|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4965199A
(en)
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US6018030A
(en)
|
1986-11-04 |
2000-01-25 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US5641648A
(en)
|
1986-11-04 |
1997-06-24 |
Protein Polymer Technologies, Inc. |
Methods for preparing synthetic repetitive DNA
|
|
US5770697A
(en)
|
1986-11-04 |
1998-06-23 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US5514581A
(en)
|
1986-11-04 |
1996-05-07 |
Protein Polymer Technologies, Inc. |
Functional recombinantly prepared synthetic protein polymer
|
|
US4863457A
(en)
|
1986-11-24 |
1989-09-05 |
Lee David A |
Drug delivery device
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US4997652A
(en)
|
1987-12-22 |
1991-03-05 |
Visionex |
Biodegradable ocular implants
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
JP3039802B2
(ja)
|
1989-07-06 |
2000-05-08 |
ザ リージェンツ オブザ ユニバーシティ オブ カリフォルニア |
繊維芽細胞成長因子のための受容体
|
|
US5164188A
(en)
|
1989-11-22 |
1992-11-17 |
Visionex, Inc. |
Biodegradable ocular implants
|
|
US5766897A
(en)
|
1990-06-21 |
1998-06-16 |
Incyte Pharmaceuticals, Inc. |
Cysteine-pegylated proteins
|
|
WO1992002536A1
(en)
|
1990-08-02 |
1992-02-20 |
The Regents Of The University Of Colorado |
Systematic polypeptide evolution by reverse translation
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
KR0185215B1
(ko)
|
1990-11-30 |
1999-05-01 |
요시다 쇼오지 |
서방성 안구삽입용 약제
|
|
US5773574A
(en)
|
1990-12-03 |
1998-06-30 |
The Scripps Research Institute |
Polypeptides for promoting cell attachment
|
|
US5235041A
(en)
|
1990-12-28 |
1993-08-10 |
Protein Polymer Technologies, Inc. |
Purification of structurally ordered recombinant protein polymers
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
ATE255131T1
(de)
|
1991-06-14 |
2003-12-15 |
Genentech Inc |
Humanisierter heregulin antikörper
|
|
US5792742A
(en)
|
1991-06-14 |
1998-08-11 |
New York University |
Fibrin-binding peptide fragments of fibronectin
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
AU2313392A
(en)
|
1991-08-01 |
1993-03-02 |
University Research Corporation |
Systematic polypeptide evolution by reverse translation
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
DE69233528T2
(de)
|
1991-11-25 |
2006-03-16 |
Enzon, Inc. |
Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
|
|
WO1993016185A2
(en)
|
1992-02-06 |
1993-08-19 |
Creative Biomolecules, Inc. |
Biosynthetic binding protein for cancer marker
|
|
CA2076465C
(en)
|
1992-03-25 |
2002-11-26 |
Ravi V. J. Chari |
Cell binding agent conjugates of analogues and derivatives of cc-1065
|
|
DE69332377T2
(de)
|
1992-07-13 |
2003-07-03 |
Bionebraska, Inc. |
Verfahren zur modifizierung rekombinanter polypeptide
|
|
PT1621554E
(pt)
|
1992-08-21 |
2009-07-13 |
Univ Bruxelles |
Imunoglobtainas desprovidas de cadeias leves
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
DE69303494T2
(de)
|
1992-11-13 |
1997-01-16 |
Idec Pharma Corp |
Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
|
|
WO1994017097A1
(en)
|
1993-01-19 |
1994-08-04 |
Regents Of The University Of Minnesota |
Synthetic fibronectin fragments as inhibitors of retroviral infections
|
|
EP0654256B1
(en)
|
1993-02-26 |
2000-08-02 |
Santen Pharmaceutical Co., Ltd. |
