DE60106666D1 - Kontinuierlicher Prozess für die Herstellung von Mikrokapseln mit verzögerten Freisetzung von wasserlöslichen Peptiden - Google Patents
Kontinuierlicher Prozess für die Herstellung von Mikrokapseln mit verzögerten Freisetzung von wasserlöslichen PeptidenInfo
- Publication number
- DE60106666D1 DE60106666D1 DE60106666T DE60106666T DE60106666D1 DE 60106666 D1 DE60106666 D1 DE 60106666D1 DE 60106666 T DE60106666 T DE 60106666T DE 60106666 T DE60106666 T DE 60106666T DE 60106666 D1 DE60106666 D1 DE 60106666D1
- Authority
- DE
- Germany
- Prior art keywords
- microcapsules
- production
- water
- continuous process
- delayed release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP000102102A AR023940A1 (es) | 2000-05-03 | 2000-05-03 | Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua |
AR0102102 | 2000-05-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60106666D1 true DE60106666D1 (de) | 2004-12-02 |
DE60106666T2 DE60106666T2 (de) | 2005-03-24 |
Family
ID=3460812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60106666T Expired - Lifetime DE60106666T2 (de) | 2000-05-03 | 2001-05-01 | Kontinuierlicher Prozess für die Herstellung von Mikrokapseln mit verzögerten Freisetzung von wasserlöslichen Peptiden |
Country Status (6)
Country | Link |
---|---|
US (1) | US6534094B2 (de) |
EP (1) | EP1151748B1 (de) |
AR (1) | AR023940A1 (de) |
AT (1) | ATE280573T1 (de) |
DE (1) | DE60106666T2 (de) |
ES (1) | ES2230231T3 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004535431A (ja) * | 2001-06-22 | 2004-11-25 | サザン バイオシステムズ, インコーポレイテッド | ゼロ次長期放出同軸インプラント |
CN1194688C (zh) * | 2001-07-03 | 2005-03-30 | 山东绿叶制药股份有限公司 | 石杉碱甲及其衍生物或其盐的注射用缓释微球及其制备方法 |
US6974592B2 (en) * | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
WO2004041251A1 (en) * | 2002-11-04 | 2004-05-21 | Ocean Nutrition Canada Limited | Microcapsules having multiple shells and method for the preparation thereof |
WO2005039745A1 (en) * | 2003-10-16 | 2005-05-06 | Basell Poliolefine Italia S.R.L. | Process for the continuous production of emulsions |
CA2565296C (en) * | 2004-04-30 | 2014-06-03 | Abraxis Bioscience, Inc. | Sustained-release microspheres and methods of making and using same |
US8034450B2 (en) * | 2005-01-21 | 2011-10-11 | Ocean Nutrition Canada Limited | Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof |
US6969530B1 (en) | 2005-01-21 | 2005-11-29 | Ocean Nutrition Canada Ltd. | Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof |
US20080206316A1 (en) * | 2005-01-27 | 2008-08-28 | Colin Barrow | Chromium-Fatty Acid Compounds and Methods of Making and Using Thereof |
WO2006117675A1 (en) * | 2005-01-27 | 2006-11-09 | Ocean Nutrition Canada Ltd. | Fatty acid-benzenediol derivatives and methods of making and using thereof |
AR048220A1 (es) * | 2005-01-28 | 2006-04-12 | Lkm S A Lab | Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido |
WO2006123359A2 (en) * | 2005-03-01 | 2006-11-23 | Sun Pharmaceutical Industries Limited | A process of making microspheres |
US20090123556A1 (en) * | 2005-03-01 | 2009-05-14 | Sun Pharmaceutical Industries Limited | Sustained release pharmaceutical compositions |
KR100622996B1 (ko) | 2005-03-03 | 2006-09-14 | 한국과학기술원 | 약물이 봉입된 비다공성 고분자 미립 담체 및 이의 제조방법 |
