JP2004000251A5 - - Google Patents
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- Publication number
- JP2004000251A5 JP2004000251A5 JP2003271241A JP2003271241A JP2004000251A5 JP 2004000251 A5 JP2004000251 A5 JP 2004000251A5 JP 2003271241 A JP2003271241 A JP 2003271241A JP 2003271241 A JP2003271241 A JP 2003271241A JP 2004000251 A5 JP2004000251 A5 JP 2004000251A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- compound
- compound according
- human ghrelin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 1
- 101800001586 Ghrelin Proteins 0.000 claims 1
- 102000012004 Ghrelin Human genes 0.000 claims 1
- 229910001424 calcium ion Inorganic materials 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003271241A JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21000299 | 1999-07-23 | ||
| JP33884199 | 1999-11-29 | ||
| JP2000126623 | 2000-04-26 | ||
| JP2003271241A JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Division JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004000251A JP2004000251A (ja) | 2004-01-08 |
| JP2004000251A5 true JP2004000251A5 (enExample) | 2007-09-06 |
| JP4227857B2 JP4227857B2 (ja) | 2009-02-18 |
Family
ID=27329078
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Expired - Lifetime JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
| JP2003271241A Expired - Lifetime JP4227857B2 (ja) | 1999-07-23 | 2003-07-07 | 新規ペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001512558A Expired - Lifetime JP3471780B2 (ja) | 1999-07-23 | 2000-07-24 | 新規ペプチド |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7385026B1 (enExample) |
| EP (3) | EP1795598B1 (enExample) |
| JP (2) | JP3471780B2 (enExample) |
| KR (1) | KR100827973B1 (enExample) |
| CN (2) | CN100506844C (enExample) |
| AT (2) | ATE449174T1 (enExample) |
| AU (2) | AU784035B2 (enExample) |
| BR (2) | BR0012688A (enExample) |
| CA (2) | CA2380058C (enExample) |
| CY (2) | CY1107724T1 (enExample) |
| DE (2) | DE60043361D1 (enExample) |
| DK (2) | DK1197496T3 (enExample) |
| ES (3) | ES2288151T3 (enExample) |
| IL (2) | IL147652A0 (enExample) |
| PT (2) | PT1795598E (enExample) |
| WO (1) | WO2001007475A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1795598E (pt) | 1999-07-23 | 2010-01-05 | Kenji Kangawa | Novos péptidos |
| CA2392019A1 (en) * | 1999-11-22 | 2001-05-31 | Zymogenetics, Inc. | Method of forming a peptide-receptor complex with zsig33 |
| US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
| EP1288230B1 (en) | 2000-05-12 | 2008-10-01 | Kaneka Corporation | Method of purifying vinyl polymer |
| EP1353683A4 (en) * | 2000-05-30 | 2004-05-12 | Merck & Co Inc | ANALOGS BY GHRELIN |
| CN1443198A (zh) * | 2000-07-24 | 2003-09-17 | 阿达纳生物科学有限公司 | Ghrelin拮抗剂 |
| BRPI0306644B8 (pt) | 2002-04-11 | 2021-05-25 | Asubio Pharma Co Ltd | método para produzir um peptídeo modificado |
| JP5000848B2 (ja) | 2002-05-21 | 2012-08-15 | 第一三共株式会社 | グレリン含有医薬組成物 |
| WO2004009124A2 (en) * | 2002-07-19 | 2004-01-29 | Cytos Biotechnology Ag | Ghrelin-carrier conjugates |
| KR101065471B1 (ko) * | 2002-07-23 | 2011-09-16 | 입센 파마 에스.에이.에스 | 그렐린 유사체 |
| TWI331922B (en) | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| WO2004027064A2 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
| EP1407779A1 (en) | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Use of ghrelin for treating low body weight and body fat in gastrectomized individuals |
| ATE550029T1 (de) * | 2003-04-30 | 2012-04-15 | Kenji Kangawa | Mittel zur prävention oder heilung von hepatopathie |
| EP1633397A2 (en) * | 2003-06-04 | 2006-03-15 | Eli Lilly And Company | Anti-ghrelin fab antibodies |
| US20060233788A1 (en) * | 2003-09-05 | 2006-10-19 | Heiman Mark L | Anti-ghrelin antibodies |
| CN1321131C (zh) * | 2003-12-26 | 2007-06-13 | 李宁 | 猪Ghrelin衍生物及其编码基因与应用 |
| WO2005068639A2 (en) * | 2004-01-20 | 2005-07-28 | Cytos Biotechnology Ag | Particle-induced ghrelin immune response |
| US7026175B2 (en) | 2004-03-29 | 2006-04-11 | Applied Materials, Inc. | High throughput measurement of via defects in interconnects |
| WO2005097173A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Use of ghrelin for the treatment of hyperthyroidism |
| WO2005097831A2 (en) * | 2004-04-07 | 2005-10-20 | Gastrotech Pharma A/S | Uses of isolated binding members capable of binding specifically to secretagogues |
| WO2005097830A2 (en) * | 2004-04-07 | 2005-10-20 | Aditech Pharma Ab | Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds |
| CA2566703A1 (en) * | 2004-05-11 | 2005-11-24 | Vishwa Deep Dixit | Methods of inhibiting proinflammatory cytokine expression using ghrelin |
| WO2005120484A1 (ja) * | 2004-06-09 | 2005-12-22 | Kurume University | グレリンの生理学的機能のレギュレーター |
| WO2006019577A1 (en) * | 2004-07-14 | 2006-02-23 | Eli Lilly And Company | Anti-ghrelin antibodies |
| WO2006045319A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of growth hormone secretagogues in the treatment of individuals suffering from renal and/or liver failure |
| WO2006045313A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Uses of secretagogues for treatment of organ transplant patients |
| JP2008521840A (ja) * | 2004-11-30 | 2008-06-26 | ガストロテック・ファルマ・アクティーゼルスカブ | 成長ホルモン分泌促進物質レセプター１ａリガンド |
| CN101128213B (zh) | 2005-02-23 | 2013-05-08 | 国立大学法人京都大学 | 胰腺β细胞再生的促进剂以及在胰腺β细胞中生产胰岛素的促进剂 |
| US7479271B2 (en) | 2005-02-23 | 2009-01-20 | Eli Lilly And Company | Humanized anti-ghrelin antibodies |
| RU2427587C2 (ru) * | 2005-09-28 | 2011-08-27 | Ипсен Фарма С.А.С. | Аналоги грелина |
| CN105381453B9 (zh) | 2005-09-29 | 2019-01-11 | 益普生制药股份有限公司 | 用于刺激胃肠运动性的组合物和方法 |
| WO2007058360A1 (ja) | 2005-11-21 | 2007-05-24 | University Of Miyazaki | デスアシルグレリン及びその誘導体を有効成分とする皮膚修復促進治療剤 |
| US20090181888A1 (en) * | 2005-11-21 | 2009-07-16 | Noboru Murakami | Skin Repair Accelerating Therapeutic Agent Containing Ghrelin and Derivatives Thereof or Substance Acting On GHS-R1a as Active Ingredient |
| US20100227806A1 (en) * | 2006-03-10 | 2010-09-09 | Tulipano Giovanni | Use Of A Ghrelin Agonist To Improve Catabolic Effects Of Glucocorticoid Treatment |
| JP5325092B2 (ja) | 2006-03-13 | 2013-10-23 | リアット・ミンツ | 悪液質および／または食欲不振症および／または食欲不振症−悪液質および／または栄養失調および／または脂肪異栄養症および／または筋肉消耗および／または食欲−刺激を治療するためのグレリンスプライス変異体の使用 |
| CA2659264C (en) * | 2006-08-01 | 2016-01-26 | The Scripps Research Institute | Immunoconjugates of ghrelin for use in vaccines and methods for controlling adiposity |
| AU2007282428A1 (en) * | 2006-08-11 | 2008-02-14 | Asubio Pharma Co., Ltd. | Spinal nerve repair promoting therapeutics containing des-acyl ghrelin or its derivatives as an active ingredient |
| CA2660517A1 (en) | 2006-08-11 | 2008-02-14 | University Of Miyazaki | Spinal nerve repair promoting therapeutics containing ghrelin or its derivatives or substances that act on ghs-rla as an active ingredient |
| NZ576470A (en) | 2006-09-27 | 2012-09-28 | Ipsen Pharma Sas | Analogs of ghrelin substituted at the n-terminal |
| BRPI0904622A2 (pt) * | 2008-05-23 | 2016-06-21 | Asubio Pharma Co Ltd | peptídeo com ação de prolongar a meia-vida de um peptídeo de interesse no plasma |
| WO2010091122A1 (en) | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| US8883721B2 (en) * | 2009-05-12 | 2014-11-11 | Mcgill University | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| US9078868B2 (en) | 2010-01-15 | 2015-07-14 | University Of Miyazaki | Therapeutic agent for accelerating recovery of animal under medical treatment |
| WO2011159917A2 (en) * | 2010-06-16 | 2011-12-22 | The Administrators Of The Tulane Educational Fund | Growth hormone secretatogue receptor antagonists and uses thereof |
| BR112013021859A2 (pt) | 2011-03-03 | 2016-10-25 | Daiichi Sankyo Co Ltd | agente hipotérmico para um animal, agente hiportérmico, agente terapêutico para hipertermia em um animal, método para reduzir a temperatura corporal de um animal, método terapêutico para hipertermia em um animal, desacilada ou o seu derivado e uso de gralina desacilada ou o seu derivado |
| JP5560248B2 (ja) * | 2011-09-07 | 2014-07-23 | 花王株式会社 | ジペプチド誘導体及びその製造方法 |
| CN107496932A (zh) | 2012-02-27 | 2017-12-22 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| CN108524919A (zh) | 2012-05-17 | 2018-09-14 | 延伸生物科学股份有限公司 | 用于改进的药物递送的载体 |
| US9486503B2 (en) | 2012-10-04 | 2016-11-08 | Shionogi & Co., Ltd. | Medicinal agent for suppressing malignant tumor metastasis |
| US20150265680A1 (en) * | 2012-10-24 | 2015-09-24 | Daiichi Sankyo Company, Limited | Therapeutic agent for amyotrophic lateral sclerosis |
| JP6143270B2 (ja) * | 2013-01-31 | 2017-06-07 | 学校法人東京薬科大学 | マイオスタチン阻害ペプチド |
| TWI662967B (zh) * | 2013-03-25 | 2019-06-21 | 日商志瑞亞新藥工業股份有限公司 | 食後期之胃運動亢進劑 |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| CN109879935B (zh) * | 2019-03-04 | 2020-11-20 | 南京工业大学 | 一种多肽的液相合成方法 |
| CA3157605A1 (en) | 2019-11-13 | 2021-05-20 | Volker Schellenberger | Barcoded xten polypeptides and compositions thereof, and methods for making and using the same |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
| CN120818010B (zh) * | 2025-09-18 | 2025-12-05 | 天津科技大学 | 一种来自植物乳杆菌属细胞外囊泡的短肽及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| ES2185628T3 (es) * | 1992-04-07 | 2003-05-01 | Scripps Research Inst | Procedimiento para preparar proteinas modificadas. |
| HUP9801337A2 (hu) * | 1995-03-31 | 1998-08-28 | American Cyanamid Company | Növekedést elősegítő tulajdonsággal rendelkező peptidek |
| IL118473A0 (en) | 1995-06-02 | 1996-09-12 | Suntory Ltd | Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof |
| CA2198966C (en) | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
| JP3982866B2 (ja) | 1996-03-04 | 2007-09-26 | アスビオファーマ株式会社 | 分泌型Ｋｅｘ２誘導体の製造方法 |
| JP4335318B2 (ja) * | 1997-03-24 | 2009-09-30 | ザイモジェネティクス，インコーポレイティド | モチリン相同体 |
| IL139686A0 (en) * | 1998-06-02 | 2002-02-10 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CN1120846C (zh) * | 1999-02-13 | 2003-09-10 | 中国人民解放军军事医学科学院基础医学研究所 | 生长激素释放肽及其应用 |
| US6420521B1 (en) * | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
| PT1795598E (pt) * | 1999-07-23 | 2010-01-05 | Kenji Kangawa | Novos péptidos |
-
2000
- 2000-07-24 PT PT07006224T patent/PT1795598E/pt unknown
- 2000-07-24 CA CA2380058A patent/CA2380058C/en not_active Expired - Lifetime
- 2000-07-24 CA CA2696819A patent/CA2696819C/en not_active Expired - Lifetime
- 2000-07-24 PT PT00946453T patent/PT1197496E/pt unknown
- 2000-07-24 DK DK00946453T patent/DK1197496T3/da active
- 2000-07-24 BR BR0012688-8A patent/BR0012688A/pt not_active IP Right Cessation
- 2000-07-24 JP JP2001512558A patent/JP3471780B2/ja not_active Expired - Lifetime
- 2000-07-24 DE DE60043361T patent/DE60043361D1/de not_active Expired - Lifetime
- 2000-07-24 EP EP07006224A patent/EP1795598B1/en not_active Expired - Lifetime
- 2000-07-24 ES ES00946453T patent/ES2288151T3/es not_active Expired - Lifetime
- 2000-07-24 DK DK07006224.5T patent/DK1795598T3/da active
- 2000-07-24 BR BRPI0012688A patent/BRPI0012688B8/pt unknown
- 2000-07-24 DE DE60035502T patent/DE60035502T2/de not_active Expired - Lifetime
- 2000-07-24 ES ES09166974T patent/ES2401939T3/es not_active Expired - Lifetime
- 2000-07-24 CN CNB008104409A patent/CN100506844C/zh not_active Expired - Lifetime
- 2000-07-24 AT AT07006224T patent/ATE449174T1/de active
- 2000-07-24 IL IL14765200A patent/IL147652A0/xx unknown
- 2000-07-24 WO PCT/JP2000/004907 patent/WO2001007475A1/ja not_active Ceased
- 2000-07-24 EP EP00946453A patent/EP1197496B8/en not_active Expired - Lifetime
- 2000-07-24 CN CN200910141231.3A patent/CN101693736B/zh not_active Expired - Lifetime
- 2000-07-24 US US09/959,577 patent/US7385026B1/en not_active Expired - Lifetime
- 2000-07-24 EP EP09166974A patent/EP2119785B1/en not_active Expired - Lifetime
- 2000-07-24 AT AT00946453T patent/ATE366813T1/de active
- 2000-07-24 KR KR1020027000758A patent/KR100827973B1/ko not_active Expired - Lifetime
- 2000-07-24 AU AU60231/00A patent/AU784035B2/en not_active Expired
- 2000-07-24 ES ES07006224T patent/ES2335235T3/es not_active Expired - Lifetime
-
2002
- 2002-01-15 IL IL147652A patent/IL147652A/en active IP Right Grant
-
2003
- 2003-07-07 JP JP2003271241A patent/JP4227857B2/ja not_active Expired - Lifetime
-
2006
- 2006-04-13 AU AU2006201580A patent/AU2006201580B2/en not_active Expired
-
2007
- 2007-08-28 CY CY20071101137T patent/CY1107724T1/el unknown
-
2008
- 2008-01-30 US US12/010,838 patent/US8227570B2/en not_active Expired - Fee Related
-
2010
- 2010-01-05 CY CY20101100012T patent/CY1109714T1/el unknown
- 2010-03-22 US US12/728,495 patent/US9573986B2/en not_active Expired - Fee Related
-
2011
- 2011-03-31 US US13/076,844 patent/US8524871B2/en not_active Expired - Fee Related
-
2012
- 2012-06-12 US US13/494,673 patent/US9938332B2/en not_active Expired - Fee Related
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