DE69316101D1 - Herstellung von Mikrokapseln, die wasserlösliche Arzneimittel enthalten - Google Patents
Herstellung von Mikrokapseln, die wasserlösliche Arzneimittel enthaltenInfo
- Publication number
- DE69316101D1 DE69316101D1 DE69316101T DE69316101T DE69316101D1 DE 69316101 D1 DE69316101 D1 DE 69316101D1 DE 69316101 T DE69316101 T DE 69316101T DE 69316101 T DE69316101 T DE 69316101T DE 69316101 D1 DE69316101 D1 DE 69316101D1
- Authority
- DE
- Germany
- Prior art keywords
- manufacture
- containing water
- soluble drugs
- microcapsules containing
- microcapsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21146292 | 1992-08-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69316101D1 true DE69316101D1 (de) | 1998-02-12 |
DE69316101T2 DE69316101T2 (de) | 1998-10-22 |
Family
ID=16606344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69316101T Expired - Lifetime DE69316101T2 (de) | 1992-08-07 | 1993-08-03 | Herstellung von Mikrokapseln, die wasserlösliche Arzneimittel enthalten |
Country Status (11)
Country | Link |
---|---|
US (1) | US5611971A (de) |
EP (1) | EP0582459B1 (de) |
JP (1) | JP2608242B2 (de) |
KR (1) | KR100328098B1 (de) |
AT (1) | ATE161716T1 (de) |
CA (1) | CA2103518C (de) |
DE (1) | DE69316101T2 (de) |
DK (1) | DK0582459T3 (de) |
ES (1) | ES2110573T3 (de) |
GR (1) | GR3026291T3 (de) |
HU (1) | HU209976B (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
JP2909418B2 (ja) * | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
CA2192782C (en) * | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
CA2192773C (en) | 1995-12-15 | 2008-09-23 | Hiroaki Okada | Production of sustained-release preparation for injection |
BRPI9607752B8 (pt) * | 1996-01-24 | 2019-11-05 | Us Gov As Represented By The Secretary Of The Army | formulação farmacêutica de microcápsula de liberação controlada. |
US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
JP3887462B2 (ja) * | 1997-06-25 | 2007-02-28 | エイケン工業株式会社 | 液体加熱装置 |
KR100595340B1 (ko) | 1998-01-21 | 2006-07-03 | 다케다 야쿠힌 고교 가부시키가이샤 | 서방형 제제의 동결 건조법 |
US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
US6270802B1 (en) | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
US6907679B2 (en) * | 1998-11-12 | 2005-06-21 | Qlt Usa, Inc. | Method for lyophilizing an active agent |
CA2403962C (en) * | 2000-03-31 | 2009-12-15 | Kirin Beer Kabushiki Kaisha | Powdery preparation for transmucosal administration comprising a medicine of high molecular weight and exhibiting an improved storage stability |
AR023940A1 (es) | 2000-05-03 | 2002-09-04 | Eriochem Sa | Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua |
CA2424069A1 (en) * | 2000-10-12 | 2002-04-18 | Tanabe Seiyaku Co., Ltd. | Method of forming polypeptide particles |
ATE361057T1 (de) | 2000-12-21 | 2007-05-15 | Alrise Biosystems Gmbh | Verfahren umfassend einen induzierten phasenübergang zur herstellung von hydrophobe wirkstoffe enthaltenden mikropartikeln |
KR20030020789A (ko) * | 2001-09-04 | 2003-03-10 | 서경도 | 고분자 가교망에 의한 수용성 물질의 포집법 |
AU2002358831B2 (en) * | 2001-10-10 | 2007-09-06 | Pierre Fabre Medicament | Prolonged release biodegradable microspheres and method for preparing same |
ES2194590B2 (es) * | 2001-10-10 | 2006-02-16 | Pierre Fabre Iberica S.A. | Microesferas biodegradables con liberacion prolongada y su procedimiento de preparacion. |
FR2830448B1 (fr) * | 2001-10-10 | 2004-03-19 | Pf Medicament | Microspheres biodegradables a liberation prolongee et leur procede de preparation |
JP2003252751A (ja) * | 2001-12-26 | 2003-09-10 | Takeda Chem Ind Ltd | 新規マイクロスフェアおよびその製造法 |
CA2471521C (en) * | 2001-12-26 | 2010-11-02 | Takeda Chemical Industries, Ltd. | Novel microsphere and method for production thereof |
JP4530626B2 (ja) * | 2002-06-25 | 2010-08-25 | 武田薬品工業株式会社 | 徐放性組成物の製造方法 |
CA2490351C (en) | 2002-06-25 | 2011-11-01 | Takeda Pharmaceutical Company Limited | Process for producing sustained-release composition |
EP1549296A4 (de) * | 2002-08-02 | 2006-08-09 | Penwest Pharmaceuticals Co | Metformin-formulierungen mit verzögerter freisetzung |
KR20040017002A (ko) * | 2002-08-20 | 2004-02-26 | 한국화학연구원 | 삼투압유도제가 첨가된 국소이식형 항암제제 |
WO2004024056A1 (ja) | 2002-09-11 | 2004-03-25 | Tanabe Seiyaku Co., Ltd. | マイクロスフェアの製法及び製造装置 |
WO2004073749A1 (ja) * | 2003-02-19 | 2004-09-02 | Takeda Pharmaceutical Company Limited | 徐放性製剤用の分散剤 |
TW200529890A (en) * | 2004-02-10 | 2005-09-16 | Takeda Pharmaceutical | Sustained-release preparations |
TW200613012A (en) * | 2004-07-02 | 2006-05-01 | Takeda Pharmaceuticals Co | Sustained-release composition, process for producing the same and use of the same |
US7226619B1 (en) * | 2004-09-07 | 2007-06-05 | Pharmorx Inc. | Material for controlling diversion of medications |
EP1679065A1 (de) * | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Zubereitung mit kontrollierter Freisetzung von Interferon auf PEGT/PBT-Block-Copolymer-Basis |
US20060243809A1 (en) * | 2005-04-27 | 2006-11-02 | Hodgson Rodney T | Combination logo and identification code |
JP4659510B2 (ja) * | 2005-04-28 | 2011-03-30 | サンスター株式会社 | W/o/w型エマルション組成物 |
US8148560B2 (en) * | 2005-09-23 | 2012-04-03 | Teva Women's Health, Inc. | Vaginal tablets comprising misoprostol and methods of making and using the same |
KR100722607B1 (ko) | 2006-05-11 | 2007-05-28 | 주식회사 펩트론 | 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법 |
EP2094246B1 (de) * | 2006-12-18 | 2020-04-01 | Takeda Pharmaceutical Company Limited | Zusammensetzung mit verzögerter freisetzung und herstellungsverfahren dafür |
KR100837860B1 (ko) | 2007-02-28 | 2008-06-13 | 한국과학기술원 | 친수성 고분자 나노캡슐 및 그의 제조 방법 |
JP5429707B2 (ja) * | 2008-03-27 | 2014-02-26 | 国立大学法人群馬大学 | 微粒子およびその製造方法 |
US20100015240A1 (en) * | 2008-07-16 | 2010-01-21 | Danielle Biggs | Process for preparing microparticles containing bioactive peptides |
US9138309B2 (en) | 2010-02-05 | 2015-09-22 | Allergan, Inc. | Porous materials, methods of making and uses |
US9205577B2 (en) * | 2010-02-05 | 2015-12-08 | Allergan, Inc. | Porogen compositions, methods of making and uses |
US11202853B2 (en) * | 2010-05-11 | 2021-12-21 | Allergan, Inc. | Porogen compositions, methods of making and uses |
WO2017015617A1 (en) * | 2015-07-23 | 2017-01-26 | New York University | Self-inflating microcapsules |
WO2017136667A1 (en) | 2016-02-05 | 2017-08-10 | Tolmar Tharapeutics, Inc. | Vented cover plate for an array of syringes |
JP6730744B2 (ja) * | 2016-08-04 | 2020-07-29 | ゼノアックリソース株式会社 | 免疫賦活剤、医薬組成物および飲食品 |
WO2019016819A1 (en) * | 2017-07-20 | 2019-01-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | NANOPARTICLE COMPOSITIONS |
USD908916S1 (en) | 2018-06-19 | 2021-01-26 | Tolmar Therapeutics, Inc. | Syringe restrictor plate |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3703576A (en) * | 1969-08-08 | 1972-11-21 | Fuji Photo Film Co Ltd | Method of producing micro-capsules enclosing acetylsalicylic acid therein |
JPS523342B2 (de) * | 1972-01-26 | 1977-01-27 | ||
NO139560C (no) | 1972-04-29 | 1979-04-04 | Takeda Chemical Industries Ltd | Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater |
JPS528375B2 (de) | 1973-07-02 | 1977-03-09 | ||
FR2238700B1 (de) | 1973-07-24 | 1977-10-14 | Takeda Chemical Industries Ltd | |
JPS5726506B2 (de) | 1974-03-08 | 1982-06-04 | ||
CS180644B2 (en) | 1973-09-29 | 1978-01-31 | Takeda Chemical Industries Ltd | Process for preparing nonapeptides |
FR2329293A1 (fr) | 1975-10-29 | 1977-05-27 | Parke Davis & Co | Nouveaux nonapeptides et procedes pour leur production |
US4093574A (en) | 1977-02-02 | 1978-06-06 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
US4087390A (en) | 1977-02-02 | 1978-05-02 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
JPS5944308B2 (ja) | 1976-03-23 | 1984-10-29 | 武田薬品工業株式会社 | ペプタイド |
