ES2194590A1 - Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion. - Google Patents

Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.

Info

Publication number
ES2194590A1
ES2194590A1 ES200102261A ES200102261A ES2194590A1 ES 2194590 A1 ES2194590 A1 ES 2194590A1 ES 200102261 A ES200102261 A ES 200102261A ES 200102261 A ES200102261 A ES 200102261A ES 2194590 A1 ES2194590 A1 ES 2194590A1
Authority
ES
Spain
Prior art keywords
water
lactide
sustained release
soluble drug
emulsifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200102261A
Other languages
English (en)
Other versions
ES2194590B2 (es
Inventor
Eulalia Ferret
Miguel Angel Asin
Jesus Garcia
Pere Tarin
Rosa Arola
Montserrat Rutllan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Iberica SA
Original Assignee
Pierre Fabre Iberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200102261A priority Critical patent/ES2194590B2/es
Application filed by Pierre Fabre Iberica SA filed Critical Pierre Fabre Iberica SA
Priority to BRPI0213226A priority patent/BRPI0213226B1/pt
Priority to EP02793162.5A priority patent/EP1450766B1/fr
Priority to PCT/FR2002/003447 priority patent/WO2003030870A1/fr
Priority to JP2003533903A priority patent/JP2005509611A/ja
Priority to CNB02824575XA priority patent/CN100518828C/zh
Priority to US10/492,417 priority patent/US7691412B2/en
Priority to CA2463358A priority patent/CA2463358C/fr
Priority to AU2002358831A priority patent/AU2002358831B2/en
Priority to ES02793162.5T priority patent/ES2541908T3/es
Priority to MXPA04003433A priority patent/MXPA04003433A/es
Publication of ES2194590A1 publication Critical patent/ES2194590A1/es
Application granted granted Critical
Publication of ES2194590B2 publication Critical patent/ES2194590B2/es
Priority to JP2010046540A priority patent/JP2010174021A/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

La presente invención se refiere a un procedimiento de preparación de una composición farmacéutica en forma de microesferas con liberación prolongada de un principio activo hidrosoluble y microesferas obtenidas, que comprende la sucesión de las etapas siguientes: - disolución del principio activo en una cantidad apropiada de agua, - emulsionado de la solución acuosa de principio activo así obtenida con una solución de un copolímero matricial d,l-lactida-co-glicolida, de peso molecular medio comprendido entre 40.000 y 80.000 y que tiene una proporción ácido láctico/ácido glicólico comprendida entre 50/50 y 80/20, disuelto en un hidrocarburo clorado, que conduce a una primera emulsión microfina y homogénea, - emulsionado de dicha primera emulsión así obtenida en una fase acuosa externa, que contiene un surfactante, un agente que aumenta la viscosidad y un agente osmótico, - extracción-evaporación del solvente para obtener unas microesferas que se recuperan después de filtración, lavado y secado, así como las microesferas obtenidas.
ES200102261A 2001-10-10 2001-10-10 Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion. Expired - Fee Related ES2194590B2 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ES200102261A ES2194590B2 (es) 2001-10-10 2001-10-10 Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.
AU2002358831A AU2002358831B2 (en) 2001-10-10 2002-10-10 Prolonged release biodegradable microspheres and method for preparing same
PCT/FR2002/003447 WO2003030870A1 (fr) 2001-10-10 2002-10-10 Microspheres biodegradables a liberation prolongee et leur procede de preparation
JP2003533903A JP2005509611A (ja) 2001-10-10 2002-10-10 徐放型生物分解性微小球およびその製造方法
CNB02824575XA CN100518828C (zh) 2001-10-10 2002-10-10 缓释可生物降解微球体及其制备方法
US10/492,417 US7691412B2 (en) 2001-10-10 2002-10-10 Prolonged release biodegradable microspheres and method for preparing same
BRPI0213226A BRPI0213226B1 (pt) 2001-10-10 2002-10-10 processo de preparação de uma composição farmacêutica sob forma de microesferas com liberação prolongada de um princípio ativo hidrossolúvel, e, microesferas
EP02793162.5A EP1450766B1 (fr) 2001-10-10 2002-10-10 Microspheres biodegradables a liberation prolongee et leur procede de preparation
ES02793162.5T ES2541908T3 (es) 2001-10-10 2002-10-10 Microesferas biodegradables de liberación prolongada y su procedimiento de preparación
MXPA04003433A MXPA04003433A (es) 2001-10-10 2002-10-10 Microesferas biodegradables de liberacion prolongada y metodo para preparar las mismas.
CA2463358A CA2463358C (fr) 2001-10-10 2002-10-10 Microspheres biodegradables a liberation prolongee et leur procede de preparation
JP2010046540A JP2010174021A (ja) 2001-10-10 2010-03-03 徐放型生物分解性微小球およびその製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200102261A ES2194590B2 (es) 2001-10-10 2001-10-10 Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.

Publications (2)

Publication Number Publication Date
ES2194590A1 true ES2194590A1 (es) 2003-11-16
ES2194590B2 ES2194590B2 (es) 2006-02-16

Family

ID=29762961

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200102261A Expired - Fee Related ES2194590B2 (es) 2001-10-10 2001-10-10 Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.

Country Status (1)

Country Link
ES (1) ES2194590B2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112341998A (zh) * 2020-11-16 2021-02-09 成都理工大学 一种堵漏材料及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07196479A (ja) * 1994-01-04 1995-08-01 Unitika Ltd マイクロカプセルの製造法
ES2078182A1 (es) * 1994-04-15 1995-12-01 Pierre Fabre Iberica S A Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes.
ES2110573T3 (es) * 1992-08-07 1998-02-16 Takeda Chemical Industries Ltd Produccion de microcapsulas de farmacos solubles en agua.
US5733567A (en) * 1994-04-15 1998-03-31 Pierre Fabre Medicament Biodegradable, controlled-release microspheres and process for preparing them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2110573T3 (es) * 1992-08-07 1998-02-16 Takeda Chemical Industries Ltd Produccion de microcapsulas de farmacos solubles en agua.
JPH07196479A (ja) * 1994-01-04 1995-08-01 Unitika Ltd マイクロカプセルの製造法
ES2078182A1 (es) * 1994-04-15 1995-12-01 Pierre Fabre Iberica S A Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes.
US5733567A (en) * 1994-04-15 1998-03-31 Pierre Fabre Medicament Biodegradable, controlled-release microspheres and process for preparing them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
[en línea] [recuperado el 17.10.2003]. Recuperado de EPO WPI Database, DW 199539, Nö acceso 1995-299490 & JP 07196479 A (UNITIKA LTD.) 01.08.1995 (resumen) *
UCHIDA, T. et al. "Optimization of Preparative Conditions for Polylactide (PLA) Microspheres Containing Ovalbumin", Chem. Pharm. Bull., 43 (9), 1569-1573, (1995). *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112341998A (zh) * 2020-11-16 2021-02-09 成都理工大学 一种堵漏材料及其制备方法

Also Published As

Publication number Publication date
ES2194590B2 (es) 2006-02-16

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