JP2004000251A5 - - Google Patents
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- Publication number
- JP2004000251A5 JP2004000251A5 JP2003271241A JP2003271241A JP2004000251A5 JP 2004000251 A5 JP2004000251 A5 JP 2004000251A5 JP 2003271241 A JP2003271241 A JP 2003271241A JP 2003271241 A JP2003271241 A JP 2003271241A JP 2004000251 A5 JP2004000251 A5 JP 2004000251A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- compound
- compound according
- human ghrelin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 1
- 101800001586 Ghrelin Proteins 0.000 claims 1
- 102000012004 Ghrelin Human genes 0.000 claims 1
- 229910001424 calcium ion Inorganic materials 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003271241A JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21000299 | 1999-07-23 | ||
| JP33884199 | 1999-11-29 | ||
| JP2000126623 | 2000-04-26 | ||
| JP2003271241A JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Division JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004000251A JP2004000251A (ja) | 2004-01-08 |
| JP2004000251A5 true JP2004000251A5 (enExample) | 2007-09-06 |
| JP4227857B2 JP4227857B2 (ja) | 2009-02-18 |
Family
ID=27329078
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Expired - Lifetime JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
| JP2003271241A Expired - Lifetime JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Expired - Lifetime JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7385026B1 (enExample) |
| EP (3) | EP2119785B1 (enExample) |
| JP (2) | JP3471780B2 (enExample) |
| KR (1) | KR100827973B1 (enExample) |
| CN (2) | CN101693736B (enExample) |
| AT (2) | ATE366813T1 (enExample) |
| AU (2) | AU784035B2 (enExample) |
| BR (2) | BR0012688A (enExample) |
| CA (2) | CA2380058C (enExample) |
| CY (2) | CY1107724T1 (enExample) |
| DE (2) | DE60035502T2 (enExample) |
| DK (2) | DK1197496T3 (enExample) |
| ES (3) | ES2401939T3 (enExample) |
| IL (2) | IL147652A0 (enExample) |
| PT (2) | PT1197496E (enExample) |
| WO (1) | WO2001007475A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2380058C (en) | 1999-07-23 | 2011-08-09 | Kenji Kangawa | Novel peptides |
| EP1232175B1 (en) * | 1999-11-22 | 2009-07-08 | ZymoGenetics, Inc. | Method of forming a peptide-receptor complex with zsig33 polypeptides. |
| US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
| US7141646B2 (en) | 2000-05-12 | 2006-11-28 | Kaneka Corporation | Method of purifying vinyl polymer |
| CA2411667A1 (en) * | 2000-05-30 | 2001-12-06 | Merck & Co. Inc. | Ghrelin analogs |
| CN1443198A (zh) * | 2000-07-24 | 2003-09-17 | 阿达纳生物科学有限公司 | Ghrelin拮抗剂 |
| EP1493747B1 (en) * | 2002-04-11 | 2012-12-19 | Daiichi Sankyo Company, Limited | Process for producing modified peptide |
| JP5000848B2 (ja) * | 2002-05-21 | 2012-08-15 | 第一三共株式会社 | グレリン含有医薬組成物 |
| RU2325202C2 (ru) * | 2002-07-19 | 2008-05-27 | Цитос Байотекнолоджи Аг | Конъюгаты грелин-носитель |
| JP2006515271A (ja) * | 2002-07-23 | 2006-05-25 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | グレリン類似体 |
| TWI331922B (en) | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| EP1539959A2 (en) * | 2002-09-18 | 2005-06-15 | Centre Hospitalier de l'Université de Montréal (CHUM) | Ghrh analogues |
| EP1407779A1 (en) | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Use of ghrelin for treating low body weight and body fat in gastrectomized individuals |
| JP4467518B2 (ja) | 2003-04-30 | 2010-05-26 | 賢治 寒川 | 肝障害予防治療剤 |
| EP1633397A2 (en) * | 2003-06-04 | 2006-03-15 | Eli Lilly And Company | Anti-ghrelin fab antibodies |
| US20060233788A1 (en) * | 2003-09-05 | 2006-10-19 | Heiman Mark L | Anti-ghrelin antibodies |
| CN1321131C (zh) * | 2003-12-26 | 2007-06-13 | 李宁 | 猪Ghrelin衍生物及其编码基因与应用 |
| EP1706152A2 (en) * | 2004-01-20 | 2006-10-04 | Cytos Biotechnology AG | Particle-induced ghrelin immune response |
| US7026175B2 (en) | 2004-03-29 | 2006-04-11 | Applied Materials, Inc. | High throughput measurement of via defects in interconnects |
| JP2007532495A (ja) * | 2004-04-07 | 2007-11-15 | ガストロテック・ファルマ・アクティーゼルスカブ | グレリン欠乏を治療するための分泌促進薬の使用 |
| WO2005097830A2 (en) * | 2004-04-07 | 2005-10-20 | Aditech Pharma Ab | Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds |
| WO2005097831A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Uses of isolated binding members capable of binding specifically to secretagogues |
| CA2566703A1 (en) * | 2004-05-11 | 2005-11-24 | Vishwa Deep Dixit | Methods of inhibiting proinflammatory cytokine expression using ghrelin |
| WO2005120484A1 (ja) * | 2004-06-09 | 2005-12-22 | Kurume University | グレリンの生理学的機能のレギュレーター |
| US20070237775A1 (en) * | 2004-07-14 | 2007-10-11 | Eli Lilly And Company | Anti-Ghrelin Antibodies |
| EP1812045A2 (en) * | 2004-10-27 | 2007-08-01 | Gastrotech Pharma A/S | Uses of secretagogues for treatment of organ transplant patients |
| WO2006045319A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of growth hormone secretagogues in the treatment of individuals suffering from renal and/or liver failure |
| US20080300180A1 (en) * | 2004-11-30 | 2008-12-04 | Gastrotech Pharma A/S | Growth Hormone Secretagogue Receptor 1A Ligands |
| US7479271B2 (en) | 2005-02-23 | 2009-01-20 | Eli Lilly And Company | Humanized anti-ghrelin antibodies |
| JP4843827B2 (ja) | 2005-02-23 | 2011-12-21 | 国立大学法人京都大学 | 膵臓β細胞の再生促進剤及び膵臓β細胞におけるインスリン産生促進剤 |
| RU2427587C2 (ru) * | 2005-09-28 | 2011-08-27 | Ипсен Фарма С.А.С. | Аналоги грелина |
| DK1937262T3 (da) | 2005-09-29 | 2019-07-15 | Ipsen Pharma | Sammensætning til anvendelse i behandling af gastrointestinal dysmotilitet |
| CN101312745A (zh) * | 2005-11-21 | 2008-11-26 | 国立大学法人宫崎大学 | 包含生长素释放肽或其衍生物或作用于GHS-R1a的物质作为活性成分的皮肤修复促进治疗剂 |
| JPWO2007058360A1 (ja) * | 2005-11-21 | 2009-05-07 | 国立大学法人 宮崎大学 | デスアシルグレリン及びその誘導体を有効成分とする皮膚修復促進治療剤 |
| ES2424970T3 (es) | 2006-03-10 | 2013-10-10 | Ipsen Pharma | Uso de un agonista de la grelina para mejorar los efectos catabólicos del tratamiento con glucocorticoides |
| KR101201055B1 (ko) | 2006-03-13 | 2012-11-15 | 리아트 민쯔 | 악액질 및/또는 식욕감퇴 및/또는 식욕감퇴-악액질 및/또는영양장애 및/또는 지방이영양증 및/또는 근육 쇠약 및/또는 식욕-자극의 치료를 위한 그렐린 스플라이스 변이체의 용도 |
| EP2046376B1 (en) * | 2006-08-01 | 2018-08-01 | The Scripps Research Institute | Vaccines and methods for controlling adiposity |
| JPWO2008018600A1 (ja) | 2006-08-11 | 2010-01-07 | 国立大学法人 宮崎大学 | グレリン及びその誘導体又はＧＨＳ−Ｒ１ａに作用する物質を有効成分とする脊髄神経修復促進治療剤 |
| CN101516399A (zh) * | 2006-08-11 | 2009-08-26 | 国立大学法人宫崎大学 | 以去酰基化的生长素释放肽及其衍生物作为有效成分的脊髓神经修复促进治疗剂 |
| CN101541341B (zh) | 2006-09-27 | 2013-06-05 | 益普生制药两合公司 | N末端取代的生长素释放肽类似物 |
| PT2277890E (pt) | 2008-05-23 | 2016-03-31 | Daiichi Sankyo Co Ltd | Péptido capaz de prolongar o semi-período de vida do péptido de interesse no plasma |
| DK3178835T3 (da) | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| US8883721B2 (en) * | 2009-05-12 | 2014-11-11 | Mcgill University | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| WO2011087102A1 (ja) | 2010-01-15 | 2011-07-21 | 国立大学法人宮崎大学 | 加療中動物の回復促進治療剤 |
| WO2011159917A2 (en) * | 2010-06-16 | 2011-12-22 | The Administrators Of The Tulane Educational Fund | Growth hormone secretatogue receptor antagonists and uses thereof |
| JP5999712B2 (ja) | 2011-03-03 | 2016-09-28 | 国立大学法人 宮崎大学 | 高体温治療剤 |
| JP5560248B2 (ja) * | 2011-09-07 | 2014-07-23 | 花王株式会社 | ジペプチド誘導体及びその製造方法 |
| CN104302408B (zh) | 2012-02-27 | 2016-12-14 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| MX349035B (es) | 2012-05-17 | 2017-07-07 | Extend Biosciences Inc | Portadores para el suministro mejorado de farmaco. |
| WO2014054798A1 (ja) | 2012-10-04 | 2014-04-10 | 独立行政法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
| CA2889499C (en) | 2012-10-24 | 2019-09-10 | Daiichi Sankyo Company, Limited | Growth hormone secretagogue receptor agonists for treating amyotrophic lateral sclerosis |
| WO2014119753A1 (ja) * | 2013-01-31 | 2014-08-07 | 学校法人 東京薬科大学 | マイオスタチン阻害ペプチド |
| WO2014156339A1 (ja) * | 2013-03-25 | 2014-10-02 | ゼリア新薬工業株式会社 | 食後期の胃運動亢進剤 |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| CN109879935B (zh) * | 2019-03-04 | 2020-11-20 | 南京工业大学 | 一种多肽的液相合成方法 |
| EP4058466A1 (en) | 2019-11-13 | 2022-09-21 | Amunix Pharmaceuticals, Inc. | Barcoded xten polypeptides and compositions thereof, and methods for making and using the same |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| CN120818010B (zh) * | 2025-09-18 | 2025-12-05 | 天津科技大学 | 一种来自植物乳杆菌属细胞外囊泡的短肽及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| ES2185628T3 (es) * | 1992-04-07 | 2003-05-01 | Scripps Research Inst | Procedimiento para preparar proteinas modificadas. |
| MX9707433A (es) * | 1995-03-31 | 1997-12-31 | American Cyanamid Co | Peptidos con propiedades para la estimulacion del desarrollo. |
| IL118473A0 (en) | 1995-06-02 | 1996-09-12 | Suntory Ltd | Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof |
| JP3982866B2 (ja) | 1996-03-04 | 2007-09-26 | アスビオファーマ株式会社 | 分泌型Ｋｅｘ２誘導体の製造方法 |
| CA2198966C (en) | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| AU726423B2 (en) * | 1997-03-24 | 2000-11-09 | Zymogenetics Inc. | Motilin homologs |
