente de liofilizacion; seguidamente se congelan en un congelador de agitacionorbital hasta temperaturas menores de -20°C y se liofilizan en los mismos recipientes.
ARP000102102A 2000-05-03 2000-05-03 Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua AR023940A1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ARP000102102A AR023940A1 (es) 2000-05-03 2000-05-03 Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
DE60106666T DE60106666T2 (de) 2000-05-03 2001-05-01 Kontinuierlicher Prozess für die Herstellung von Mikrokapseln mit verzögerten Freisetzung von wasserlöslichen Peptiden
AT01201558T ATE280573T1 (de) 2000-05-03 2001-05-01 Kontinuierlicher prozess für die herstellung von mikrokapseln mit verzögerten freisetzung von wasserlöslichen peptiden
EP01201558A EP1151748B1 (en) 2000-05-03 2001-05-01 Continuous manufacturing procedure of microcapsules for extended release of water soluble peptides
ES01201558T ES2230231T3 (es) 2000-05-03 2001-05-01 Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua.
US09/848,623 US6534094B2 (en) 2000-05-03 2001-05-03 Manufacturing process of microcapsules for sustained release of water soluble peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP000102102A AR023940A1 (es) 2000-05-03 2000-05-03 Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua

Publications (1)

Publication Number Publication Date
AR023940A1 true AR023940A1 (es) 2002-09-04

Family

ID=3460812

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000102102A AR023940A1 (es) 2000-05-03 2000-05-03 Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua

Country Status (6)

