ES2110573T3 - Produccion de microcapsulas de farmacos solubles en agua. - Google Patents

Produccion de microcapsulas de farmacos solubles en agua.

Info

Publication number
ES2110573T3
ES2110573T3 ES93306124T ES93306124T ES2110573T3 ES 2110573 T3 ES2110573 T3 ES 2110573T3 ES 93306124 T ES93306124 T ES 93306124T ES 93306124 T ES93306124 T ES 93306124T ES 2110573 T3 ES2110573 T3 ES 2110573T3
Authority
ES
Spain
Prior art keywords
microcapsules
water
production
soluble
drugs soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93306124T
Other languages
English (en)
Inventor
Koichi Maedera
Masuhisa Hori
Tomomichi Futo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2110573T3 publication Critical patent/ES2110573T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

SE SUMINISTRA UN PROCESO PARA PRODUCIR MICROCAPSULAS DE UNA DROGA SOLUBLE EN AGUA MEDIANTE UN PROCESO DE SECADO EN AGUA, QUE COMPRENDE EL DESARROLLO DEL PROCESO EN LA PRESENCIA DE UNA SUSTANCIA PARA EL AJUSTE DE LA PRESION OSMOTICA PRESENTE EN LA FASE ACUOSA EXTERNA. ESTE PROCESO MEJORA EN LA DROGA DISPUESTA EN EL INTERIOR DE MICROCAPSULAS.
ES93306124T 1992-08-07 1993-08-03 Produccion de microcapsulas de farmacos solubles en agua. Expired - Lifetime ES2110573T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21146292 1992-08-07

Publications (1)

Publication Number Publication Date
ES2110573T3 true ES2110573T3 (es) 1998-02-16

Family

ID=16606344

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93306124T Expired - Lifetime ES2110573T3 (es) 1992-08-07 1993-08-03 Produccion de microcapsulas de farmacos solubles en agua.

Country Status (11)

Country Link
US (1) US5611971A (es)
EP (1) EP0582459B1 (es)
JP (1) JP2608242B2 (es)
KR (1) KR100328098B1 (es)
AT (1) ATE161716T1 (es)
CA (1) CA2103518C (es)
DE (1) DE69316101T2 (es)
DK (1) DK0582459T3 (es)
ES (1) ES2110573T3 (es)
GR (1) GR3026291T3 (es)
HU (1) HU209976B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2194590A1 (es) * 2001-10-10 2003-11-16 Pierre Fabre Iberica S A Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
JP2909418B2 (ja) * 1995-09-18 1999-06-23 株式会社資生堂 薬物の遅延放出型マイクロスフイア
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
CA2192782C (en) * 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
KR100511215B1 (ko) * 1996-01-24 2006-05-09 유나이티드 스테이츠 가번먼트, 애즈 리프리젠티드 바이 더 디파트먼트 오브 헬스 앤드 휴먼서비시즈 신규한비-일시방출형서방성폴리(락타이드/글리콜라이드)마이크로캡슐
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
JP3887462B2 (ja) * 1997-06-25 2007-02-28 エイケン工業株式会社 液体加熱装置
AU1982599A (en) 1998-01-21 1999-08-09 Takeda Chemical Industries Ltd. Lyophilization method for sustained-release preparations
US6099859A (en) 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6907679B2 (en) * 1998-11-12 2005-06-21 Qlt Usa, Inc. Method for lyophilizing an active agent
EP1273306A4 (en) * 2000-03-31 2005-06-22 Kirin Brewery POWDER PREPARATION INTENDED FOR MUCOUS MEMBRANES COMPRISING A POLYMERIC MEDICAMENT HAVING IMPROVED STORAGE STABILITY
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
CA2424069A1 (en) * 2000-10-12 2002-04-18 Tanabe Seiyaku Co., Ltd. Method of forming polypeptide particles
DK1343480T4 (en) 2000-12-21 2016-04-18 Alrise Biosystems Gmbh Induced phase transition method for the preparation of microparticles containing hydrophobic active agents.
KR20030020789A (ko) * 2001-09-04 2003-03-10 서경도 고분자 가교망에 의한 수용성 물질의 포집법
MXPA04003433A (es) 2001-10-10 2004-08-11 Pf Medicament Microesferas biodegradables de liberacion prolongada y metodo para preparar las mismas.
FR2830448B1 (fr) * 2001-10-10 2004-03-19 Pf Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
CA2471521C (en) * 2001-12-26 2010-11-02 Takeda Chemical Industries, Ltd. Novel microsphere and method for production thereof
JP2003252751A (ja) * 2001-12-26 2003-09-10 Takeda Chem Ind Ltd 新規マイクロスフェアおよびその製造法
EP1532985B1 (en) 2002-06-25 2016-10-12 Takeda Pharmaceutical Company Limited Process for producing a sustained-release composition
JP4530626B2 (ja) * 2002-06-25 2010-08-25 武田薬品工業株式会社 徐放性組成物の製造方法
WO2004012715A1 (en) * 2002-08-02 2004-02-12 Penwest Pharmaceuticals Company Sustained release formulations of metformin
KR20040017002A (ko) * 2002-08-20 2004-02-26 한국화학연구원 삼투압유도제가 첨가된 국소이식형 항암제제
JP4690040B2 (ja) * 2002-09-11 2011-06-01 田辺三菱製薬株式会社 マイクロスフェアの製法及び製造装置
EP1595549A4 (en) * 2003-02-19 2010-09-22 Takeda Pharmaceutical DISPERSING AGENT FOR SUSTAINED RELEASE PREPARATIONS
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
US7226619B1 (en) * 2004-09-07 2007-06-05 Pharmorx Inc. Material for controlling diversion of medications
EP1679065A1 (en) * 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
US20060243809A1 (en) * 2005-04-27 2006-11-02 Hodgson Rodney T Combination logo and identification code
JP4659510B2 (ja) * 2005-04-28 2011-03-30 サンスター株式会社 Ｗ／ｏ／ｗ型エマルション組成物
WO2007035954A2 (en) * 2005-09-23 2007-03-29 Duramed Pharmaceuticals, Inc. Vaginal tablets comprising misoprostol and methods of making and using the same
KR100722607B1 (ko) 2006-05-11 2007-05-28 주식회사 펩트론 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법
NO347209B1 (no) 2006-12-18 2023-07-03 Takeda Pharmaceutical Sammensetning med forlenget frigjøring og fremgangsmåte for å produsere det samme
KR100837860B1 (ko) 2007-02-28 2008-06-13 한국과학기술원 친수성 고분자 나노캡슐 및 그의 제조 방법
JP5429707B2 (ja) * 2008-03-27 2014-02-26 国立大学法人群馬大学 微粒子およびその製造方法
CA2730760A1 (en) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles containing bioactive peptides
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
US9205577B2 (en) * 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
US11202853B2 (en) * 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
WO2017015617A1 (en) 2015-07-23 2017-01-26 New York University Self-inflating microcapsules
EA037154B1 (ru) 2016-02-05 2021-02-11 Толмар Терапьютикс, Инк. Вентилируемая покрывающая пластина для массива шприцов
CN109562161A (zh) * 2016-08-04 2019-04-02 全药克资源株式会社 免疫活化剂、药物组合物及饮食品
EP3655009B1 (en) * 2017-07-20 2023-10-11 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Nanoparticle compositions
USD908916S1 (en) 2018-06-19 2021-01-26 Tolmar Therapeutics, Inc. Syringe restrictor plate