Biodegradable sclera plug
|
|
WO1995011922A1
(en)
|
1993-10-29 |
1995-05-04 |
Affymax Technologies N.V. |
In vitro peptide and antibody display libraries
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5443505A
(en)
|
1993-11-15 |
1995-08-22 |
Oculex Pharmaceuticals, Inc. |
Biocompatible ocular implants
|
|
US5516522A
(en)
|
1994-03-14 |
1996-05-14 |
Board Of Supervisors Of Louisiana State University |
Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5559000A
(en)
|
1995-01-18 |
1996-09-24 |
The Scripps Research Institute |
Encoded reaction cassette
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5869079A
(en)
|
1995-06-02 |
1999-02-09 |
Oculex Pharmaceuticals, Inc. |
Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
|
|
US6369116B1
(en)
|
1995-06-02 |
2002-04-09 |
Oculex Pharmaceuticals, Inc. |
Composition and method for treating glaucoma
|
|
DE19646372C1
(de)
|
1995-11-11 |
1997-06-19 |
Evotec Biosystems Gmbh |
Genotyp und Phänotyp koppelnde Verbindung
|
|
JP2000515002A
(ja)
|
1996-06-27 |
2000-11-14 |
フラームス・インテルウニフェルジテール・インスティテュート・フォール・ビオテヒノロジー・ヴェーゼットウェー |
標的分子の活性部位またはクレフトと特異的に相互作用する認識分子
|
|
GB9618960D0
(en)
|
1996-09-11 |
1996-10-23 |
Medical Science Sys Inc |
Proteases
|
|
US5922676A
(en)
|
1996-09-20 |
1999-07-13 |
The Burnham Institute |
Methods of inhibiting cancer by using superfibronectin
|
|
EP0962527B1
(en)
|
1996-10-17 |
2004-08-04 |
Mitsubishi Chemical Corporation |
Molecule that homologizes genotype and phenotype and utilization thereof
|
|
WO1998031794A1
(fr)
|
1997-01-17 |
1998-07-23 |
Toa Gosei Co., Ltd. |
Polypeptide liant le facteur vegf
|
|
DK0971946T3
(da)
|
1997-01-21 |
2006-10-30 |
Gen Hospital Corp |
Selektion af proteiner ved anvendelse af RNA-protein-fusioner
|
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
|
AU7266698A
(en)
*
|
1997-04-30 |
1998-11-24 |
Enzon, Inc. |
Polyalkylene oxide-modified single chain polypeptides
|
|
EP1012280B1
(en)
|
1997-06-11 |
2004-11-10 |
Borean Pharma A/S |
Trimerising module
|
|
JP3614866B2
(ja)
|
1997-06-12 |
2005-01-26 |
リサーチ コーポレイション テクノロジーズ,インコーポレイティド |
人工抗体ポリペプチド
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
US6159722A
(en)
|
1997-12-03 |
2000-12-12 |
Boehringer Mannheim Gmbh |
Chimeric serine proteases
|
|
EP1068356B8
(en)
|
1998-04-03 |
2007-01-03 |
Adnexus Therapeutics, Inc. |
Addressable protein arrays
|
|
GB9827228D0
(en)
|
1998-12-10 |
1999-02-03 |
Univ Nottingham |
Cancer detection method and reagents
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
EP1137941B2
(en)
*
|
1998-12-10 |
2013-09-11 |
Bristol-Myers Squibb Company |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7115396B2
(en)
*
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
IL145941A
(en)
|
1999-04-28 |
2007-08-19 |
Univ Texas |
Compositions and methods for cancer treatment by selectively inhibiting vegf
|
|
IL147037A0
(en)
|
1999-07-27 |
2002-08-14 |
Phylos Inc |
Peptide acceptor ligation methods
|
|
US6399857B1
(en)
*
|
1999-09-22 |
2002-06-04 |
Paradigm Genetics, Inc. |
Modified nucleotide sequence encoding a LexA DNA binding domain optimized for arabidopsis species
|
|
ES2276708T3
(es)
|
1999-11-24 |
2007-07-01 |
Immunogen, Inc. |
Agentes citotoxicos que comprenden taxanos y su uso terapeutico.