US9968120B2 (en) * | 2006-05-17 | 2018-05-15 | Dsm Nutritional Products Ag | Homogenized formulations containing microcapsules and methods of making and using thereof |
US7942867B2 (en) * | 2005-11-09 | 2011-05-17 | The Invention Science Fund I, Llc | Remotely controlled substance delivery device |
EP2007224A2 (de) * | 2006-04-07 | 2008-12-31 | Ocean Nutrition Canada Limited | Emulsionen und mikrokapseln mit stoffen mit geringer grenzflächenspannung, herstellungsverfahren und verwendung |
KR20090046773A (ko) * | 2006-06-05 | 2009-05-11 | 오션 뉴트리션 캐나다 리미티드 | 개선된 쉘을 가지는 마이크로캡슐 |
KR100853309B1 (ko) * | 2006-11-01 | 2008-08-20 | 나재운 | 시프로플록사신이 담지된 폴리락타이드글리콜라이드공중합체의 서방출 및 생분해성 나노입자 및 그 제조방법 |
KR100816065B1 (ko) * | 2006-11-27 | 2008-03-24 | 동국제약 주식회사 | 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐 |
CA2675123C (en) | 2007-01-10 | 2017-04-11 | Ocean Nutrition Canada Limited | Vegetarian microcapsules |
AU2008214359B2 (en) | 2007-02-05 | 2014-01-16 | Apellis Pharmaceuticals, Inc. | Local complement inhibition for treatment of complement-mediated disorders |
US8673859B2 (en) * | 2007-03-20 | 2014-03-18 | New York University | GM-CSF cosmeceutical compositions and methods of use thereof |
ATE516316T1 (de) * | 2008-02-13 | 2011-07-15 | Bayer Materialscience Ag | Verfahren zur herstellung von polycarbonaten |
WO2010121307A1 (en) * | 2009-04-21 | 2010-10-28 | The University Of Queensland | Complex emulsions |
US20110053776A1 (en) * | 2009-09-01 | 2011-03-03 | Bahr James T | Blends of micro-encapsulated pesticide formulations |
JP2013514968A (ja) * | 2009-12-22 | 2013-05-02 | 武田薬品工業株式会社 | 徐放性製剤 |
WO2011162413A1 (en) * | 2010-06-25 | 2011-12-29 | Takeda Pharmaceutical Company Limited | Sustained-release formulation |
KR101978361B1 (ko) * | 2011-09-13 | 2019-05-14 | 리켄 비타민 가부시키가이샤 | 다심형 젤라틴 마이크로캅셀의 제조 방법 |
HUE045661T2 (hu) | 2011-12-14 | 2020-01-28 | Abraxis Bioscience Llc | Polimer segédanyagok alkalmazása részecskék liofilizálásához vagy fagyasztásához |
CN103191021A (zh) * | 2012-01-10 | 2013-07-10 | 山东绿叶制药有限公司 | 一种连续生产微球的设备及其应用 |
EP2689835B1 (de) * | 2012-07-26 | 2019-05-08 | Papierfabrik August Koehler SE | Duftölverkapselung |
US20150224176A1 (en) * | 2012-08-14 | 2015-08-13 | Wockhardt Limited | Pharmaceutical microparticulate compositions of polypeptides |
JP6135292B2 (ja) * | 2013-05-10 | 2017-05-31 | ニプロ株式会社 | マイクロカプセル製剤の製造方法 |
KR101686986B1 (ko) * | 2014-07-28 | 2016-12-16 | 에스케이케미칼주식회사 | 류프로라이드를 포함하는 속효성과 지속성을 동시에 갖는 약제학적 조성물 |
US20190380967A1 (en) * | 2017-01-23 | 2019-12-19 | Savior Lifetec Corporation | Preparation of microparticles of an active ingredient |
CN107766606B (zh) * | 2017-09-01 | 2020-03-31 | 燕山大学 | 提升二次冷轧机组直喷系统乳化液工艺润滑性能的方法 |
KR102171829B1 (ko) | 2019-11-15 | 2020-10-29 | 한국신발피혁연구원 | 웨트 슈트용 클로로프렌 발포체 조성물 |
CN111000798B (zh) * | 2019-12-26 | 2021-11-23 | 四川恒博生物科技有限公司 | 一种采用原位凝胶技术的犬用非手术去势注射液 |
US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
CN115501143B (zh) * | 2022-10-21 | 2023-08-22 | 中科未来(无锡)生物技术研究院有限公司 | 一种含有雪莲培养物的抗敏舒缓组合物及其制备方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2800457A (en) | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
FR1362933A (fr) | 1962-07-11 | 1964-06-05 | Gevaert Photo Prod Nv | Procédé pour l'encapsulage d'eau et de composés en phase aqueuse |
