JP2006514822A5 - - Google Patents

Info

Publication number

JP2006514822A5

JP2006514822A5 JP2004527586A JP2004527586A JP2006514822A5 JP 2006514822 A5 JP2006514822 A5 JP 2006514822A5 JP 2004527586 A JP2004527586 A JP 2004527586A JP 2004527586 A JP2004527586 A JP 2004527586A JP 2006514822 A5 JP2006514822 A5 JP 2006514822A5

Authority

JP

Japan

Prior art keywords

gly

asp

peptide derivative

thrombin peptide

glu

Prior art date

2003-07-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims 30
• 108090000190 Thrombin Proteins 0.000 claims 23
• 229960004072 thrombin Drugs 0.000 claims 23
• 150000001413 amino acids Chemical group 0.000 claims 18
• 235000001014 amino acid Nutrition 0.000 claims 10
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
• 235000004279 alanine Nutrition 0.000 claims 6
• 229920001184 polypeptide Polymers 0.000 claims 6
• 102000004196 processed proteins & peptides Human genes 0.000 claims 6
• 150000001408 amides Chemical group 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 239000004471 Glycine Substances 0.000 claims 4
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
• 210000000988 bone and bone Anatomy 0.000 claims 3
• 210000004899 c-terminal region Anatomy 0.000 claims 3
• 235000018417 cysteine Nutrition 0.000 claims 3
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 2
• 125000001931 aliphatic group Chemical group 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
• HZKLCOYAVAAQRD-VGMNWLOBSA-N (3s)-3-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1r)-1-carboxyethyl]amino]-4-oxobutanoic acid Chemical compound OC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCN=C(N)N HZKLCOYAVAAQRD-VGMNWLOBSA-N 0.000 claims 1
• 229940117028 Thrombin receptor agonist Drugs 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 108010086780 arginyl-glycyl-aspartyl-alanine Proteins 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 230000008468 bone growth Effects 0.000 claims 1
• 230000000747 cardiac effect Effects 0.000 claims 1
• 210000000845 cartilage Anatomy 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000012010 growth Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 208000037803 restenosis Diseases 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• OXHYRVSBKWIFES-WWSDOYNLSA-N trap-14 peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 OXHYRVSBKWIFES-WWSDOYNLSA-N 0.000 claims 1
• 239000011800 void material Substances 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1