JP2004000251A5 - - Google Patents
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- Publication number
- JP2004000251A5 JP2004000251A5 JP2003271241A JP2003271241A JP2004000251A5 JP 2004000251 A5 JP2004000251 A5 JP 2004000251A5 JP 2003271241 A JP2003271241 A JP 2003271241A JP 2003271241 A JP2003271241 A JP 2003271241A JP 2004000251 A5 JP2004000251 A5 JP 2004000251A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- compound
- compound according
- human ghrelin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 1
- 101800001586 Ghrelin Proteins 0.000 claims 1
- 102000012004 Ghrelin Human genes 0.000 claims 1
- 229910001424 calcium ion Inorganic materials 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003271241A JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21000299 | 1999-07-23 | ||
| JP33884199 | 1999-11-29 | ||
| JP2000126623 | 2000-04-26 | ||
| JP2003271241A JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Division JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004000251A JP2004000251A (ja) | 2004-01-08 |
| JP2004000251A5 true JP2004000251A5 (enExample) | 2007-09-06 |
| JP4227857B2 JP4227857B2 (ja) | 2009-02-18 |
Family
ID=27329078
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Expired - Lifetime JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
| JP2003271241A Expired - Lifetime JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Expired - Lifetime JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7385026B1 (enExample) |
| EP (3) | EP2119785B1 (enExample) |
| JP (2) | JP3471780B2 (enExample) |
| KR (1) | KR100827973B1 (enExample) |
| CN (2) | CN100506844C (enExample) |
| AT (2) | ATE449174T1 (enExample) |
| AU (2) | AU784035B2 (enExample) |
| BR (2) | BRPI0012688B8 (enExample) |
| CA (2) | CA2696819C (enExample) |
| CY (2) | CY1107724T1 (enExample) |
| DE (2) | DE60035502T2 (enExample) |
| DK (2) | DK1795598T3 (enExample) |
| ES (3) | ES2401939T3 (enExample) |
| IL (2) | IL147652A0 (enExample) |
| PT (2) | PT1795598E (enExample) |
| WO (1) | WO2001007475A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100506844C (zh) | 1999-07-23 | 2009-07-01 | 寒川贤治 | 新的肽 |
| CA2392019A1 (en) | 1999-11-22 | 2001-05-31 | Zymogenetics, Inc. | Method of forming a peptide-receptor complex with zsig33 |
| US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
| WO2001085804A1 (fr) | 2000-05-12 | 2001-11-15 | Kaneka Corporation | Procede de purification de polymere vinylique |
| US6967237B2 (en) | 2000-05-30 | 2005-11-22 | Merck & Co., Inc. | Ghrelin analogs |
| AU2001283938A1 (en) * | 2000-07-24 | 2002-02-05 | Ardana Bioscience Limited | Ghrelin antagonists |
| IL162780A0 (en) * | 2002-04-11 | 2005-11-20 | Kenji Kangawa | Method for producing modified peptide |
| ES2615484T3 (es) * | 2002-05-21 | 2017-06-07 | Daiichi Sankyo Company, Limited | Composiciones medicinales que contienen grelina |
| MXPA04011247A (es) * | 2002-07-19 | 2005-02-17 | Cytos Biotechnology Ag | Conjugados portadores de grelina. |
| EP1578778B1 (en) * | 2002-07-23 | 2011-01-26 | Ipsen Pharma | Ghrelin analogs |