| IL139686A0 (en) | 1998-06-02 | 2002-02-10 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CN1120846C (zh) * | 1999-02-13 | 2003-09-10 | 中国人民解放军军事医学科学院基础医学研究所 | 生长激素释放肽及其应用 |
| US6420521B1 (en) * | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
| CA2380058C (en) * | 1999-07-23 | 2011-08-09 | Kenji Kangawa | Novel peptides |
-
2000
- 2000-07-24 CA CA2380058A patent/CA2380058C/en not_active Expired - Lifetime
- 2000-07-24 PT PT00946453T patent/PT1197496E/pt unknown
- 2000-07-24 BR BR0012688-8A patent/BR0012688A/pt not_active IP Right Cessation
- 2000-07-24 IL IL14765200A patent/IL147652A0/xx unknown
- 2000-07-24 PT PT07006224T patent/PT1795598E/pt unknown
- 2000-07-24 DK DK00946453T patent/DK1197496T3/da active
- 2000-07-24 AT AT00946453T patent/ATE366813T1/de active
- 2000-07-24 EP EP09166974A patent/EP2119785B1/en not_active Expired - Lifetime
- 2000-07-24 BR BRPI0012688A patent/BRPI0012688B8/pt unknown
- 2000-07-24 AT AT07006224T patent/ATE449174T1/de active
- 2000-07-24 CN CN200910141231.3A patent/CN101693736B/zh not_active Expired - Lifetime
- 2000-07-24 ES ES09166974T patent/ES2401939T3/es not_active Expired - Lifetime
- 2000-07-24 WO PCT/JP2000/004907 patent/WO2001007475A1/ja not_active Ceased
- 2000-07-24 DE DE60035502T patent/DE60035502T2/de not_active Expired - Lifetime
- 2000-07-24 JP JP2001512558A patent/JP3471780B2/ja not_active Expired - Lifetime
- 2000-07-24 AU AU60231/00A patent/AU784035B2/en not_active Expired
- 2000-07-24 EP EP00946453A patent/EP1197496B8/en not_active Expired - Lifetime
- 2000-07-24 CA CA2696819A patent/CA2696819C/en not_active Expired - Lifetime
- 2000-07-24 ES ES07006224T patent/ES2335235T3/es not_active Expired - Lifetime
- 2000-07-24 US US09/959,577 patent/US7385026B1/en not_active Expired - Lifetime
- 2000-07-24 KR KR1020027000758A patent/KR100827973B1/ko not_active Expired - Lifetime
- 2000-07-24 CN CNB008104409A patent/CN100506844C/zh not_active Expired - Lifetime
- 2000-07-24 DE DE60043361T patent/DE60043361D1/de not_active Expired - Lifetime
- 2000-07-24 DK DK07006224.5T patent/DK1795598T3/da active
- 2000-07-24 EP EP07006224A patent/EP1795598B1/en not_active Expired - Lifetime
- 2000-07-24 ES ES00946453T patent/ES2288151T3/es not_active Expired - Lifetime
-
2002
- 2002-01-15 IL IL147652A patent/IL147652A/en active IP Right Grant
-
2003
- 2003-07-07 JP JP2003271241A patent/JP4227857B2/ja not_active Expired - Lifetime
-
2006
- 2006-04-13 AU AU2006201580A patent/AU2006201580B2/en not_active Expired
-
2007
- 2007-08-28 CY CY20071101137T patent/CY1107724T1/el unknown
-
2008
- 2008-01-30 US US12/010,838 patent/US8227570B2/en not_active Expired - Fee Related
-
2010
- 2010-01-05 CY CY20101100012T patent/CY1109714T1/el unknown
- 2010-03-22 US US12/728,495 patent/US9573986B2/en not_active Expired - Fee Related
-
2011
- 2011-03-31 US US13/076,844 patent/US8524871B2/en not_active Expired - Fee Related
-
2012
- 2012-06-12 US US13/494,673 patent/US9938332B2/en not_active Expired - Fee Related
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