ES2194590A1 - Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion. - Google Patents
Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.Info
- Publication number
- ES2194590A1 ES2194590A1 ES200102261A ES200102261A ES2194590A1 ES 2194590 A1 ES2194590 A1 ES 2194590A1 ES 200102261 A ES200102261 A ES 200102261A ES 200102261 A ES200102261 A ES 200102261A ES 2194590 A1 ES2194590 A1 ES 2194590A1
- Authority
- ES
- Spain
- Prior art keywords
- water
- lactide
- sustained release
- soluble drug
- emulsifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004005 microsphere Substances 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000000839 emulsion Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000013268 sustained release Methods 0.000 title abstract 3
- 239000012730 sustained-release form Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000005538 encapsulation Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 230000001804 emulsifying effect Effects 0.000 abstract 4
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 238000001704 evaporation Methods 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 239000002357 osmotic agent Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 239000002562 thickening agent Substances 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a un procedimiento de preparación de una composición farmacéutica en forma de microesferas con liberación prolongada de un principio activo hidrosoluble y microesferas obtenidas, que comprende la sucesión de las etapas siguientes: - disolución del principio activo en una cantidad apropiada de agua, - emulsionado de la solución acuosa de principio activo así obtenida con una solución de un copolímero matricial d,l-lactida-co-glicolida, de peso molecular medio comprendido entre 40.000 y 80.000 y que tiene una proporción ácido láctico/ácido glicólico comprendida entre 50/50 y 80/20, disuelto en un hidrocarburo clorado, que conduce a una primera emulsión microfina y homogénea, - emulsionado de dicha primera emulsión así obtenida en una fase acuosa externa, que contiene un surfactante, un agente que aumenta la viscosidad y un agente osmótico, - extracción-evaporación del solvente para obtener unas microesferas que se recuperan después de filtración, lavado y secado, así como las microesferas obtenidas.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200102261A ES2194590B2 (es) | 2001-10-10 | 2001-10-10 | Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion. |
PCT/FR2002/003447 WO2003030870A1 (fr) | 2001-10-10 | 2002-10-10 | Microspheres biodegradables a liberation prolongee et leur procede de preparation |
ES02793162.5T ES2541908T3 (es) | 2001-10-10 | 2002-10-10 | Microesferas biodegradables de liberación prolongada y su procedimiento de preparación |
BRPI0213226A BRPI0213226B1 (pt) | 2001-10-10 | 2002-10-10 | processo de preparação de uma composição farmacêutica sob forma de microesferas com liberação prolongada de um princípio ativo hidrossolúvel, e, microesferas |
US10/492,417 US7691412B2 (en) | 2001-10-10 | 2002-10-10 | Prolonged release biodegradable microspheres and method for preparing same |
AU2002358831A AU2002358831B2 (en) | 2001-10-10 | 2002-10-10 | Prolonged release biodegradable microspheres and method for preparing same |
MXPA04003433A MXPA04003433A (es) | 2001-10-10 | 2002-10-10 | Microesferas biodegradables de liberacion prolongada y metodo para preparar las mismas. |
CA2463358A CA2463358C (fr) | 2001-10-10 | 2002-10-10 | Microspheres biodegradables a liberation prolongee et leur procede de preparation |
EP02793162.5A EP1450766B1 (fr) | 2001-10-10 | 2002-10-10 | Microspheres biodegradables a liberation prolongee et leur procede de preparation |
CNB02824575XA CN100518828C (zh) | 2001-10-10 | 2002-10-10 | 缓释可生物降解微球体及其制备方法 |
JP2003533903A JP2005509611A (ja) | 2001-10-10 | 2002-10-10 | 徐放型生物分解性微小球およびその製造方法 |
JP2010046540A JP2010174021A (ja) | 2001-10-10 | 2010-03-03 | 徐放型生物分解性微小球およびその製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200102261A ES2194590B2 (es) | 2001-10-10 | 2001-10-10 | Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2194590A1 true ES2194590A1 (es) | 2003-11-16 |
ES2194590B2 ES2194590B2 (es) | 2006-02-16 |
Family
ID=29762961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200102261A Expired - Fee Related ES2194590B2 (es) | 2001-10-10 | 2001-10-10 | Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2194590B2 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112341998A (zh) * | 2020-11-16 | 2021-02-09 | 成都理工大学 | 一种堵漏材料及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07196479A (ja) * | 1994-01-04 | 1995-08-01 | Unitika Ltd | マイクロカプセルの製造法 |
ES2078182A1 (es) * | 1994-04-15 | 1995-12-01 | Pierre Fabre Iberica S A | Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes. |
ES2110573T3 (es) * | 1992-08-07 | 1998-02-16 | Takeda Chemical Industries Ltd | Produccion de microcapsulas de farmacos solubles en agua. |
US5733567A (en) * | 1994-04-15 | 1998-03-31 | Pierre Fabre Medicament | Biodegradable, controlled-release microspheres and process for preparing them |
-
2001
- 2001-10-10 ES ES200102261A patent/ES2194590B2/es not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2110573T3 (es) * | 1992-08-07 | 1998-02-16 | Takeda Chemical Industries Ltd | Produccion de microcapsulas de farmacos solubles en agua. |
JPH07196479A (ja) * | 1994-01-04 | 1995-08-01 | Unitika Ltd | マイクロカプセルの製造法 |
ES2078182A1 (es) * | 1994-04-15 | 1995-12-01 | Pierre Fabre Iberica S A | Procedimiento para la preparacion de microesferas biodegradables con liberacion controlada y microesferas correspondientes. |
US5733567A (en) * | 1994-04-15 | 1998-03-31 | Pierre Fabre Medicament | Biodegradable, controlled-release microspheres and process for preparing them |
Non-Patent Citations (2)
Title |
---|
[en línea] [recuperado el 17.10.2003]. Recuperado de EPO WPI Database, DW 199539, Nö acceso 1995-299490 & JP 07196479 A (UNITIKA LTD.) 01.08.1995 (resumen) * |
UCHIDA, T. et al. "Optimization of Preparative Conditions for Polylactide (PLA) Microspheres Containing Ovalbumin", Chem. Pharm. Bull., 43 (9), 1569-1573, (1995). * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112341998A (zh) * | 2020-11-16 | 2021-02-09 | 成都理工大学 | 一种堵漏材料及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
ES2194590B2 (es) | 2006-02-16 |
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