JP2006514820A5 - - Google Patents
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- JP2006514820A5 JP2006514820A5 JP2003586178A JP2003586178A JP2006514820A5 JP 2006514820 A5 JP2006514820 A5 JP 2006514820A5 JP 2003586178 A JP2003586178 A JP 2003586178A JP 2003586178 A JP2003586178 A JP 2003586178A JP 2006514820 A5 JP2006514820 A5 JP 2006514820A5
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- JP
- Japan
- Prior art keywords
- peptide
- seq
- group
- nos
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 40
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000003368 amide group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 108091006116 chimeric peptides Proteins 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 230000008707 rearrangement Effects 0.000 claims 2
- 102000001490 Opioid Peptides Human genes 0.000 claims 1
- 108010093625 Opioid Peptides Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003399 opiate peptide Substances 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/126,845 US20030181367A1 (en) | 1999-09-27 | 2002-04-19 | Conjugates of membrane translocating agents and pharmaceutically active agents |
| PCT/US2003/012543 WO2003089458A2 (en) | 2002-04-19 | 2003-04-21 | Conjugates of membrane translocating agents and pharmaceutically active agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010128982A Division JP5211109B2 (ja) | 2002-04-19 | 2010-06-04 | 膜転位剤および製薬学的有効成分の複合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514820A JP2006514820A (ja) | 2006-05-18 |
| JP2006514820A5 true JP2006514820A5 (enExample) | 2006-07-06 |
Family
ID=29248426
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586178A Withdrawn JP2006514820A (ja) | 2002-04-19 | 2003-04-21 | 膜転位剤および製薬学的有効成分の複合物 |
| JP2010128982A Expired - Fee Related JP5211109B2 (ja) | 2002-04-19 | 2010-06-04 | 膜転位剤および製薬学的有効成分の複合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010128982A Expired - Fee Related JP5211109B2 (ja) | 2002-04-19 | 2010-06-04 | 膜転位剤および製薬学的有効成分の複合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20030181367A1 (enExample) |
| EP (2) | EP1575987A4 (enExample) |
| JP (2) | JP2006514820A (enExample) |
| AU (1) | AU2003228658A1 (enExample) |
| CA (1) | CA2482719A1 (enExample) |
| WO (1) | WO2003089458A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3192786B2 (ja) | 1992-12-15 | 2001-07-30 | 積水化学工業株式会社 | 長尺体の分離供給装置 |
| US6521737B1 (en) * | 1995-11-10 | 2003-02-18 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| US7176185B2 (en) | 2003-11-25 | 2007-02-13 | Tsrl, Inc. | Short peptide carrier system for cellular delivery of agent |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| US8586081B2 (en) * | 2007-09-20 | 2013-11-19 | University Of Massachusetts | Detoxified recombinant botulinum neurotoxin |
| ES2334315B1 (es) * | 2008-07-29 | 2011-02-28 | Universitat Pompeu Fabra | Peptidos con capacidad de penetracion celular y sus usos. |
| SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| KR102112373B1 (ko) | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
| MX375442B (es) | 2012-09-21 | 2025-03-06 | Intensity Therapeutics Inc | Un agente terapéutico y un agente mejorador de la permeación intracelular para usarse en el tratamiento de cáncer. |
| US9788765B2 (en) | 2012-09-28 | 2017-10-17 | Dexcom, Inc. | Zwitterion surface modifications for continuous sensors |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| US9737250B2 (en) | 2013-03-15 | 2017-08-22 | Dexcom, Inc. | Membrane for continuous analyte sensors |
| BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN108473538B (zh) * | 2015-10-28 | 2022-01-28 | 塔弗达治疗有限公司 | Sstr靶向缀合物及其颗粒和制剂 |
| WO2017117468A1 (en) | 2015-12-30 | 2017-07-06 | Dexcom, Inc. | Enzyme immobilized adhesive layer for analyte sensors |
| AU2024369666A1 (en) * | 2023-10-30 | 2026-06-11 | Adjuvia Therapeutics | Pharmaceutical composition and method of treating disease using a molecular complex assembled on astaxanthin core |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4847240A (en) | 1978-01-16 | 1989-07-11 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
| US4244946A (en) * | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
| US4305872A (en) * | 1979-10-19 | 1981-12-15 | Kenneth Wingrove | Polypeptide derivatives |
| US4316891A (en) * | 1980-06-14 | 1982-02-23 | The Salk Institute For Biological Studies | Extended N-terminal somatostatin |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US5449616A (en) * | 1990-05-23 | 1995-09-12 | University Of Iowa Research Foundation | Nucleic acid encoding dystrophin-associated protein |
| IE80466B1 (en) * | 1995-11-10 | 1998-07-29 | Elan Corp Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| US6361938B1 (en) * | 1996-11-08 | 2002-03-26 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| WO1998047913A2 (en) * | 1997-04-18 | 1998-10-29 | The University Of Medicine And Dentistry Of New Jersey | Inhibition of hiv-1 replication by a tat rna-binding domain peptide analog |
| CA2290756A1 (en) | 1997-05-15 | 1998-11-19 | Cytogen Corporation | Random peptides that bind to gastro-intestinal tract (git) transport receptors and related methods |
| US6380370B1 (en) * | 1997-08-14 | 2002-04-30 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics |
| IE970794A1 (en) * | 1997-09-24 | 2000-08-23 | Elan Corp Plc | Composition and method for enhancing paracellular transport across cell layers |
| US6423334B1 (en) * | 1997-10-01 | 2002-07-23 | Elan Corporation, Plc | Composition and method for enhancing transport across gastrointestinal tract cell layers |
| US6248558B1 (en) | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
| EP1086126A1 (en) | 1998-06-10 | 2001-03-28 | The Queen's University of Belfast | Cell-permeable peptide |
| JP2002518521A (ja) | 1998-06-20 | 2002-06-25 | ワシントン・ユニバーシティ | 医用画像解析、診断および治療のための膜透過性ペプチド錯体 |
| US6451601B1 (en) | 1999-04-12 | 2002-09-17 | Modex Therapeutiques, S.A. | Transiently immortalized cells for use in gene therapy |
| WO2001013957A2 (en) | 1999-08-24 | 2001-03-01 | Cellgate, Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
| JP4799790B2 (ja) * | 1999-09-27 | 2011-10-26 | メリオン リサーチ スリー リミテッド | 膜転位ペプチド、同ペプチドを含有する組成物、同ペプチドを含有する医薬製剤及び同ペプチドの製剤の調製における使用 |
| JP2004535388A (ja) * | 2001-04-30 | 2004-11-25 | ターゲティッド ジェネティクス コーポレイション | 脂質含有薬物送達複合体およびそれらの生成方法 |
| MXPA05006084A (es) | 2002-12-11 | 2005-09-30 | Donaldson Co Inc | Medio filtrante con forma de z con sistemas de limpieza de flujo inverso y metodos. |
| JP5008350B2 (ja) | 2006-07-05 | 2012-08-22 | 花王株式会社 | ガラス基板用の研磨液組成物 |
| US7981998B2 (en) | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
-
2002
- 2002-04-19 US US10/126,845 patent/US20030181367A1/en not_active Abandoned
-
2003
- 2003-04-21 EP EP03726420A patent/EP1575987A4/en not_active Withdrawn
- 2003-04-21 CA CA002482719A patent/CA2482719A1/en not_active Abandoned
- 2003-04-21 JP JP2003586178A patent/JP2006514820A/ja not_active Withdrawn
- 2003-04-21 WO PCT/US2003/012543 patent/WO2003089458A2/en not_active Ceased
- 2003-04-21 EP EP11182821A patent/EP2431055A1/en not_active Withdrawn
- 2003-04-21 AU AU2003228658A patent/AU2003228658A1/en not_active Abandoned
-
2004
- 2004-09-30 US US10/955,656 patent/US20050101762A1/en not_active Abandoned
-
2005
- 2005-12-16 US US11/303,372 patent/US7638599B2/en not_active Expired - Fee Related
-
2009
- 2009-12-23 US US12/645,922 patent/US8017727B2/en not_active Expired - Fee Related
-
2010
- 2010-06-04 JP JP2010128982A patent/JP5211109B2/ja not_active Expired - Fee Related
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