JP2004000251A5 - - Google Patents
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- Publication number
- JP2004000251A5 JP2004000251A5 JP2003271241A JP2003271241A JP2004000251A5 JP 2004000251 A5 JP2004000251 A5 JP 2004000251A5 JP 2003271241 A JP2003271241 A JP 2003271241A JP 2003271241 A JP2003271241 A JP 2003271241A JP 2004000251 A5 JP2004000251 A5 JP 2004000251A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- compound
- compound according
- human ghrelin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 1
- 101800001586 Ghrelin Proteins 0.000 claims 1
- 102000012004 Ghrelin Human genes 0.000 claims 1
- 229910001424 calcium ion Inorganic materials 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003271241A JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21000299 | 1999-07-23 | ||
| JP33884199 | 1999-11-29 | ||
| JP2000126623 | 2000-04-26 | ||
| JP2003271241A JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Division JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004000251A JP2004000251A (ja) | 2004-01-08 |
| JP2004000251A5 true JP2004000251A5 (enExample) | 2007-09-06 |
| JP4227857B2 JP4227857B2 (ja) | 2009-02-18 |
Family
ID=27329078
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Expired - Lifetime JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
| JP2003271241A Expired - Lifetime JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Expired - Lifetime JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7385026B1 (enExample) |
| EP (3) | EP1795598B1 (enExample) |
| JP (2) | JP3471780B2 (enExample) |
| KR (1) | KR100827973B1 (enExample) |
| CN (2) | CN100506844C (enExample) |
| AT (2) | ATE366813T1 (enExample) |
| AU (2) | AU784035B2 (enExample) |
| BR (2) | BRPI0012688B8 (enExample) |
| CA (2) | CA2380058C (enExample) |
| CY (2) | CY1107724T1 (enExample) |
| DE (2) | DE60035502T2 (enExample) |
| DK (2) | DK1197496T3 (enExample) |
| ES (3) | ES2335235T3 (enExample) |
| IL (2) | IL147652A0 (enExample) |
| PT (2) | PT1197496E (enExample) |
| WO (1) | WO2001007475A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0012688B8 (pt) | 1999-07-23 | 2021-05-25 | Kangawa Kenji | método para produzir um composto tipo peptídeo, vetor compreendendo um dna que codifica o composto tipo peptídeo, células microbianas hospedeiras e células microbianas hospedeiras transformadas |
| CA2392019A1 (en) * | 1999-11-22 | 2001-05-31 | Zymogenetics, Inc. | Method of forming a peptide-receptor complex with zsig33 |
| US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
| US7141646B2 (en) | 2000-05-12 | 2006-11-28 | Kaneka Corporation | Method of purifying vinyl polymer |
| CA2411667A1 (en) | 2000-05-30 | 2001-12-06 | Merck & Co. Inc. | Ghrelin analogs |
| CA2416643A1 (en) * | 2000-07-24 | 2002-01-31 | Ardana Bioscience Limited | Ghrelin antagonists |
| EP1493747B1 (en) * | 2002-04-11 | 2012-12-19 | Daiichi Sankyo Company, Limited | Process for producing modified peptide |
| US20060166871A1 (en) * | 2002-05-21 | 2006-07-27 | Daiichi Suntory Pharma., Ltd. | Medical compositions containing ghrelin |
| US20040076645A1 (en) * | 2002-07-19 | 2004-04-22 | Bachmann Martin F. | Ghrelin-carrier conjugates |
| BR0312871A (pt) | 2002-07-23 | 2007-07-10 | Sod Conseils Rech Applic | análogos de grelina, método para identificação de um composto capaz de se ligar a um receptor de ghs e usos de tais análogos |