FR1362934A (fr) | 1962-07-11 | 1964-06-05 | Gevaert Photo Prod Nv | Méthode pour l'encapsulage d'eau et de composés en phase aqueuse |
US3297033A (en) | 1963-10-31 | 1967-01-10 | American Cyanamid Co | Surgical sutures |
BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US3839297A (en) | 1971-11-22 | 1974-10-01 | Ethicon Inc | Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures |
GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
DE2438350C3 (de) | 1974-08-09 | 1979-06-13 | Hoechst Ag, 6000 Frankfurt | Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
US4010125A (en) | 1975-06-12 | 1977-03-01 | Schally Andrew Victor | [D-Trp6 ]-LH-RH and intermediates therefor |
GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
US4234571A (en) | 1979-06-11 | 1980-11-18 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone |
US4273920A (en) | 1979-09-12 | 1981-06-16 | Eli Lilly And Company | Polymerization process and product |
US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
CH653553A5 (en) * | 1982-11-01 | 1986-01-15 | Sandoz Ag | Microencapsulation process |
CH661206A5 (fr) | 1983-09-23 | 1987-07-15 | Debiopharm Sa | Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes. |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
EP0190833B1 (de) | 1985-02-07 | 1991-03-27 | Takeda Chemical Industries, Ltd. | Verfahren zur Herstellung von Mikrokapseln |
US5271945A (en) | 1988-07-05 | 1993-12-21 | Takeda Chemical Industries, Ltd. | Sustained release microcapsule for water soluble drug |
DE69220317T2 (de) | 1991-10-01 | 1997-10-16 | Takeda Chemical Industries Ltd | Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe |
FR2693905B1 (fr) | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
DE69316101T2 (de) | 1992-08-07 | 1998-10-22 | Takeda Chemical Industries Ltd | Herstellung von Mikrokapseln, die wasserlösliche Arzneimittel enthalten |
DE69429820T3 (de) * | 1993-11-19 | 2013-02-28 | Alkermes Controlled Therapeutics, Inc. | Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel |
FR2718642B1 (fr) * | 1994-04-15 | 1996-07-12 | Pf Medicament | Microsphères biodégradables à libération contrôlée et leur procédé de préparation. |
JP2909418B2 (ja) | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
DE19925184A1 (de) * | 1999-05-26 | 2000-11-30 | Schering Ag | Kontinuierliches Verfahren zur Herstellung von morphologisch einheitlichen Mikro- und Nanopartikeln mittels Mikromischer sowie nach diesem Verfahren hergestellte Partikel |
-
2000
- 2000-05-03 AR ARP000102102A patent/AR023940A1/es not_active Application Discontinuation
-
2001
- 2001-05-01 DE DE60106666T patent/DE60106666T2/de not_active Expired - Lifetime
- 2001-05-01 ES ES01201558T patent/ES2230231T3/es not_active Expired - Lifetime
- 2001-05-01 AT AT01201558T patent/ATE280573T1/de active
- 2001-05-01 EP EP01201558A patent/EP1151748B1/de not_active Expired - Lifetime
- 2001-05-03 US US09/848,623 patent/US6534094B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6534094B2 (en) | 2003-03-18 |
US20020031553A1 (en) | 2002-03-14 |
AR023940A1 (es) | 2002-09-04 |
DE60106666T2 (de) | 2005-03-24 |
EP1151748B1 (de) | 2004-10-27 |
ES2230231T3 (es) | 2005-05-01 |
EP1151748A1 (de) | 2001-11-07 |
ATE280573T1 (de) | 2004-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |