JP2004538320A5 - - Google Patents

Info

Publication number

JP2004538320A5

JP2004538320A5 JP2003518575A JP2003518575A JP2004538320A5 JP 2004538320 A5 JP2004538320 A5 JP 2004538320A5 JP 2003518575 A JP2003518575 A JP 2003518575A JP 2003518575 A JP2003518575 A JP 2003518575A JP 2004538320 A5 JP2004538320 A5 JP 2004538320A5

Authority

JP

Japan

Prior art keywords

gly

asp

thrombin peptide

amino acids

peptide derivative

Prior art date

2002-01-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 42
• 108090000190 Thrombin Proteins 0.000 claims description 41
• 150000001413 amino acids Chemical group 0.000 claims description 41
• 229960004072 thrombin Drugs 0.000 claims description 41
• 239000012634 fragment Substances 0.000 claims description 21
• 210000004899 c-terminal region Anatomy 0.000 claims description 9
• 230000001684 chronic effect Effects 0.000 claims description 6
• 230000002500 effect on skin Effects 0.000 claims description 6
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 5
• 239000000556 agonist Substances 0.000 claims description 5
• 206010040943 Skin Ulcer Diseases 0.000 claims description 4
• 208000025865 Ulcer Diseases 0.000 claims description 4
• 238000006467 substitution reaction Methods 0.000 claims description 4
• 231100000397 ulcer Toxicity 0.000 claims description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
• 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 3
• 229910052757 nitrogen Inorganic materials 0.000 claims description 3
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
• 231100000019 skin ulcer Toxicity 0.000 claims description 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 125000003275 alpha amino acid group Chemical group 0.000 claims 8
• 102000003790 Thrombin receptors Human genes 0.000 claims 2
• 108090000166 Thrombin receptors Proteins 0.000 claims 2
• 229940088710 antibiotic agent Drugs 0.000 claims 2
• 230000035876 healing Effects 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• 206010011985 Decubitus ulcer Diseases 0.000 claims 1
• 206010056340 Diabetic ulcer Diseases 0.000 claims 1
• 208000004210 Pressure Ulcer Diseases 0.000 claims 1
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
• 208000000558 Varicose Ulcer Diseases 0.000 claims 1
• 229940035676 analgesics Drugs 0.000 claims 1
• 238000010171 animal model Methods 0.000 claims 1
• 239000000730 antalgic agent Substances 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 230000000844 anti-bacterial effect Effects 0.000 claims 1
• 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000000645 desinfectant Substances 0.000 claims 1
• 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
• 238000000034 method Methods 0.000 description 3
• 102000004196 processed proteins & peptides Human genes 0.000 description 2
• 108010094028 Prothrombin Proteins 0.000 description 1
• 102100027378 Prothrombin Human genes 0.000 description 1
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000002757 morpholinyl group Chemical group 0.000 description 1
• 125000003386 piperidinyl group Chemical group 0.000 description 1
• 229920001184 polypeptide Polymers 0.000 description 1
• 229940039716 prothrombin Drugs 0.000 description 1
• 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
• 229960003766 thrombin (human) Drugs 0.000 description 1