| TWI331922B (en) | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| US20060128615A1 (en) * | 2002-09-18 | 2006-06-15 | Pierrette Gaudreau | Ghrh analogues |
| EP1407779A1 (en) * | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Use of ghrelin for treating low body weight and body fat in gastrectomized individuals |
| CA2523576A1 (en) * | 2003-04-30 | 2004-11-11 | Kenji Kangawa | Preventives or remedies for hepatopathy |
| US20060269550A1 (en) * | 2003-06-04 | 2006-11-30 | Heiman Mark L | Anti-ghrelin fab antibodies |
| US20060233788A1 (en) * | 2003-09-05 | 2006-10-19 | Heiman Mark L | Anti-ghrelin antibodies |
| CN1321131C (zh) * | 2003-12-26 | 2007-06-13 | 李宁 | 猪Ghrelin衍生物及其编码基因与应用 |
| US20050191317A1 (en) * | 2004-01-20 | 2005-09-01 | Cytos Biotechnology Ag | Ghrelin-carrier conjugates |
| US7026175B2 (en) | 2004-03-29 | 2006-04-11 | Applied Materials, Inc. | High throughput measurement of via defects in interconnects |
| JP2007532495A (ja) * | 2004-04-07 | 2007-11-15 | ガストロテック・ファルマ・アクティーゼルスカブ | グレリン欠乏を治療するための分泌促進薬の使用 |
| WO2005097830A2 (en) * | 2004-04-07 | 2005-10-20 | Aditech Pharma Ab | Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds |
| WO2005097831A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Uses of isolated binding members capable of binding specifically to secretagogues |
| US20080269116A1 (en) * | 2004-05-11 | 2008-10-30 | Taub Dennis D | Methods of Inhibiting Proinflammatory Cytokine Expression Using Ghrelin |
| WO2005120484A1 (ja) * | 2004-06-09 | 2005-12-22 | Kurume University | グレリンの生理学的機能のレギュレーター |
| KR20070034583A (ko) * | 2004-07-14 | 2007-03-28 | 일라이 릴리 앤드 캄파니 | 항-그렐린 항체 |
| EP1812044A2 (en) * | 2004-10-27 | 2007-08-01 | Gastrotech Pharma A/S | Uses of growth hormone secretagogues in the treatment of individuals suffering from renal and/or liver failure |
| WO2006045313A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of secretagogues for treatment of organ transplant patients |
| WO2006058539A2 (en) * | 2004-11-30 | 2006-06-08 | Gastrotech Pharma A/S | Growth hormone secretagogue receptor 1a ligands |
| AU2006216218B2 (en) | 2005-02-23 | 2011-08-11 | Daiichi Sankyo Company, Limited | Promoter of regeneration of pancreatic beta cell, and promoter of insulin production in pancreatic beta cell |
| WO2006091381A1 (en) * | 2005-02-23 | 2006-08-31 | Eli Lilly And Company | Humanized anti-ghrelin antibodies |
| RU2427587C2 (ru) * | 2005-09-28 | 2011-08-27 | Ипсен Фарма С.А.С. | Аналоги грелина |
| DK1937262T3 (da) | 2005-09-29 | 2019-07-15 | Ipsen Pharma | Sammensætning til anvendelse i behandling af gastrointestinal dysmotilitet |
| CA2630006A1 (en) * | 2005-11-21 | 2007-05-24 | Asubio Pharma Co., Ltd. | Skin repair accelerating therapeutic agent containing ghrelin and derivatives thereof or substance acting on ghs-r1a as active ingredient |
| KR20080082651A (ko) * | 2005-11-21 | 2008-09-11 | 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 | 데스아실 그렐린 및 그 유도체를 유효 성분으로 하는 피부수복 촉진 치료제 |
| EP2012809B1 (en) | 2006-03-10 | 2013-05-22 | Ipsen Pharma | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment |
| CN101443358B (zh) | 2006-03-13 | 2016-05-11 | 利亚特·明茨 | 生长素释放肽剪接变体在治疗恶病质和/或压食和/或厌食-恶病质和/或营养不良和/或脂肪营养障碍和/或肌肉消耗和/或刺激食欲中的用途 |
| CN101500602A (zh) * | 2006-08-01 | 2009-08-05 | 斯克里普斯研究院 | 控制肥胖症的疫苗及方法 |
| AU2007282343A1 (en) | 2006-08-11 | 2008-02-14 | Asubio Pharma Co., Ltd. | Spinal nerve repair promoting therapeutics containing ghrelin or its derivatives or substances that act on GHS-R1a as an active ingredient |
| CA2660689A1 (en) * | 2006-08-11 | 2008-02-14 | University Of Miyazaki | Spinal nerve repair promoting therapeutics containing des-acyl ghrelin or its derivatives as an active ingredient |
| WO2008039415A2 (en) * | 2006-09-27 | 2008-04-03 | Ipsen Pharma S.A.S. | Analogs of ghrelin substituted at the n-terminal |
| CA2698582C (en) | 2008-05-23 | 2016-09-13 | Asubio Pharma Co., Ltd. | Peptide having an extending action for half-life of object peptide in plasma |
| CN108530543B (zh) | 2009-02-03 | 2023-06-23 | 阿穆尼克斯制药公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| US8883721B2 (en) * | 2009-05-12 | 2014-11-11 | Mcgill University | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| WO2011087102A1 (ja) | 2010-01-15 | 2011-07-21 | 国立大学法人宮崎大学 | 加療中動物の回復促進治療剤 |
| CA2805406A1 (en) | 2010-06-16 | 2011-12-22 | Mcgill University | Growth hormone secretatogue receptor antagonists and uses thereof |
| BR112013021859A2 (pt) | 2011-03-03 | 2016-10-25 | Daiichi Sankyo Co Ltd | agente hipotérmico para um animal, agente hiportérmico, agente terapêutico para hipertermia em um animal, método para reduzir a temperatura corporal de um animal, método terapêutico para hipertermia em um animal, desacilada ou o seu derivado e uso de gralina desacilada ou o seu derivado |
| JP5560248B2 (ja) * | 2011-09-07 | 2014-07-23 | 花王株式会社 | ジペプチド誘導体及びその製造方法 |
| EA037979B1 (ru) | 2012-02-27 | 2021-06-18 | Амуникс Оперейтинг Инк. | Композиции конъюгата xten и способы их получения |
| KR20220051197A (ko) | 2012-05-17 | 2022-04-26 | 익스텐드 바이오사이언시즈, 인크. | 개선된 약물 전달용 캐리어 |
| WO2014054798A1 (ja) | 2012-10-04 | 2014-04-10 | 独立行政法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
| WO2014065341A1 (ja) | 2012-10-24 | 2014-05-01 | 第一三共株式会社 | 筋萎縮性側索硬化症治療剤 |
| JP6143270B2 (ja) * | 2013-01-31 | 2017-06-07 | 学校法人東京薬科大学 | マイオスタチン阻害ペプチド |
| JP6295247B2 (ja) * | 2013-03-25 | 2018-03-14 | ゼリア新薬工業株式会社 | 食後期の胃運動亢進剤 |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| CA2964463C (en) | 2014-10-22 | 2024-02-13 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| CN109879935B (zh) * | 2019-03-04 | 2020-11-20 | 南京工业大学 | 一种多肽的液相合成方法 |
| WO2021097186A1 (en) | 2019-11-13 | 2021-05-20 | Amunix Pharmaceuticals, Inc. | Barcoded xten polypeptides and compositions thereof, and methods for making and using the same |
| KR20250075704A (ko) | 2022-09-30 | 2025-05-28 | 익스텐드 바이오사이언시즈, 인크. | 장기-지속형 부갑상선 호르몬 |
| CN120818010B (zh) * | 2025-09-18 | 2025-12-05 | 天津科技大学 | 一种来自植物乳杆菌属细胞外囊泡的短肽及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| AU686999B2 (en) * | 1992-04-07 | 1998-02-19 | Scripps Research Institute, The | Process for preparing modified proteins |
| CA2216755A1 (en) * | 1995-03-31 | 1996-10-03 | Brian Lee Buckwalter | Peptides with growth promotion properties |
| IL118473A0 (en) | 1995-06-02 | 1996-09-12 | Suntory Ltd | Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof |
| JP3982866B2 (ja) | 1996-03-04 | 2007-09-26 | アスビオファーマ株式会社 | 分泌型Ｋｅｘ２誘導体の製造方法 |
| CA2198966C (en) | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| WO1999063088A2 (en) * | 1998-06-02 | 1999-12-09 | Genentech, Inc. | Membrane-bound proteins and nucleic acids encoding the same |
| BR9808059A (pt) * | 1997-03-24 | 2000-03-08 | Zimogenetics Inc | Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástrica |
| CN1120846C (zh) * | 1999-02-13 | 2003-09-10 | 中国人民解放军军事医学科学院基础医学研究所 | 生长激素释放肽及其应用 |
| US6420521B1 (en) * | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
| BRPI0012688B8 (pt) * | 1999-07-23 | 2021-05-25 | Kangawa Kenji | método para produzir um composto tipo peptídeo, vetor compreendendo um dna que codifica o composto tipo peptídeo, células microbianas hospedeiras e células microbianas hospedeiras transformadas |
-
2000
- 2000-07-24 BR BRPI0012688A patent/BRPI0012688B8/pt unknown
- 2000-07-24 ES ES07006224T patent/ES2335235T3/es not_active Expired - Lifetime
- 2000-07-24 AT AT00946453T patent/ATE366813T1/de active
- 2000-07-24 CN CNB008104409A patent/CN100506844C/zh not_active Expired - Lifetime
- 2000-07-24 DE DE60035502T patent/DE60035502T2/de not_active Expired - Lifetime
- 2000-07-24 DK DK00946453T patent/DK1197496T3/da active
- 2000-07-24 KR KR1020027000758A patent/KR100827973B1/ko not_active Expired - Lifetime
- 2000-07-24 US US09/959,577 patent/US7385026B1/en not_active Expired - Lifetime
- 2000-07-24 CA CA2380058A patent/CA2380058C/en not_active Expired - Lifetime
- 2000-07-24 IL IL14765200A patent/IL147652A0/xx unknown
- 2000-07-24 AT AT07006224T patent/ATE449174T1/de active
- 2000-07-24 EP EP07006224A patent/EP1795598B1/en not_active Expired - Lifetime
- 2000-07-24 EP EP09166974A patent/EP2119785B1/en not_active Expired - Lifetime
- 2000-07-24 JP JP2001512558A patent/JP3471780B2/ja not_active Expired - Lifetime
- 2000-07-24 BR BR0012688-8A patent/BR0012688A/pt not_active IP Right Cessation
- 2000-07-24 DK DK07006224.5T patent/DK1795598T3/da active
- 2000-07-24 WO PCT/JP2000/004907 patent/WO2001007475A1/ja not_active Ceased
- 2000-07-24 PT PT00946453T patent/PT1197496E/pt unknown
- 2000-07-24 ES ES09166974T patent/ES2401939T3/es not_active Expired - Lifetime
- 2000-07-24 ES ES00946453T patent/ES2288151T3/es not_active Expired - Lifetime
- 2000-07-24 CN CN200910141231.3A patent/CN101693736B/zh not_active Expired - Lifetime
- 2000-07-24 AU AU60231/00A patent/AU784035B2/en not_active Expired
- 2000-07-24 CA CA2696819A patent/CA2696819C/en not_active Expired - Lifetime
- 2000-07-24 DE DE60043361T patent/DE60043361D1/de not_active Expired - Lifetime
- 2000-07-24 PT PT07006224T patent/PT1795598E/pt unknown
- 2000-07-24 EP EP00946453A patent/EP1197496B8/en not_active Expired - Lifetime
-
2002
- 2002-01-15 IL IL147652A patent/IL147652A/en active IP Right Grant
-
2003
- 2003-07-07 JP JP2003271241A patent/JP4227857B2/ja not_active Expired - Lifetime
-
2006
- 2006-04-13 AU AU2006201580A patent/AU2006201580B2/en not_active Expired
-
2007
- 2007-08-28 CY CY20071101137T patent/CY1107724T1/el unknown
-
2008
- 2008-01-30 US US12/010,838 patent/US8227570B2/en not_active Expired - Fee Related
-
2010
- 2010-01-05 CY CY20101100012T patent/CY1109714T1/el unknown
- 2010-03-22 US US12/728,495 patent/US9573986B2/en not_active Expired - Fee Related
-
2011
- 2011-03-31 US US13/076,844 patent/US8524871B2/en not_active Expired - Fee Related
-
2012
- 2012-06-12 US US13/494,673 patent/US9938332B2/en not_active Expired - Fee Related
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