| TWI331922B (en) | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| US20060128615A1 (en) * | 2002-09-18 | 2006-06-15 | Pierrette Gaudreau | Ghrh analogues |
| EP1407779A1 (en) * | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Use of ghrelin for treating low body weight and body fat in gastrectomized individuals |
| ES2383685T3 (es) * | 2003-04-30 | 2012-06-25 | Kenji Kangawa | Preventivos o remedios para hepatopatía |
| EP1633397A2 (en) * | 2003-06-04 | 2006-03-15 | Eli Lilly And Company | Anti-ghrelin fab antibodies |
| WO2005026211A2 (en) * | 2003-09-05 | 2005-03-24 | Eli Lilly And Company | Anti-ghrelin antibodies |
| CN1321131C (zh) * | 2003-12-26 | 2007-06-13 | 李宁 | 猪Ghrelin衍生物及其编码基因与应用 |
| CN1905903A (zh) * | 2004-01-20 | 2007-01-31 | 赛托斯生物技术公司 | 生长素释放肽－载体偶联物 |
| US7026175B2 (en) | 2004-03-29 | 2006-04-11 | Applied Materials, Inc. | High throughput measurement of via defects in interconnects |
| JP2007532495A (ja) * | 2004-04-07 | 2007-11-15 | ガストロテック・ファルマ・アクティーゼルスカブ | グレリン欠乏を治療するための分泌促進薬の使用 |
| WO2005097831A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Uses of isolated binding members capable of binding specifically to secretagogues |
| WO2005097830A2 (en) * | 2004-04-07 | 2005-10-20 | Aditech Pharma Ab | Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds |
| EP1750745A1 (en) * | 2004-05-11 | 2007-02-14 | The United States of America, represented by the Secretary, Department of Health and Human Services | Methods of inhibiting proinflammatory cytokine expression using ghrelin |
| WO2005120484A1 (ja) * | 2004-06-09 | 2005-12-22 | Kurume University | グレリンの生理学的機能のレギュレーター |
| EP1776386A1 (en) * | 2004-07-14 | 2007-04-25 | Eli Lilly And Company | Anti-ghrelin antibodies |
| WO2006045319A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of growth hormone secretagogues in the treatment of individuals suffering from renal and/or liver failure |
| WO2006045313A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of secretagogues for treatment of organ transplant patients |
| JP2008521840A (ja) * | 2004-11-30 | 2008-06-26 | ガストロテック・ファルマ・アクティーゼルスカブ | 成長ホルモン分泌促進物質レセプター１ａリガンド |
| US7803768B2 (en) | 2005-02-23 | 2010-09-28 | Kyoto University | Method for treatment of hyperglycemia in a subject in need thereof |
| US7479271B2 (en) | 2005-02-23 | 2009-01-20 | Eli Lilly And Company | Humanized anti-ghrelin antibodies |
| RU2427587C2 (ru) * | 2005-09-28 | 2011-08-27 | Ипсен Фарма С.А.С. | Аналоги грелина |
| CN105381453B9 (zh) | 2005-09-29 | 2019-01-11 | 益普生制药股份有限公司 | 用于刺激胃肠运动性的组合物和方法 |
| US20090305969A1 (en) | 2005-11-21 | 2009-12-10 | Noboru Murakami | Skin Repair Accelerating Therapeutic Agent Containing Desacyl Ghrelin and Derivatives Thereof as Active Ingredient |
| JPWO2007058359A1 (ja) * | 2005-11-21 | 2009-05-07 | 国立大学法人 宮崎大学 | グレリン及びその誘導体又はＧＨＳ−Ｒ１ａに作用する物質を有効成分とする皮膚修復促進治療剤 |
| WO2007106385A2 (en) * | 2006-03-10 | 2007-09-20 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment |
| US7981860B2 (en) | 2006-03-13 | 2011-07-19 | Liat Mintz | Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation |
| US9675679B2 (en) * | 2006-08-01 | 2017-06-13 | The Scripps Research Institute | Vaccines and methods for controlling adiposity |
| KR20090060291A (ko) | 2006-08-11 | 2009-06-11 | 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 | 그렐린 및 그 유도체 또는 ＧＨＳ―Ｒ１ａ에 작용하는 물질을 유효성분으로 포함하는 척수 신경 수복 촉진 치료제 |
| EP2070549A1 (en) * | 2006-08-11 | 2009-06-17 | University of Miyazaki | Therapeutic agent for acceleration of spinal nerve repair comprising desacyl ghrelin or derivative thereof as active ingredient |
| WO2008039415A2 (en) | 2006-09-27 | 2008-04-03 | Ipsen Pharma S.A.S. | Analogs of ghrelin substituted at the n-terminal |
| KR20130018965A (ko) | 2008-05-23 | 2013-02-25 | 다이이찌 산쿄 가부시키가이샤 | 목적 펩타이드의 혈장내 반감기 연장 작용을 가진 펩타이드 |
| CN108530543B (zh) | 2009-02-03 | 2023-06-23 | 阿穆尼克斯制药公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| US8883721B2 (en) * | 2009-05-12 | 2014-11-11 | Mcgill University | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| EP2524697B1 (en) | 2010-01-15 | 2016-09-21 | University of Miyazaki | Ghrelin for promoting recovery of animal under medical treatment |
| WO2011159917A2 (en) * | 2010-06-16 | 2011-12-22 | The Administrators Of The Tulane Educational Fund | Growth hormone secretatogue receptor antagonists and uses thereof |
| US9555077B2 (en) | 2011-03-03 | 2017-01-31 | University Of Miyazaki | Methods of lowering body temperature by administration of desacyl ghrelin or its derivative |
| JP5560248B2 (ja) * | 2011-09-07 | 2014-07-23 | 花王株式会社 | ジペプチド誘導体及びその製造方法 |
| CA2865578C (en) | 2012-02-27 | 2023-01-17 | Amunix Operating Inc. | Xten conjugate compositions and methods of making same |
| KR20220051197A (ko) | 2012-05-17 | 2022-04-26 | 익스텐드 바이오사이언시즈, 인크. | 개선된 약물 전달용 캐리어 |
| WO2014054798A1 (ja) | 2012-10-04 | 2014-04-10 | 独立行政法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
| KR102499918B1 (ko) | 2012-10-24 | 2023-02-14 | 다이이찌 산쿄 가부시키가이샤 | 근위축성 측삭 경화증 치료제 |
| JP6143270B2 (ja) * | 2013-01-31 | 2017-06-07 | 学校法人東京薬科大学 | マイオスタチン阻害ペプチド |
| TWI662967B (zh) * | 2013-03-25 | 2019-06-21 | 日商志瑞亞新藥工業股份有限公司 | 食後期之胃運動亢進劑 |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| CN109879935B (zh) * | 2019-03-04 | 2020-11-20 | 南京工业大学 | 一种多肽的液相合成方法 |
| IL292863A (en) | 2019-11-13 | 2022-07-01 | Amunix Pharmaceuticals Inc | Barcoded xanthan polypeptides and their compositions, and methods for their preparation and use |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| CN120818010B (zh) * | 2025-09-18 | 2025-12-05 | 天津科技大学 | 一种来自植物乳杆菌属细胞外囊泡的短肽及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| ATE227307T1 (de) * | 1992-04-07 | 2002-11-15 | Scripps Research Inst | Verfahren zur herstellung modifizierten proteine |
| EP0819137A1 (en) * | 1995-03-31 | 1998-01-21 | American Cyanamid Company | Peptides with growth promotion properties |
| IL118473A0 (en) | 1995-06-02 | 1996-09-12 | Suntory Ltd | Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof |
| CA2198966C (en) | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| JP3982866B2 (ja) | 1996-03-04 | 2007-09-26 | アスビオファーマ株式会社 | 分泌型Ｋｅｘ２誘導体の製造方法 |
| WO1999063088A2 (en) * | 1998-06-02 | 1999-12-09 | Genentech, Inc. | Membrane-bound proteins and nucleic acids encoding the same |
| CA2284733C (en) | 1997-03-24 | 2010-10-26 | Zymogenetics, Inc. | Motilin homologs |
| CN1120846C (zh) * | 1999-02-13 | 2003-09-10 | 中国人民解放军军事医学科学院基础医学研究所 | 生长激素释放肽及其应用 |
| US6420521B1 (en) * | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
| CN100506844C (zh) * | 1999-07-23 | 2009-07-01 | 寒川贤治 | 新的肽 |
-
2000
- 2000-07-24 CN CNB008104409A patent/CN100506844C/zh not_active Expired - Lifetime
- 2000-07-24 BR BRPI0012688A patent/BRPI0012688B8/pt unknown
- 2000-07-24 BR BR0012688-8A patent/BR0012688A/pt not_active IP Right Cessation
- 2000-07-24 ES ES09166974T patent/ES2401939T3/es not_active Expired - Lifetime
- 2000-07-24 IL IL14765200A patent/IL147652A0/xx unknown
- 2000-07-24 WO PCT/JP2000/004907 patent/WO2001007475A1/ja not_active Ceased
- 2000-07-24 AU AU60231/00A patent/AU784035B2/en not_active Expired
- 2000-07-24 CA CA2696819A patent/CA2696819C/en not_active Expired - Lifetime
- 2000-07-24 EP EP09166974A patent/EP2119785B1/en not_active Expired - Lifetime
- 2000-07-24 AT AT07006224T patent/ATE449174T1/de active
- 2000-07-24 EP EP00946453A patent/EP1197496B8/en not_active Expired - Lifetime
- 2000-07-24 ES ES07006224T patent/ES2335235T3/es not_active Expired - Lifetime
- 2000-07-24 PT PT07006224T patent/PT1795598E/pt unknown
- 2000-07-24 KR KR1020027000758A patent/KR100827973B1/ko not_active Expired - Lifetime
- 2000-07-24 CA CA2380058A patent/CA2380058C/en not_active Expired - Lifetime
- 2000-07-24 US US09/959,577 patent/US7385026B1/en not_active Expired - Lifetime
- 2000-07-24 CN CN200910141231.3A patent/CN101693736B/zh not_active Expired - Lifetime
- 2000-07-24 EP EP07006224A patent/EP1795598B1/en not_active Expired - Lifetime
- 2000-07-24 JP JP2001512558A patent/JP3471780B2/ja not_active Expired - Lifetime
- 2000-07-24 DK DK07006224.5T patent/DK1795598T3/da active
- 2000-07-24 PT PT00946453T patent/PT1197496E/pt unknown
- 2000-07-24 ES ES00946453T patent/ES2288151T3/es not_active Expired - Lifetime
- 2000-07-24 DK DK00946453T patent/DK1197496T3/da active
- 2000-07-24 AT AT00946453T patent/ATE366813T1/de active
- 2000-07-24 DE DE60035502T patent/DE60035502T2/de not_active Expired - Lifetime
- 2000-07-24 DE DE60043361T patent/DE60043361D1/de not_active Expired - Lifetime
-
2002
- 2002-01-15 IL IL147652A patent/IL147652A/en active IP Right Grant
-
2003
- 2003-07-07 JP JP2003271241A patent/JP4227857B2/ja not_active Expired - Lifetime
-
2006
- 2006-04-13 AU AU2006201580A patent/AU2006201580B2/en not_active Expired
-
2007
- 2007-08-28 CY CY20071101137T patent/CY1107724T1/el unknown
-
2008
- 2008-01-30 US US12/010,838 patent/US8227570B2/en not_active Expired - Fee Related
-
2010
- 2010-01-05 CY CY20101100012T patent/CY1109714T1/el unknown
- 2010-03-22 US US12/728,495 patent/US9573986B2/en not_active Expired - Fee Related
-
2011
- 2011-03-31 US US13/076,844 patent/US8524871B2/en not_active Expired - Fee Related
-
2012
- 2012-06-12 US US13/494,673 patent/US9938332B2/en not_active Expired - Fee Related
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