Country Link
US (1) US6534094B2 (es)
EP (1) EP1151748B1 (es)
AR (1) AR023940A1 (es)
AT (1) ATE280573T1 (es)
DE (1) DE60106666T2 (es)
ES (1) ES2230231T3 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002324447B2 (en) * 2001-06-22 2006-06-29 Durect Corporation Zero-order prolonged release coaxial implants
CN1194688C (zh) * 2001-07-03 2005-03-30 山东绿叶制药股份有限公司 石杉碱甲及其衍生物或其盐的注射用缓释微球及其制备方法
US6974592B2 (en) * 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
DE60332958D1 (de) * 2002-11-04 2010-07-22 Ocean Nutrition Canada Ltd Mikrokapseln mit mehrfachen hüllen und verfahren zu deren herstellung
JP4732353B2 (ja) * 2003-10-16 2011-07-27 バーゼル・ポリオレフィン・イタリア・ソチエタ・ア・レスポンサビリタ・リミタータ エマルジョンの連続製造方法
WO2005110369A2 (en) * 2004-04-30 2005-11-24 American Pharmaceutical Partners, Inc. Sustained-release microspheres and methods of making and using same
US6969530B1 (en) 2005-01-21 2005-11-29 Ocean Nutrition Canada Ltd. Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
US8034450B2 (en) * 2005-01-21 2011-10-11 Ocean Nutrition Canada Limited Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
US20080206316A1 (en) * 2005-01-27 2008-08-28 Colin Barrow Chromium-Fatty Acid Compounds and Methods of Making and Using Thereof
DE602006011127D1 (de) * 2005-01-27 2010-01-28 Ocean Nutrition Canada Ltd Fettsäure-benzenediol-derivate sowie herstellungs- und verwendungsverfahren dafür
AR048220A1 (es) * 2005-01-28 2006-04-12 Lkm S A Lab Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido
WO2006123361A2 (en) * 2005-03-01 2006-11-23 Sun Pharmaceutical Industries Limited Microspheres containing goserelin or a pharmaceutically acceptable salt thereof
US20090104274A1 (en) * 2005-03-01 2009-04-23 Ajay Khopade Process of making microspheres
KR100622996B1 (ko) 2005-03-03 2006-09-14 한국과학기술원 약물이 봉입된 비다공성 고분자 미립 담체 및 이의 제조방법
US9968120B2 (en) * 2006-05-17 2018-05-15 Dsm Nutritional Products Ag Homogenized formulations containing microcapsules and methods of making and using thereof
US8882747B2 (en) * 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
AU2007238985B2 (en) * 2006-04-07 2012-09-20 Dsm Nutritional Products Ag Emulsions and microcapsules with substances having low interfacial tension, methods of making and using thereof
WO2008017962A2 (en) * 2006-06-05 2008-02-14 Ocean Nutrition Canada Ltd. Microcapsules with improved shells
KR100853309B1 (ko) 2006-11-01 2008-08-20 나재운 시프로플록사신이 담지된 폴리락타이드글리콜라이드공중합체의 서방출 및 생분해성 나노입자 및 그 제조방법
KR100816065B1 (ko) * 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
EP2124905B1 (en) 2007-01-10 2016-09-07 DSM Nutritional Products AG Microcapsules including pea protein
ES2545775T3 (es) 2007-02-05 2015-09-15 Apellis Pharmaceuticals, Inc. Análogos de compstatina para uso en el tratamiento de afecciones inflamatorias del sistema respiratorio
EP2139447A2 (en) * 2007-03-20 2010-01-06 Harold Brem Gm-csf cosmeceutical compositions and methods of use thereof
EP2090605B1 (de) * 2008-02-13 2011-07-13 Bayer MaterialScience AG Verfahren zur Herstellung von Polycarbonaten
WO2010121307A1 (en) * 2009-04-21 2010-10-28 The University Of Queensland Complex emulsions
US20110053776A1 (en) * 2009-09-01 2011-03-03 Bahr James T Blends of micro-encapsulated pesticide formulations
CN102665690A (zh) * 2009-12-22 2012-09-12 武田药品工业株式会社 缓释制剂
EA021663B1 (ru) * 2010-06-25 2015-08-31 Такеда Фармасьютикал Компани Лимитед Композиция с замедленным высвобождением, способ ее получения и способ лечения рака
WO2013039096A1 (ja) * 2011-09-13 2013-03-21 理研ビタミン株式会社 多芯型ゼラチンマイクロカプセルの製造方法
SI2790675T1 (sl) 2011-12-14 2019-11-29 Abraxis Bioscience Llc Uporaba polimernih pomožnih snovi za liofilizacijo ali zamrzovanje delcev
CN103191021A (zh) * 2012-01-10 2013-07-10 山东绿叶制药有限公司 一种连续生产微球的设备及其应用
EP2689835B1 (de) * 2012-07-26 2019-05-08 Papierfabrik August Koehler SE Duftölverkapselung
US20150224176A1 (en) * 2012-08-14 2015-08-13 Wockhardt Limited Pharmaceutical microparticulate compositions of polypeptides
JP6135292B2 (ja) * 2013-05-10 2017-05-31 ニプロ株式会社 マイクロカプセル製剤の製造方法
KR101686986B1 (ko) * 2014-07-28 2016-12-16 에스케이케미칼주식회사 류프로라이드를 포함하는 속효성과 지속성을 동시에 갖는 약제학적 조성물
US20190380967A1 (en) * 2017-01-23 2019-12-19 Savior Lifetec Corporation Preparation of microparticles of an active ingredient
CN107766606B (zh) * 2017-09-01 2020-03-31 燕山大学 提升二次冷轧机组直喷系统乳化液工艺润滑性能的方法
KR102171829B1 (ko) 2019-11-15 2020-10-29 한국신발피혁연구원 웨트 슈트용 클로로프렌 발포체 조성물
CN111000798B (zh) * 2019-12-26 2021-11-23 四川恒博生物科技有限公司 一种采用原位凝胶技术的犬用非手术去势注射液
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans
CN115501143B (zh) * 2022-10-21 2023-08-22 中科未来(无锡)生物技术研究院有限公司 一种含有雪莲培养物的抗敏舒缓组合物及其制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800457A (en) 1953-06-30 1957-07-23 Ncr Co Oil-containing microscopic capsules and method of making them
FR1362933A (fr) 1962-07-11 1964-06-05 Gevaert Photo Prod Nv Procédé pour l'encapsulage d'eau et de composés en phase aqueuse
FR1362934A (fr) 1962-07-11 1964-06-05 Gevaert Photo Prod Nv Méthode pour l'encapsulage d'eau et de composés en phase aqueuse
US3297033A (en) 1963-10-31 1967-01-10 American Cyanamid Co Surgical sutures
BE744162A (fr) 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3839297A (en) 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
GB1413186A (en) 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
DE2438350C3 (de) 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US4010125A (en) 1975-06-12 1977-03-01 Schally Andrew Victor [D-Trp6 ]-LH-RH and intermediates therefor
GB1524747A (en) 1976-05-11 1978-09-13 Ici Ltd Polypeptide
US4234571A (en) 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
US4273920A (en) 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
CH653553A5 (en) * 1982-11-01 1986-01-15 Sandoz Ag Microencapsulation process
CH661206A5 (fr) 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
EP0190833B1 (en) 1985-02-07 1991-03-27 Takeda Chemical Industries, Ltd. Method for producing microcapsule
US5271945A (en) 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
CA2079509C (en) 1991-10-01 2002-05-14 Shigeyuki Takada Prolonged release microparticle preparation and production of the same
FR2693905B1 (fr) 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
EP0582459B1 (en) 1992-08-07 1998-01-07 Takeda Chemical Industries, Ltd. Production of microcapsules of water-soluble drugs
EP2275089A1 (en) * 1993-11-19 2011-01-19 Alkermes Controlled Therapeutics, Inc. Preparation of biodegradable microparticles containing a biologically active agent
FR2718642B1 (fr) * 1994-04-15 1996-07-12 Pf Medicament Microsphères biodégradables à libération contrôlée et leur procédé de préparation.
JP2909418B2 (ja) 1995-09-18 1999-06-23 株式会社資生堂 薬物の遅延放出型マイクロスフイア
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
DE19925184A1 (de) * 1999-05-26 2000-11-30 Schering Ag Kontinuierliches Verfahren zur Herstellung von morphologisch einheitlichen Mikro- und Nanopartikeln mittels Mikromischer sowie nach diesem Verfahren hergestellte Partikel

Also Published As

Publication number Publication date
EP1151748B1 (en) 2004-10-27
EP1151748A1 (en) 2001-11-07
DE60106666T2 (de) 2005-03-24
US20020031553A1 (en) 2002-03-14
DE60106666D1 (de) 2004-12-02
US6534094B2 (en) 2003-03-18
ES2230231T3 (es) 2005-05-01
ATE280573T1 (de) 2004-11-15

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