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3703576A (en) * 1969-08-08 1972-11-21 Fuji Photo Film Co Ltd Method of producing micro-capsules enclosing acetylsalicylic acid therein
JPS523342B2 (es) * 1972-01-26 1977-01-27
NO139560C (no) 1972-04-29 1979-04-04 Takeda Chemical Industries Ltd Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater
JPS528375B2 (es) 1973-07-02 1977-03-09
FR2238700B1 (es) 1973-07-24 1977-10-14 Takeda Chemical Industries Ltd
AT347054B (de) 1973-09-29 1978-12-11 Takeda Chemical Industries Ltd Verfahren zur herstellung von neuen nonapeptidamid-derivaten
JPS5726506B2 (es) 1974-03-08 1982-06-04
GB1542703A (en) 1975-10-29 1979-03-21 Parke Davis & Co Nonapeptides and methods for their production
US4087390A (en) 1977-02-02 1978-05-02 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4093574A (en) 1977-02-02 1978-06-06 Eli Lilly And Company Somatostatin analogs and intermediates thereto
JPS5944308B2 (ja) 1976-03-23 1984-10-29 武田薬品工業株式会社 ペプタイド
US4100117A (en) 1977-04-21 1978-07-11 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4124577A (en) 1977-06-13 1978-11-07 Warner-Lambert Nonapeptides and methods for their production
US4253998A (en) 1979-03-09 1981-03-03 American Home Products Corporation Peptides related to somatostatin
JPS54148722A (en) 1978-05-12 1979-11-21 Takeda Chem Ind Ltd Nonapeptide and its preparation
US4277394A (en) 1979-04-23 1981-07-07 Takeda Chemical Industries, Ltd Tetrapeptidehydrazide derivatives
US4317815A (en) 1979-06-13 1982-03-02 Coy David Howard LH-RH Antagonists
US4253997A (en) 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
JPS5692846A (en) 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
JPH0678425B2 (ja) 1984-07-06 1994-10-05 和光純薬工業株式会社 重合体の新規製造法
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JP2837675B2 (ja) * 1987-09-22 1998-12-16 中外製薬株式会社 徐放性微粒製剤
ES2059571T3 (es) 1988-01-19 1994-11-16 Takeda Chemical Industries Ltd Fumagilina como agente angiostatico.
DE68915900T2 (de) 1988-09-01 1994-11-24 Takeda Chemical Industries Ltd Angiogenese hemmendes Mittel.
EP0682020A1 (en) 1988-09-01 1995-11-15 Takeda Chemical Industries, Ltd. Fumagillol derivatives useful as angiogenesis inhibitors
EP0386667B1 (en) 1989-03-06 1993-11-18 Takeda Chemical Industries, Ltd. 6-Amino-6-desoxyfumagillols, production and use thereof
EP0415294A3 (en) 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
JPH0446116A (ja) 1990-06-13 1992-02-17 Eisai Co Ltd マイクロスフィアの製造方法
JPH0446115A (ja) 1990-06-13 1992-02-17 Eisai Co Ltd マイクロスフィアの製造法
JP3116311B2 (ja) 1990-06-13 2000-12-11 エーザイ株式会社 マイクロスフィアの製法
CA2046830C (en) * 1990-07-19 1999-12-14 Patrick P. Deluca Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer
JP2693631B2 (ja) * 1990-09-13 1997-12-24 富士通株式会社 スキャンアウト制御システム
JPH04124127A (ja) * 1990-09-14 1992-04-24 Chugai Pharmaceut Co Ltd マイクロカプセル型徐放性製剤及びその製造法
JP3214888B2 (ja) * 1991-03-15 2001-10-02 エーザイ株式会社 多重層エマルションおよびその製造方法
JPH07196479A (ja) * 1994-01-04 1995-08-01 Unitika Ltd マイクロカプセルの製造法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2194590A1 (es) * 2001-10-10 2003-11-16 Pierre Fabre Iberica S A Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion.

Also Published As

Publication number Publication date
EP0582459A2 (en) 1994-02-09
JP2608242B2 (ja) 1997-05-07
DE69316101D1 (de) 1998-02-12
DE69316101T2 (de) 1998-10-22
HU209976B (en) 1995-01-30
US5611971A (en) 1997-03-18
EP0582459B1 (en) 1998-01-07
JPH06145046A (ja) 1994-05-24
CA2103518A1 (en) 1994-02-08
CA2103518C (en) 2004-03-30
EP0582459A3 (en) 1994-06-29
HUT65235A (en) 1994-05-02
KR940003540A (ko) 1994-03-12
ATE161716T1 (de) 1998-01-15
GR3026291T3 (en) 1998-06-30
HU9302284D0 (en) 1993-10-28
KR100328098B1 (ko) 2002-08-13
DK0582459T3 (da) 1998-04-27

Similar Documents

Publication Publication Date Title
ES2110573T3 (es) Produccion de microcapsulas de farmacos solubles en agua.
DE69102080D1 (de) Herstellung eines stabilen, wässrigen Kieselsäuresols.
NO890113L (no) Vannloeselig polymer, saerlig for vaskemidler.
FI891021A0 (fi) Menetelmä lääkeaineina käyttökelpoisten 1,2,4-triatsolijohdannaisten valmistamiseksi
FI104087B1 (fi) Menetelmä vesidispersioiden valmistamiseksi eteeni/a,b-tyydyttymätön karboksyylihappo-interpolymeereistä
DE60120189D1 (de) Herstellung von konzentrierten bioziden lösungen
EG20644A (en) Solid microspheres for agiculturaly active compounds and process for their production
BE847154A (fr) Procede d'obtention d'acides carboxyliques a partir de leurs-solutions aqueuses,
NO940828D0 (no) Fremgangsmåte for fremstilling av en vandig, industriell natriumklorid-lösning
HU9302360D0 (en) Method for producing imidazole derivatives
HU9301765D0 (en) Compounds of cerium (iv) as well as their production and application
NO308743B1 (no) FremgangsmÕte for fremstilling av N-acetyl- neuraminsyrederivater
MA21842A1 (fr) Derives de la thieno - triazolo - diazepine , ainsi qu'un procede de preparation desdits composes .
FI102185B1 (fi) Anionisten diatsoväriaineiden konsentroidut, vesipitoiset liuokset
NO985489L (no) FremgangsmÕte for fremstilling av nikotinsyre
SE0000055D0 (sv) Novel process
TW427991B (en) Production of pharmaceutically acceptable salts of clavulanic acid
SE8202269L (sv) Forfarande for framstellning av fast natriumamoxicillin
EP1072585A3 (en) Process for producing dimethylcyanamide
FR2655645B1 (fr) Procede de preparation d'acides hexenediouiques-1,6 a partir du butenediol.
FI890658A (fi) Foerfarande foer framstaellning av 1,2-disulfonfoereningar.
KR960004204A (ko) 활성환 이산화염소 수용액의 제조방법
SE9402347L (sv) Förfarande för tillverkning av kaliumformiat I
TR199600916A2 (tr) Sübstitüe edilmis benzol dikarbonik asit diguanidid'leri, bunlarin üretilmesine mahsus usul, bunlarin ilac veya diagnostik olarak kullanilmalari ve bunlari iceren ilac.
SU1541218A1 (ru) Способ получения производных декстрана

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 582459

Country of ref document: ES