JP2002509854A5 - - Google Patents
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- Publication number
- JP2002509854A5 JP2002509854A5 JP2000510458A JP2000510458A JP2002509854A5 JP 2002509854 A5 JP2002509854 A5 JP 2002509854A5 JP 2000510458 A JP2000510458 A JP 2000510458A JP 2000510458 A JP2000510458 A JP 2000510458A JP 2002509854 A5 JP2002509854 A5 JP 2002509854A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- amino acid
- pthrp
- analog
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 15
- 108700020797 Parathyroid Hormone-Related Proteins 0.000 description 11
- 102000043299 Parathyroid hormone-related Human genes 0.000 description 11
- 125000000539 amino acid group Chemical group 0.000 description 8
- 210000000988 bone and bone Anatomy 0.000 description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- MWMJCGBSIORNCD-AVGNSLFASA-N Glu-Leu-Leu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O MWMJCGBSIORNCD-AVGNSLFASA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- QNBVTHNJGCOVFA-AVGNSLFASA-N Leu-Leu-Glu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CCC(O)=O QNBVTHNJGCOVFA-AVGNSLFASA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000013003 healing agent Substances 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5832497P | 1997-09-09 | 1997-09-09 | |
| US60/058,324 | 1997-09-09 | ||
| PCT/EP1998/005550 WO1999012561A2 (en) | 1997-09-09 | 1998-09-02 | FRACTURE HEALING USING PTHrP ANALOGS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002509854A JP2002509854A (ja) | 2002-04-02 |
| JP2002509854A5 true JP2002509854A5 (enExample) | 2006-01-05 |
Family
ID=22016113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000510458A Pending JP2002509854A (ja) | 1997-09-09 | 1998-09-02 | ＰＴＨｒＰ類似体を使用する骨折治癒 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6583114B2 (enExample) |
| EP (1) | EP1005359B1 (enExample) |
| JP (1) | JP2002509854A (enExample) |
| KR (1) | KR100679778B1 (enExample) |
| CN (1) | CN1210059C (enExample) |
| AR (1) | AR015435A1 (enExample) |
| AT (1) | ATE297754T1 (enExample) |
| AU (1) | AU752925B2 (enExample) |
| BR (1) | BR9812068A (enExample) |
| CA (1) | CA2302255C (enExample) |
| CO (1) | CO4890856A1 (enExample) |
| CZ (1) | CZ298701B6 (enExample) |
| DE (1) | DE69830591T2 (enExample) |
| ES (1) | ES2244090T3 (enExample) |
| HR (1) | HRP20000109A2 (enExample) |
| HU (1) | HU226866B1 (enExample) |
| IL (2) | IL134719A0 (enExample) |
| MA (1) | MA26545A1 (enExample) |
| MY (1) | MY121291A (enExample) |
| NO (1) | NO323740B1 (enExample) |
| NZ (1) | NZ502970A (enExample) |
| PE (1) | PE117399A1 (enExample) |
| PL (1) | PL195703B1 (enExample) |
| RS (1) | RS49707B (enExample) |
| RU (1) | RU2224539C2 (enExample) |
| SA (1) | SA98190565B1 (enExample) |
| TR (1) | TR200000649T2 (enExample) |
| TW (1) | TW552139B (enExample) |
| UY (1) | UY25172A1 (enExample) |
| WO (1) | WO1999012561A2 (enExample) |
| ZA (1) | ZA988030B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1295605A3 (en) * | 1998-08-19 | 2003-10-29 | Eli Lilly And Company | Method of increasing bone toughness and stiffness and reducing fractures |
| US20040033950A1 (en) | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
| AR033639A1 (es) * | 1998-08-19 | 2004-01-07 | Lilly Co Eli | Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis |
| EP1769804B1 (en) * | 1998-08-19 | 2012-09-19 | Eli Lilly And Company | hPTH(1-34) for use in preventing or reducing the incidence or severity of vertebral and / or non vertebral fracture in a male human |
| CA2245903A1 (en) * | 1998-09-28 | 2000-03-28 | Mcgill University | Use of pex in the treatment of metabolic bone diseases |
| CZ20013174A3 (cs) | 1999-03-05 | 2002-02-13 | The Procter & Gamble Company | C16 nenasycené FP-selektivní prostaglandinové analogy |
| US20020037914A1 (en) | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US6560487B1 (en) * | 2000-05-08 | 2003-05-06 | International Rehabilitative Sciences, Inc. | Electro-medical device for use with biologics |
| US6393328B1 (en) * | 2000-05-08 | 2002-05-21 | International Rehabilitative Sciences, Inc. | Multi-functional portable electro-medical device |
| US6675048B2 (en) * | 2000-05-08 | 2004-01-06 | International Rehabilitative Sciences, Inc. | Electro-medical device for use with biologics |
| MXPA04006728A (es) | 2002-01-10 | 2005-08-19 | Osteotrophin Llc | Tratamiento de desordenes oseos con medicamentos anabolicos esqueleticos. |
| US7399826B1 (en) | 2003-10-02 | 2008-07-15 | Ali Sadat M | Peptide for promoting healing of fractures |
| JP2008515437A (ja) * | 2004-10-08 | 2008-05-15 | フォーブス メディ−テック（リサーチ） インコーポレーテッド | 血管活性腸管ポリペプチド医薬品 |
| BRPI0618469A2 (pt) * | 2005-11-10 | 2011-08-30 | Univ Michigan Tech | hormÈnio paratiróide de urso preto e métodos de uso de hormÈnio paratiróide de urso preto |
| WO2007133580A2 (en) * | 2006-05-09 | 2007-11-22 | Zelos Therapeutics, Inc. | Use of pth (1-31) and optionally g-csf for hematopoietic stimulation |
| US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
| JP5375611B2 (ja) | 2006-10-03 | 2013-12-25 | ラジウス ヘルス，インコーポレイテッド | 骨同化作用を有するタンパク質のための薬物送達方法 |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| JP5564167B2 (ja) * | 2008-05-22 | 2014-07-30 | 日本たばこ産業株式会社 | 苦味マスキング剤及び苦味低減方法 |
| US8870876B2 (en) | 2009-02-13 | 2014-10-28 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| CN102448482A (zh) | 2009-03-27 | 2012-05-09 | 范安德尔研究所 | 甲状旁腺素肽和甲状旁腺素相关蛋白肽及使用方法 |
| US8277459B2 (en) | 2009-09-25 | 2012-10-02 | Tarsus Medical Inc. | Methods and devices for treating a structural bone and joint deformity |
| EP2509996A1 (en) | 2009-12-07 | 2012-10-17 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| US8652141B2 (en) | 2010-01-21 | 2014-02-18 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US8696719B2 (en) | 2010-06-03 | 2014-04-15 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| PT3122426T (pt) | 2014-03-28 | 2023-02-28 | Univ Duke | Tratamento de cancro da mama utilizando moduladores seletivos do recetor de estrogénio |
| CN104146961B (zh) * | 2014-07-04 | 2018-02-27 | 深圳职业技术学院 | 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法 |
| EP3288383A4 (en) | 2015-04-29 | 2019-01-23 | Radius Pharmaceuticals, Inc. | METHOD FOR THE TREATMENT OF CANCER |
| CN108025042A (zh) * | 2015-07-06 | 2018-05-11 | 董正欣 | PTHrP类似物的新型制剂 |
| AU2017253674B2 (en) | 2016-04-18 | 2021-07-29 | Kindeva Drug Delivery L.P. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
| ES2981967T3 (es) | 2017-01-05 | 2024-10-14 | Radius Pharmaceuticals Inc | Formas polimórficas de RAD1901-2HCl |
| US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
| JP7473486B2 (ja) | 2018-07-04 | 2024-04-23 | ラジウス ファーマシューティカルズ，インコーポレイテッド | Ｒａｄ１９０１－２ｈｃｌの多形形態 |
| JOP20210218A1 (ar) | 2019-02-12 | 2023-01-30 | Radius Pharmaceuticals Inc | عمليات ومركبات |
| CN114364327A (zh) * | 2019-09-12 | 2022-04-15 | 雷迪厄斯健康公司 | 用阿巴帕肽改善脊柱融合的方法 |
| CN112646042A (zh) * | 2019-10-10 | 2021-04-13 | 陕西麦科奥特科技有限公司 | 活性多肽化合物 |
| AU2022205801A1 (en) * | 2021-01-05 | 2023-07-13 | Radius Health, Inc. | Treatment of long bone fractures with abaloparatide |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3935738A1 (de) * | 1989-10-27 | 1991-05-08 | Forssmann Wolf Georg | Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff |
| US5821225A (en) * | 1992-07-14 | 1998-10-13 | Syntex (U.S.A.) Inc. | Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| US5977070A (en) * | 1992-07-14 | 1999-11-02 | Piazza; Christin Teresa | Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis |
| GB9308033D0 (en) * | 1993-04-19 | 1993-06-02 | Sandoz Ltd | Organic compounds |
| AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| WO1995002610A1 (en) * | 1993-07-13 | 1995-01-26 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| WO1995011697A1 (en) * | 1993-10-27 | 1995-05-04 | Chugai Seiyaku Kabushiki Kaisha | Cure accelerator in chondroplasty |
| JPH08310965A (ja) * | 1995-05-16 | 1996-11-26 | Chugai Pharmaceut Co Ltd | 骨癒合促進剤 |
| US5717062A (en) * | 1995-06-07 | 1998-02-10 | Beth Israel Hospital Association | Cyclic analogs of PTH and PTHrP |
| US5955574A (en) * | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
| US5723577A (en) * | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
-
1998
- 1998-09-02 TR TR2000/00649T patent/TR200000649T2/xx unknown
- 1998-09-02 HU HU0004560A patent/HU226866B1/hu unknown
- 1998-09-02 DE DE69830591T patent/DE69830591T2/de not_active Expired - Lifetime
- 1998-09-02 BR BR9812068-9A patent/BR9812068A/pt not_active IP Right Cessation
- 1998-09-02 JP JP2000510458A patent/JP2002509854A/ja active Pending
- 1998-09-02 ZA ZA988030A patent/ZA988030B/xx unknown
- 1998-09-02 AT AT98951341T patent/ATE297754T1/de active
- 1998-09-02 KR KR1020007002454A patent/KR100679778B1/ko not_active Expired - Lifetime
- 1998-09-02 IL IL13471998A patent/IL134719A0/xx unknown
- 1998-09-02 CZ CZ20000862A patent/CZ298701B6/cs not_active IP Right Cessation
- 1998-09-02 PL PL98339449A patent/PL195703B1/pl unknown
- 1998-09-02 CA CA2302255A patent/CA2302255C/en not_active Expired - Lifetime
- 1998-09-02 HR HR20000109A patent/HRP20000109A2/hr not_active Application Discontinuation
- 1998-09-02 AU AU97406/98A patent/AU752925B2/en not_active Expired
- 1998-09-02 CN CNB988089696A patent/CN1210059C/zh not_active Expired - Lifetime
- 1998-09-02 RU RU2000109305/15A patent/RU2224539C2/ru active
- 1998-09-02 ES ES98951341T patent/ES2244090T3/es not_active Expired - Lifetime
- 1998-09-02 EP EP98951341A patent/EP1005359B1/en not_active Expired - Lifetime
- 1998-09-02 NZ NZ502970A patent/NZ502970A/en not_active IP Right Cessation
- 1998-09-02 RS YUP-127/00A patent/RS49707B/sr unknown
- 1998-09-02 WO PCT/EP1998/005550 patent/WO1999012561A2/en not_active Ceased
- 1998-09-03 US US09/146,802 patent/US6583114B2/en not_active Expired - Lifetime
- 1998-09-07 UY UY25172A patent/UY25172A1/es not_active Application Discontinuation
- 1998-09-07 TW TW087114825A patent/TW552139B/zh not_active IP Right Cessation
- 1998-09-07 MY MYPI98004075A patent/MY121291A/en unknown
- 1998-09-07 CO CO98051174A patent/CO4890856A1/es unknown
- 1998-09-07 PE PE1998000838A patent/PE117399A1/es not_active Application Discontinuation
- 1998-09-07 AR ARP980104456A patent/AR015435A1/es unknown
- 1998-09-08 MA MA25247A patent/MA26545A1/fr unknown
- 1998-09-21 SA SA98190565A patent/SA98190565B1/ar unknown
-
2000
- 2000-02-24 IL IL134719A patent/IL134719A/en not_active IP Right Cessation
- 2000-03-08 NO NO20001195A patent/NO323740B1/no not_active IP Right Cessation
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