US4100117A (en) | 1977-04-21 | 1978-07-11 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
US4124577A (en) | 1977-06-13 | 1978-11-07 | Warner-Lambert | Nonapeptides and methods for their production |
US4253998A (en) | 1979-03-09 | 1981-03-03 | American Home Products Corporation | Peptides related to somatostatin |
JPS54148722A (en) | 1978-05-12 | 1979-11-21 | Takeda Chem Ind Ltd | Nonapeptide and its preparation |
US4277394A (en) | 1979-04-23 | 1981-07-07 | Takeda Chemical Industries, Ltd | Tetrapeptidehydrazide derivatives |
US4317815A (en) | 1979-06-13 | 1982-03-02 | Coy David Howard | LH-RH Antagonists |
US4253997A (en) | 1979-12-17 | 1981-03-03 | American Home Products Corporation | Anti-ovulatory decapeptides |
JPS5692846A (en) | 1979-12-27 | 1981-07-27 | Takeda Chem Ind Ltd | Tetrapeptide derivative and its preparation |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
JPH0678425B2 (ja) | 1984-07-06 | 1994-10-05 | 和光純薬工業株式会社 | 重合体の新規製造法 |
DE3678308D1 (de) * | 1985-02-07 | 1991-05-02 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
JP2837675B2 (ja) * | 1987-09-22 | 1998-12-16 | 中外製薬株式会社 | 徐放性微粒製剤 |
DE68910138T2 (de) | 1988-01-19 | 1994-04-28 | Takeda Chemical Industries Ltd | Fumagillin als angiostatisches Mittel. |
EP0357061B1 (de) | 1988-09-01 | 1994-06-08 | Takeda Chemical Industries, Ltd. | Angiogenese hemmendes Mittel |
ES2099064T3 (es) | 1988-09-01 | 1997-05-16 | Takeda Chemical Industries Ltd | Derivados de fumagillol. |
DE69004598T2 (de) | 1989-03-06 | 1994-03-24 | Takeda Chemical Industries Ltd | 6-Amino-6-desoxyfumagillole, ihre Herstellung und ihre Verwendung. |
EP0415294A3 (en) | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
JP3116311B2 (ja) | 1990-06-13 | 2000-12-11 | エーザイ株式会社 | マイクロスフィアの製法 |
JPH0446115A (ja) | 1990-06-13 | 1992-02-17 | Eisai Co Ltd | マイクロスフィアの製造法 |
JPH0446116A (ja) | 1990-06-13 | 1992-02-17 | Eisai Co Ltd | マイクロスフィアの製造方法 |
CA2046830C (en) * | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
JP2693631B2 (ja) * | 1990-09-13 | 1997-12-24 | 富士通株式会社 | スキャンアウト制御システム |
JPH04124127A (ja) * | 1990-09-14 | 1992-04-24 | Chugai Pharmaceut Co Ltd | マイクロカプセル型徐放性製剤及びその製造法 |
JP3214888B2 (ja) * | 1991-03-15 | 2001-10-02 | エーザイ株式会社 | 多重層エマルションおよびその製造方法 |
JPH07196479A (ja) * | 1994-01-04 | 1995-08-01 | Unitika Ltd | マイクロカプセルの製造法 |
-
1993
- 1993-08-03 DE DE69316101T patent/DE69316101T2/de not_active Expired - Lifetime
- 1993-08-03 ES ES93306124T patent/ES2110573T3/es not_active Expired - Lifetime
- 1993-08-03 EP EP93306124A patent/EP0582459B1/de not_active Expired - Lifetime
- 1993-08-03 DK DK93306124.4T patent/DK0582459T3/da active
- 1993-08-03 AT AT93306124T patent/ATE161716T1/de active
- 1993-08-06 US US08/102,790 patent/US5611971A/en not_active Expired - Lifetime
- 1993-08-06 CA CA002103518A patent/CA2103518C/en not_active Expired - Lifetime
- 1993-08-06 HU HU9302284A patent/HU209976B/hu unknown
- 1993-08-06 JP JP5195945A patent/JP2608242B2/ja not_active Expired - Fee Related
- 1993-08-06 KR KR1019930015303A patent/KR100328098B1/ko not_active IP Right Cessation
-
1998
- 1998-03-06 GR GR980400462T patent/GR3026291T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69316101T2 (de) | 1998-10-22 |
CA2103518A1 (en) | 1994-02-08 |
CA2103518C (en) | 2004-03-30 |
JPH06145046A (ja) | 1994-05-24 |
DK0582459T3 (da) | 1998-04-27 |
EP0582459A2 (de) | 1994-02-09 |
GR3026291T3 (en) | 1998-06-30 |
HUT65235A (en) | 1994-05-02 |
JP2608242B2 (ja) | 1997-05-07 |
EP0582459B1 (de) | 1998-01-07 |
HU9302284D0 (en) | 1993-10-28 |
EP0582459A3 (en) | 1994-06-29 |
KR940003540A (ko) | 1994-03-12 |
ES2110573T3 (es) | 1998-02-16 |
HU209976B (en) | 1995-01-30 |
ATE161716T1 (de) | 1998-01-15 |
US5611971A (en) | 1997-03-18 |
KR100328098B1 (ko) | 2002-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de | ||
8370 | Indication related to discontinuation of the patent is to be deleted | ||
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP |