|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4965199A
(en)
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US5514581A
(en)
|
1986-11-04 |
1996-05-07 |
Protein Polymer Technologies, Inc. |
Functional recombinantly prepared synthetic protein polymer
|
|
US5641648A
(en)
|
1986-11-04 |
1997-06-24 |
Protein Polymer Technologies, Inc. |
Methods for preparing synthetic repetitive DNA
|
|
US6018030A
(en)
|
1986-11-04 |
2000-01-25 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US5770697A
(en)
|
1986-11-04 |
1998-06-23 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US4863457A
(en)
|
1986-11-24 |
1989-09-05 |
Lee David A |
Drug delivery device
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US4997652A
(en)
|
1987-12-22 |
1991-03-05 |
Visionex |
Biodegradable ocular implants
|
|
EP0435911B1
(en)
|
1988-09-23 |
1996-03-13 |
Cetus Oncology Corporation |
Cell culture medium for enhanced cell growth, culture longevity and product expression
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
DE69033109T2
(de)
|
1989-07-06 |
1999-11-18 |
The Regents Of The University Of California, Oakland |
Rezeptoren für fibroblasten-wachstumsfaktoren
|
|
US5164188A
(en)
|
1989-11-22 |
1992-11-17 |
Visionex, Inc. |
Biodegradable ocular implants
|
|
US5766897A
(en)
|
1990-06-21 |
1998-06-16 |
Incyte Pharmaceuticals, Inc. |
Cysteine-pegylated proteins
|
|
AU8498091A
(en)
|
1990-08-02 |
1992-03-02 |
Regents Of The University Of Colorado, The |
Systematic polypeptide evolution by reverse translation
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
KR0185215B1
(ko)
|
1990-11-30 |
1999-05-01 |
요시다 쇼오지 |
서방성 안구삽입용 약제
|
|
US5773574A
(en)
|
1990-12-03 |
1998-06-30 |
The Scripps Research Institute |
Polypeptides for promoting cell attachment
|
|
US5235041A
(en)
|
1990-12-28 |
1993-08-10 |
Protein Polymer Technologies, Inc. |
Purification of structurally ordered recombinant protein polymers
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
EP0590058B1
(en)
|
1991-06-14 |
2003-11-26 |
Genentech, Inc. |
HUMANIZED Heregulin ANTIBODy
|
|
US5792742A
(en)
|
1991-06-14 |
1998-08-11 |
New York University |
Fibrin-binding peptide fragments of fibronectin
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
WO1993003172A1
(en)
|
1991-08-01 |
1993-02-18 |
University Research Corporation |
Systematic polypeptide evolution by reverse translation
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
AU3178993A
(en)
|
1991-11-25 |
1993-06-28 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
ATE419355T1
(de)
|
1992-02-06 |
2009-01-15 |
Novartis Vaccines & Diagnostic |
Marker für krebs und biosynthetisches bindeprotein dafür
|
|
ES2149768T3
(es)
|
1992-03-25 |
2000-11-16 |
Immunogen Inc |
Conjugados de agentes enlazantes de celulas derivados de cc-1065.
|
|
NZ255041A
(en)
|
1992-07-13 |
1996-11-26 |
Bionebraska Inc |
Preparation of a recombinant single copy polypeptide or portion thereof modified with a terminal alpha amino carbon reactive group and reactive side chain groups involving biologically added protective groups
|
|
EP0656946B2
(en)
|
1992-08-21 |
2010-03-31 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
ES2091684T3
(es)
|
1992-11-13 |
1996-11-01 |
Idec Pharma Corp |
Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b.
|
|
WO1994017097A1
(en)
|
1993-01-19 |
1994-08-04 |
Regents Of The University Of Minnesota |
Synthetic fibronectin fragments as inhibitors of retroviral infections
|
|
EP0654256B1
(en)
|
1993-02-26 |
2000-08-02 |
Santen Pharmaceutical Co., Ltd. |
Biodegradable sclera plug
|
|
AU8124694A
(en)
|
1993-10-29 |
1995-05-22 |
Affymax Technologies N.V. |
In vitro peptide and antibody display libraries
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5443505A
(en)
|
1993-11-15 |
1995-08-22 |
Oculex Pharmaceuticals, Inc. |
Biocompatible ocular implants
|
|
US5516522A
(en)
|
1994-03-14 |
1996-05-14 |
Board Of Supervisors Of Louisiana State University |
Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5559000A
(en)
|
1995-01-18 |
1996-09-24 |
The Scripps Research Institute |
Encoded reaction cassette
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5869079A
(en)
|
1995-06-02 |
1999-02-09 |
Oculex Pharmaceuticals, Inc. |
Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
|
|
US6369116B1
(en)
|
1995-06-02 |
2002-04-09 |
Oculex Pharmaceuticals, Inc. |
Composition and method for treating glaucoma
|
|
DE19646372C1
(de)
|
1995-11-11 |
1997-06-19 |
Evotec Biosystems Gmbh |
Genotyp und Phänotyp koppelnde Verbindung
|
|
CA2258518C
(en)
|
1996-06-27 |
2011-11-22 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Recognition molecules interacting specifically with the active site or cleft of a target molecule
|
|
GB9618960D0
(en)
|
1996-09-11 |
1996-10-23 |
Medical Science Sys Inc |
Proteases
|
|
US5922676A
(en)
|
1996-09-20 |
1999-07-13 |
The Burnham Institute |
Methods of inhibiting cancer by using superfibronectin
|
|
DE69739163D1
(de)
|
1996-10-17 |
2009-01-22 |
Mitsubishi Chem Corp |
Molekül, welches Genotyp und Phänotyp zusammenführt und dessen Anwendungen
|
|
JP3837748B2
(ja)
|
1997-01-17 |
2006-10-25 |
東亞合成株式会社 |
Ｖｅｇｆ結合性ポリペプチド
|
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
PT971946E
(pt)
|
1997-01-21 |
2006-11-30 |
Gen Hospital Corp |
Selecção de proteínas utilizando fusões arn-proteína
|
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
|
WO1998048837A1
(en)
*
|
1997-04-30 |
1998-11-05 |
Enzon, Inc. |
Polyalkylene oxide-modified single chain polypeptides
|
|
WO1998056906A1
(en)
|
1997-06-11 |
1998-12-17 |
Thoegersen Hans Christian |
Trimerising module
|
|
EP0985039B1
(en)
|
1997-06-12 |
2008-02-20 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
US6159722A
(en)
|
1997-12-03 |
2000-12-12 |
Boehringer Mannheim Gmbh |
Chimeric serine proteases
|
|
CA2323638A1
(en)
|
1998-04-03 |
1999-10-14 |
Phylos, Inc. |
Addressable protein arrays
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
GB9827228D0
(en)
|
1998-12-10 |
1999-02-03 |
Univ Nottingham |
Cancer detection method and reagents
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
PT1137941E
(pt)
*
|
1998-12-10 |
2009-10-15 |
Brystol Myers Squibb Company |
Esqueletos de proteínas para compostos miméticos de anticorpos e outras proteínas de ligação
|
|
CN1308347C
(zh)
|
1999-04-28 |
2007-04-04 |
德克萨斯大学董事会 |
用于通过选择性抑制vegf来治疗癌症的组合物和方法
|
|
ES2284508T3
(es)
|
1999-07-27 |
2007-11-16 |
Adnexus Therapeutics, Inc. |
Procedimientos de ligadura de aceptador de peptidos.
|
|
US6399857B1
(en)
*
|
1999-09-22 |
2002-06-04 |
Paradigm Genetics, Inc. |
Modified nucleotide sequence encoding a LexA DNA binding domain optimized for arabidopsis species
|
|
CA2388063C
(en)
|
1999-11-24 |
2010-06-08 |
Immunogen, Inc. |
Cytotoxic agents comprising taxanes and their therapeutic use
|
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
JP2003528632A
(ja)
|
2000-03-31 |
2003-09-30 |
インスティティ・パスツール |
血管内皮成長因子（ｖｅｇｆ）−媒介性脈管形成を阻害するペプチド、該ペプチドをエンコードするポリヌクレオチド及びその使用方法
|
|
EP1364009A2
(en)
|
2000-06-15 |
2003-11-26 |
Board of Regents, The University of Texas System |
Regulatable, catalytically active nucleic acids
|
|
AU2001277867B2
(en)
|
2000-07-11 |
2006-12-07 |
Research Corporation Technologies, Inc. |
Artificial antibody polypeptides
|
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
|
EP1332209B1
(en)
|
2000-09-08 |
2009-11-11 |
Universität Zürich |
Collections of repeat proteins comprising repeat modules
|
|
ATE516820T1
(de)
|
2000-09-29 |
2011-08-15 |
Schering Corp |
Pegyliertes interleukin 10
|
|
AU1325102A
(en)
|
2000-10-16 |
2002-04-29 |
Phylos Inc |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7598352B2
(en)
|
2000-11-17 |
2009-10-06 |
University Of Rochester |
Method of identifying polypeptide monobodies which bind to target proteins and use thereof
|
|
US6699493B2
(en)
|
2000-11-29 |
2004-03-02 |
Oculex Pharmaceuticals, Inc. |
Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
|
|
AU2156802A
(en)
|
2000-12-13 |
2002-06-24 |
Borean Pharma As |
Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains
|
|
US6509027B2
(en)
*
|
2001-02-12 |
2003-01-21 |
Supergen, Inc. |
Injectable pharmaceutical composition comprising coated particles of camptothecin
|
|
EP1572718A4
(en)
|
2001-04-04 |
2006-03-15 |
Univ Rochester |
ALPHA NU BETA-3 INTEGRIN BINDING POLYPEPTIDE ANTIBODY AND THEIR USE
|
|
PT1390535E
(pt)
|
2001-04-26 |
2010-10-04 |
Amgen Mountain View Inc |
Bibliotecas combinatórias de domínios monoméricos
|
|
US20050053973A1
(en)
|
2001-04-26 |
2005-03-10 |
Avidia Research Institute |
Novel proteins with targeted binding
|
|
US20040175756A1
(en)
|
2001-04-26 |
2004-09-09 |
Avidia Research Institute |
Methods for using combinatorial libraries of monomer domains
|
|
US20050048512A1
(en)
|
2001-04-26 |
2005-03-03 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
|
US20050089932A1
(en)
|
2001-04-26 |
2005-04-28 |
Avidia Research Institute |
Novel proteins with targeted binding
|
|
US20030004561A1
(en)
|
2001-06-28 |
2003-01-02 |
Steve Bigus |
Peeling sheath for self-expanding stent
|
|
WO2003022858A2
(de)
|
2001-09-11 |
2003-03-20 |
Nascacell Gmbh |
Verfahren zum screenen von inhibitoren für die protein-protein-wechselwirkung sowie ribozyme hierzu
|
|
EP1430136A1
(en)
|
2001-09-27 |
2004-06-23 |
Pieris ProteoLab AG |
Muteins of apolipoprotein d
|
|
WO2003029462A1
(en)
|
2001-09-27 |
2003-04-10 |
Pieris Proteolab Ag |
Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
|
|
JP2005289809A
(ja)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
US20030211078A1
(en)
|
2001-12-07 |
2003-11-13 |
Heavner George A. |
Pseudo-antibody constructs
|
|
US20080193445A1
(en)
*
|
2002-01-18 |
2008-08-14 |
Liliane Goetsch |
Novel anti-IGF-IR antibodies and uses thereof
|
|
US7241444B2
(en)
|
2002-01-18 |
2007-07-10 |
Pierre Fabre Medicament |
Anti-IGF-IR antibodies and uses thereof
|
|
GB0201273D0
(en)
*
|
2002-01-21 |
2002-03-06 |
Isis Innovation |
Fibronectin variants and screening methods
|
|
NZ534378A
(en)
|
2002-02-22 |
2006-10-27 |
Schering Corp |
Pharmaceutical formulations of antineoplastic agents, in particular temozolomide, processes of making and using the same
|
|
CA2478169C
(en)
|
2002-03-04 |
2013-04-16 |
Imclone Systems Incorporated |
Human antibodies specific to kdr and uses thereof
|
|
US7332585B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The California University |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
AU2003243436A1
(en)
|
2002-06-06 |
2003-12-22 |
Shohei Koide |
Reconstituted polypeptides
|
|
US8034904B2
(en)
|
2002-06-14 |
2011-10-11 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
AU2003239777A1
(en)
|
2002-07-05 |
2004-01-23 |
Borean Pharma A/S |
Multimerised growth hormone fusion proteins
|
|
CA2497047A1
(en)
|
2002-08-27 |
2004-03-11 |
Compound Therapeutics, Inc. |
Adzymes and uses thereof
|
|
US20050074865A1
(en)
|
2002-08-27 |
2005-04-07 |
Compound Therapeutics, Inc. |
Adzymes and uses thereof
|
|
WO2004029224A2
(en)
|
2002-09-30 |
2004-04-08 |
Compound Therapeutics, Inc. |
Methods of engineering spatially conserved motifs in polypeptides
|
|
CN101899106A
(zh)
|
2002-10-29 |
2010-12-01 |
阿纳福公司 |
三聚细胞因子的三聚结合蛋白
|
|
WO2005044858A1
(en)
|
2003-11-07 |
2005-05-19 |
Ablynx N.V. |
Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor
|
|
EP1603948A1
(en)
|
2003-03-14 |
2005-12-14 |
Pharmacia Corporation |
Antibodies to igf-i receptor for the treatment of cancers
|
|
AU2004232405B2
(en)
|
2003-04-23 |
2008-06-19 |
F. Hoffman - La Roche Ltd. |
Cleavage of fusion proteins using granzyme B protease
|
|
US7638605B2
(en)
*
|
2003-05-01 |
2009-12-29 |
ImClone, LLC |
Fully human antibodies directed against the human insulin-like growth factor-1 receptor
|
|
AR046071A1
(es)
|
2003-07-10 |
2005-11-23 |
Hoffmann La Roche |
Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos
|
|
US7053701B2
(en)
|
2003-11-04 |
2006-05-30 |
Vice Michael W |
Power amplifier output stage with multiple power states and improved efficiency
|
|
EP2302229B1
(en)
|
2003-11-17 |
2016-06-08 |
Telezygology Inc. |
Shape memory releasable fastening system
|
|
US20080220049A1
(en)
*
|
2003-12-05 |
2008-09-11 |
Adnexus, A Bristol-Myers Squibb R&D Company |
Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
|
|
KR20060129246A
(ko)
|
2003-12-05 |
2006-12-15 |
컴파운드 쎄라퓨틱스, 인크. |
타입 2 혈관 내피 성장 인자 수용체의 억제제
|
|
SI1729795T1
(sl)
|
2004-02-09 |
2016-04-29 |
Human Genome Sciences, Inc. |
Albuminski fuzijski proteini
|
|
US20050202043A1
(en)
|
2004-02-23 |
2005-09-15 |
Borean Pharma A/S |
Multimerised HIV fusion inhibitors
|
|
BRPI0507949A
(pt)
|
2004-02-23 |
2007-07-24 |
Borean Pharma As |
inibidores de fusão de hiv multimerizados
|
|
US20050244469A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Extended therapeutic effect ocular implant treatments
|
|
WO2005110374A1
(en)
|
2004-04-30 |
2005-11-24 |
Allergan, Inc. |
Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
|
|
US20060182783A1
(en)
|
2004-04-30 |
2006-08-17 |
Allergan, Inc. |
Sustained release intraocular drug delivery systems
|
|
US20070059336A1
(en)
|
2004-04-30 |
2007-03-15 |
Allergan, Inc. |
Anti-angiogenic sustained release intraocular implants and related methods
|
|
JP2008512352A
(ja)
|
2004-07-17 |
2008-04-24 |
イムクローン システムズ インコーポレイティド |
新規な四価の二重特異性抗体
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
EP1804751A2
(en)
|
2004-10-04 |
2007-07-11 |
QLT USA, Inc. |
Ocular delivery of polymeric delivery formulations
|
|
DE102004049479A1
(de)
|
2004-10-11 |
2006-04-13 |
Scil Proteins Gmbh |
Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
|
|
BRPI0518042A
(pt)
|
2004-11-22 |
2008-10-28 |
Borean Pharma Aps |
polipeptìdeo capaz de se ligar ao fator de necrose de tumor (tnf), ácido nucléico isolado, vetor de expressão, célula hospedeira, método para preparação do referido polipeptìdeo, composição farmacêutica, método de ensaio para detecção de tnf e uso
|
|
EP2899277A1
(en)
|
2004-11-26 |
2015-07-29 |
Pieris AG |
Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4)
|
|
JP2008521911A
(ja)
*
|
2004-12-02 |
2008-06-26 |
シェーリング コーポレイション |
癌の処置において髄腔内にテモゾロミド処方物を使用する方法
|
|
WO2006091209A2
(en)
|
2005-02-23 |
2006-08-31 |
Merrimack Pharmaceuticals, Inc. |
Bispecific binding agents for modulating biological activity
|
|
FR2888850B1
(fr)
|
2005-07-22 |
2013-01-11 |
Pf Medicament |
Nouveaux anticorps anti-igf-ir et leurs applications
|
|
US7612181B2
(en)
*
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US7887273B2
(en)
|
2005-09-15 |
2011-02-15 |
Newfrey Llc |
Blind rivet and method
|
|
US20070072933A1
(en)
|
2005-09-26 |
2007-03-29 |
Peyman Gholam A |
Delivery of an ocular agent
|
|
CA2623687A1
(en)
|
2005-10-07 |
2007-04-19 |
The Regents Of The University Of California |
Nucleic acids encoding modified cytochrome p450 enzymes and methods of use thereof
|
|
MX339797B
(es)
|
2005-10-18 |
2016-06-10 |
Allergan Inc |
Terapia ocular que usa derivados glucocorticoides que penetran selectivamente los tejidos del segmento posterior.
|
|
WO2007053807A2
(en)
|
2005-10-31 |
2007-05-10 |
Wisconsin Alumni Research Foundation |
Calcitriol for treating intraocular diseases associated with angiogenesis
|
|
EA201692543A1
(ru)
|
2005-11-23 |
2017-08-31 |
Акселерон Фарма Инк. |
Антагонисты активина-actriia и их применение для стимулирования роста кости
|
|
BRPI0707446A2
(pt)
|
2006-02-02 |
2011-05-03 |
Allergan Inc |
composições e métodos para o tratamento de doença oftálmica
|
|
CN101384279B
(zh)
|
2006-02-24 |
2012-02-22 |
奇斯药制品公司 |
抗淀粉样蛋白免疫原性组合物、方法和用途
|
|
EP2013229A2
(en)
|
2006-04-21 |
2009-01-14 |
Transgene S.A. |
Hpv-18-based papillomavirus vaccine
|
|
WO2008031098A1
(en)
|
2006-09-09 |
2008-03-13 |
The University Of Chicago |
Binary amino acid libraries for fibronectin type iii polypeptide monobodies
|
|
JP2010507099A
(ja)
|
2006-10-16 |
2010-03-04 |
ザ アリゾナ ボード オブ リージェンツ ア ボディ コーポレイト オブ ザ ステイト オブ アリゾナ アクティング フォー アンド オン ビハーフ オブ アリゾナ ステイト ユニバーシティー |
合成抗体
|
|
CA2670471A1
(en)
|
2006-11-22 |
2008-06-05 |
Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) |
Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
|
|
US20100021511A1
(en)
*
|
2007-01-05 |
2010-01-28 |
Fujifilm Corporation |
Dispersion composition, cosmetic preparation for skin care, and method for producing dispersion composition
|
|
WO2008097497A2
(en)
|
2007-02-02 |
2008-08-14 |
Adnexus, A Bristol-Myers Squibb R & D Company |
Vegf pathway blockade
|
|
US20100166747A1
(en)
|
2007-03-02 |
2010-07-01 |
Beltran Pedro J |
Methods and compositions for treating tumor diseases
|
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
|
EP2162540A2
(en)
|
2007-05-22 |
2010-03-17 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
US8680019B2
(en)
|
2007-08-10 |
2014-03-25 |
Protelica, Inc. |
Universal fibronectin Type III binding-domain libraries
|
|
US20090176654A1
(en)
|
2007-08-10 |
2009-07-09 |
Protelix, Inc. |
Universal fibronectin type III binding-domain libraries
|
|
US8470966B2
(en)
|
2007-08-10 |
2013-06-25 |
Protelica, Inc. |
Universal fibronectin type III binding-domain libraries
|
|
US20100285000A1
(en)
*
|
2007-08-20 |
2010-11-11 |
Bristol-Myers Squibb Company |
Use of vegfr-2 inhibitors for treating metastatic cancer
|
|
EP3241846B1
(en)
|
2007-10-04 |
2022-02-23 |
ZymoGenetics, Inc. |
B7 family member zb7h6 and related compositions and methods
|
|
US8633297B2
(en)
|
2007-10-31 |
2014-01-21 |
Medimmune, Llc |
Protein scaffolds
|
|
EP2217274A1
(en)
*
|
2007-11-28 |
2010-08-18 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with mtor inhibitors
|
|
JP2011507529A
(ja)
|
2007-12-19 |
2011-03-10 |
セントコア・オーソ・バイオテツク・インコーポレーテツド |
Ｍ１３ファージのｐＩＸへの融合を介する代替の足場タンパク質融合ファージ提示
|
|
AU2008345424A1
(en)
|
2007-12-27 |
2009-07-09 |
Novartis Ag |
Improved fibronectin-based binding molecules and their use
|
|
CN102007145A
(zh)
|
2008-02-14 |
2011-04-06 |
百时美施贵宝公司 |
基于结合egfr的工程化蛋白质的靶向治疗剂
|
|
MX2010011957A
(es)
|
2008-05-02 |
2011-03-04 |
Novartis Ag Star |
Moleculas de union basadas en fibronectina mejoradas y usos de las mismas.
|
|
EP2799448A1
(en)
|
2008-05-22 |
2014-11-05 |
Bristol-Myers Squibb Company |
Multivalent fibronectin based scaffold domain proteins
|
|
US8415291B2
(en)
|
2008-10-31 |
2013-04-09 |
Centocor Ortho Biotech Inc. |
Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
|
|
CN102307896B
(zh)
|
2008-10-31 |
2016-10-12 |
森托科尔奥索生物科技公司 |
基于iii型纤连蛋白结构域的支架组合物、方法及用途
|
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
|
|
WO2010069913A1
(en)
|
2008-12-16 |
2010-06-24 |
Novartis Ag |
Yeast display systems
|
|
US20100210511A1
(en)
|
2009-02-11 |
2010-08-19 |
Bristol-Myers Squibb Company |
Combination VEGFR2 Therapy with Temozolomide
|
|
CA2752211C
(en)
|
2009-02-12 |
2020-03-24 |
Janssen Biotech, Inc. |
Fibronectin type iii domain based scaffold compositions, methods and uses
|
|
US8067201B2
(en)
|
2009-04-17 |
2011-11-29 |
Bristol-Myers Squibb Company |
Methods for protein refolding
|
|
EP2464663A4
(en)
|
2009-08-13 |
2013-05-29 |
Massachusetts Inst Technology |
MANIPULATED PROTEINS WITH MUTANT FIBRONECTIN DOMAINS
|
|
ES2860453T3
(es)
|
2009-10-30 |
2021-10-05 |
Novartis Ag |
Bibliotecas universales del dominio de unión del lado inferior de la fibronectina de tipo III
|
|
WO2011051466A1
(en)
|
2009-11-02 |
2011-05-05 |
Novartis Ag |
Anti-idiotypic fibronectin-based binding molecules and uses thereof
|
|
US20110123545A1
(en)
|
2009-11-24 |
2011-05-26 |
Bristol-Myers Squibb Company |
Combination of vegfr2 and igf1r inhibitors for the treatment of proliferative diseases
|
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
|
WO2011100700A2
(en)
|
2010-02-12 |
2011-08-18 |
University Of Rochester |
Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies
|
|
BR112012019881A2
(pt)
|
2010-02-18 |
2017-06-27 |
Bristol Myers Squibb Co |
proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23
|
|
AU2011240620A1
(en)
|
2010-04-13 |
2012-10-18 |
Medimmune, Llc |
Fibronectin type III domain-based multimeric scaffolds
|
|
EP3424949A1
(en)
|
2010-04-13 |
2019-01-09 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind pcsk9
|
|
HUE029622T2
(en)
|
2010-04-30 |
2017-03-28 |
Janssen Biotech Inc |
Stabilized fibronectin domain compositions, methods and uses
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
EP2576615B1
(en)
|
2010-05-26 |
2016-03-30 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins having improved stability
|
|
AU2011283646B2
(en)
|
2010-07-30 |
2015-07-09 |
Novartis Ag |
Fibronectin cradle molecules and libraries thereof
|
|
EP2655411A1
(en)
|
2010-12-22 |
2013-10-30 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind il-23
|
|
ES2608835T3
(es)
|
2011-04-13 |
2017-04-17 |
Bristol-Myers Squibb Company |
Proteínas de fusión Fc que comprenden nuevos enlazadores o disposiciones
|
|
WO2012158739A1
(en)
|
2011-05-17 |
2012-11-22 |
Bristol-Myers Squibb Company |
Improved methods for the selection of binding proteins
|
|
EP2709669A1
(en)
|
2011-05-17 |
2014-03-26 |
Bristol-Myers Squibb Company |
Methods for maintaining pegylation of polypeptides
|
|
EP2761066B1
(en)
|
2011-09-27 |
2018-12-05 |
Janssen Biotech, Inc. |
Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces
|