|
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
AU4445601A
(en)
|
2000-03-31 |
2001-10-08 |
Centre National De La Recherche Scientifique-Cnrs |
Peptides blocking vascular endothelial growth factor (vegf)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof
|
|
JP2004515219A
(ja)
|
2000-06-15 |
2004-05-27 |
ボード・オブ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム |
調節可能な触媒活性な核酸
|
|
ES2564161T3
(es)
|
2000-07-11 |
2016-03-18 |
Research Corporation Technologies, Inc |
Polipéptidos de anticuerpos artificiales
|
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
|
JP5291279B2
(ja)
|
2000-09-08 |
2013-09-18 |
ウニヴェルジテート・チューリッヒ |
反復モジュールを含む反復タンパク質の集合体
|
|
ATE516820T1
(de)
|
2000-09-29 |
2011-08-15 |
Schering Corp |
Pegyliertes interleukin 10
|
|
EP2141243A3
(en)
|
2000-10-16 |
2010-01-27 |
Brystol-Myers Squibb Company |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7598352B2
(en)
|
2000-11-17 |
2009-10-06 |
University Of Rochester |
Method of identifying polypeptide monobodies which bind to target proteins and use thereof
|
|
AU2002236495B2
(en)
|
2000-11-29 |
2006-05-11 |
Allergan, Inc. |
Intraocular implants for preventing transplant rejection in the eye
|
|
ATE431851T1
(de)
|
2000-12-13 |
2009-06-15 |
Anaphore Inc |
Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur
|
|
US6509027B2
(en)
*
|
2001-02-12 |
2003-01-21 |
Supergen, Inc. |
Injectable pharmaceutical composition comprising coated particles of camptothecin
|
|
AU2002307146B2
(en)
|
2001-04-04 |
2007-02-01 |
University Of Rochester |
AlphaNuBeta3 integrin-binding polypeptide monobodies and their use
|
|
US20040175756A1
(en)
|
2001-04-26 |
2004-09-09 |
Avidia Research Institute |
Methods for using combinatorial libraries of monomer domains
|
|
US20050048512A1
(en)
|
2001-04-26 |
2005-03-03 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
|
US20050053973A1
(en)
|
2001-04-26 |
2005-03-10 |
Avidia Research Institute |
Novel proteins with targeted binding
|
|
JP4369662B2
(ja)
|
2001-04-26 |
2009-11-25 |
アビディア インコーポレイテッド |
単量体ドメインのコンビナトリアルライブラリー
|
|
US20050089932A1
(en)
|
2001-04-26 |
2005-04-28 |
Avidia Research Institute |
Novel proteins with targeted binding
|
|
US20030004561A1
(en)
|
2001-06-28 |
2003-01-02 |
Steve Bigus |
Peeling sheath for self-expanding stent
|
|
WO2003022858A2
(de)
|
2001-09-11 |
2003-03-20 |
Nascacell Gmbh |
Verfahren zum screenen von inhibitoren für die protein-protein-wechselwirkung sowie ribozyme hierzu
|
|
EP1430136A1
(en)
|
2001-09-27 |
2004-06-23 |
Pieris ProteoLab AG |
Muteins of apolipoprotein d
|
|
WO2003029462A1
(en)
|
2001-09-27 |
2003-04-10 |
Pieris Proteolab Ag |
Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
|
|
JP2005289809A
(ja)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
WO2003049684A2
(en)
|
2001-12-07 |
2003-06-19 |
Centocor, Inc. |
Pseudo-antibody constructs
|
|
US20080193445A1
(en)
*
|
2002-01-18 |
2008-08-14 |
Liliane Goetsch |
Novel anti-IGF-IR antibodies and uses thereof
|
|
US7241444B2
(en)
|
2002-01-18 |
2007-07-10 |
Pierre Fabre Medicament |
Anti-IGF-IR antibodies and uses thereof
|
|
GB0201273D0
(en)
*
|
2002-01-21 |
2002-03-06 |
Isis Innovation |
Fibronectin variants and screening methods
|
|
ATE397440T1
(de)
|
2002-02-22 |
2008-06-15 |
Schering Corp |
Pharmazeutische zubereitungen von antineoplastischen wirkstoffen, insbesondere temozolomid, verfahren zu ihrer herstellung und deren verwendung
|
|
US7498414B2
(en)
|
2002-03-04 |
2009-03-03 |
Imclone Systems Incorporated |
Human antibodies specific to KDR and uses thereof
|
|
US7332585B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The California University |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
WO2003104418A2
(en)
*
|
2002-06-06 |
2003-12-18 |
Research Corporation Technologies, Inc. |
Reconstituted polypeptides
|
|
US8034904B2
(en)
|
2002-06-14 |
2011-10-11 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
WO2004005335A2
(en)
|
2002-07-05 |
2004-01-15 |
Borean Pharma A/S |
Multimerised growth hormone fusion proteins
|
|
US20050074865A1
(en)
|
2002-08-27 |
2005-04-07 |
Compound Therapeutics, Inc. |
Adzymes and uses thereof
|
|
AU2003262937B2
(en)
|
2002-08-27 |
2009-05-07 |
Bristol-Myers Squibb Company |
Adzymes and uses thereof
|
|
WO2004029224A2
(en)
|
2002-09-30 |
2004-04-08 |
Compound Therapeutics, Inc. |
Methods of engineering spatially conserved motifs in polypeptides
|
|
EP1558640B1
(en)
|
2002-10-29 |
2011-04-13 |
Anaphore, Inc. |
Trimeric binding proteins for trimeric cytokines
|
|
MXPA05009837A
(es)
|
2003-03-14 |
2005-12-05 |
Pharmacia Corp |
Anticuerpos para el receptor del factor de crecimiento tipo insulina-i, para el tratamiento de canceres.
|
|
NZ561162A
(en)
|
2003-04-23 |
2009-11-27 |
Hoffmann La Roche |
Human granzyme B protease variant wherein cystein 228 is mutated to phenylalanine
|
|
CA2524305C
(en)
*
|
2003-05-01 |
2015-12-08 |
Imclone Systems Incorporated |
Fully human antibodies directed against the human insulin-like growth factor-1 receptor
|
|
US7579157B2
(en)
|
2003-07-10 |
2009-08-25 |
Hoffmann-La Roche Inc. |
Antibody selection method against IGF-IR
|
|
US7053701B2
(en)
|
2003-11-04 |
2006-05-30 |
Vice Michael W |
Power amplifier output stage with multiple power states and improved efficiency
|
|
PT1687338E
(pt)
|
2003-11-07 |
2011-01-20 |
Ablynx Nv |
Anticorpos de domínio único vhh de camelídeos direccionados para o receptor do factor de crescimento epidérmico e suas utilizações
|
|
JP5261638B2
(ja)
|
2003-11-17 |
2013-08-14 |
テレズィゴロジー インク. |
締付具
|
|
US20080220049A1
(en)
*
|
2003-12-05 |
2008-09-11 |
Adnexus, A Bristol-Myers Squibb R&D Company |
Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
|
|
WO2005056764A2
(en)
*
|
2003-12-05 |
2005-06-23 |
Compound Therapeutics, Inc. |
Inhibitors of type 2 vascular endothelial growth factor receptors
|
|
JP5010923B2
(ja)
|
2004-02-09 |
2012-08-29 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
アルブミン融合蛋白質
|
|
CN1980952A
(zh)
|
2004-02-23 |
2007-06-13 |
伯瑞恩药物私人有限公司 |
多聚化hiv融合抑制物
|
|
WO2005080418A2
(en)
|
2004-02-23 |
2005-09-01 |
Borean Pharma A/S |
Multimerised hiv fusion inhibitors
|
|
US20050244469A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Extended therapeutic effect ocular implant treatments
|
|
US20060182783A1
(en)
|
2004-04-30 |
2006-08-17 |
Allergan, Inc. |
Sustained release intraocular drug delivery systems
|
|
US20070059336A1
(en)
|
2004-04-30 |
2007-03-15 |
Allergan, Inc. |
Anti-angiogenic sustained release intraocular implants and related methods
|
|
US20050244472A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
|
|
WO2006020258A2
(en)
|
2004-07-17 |
2006-02-23 |
Imclone Systems Incorporated |
Novel tetravalent bispecific antibody
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
WO2006041942A2
(en)
|
2004-10-04 |
2006-04-20 |
Qlt Usa, Inc. |
Ocular delivery of polymeric delivery formulations
|
|
DE102004049479A1
(de)
|
2004-10-11 |
2006-04-13 |
Scil Proteins Gmbh |
Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
|
|
NZ555353A
(en)
|
2004-11-22 |
2009-12-24 |
Anaphore Inc |
TNF antagonists
|
|
EP2899277A1
(en)
|
2004-11-26 |
2015-07-29 |
Pieris AG |
Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4)
|
|
EP1838307A1
(en)
*
|
2004-12-02 |
2007-10-03 |
Schering Corporation |
Methods of using temozolomide formulation intrathecally in the treatment of cancers
|
|
JP2008531557A
(ja)
|
2005-02-23 |
2008-08-14 |
メリマック ファーマシューティカルズ インコーポレーティッド |
生物活性を調節するための二重特異性結合剤
|
|
FR2888850B1
(fr)
|
2005-07-22 |
2013-01-11 |
Pf Medicament |
Nouveaux anticorps anti-igf-ir et leurs applications
|
|
US7612181B2
(en)
*
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US7887273B2
(en)
|
2005-09-15 |
2011-02-15 |
Newfrey Llc |
Blind rivet and method
|
|
US20070072933A1
(en)
|
2005-09-26 |
2007-03-29 |
Peyman Gholam A |
Delivery of an ocular agent
|
|
BRPI0616883A2
(pt)
|
2005-10-07 |
2011-07-05 |
Univ California |
ácidos nucléicos que codificam enzima modificada de citocromo p450 e métodos de uso dos mesmos
|
|
WO2007047607A2
(en)
|
2005-10-18 |
2007-04-26 |
Allergan, Inc. |
Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues
|
|
US20070099879A1
(en)
|
2005-10-31 |
2007-05-03 |
Wisconsin Alumni Research Foundation (Warf) |
Method of using calcitriol for treating intraocular diseases associated with angiogenesis
|
|
EP2781222B1
(en)
|
2005-11-23 |
2017-08-02 |
Acceleron Pharma, Inc. |
Activin-actriia antagonists in use for promoting bone growth
|
|
US7964191B2
(en)
|
2006-02-02 |
2011-06-21 |
Allergan, Inc. |
Compositions and methods for the treatment of ophthalmic disease
|
|
EP1996227A2
(en)
|
2006-02-24 |
2008-12-03 |
CHIESI FARMACEUTICI S.p.A. |
Anti-amyloid immunogenic compositions, methods and uses
|
|
CN101426810A
(zh)
|
2006-04-21 |
2009-05-06 |
特朗斯吉恩股份有限公司 |
基于hpv-18的乳头瘤病毒疫苗
|
|
WO2008031098A1
(en)
|
2006-09-09 |
2008-03-13 |
The University Of Chicago |
Binary amino acid libraries for fibronectin type iii polypeptide monobodies
|
|
US20110143953A1
(en)
|
2006-10-16 |
2011-06-16 |
Arizona Board Of Regents, A Body Corporate Of The State Of Arizona |
Synthetic Antibodies
|
|
JP5537946B2
(ja)
|
2006-11-22 |
2014-07-02 |
ブリストル−マイヤーズ スクイブ カンパニー |
Igf−irを含むチロシンキナーゼ受容体に対する改変タンパク質に基づく標的治療薬
|
|
US20100021511A1
(en)
*
|
2007-01-05 |
2010-01-28 |
Fujifilm Corporation |
Dispersion composition, cosmetic preparation for skin care, and method for producing dispersion composition
|
|
US20100144599A1
(en)
*
|
2007-02-02 |
2010-06-10 |
Bristol-Myers Squibb Company |
Vegf pathway blockade
|
|
AU2008223541B2
(en)
|
2007-03-02 |
2012-04-05 |
Amgen Inc. |
Methods and compositions for treating tumor diseases
|
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
|
EP2738257A1
(en)
|
2007-05-22 |
2014-06-04 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
AU2008287426B2
(en)
|
2007-08-10 |
2014-06-26 |
Protelica, Inc. |
Universal fibronectin type III binding-domain libraries
|
|
US8680019B2
(en)
|
2007-08-10 |
2014-03-25 |
Protelica, Inc. |
Universal fibronectin Type III binding-domain libraries
|
|
US8470966B2
(en)
|
2007-08-10 |
2013-06-25 |
Protelica, Inc. |
Universal fibronectin type III binding-domain libraries
|
|
US20100285000A1
(en)
*
|
2007-08-20 |
2010-11-11 |
Bristol-Myers Squibb Company |
Use of vegfr-2 inhibitors for treating metastatic cancer
|
|
WO2009046407A2
(en)
|
2007-10-04 |
2009-04-09 |
Zymogenetics, Inc. |
B7 FAMILY MEMBER zB7H6 AND RELATED COMPOSITIONS AND METHODS
|
|
RU2010121967A
(ru)
|
2007-10-31 |
2011-12-10 |
Медиммун, Ллк (Us) |
Белковые каркасные структуры
|
|
EP2217274A1
(en)
|
2007-11-28 |
2010-08-18 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with mtor inhibitors
|
|
EP2238247A2
(en)
|
2007-12-19 |
2010-10-13 |
Centocor Ortho Biotech Inc. |
Alternative scaffold protein fusions phage display via fusion to plx of m13 phage
|
|
WO2009083804A2
(en)
|
2007-12-27 |
2009-07-09 |
Novartis Ag |
Improved fibronectin-based binding molecules and their use
|
|
JP2011517314A
(ja)
|
2008-02-14 |
2011-06-02 |
ブリストル−マイヤーズ スクイブ カンパニー |
Egfrに結合する操作されたタンパク質に基づく標的化された治療薬
|
|
US9296810B2
(en)
|
2008-05-02 |
2016-03-29 |
Novartis Ag |
Fibronectin-based binding molecules and uses thereof
|
|
PE20091931A1
(es)
|
2008-05-22 |
2009-12-31 |
Bristol Myers Squibb Co |
Proteinas de dominio de armazon basadas en fibronectina multivalentes
|
|
BRPI0919881B1
(pt)
|
2008-10-31 |
2021-09-08 |
Centocor Ortho Biotech Inc |
Proteína de arcabouço e seu método de geração, biblioteca e seu método de construção, molécula de ácido nucleico, vetor de ácido nucleico, célula hospedeira, composição, dispositivo médico e artigo de fabricação
|
|
US8415291B2
(en)
|
2008-10-31 |
2013-04-09 |
Centocor Ortho Biotech Inc. |
Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
|
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之egfr/igfir結合分子
|
|
CN102245771B
(zh)
|
2008-12-16 |
2013-04-10 |
诺瓦提斯公司 |
酵母展示系统
|
|
EP2396000A1
(en)
|
2009-02-11 |
2011-12-21 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with temozolomide
|
|
WO2010093627A2
(en)
|
2009-02-12 |
2010-08-19 |
Centocor Ortho Biotech Inc. |
Fibronectin type iii domain based scaffold compositions, methods and uses
|
|
US8067201B2
(en)
|
2009-04-17 |
2011-11-29 |
Bristol-Myers Squibb Company |
Methods for protein refolding
|
|
US20120270797A1
(en)
|
2009-08-13 |
2012-10-25 |
Massachusetts Institute Of Technology |
Engineered proteins including mutant fibronectin domains
|
|
ES2860453T3
(es)
|
2009-10-30 |
2021-10-05 |
Novartis Ag |
Bibliotecas universales del dominio de unión del lado inferior de la fibronectina de tipo III
|
|
WO2011051466A1
(en)
|
2009-11-02 |
2011-05-05 |
Novartis Ag |
Anti-idiotypic fibronectin-based binding molecules and uses thereof
|
|
US20110123545A1
(en)
|
2009-11-24 |
2011-05-26 |
Bristol-Myers Squibb Company |
Combination of vegfr2 and igf1r inhibitors for the treatment of proliferative diseases
|
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
|
US8961977B2
(en)
|
2010-02-12 |
2015-02-24 |
University Of Rochester |
Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies
|
|
KR20130010461A
(ko)
|
2010-02-18 |
2013-01-28 |
브리스톨-마이어스 스큅 컴퍼니 |
Il―23에 결합하는 피브로넥틴 기반 스캐폴드 도메인 단백질
|
|
CA2796010C
(en)
|
2010-04-13 |
2020-05-12 |
Medimmune, Llc |
Trail r2-specific multimeric scaffolds
|
|
ES2689875T3
(es)
|
2010-04-13 |
2018-11-16 |
Bristol-Myers Squibb Company |
Proteínas con un dominio de armazón a base de fibronectina que se unen a PCSK9
|
|
JP5997134B2
(ja)
|
2010-04-30 |
2016-09-28 |
ヤンセン バイオテツク,インコーポレーテツド |
安定したフィブロネクチンドメイン組成物、方法及び用途
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
US9562089B2
(en)
|
2010-05-26 |
2017-02-07 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins having improved stability
|
|
MX345300B
(es)
|
2010-07-30 |
2017-01-24 |
Novartis Ag * |
Moléculas andamio de fibronectina y bibliotecas de las mismas.
|
|
WO2012088006A1
(en)
|
2010-12-22 |
2012-06-28 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind il-23
|
|
ES2608835T3
(es)
|
2011-04-13 |
2017-04-17 |
Bristol-Myers Squibb Company |
Proteínas de fusión Fc que comprenden nuevos enlazadores o disposiciones
|
|
US20140187488A1
(en)
|
2011-05-17 |
2014-07-03 |
Bristol-Myers Squibb Company |
Methods for maintaining pegylation of polypeptides
|
|
US9347058B2
(en)
|
2011-05-17 |
2016-05-24 |
Bristol-Myers Squibb Company |
Methods for the selection of binding proteins
|
|
BR112014007469B1
(pt)
|
2011-09-27 |
2022-06-14 |
Janssen Biotech, Inc |
Método de fabricação de uma biblioteca de domínios de módulo de fibronectina tipo iii (fn3), biblioteca e método para obter um arcabouço de proteína
|