ZA988030B - Fracture healing using pthrp analogs - Google Patents

Fracture healing using pthrp analogs

Info

Publication number
ZA988030B
ZA988030B ZA988030A ZA988030A ZA988030B ZA 988030 B ZA988030 B ZA 988030B ZA 988030 A ZA988030 A ZA 988030A ZA 988030 A ZA988030 A ZA 988030A ZA 988030 B ZA988030 B ZA 988030B
Authority
ZA
South Africa
Prior art keywords
fracture healing
pthrp analogs
pthrp
analogs
healing
Prior art date
Application number
ZA988030A
Other languages
English (en)
Inventor
Brian Henry Vickery
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA988030B publication Critical patent/ZA988030B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA988030A 1997-09-09 1998-09-02 Fracture healing using pthrp analogs ZA988030B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09

Publications (1)

Publication Number Publication Date
ZA988030B true ZA988030B (en) 1999-03-09

Family

ID=22016113

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA988030A ZA988030B (en) 1997-09-09 1998-09-02 Fracture healing using pthrp analogs

Country Status (31)

Country Link
US (1) US6583114B2 (enExample)
EP (1) EP1005359B1 (enExample)
JP (1) JP2002509854A (enExample)
KR (1) KR100679778B1 (enExample)
CN (1) CN1210059C (enExample)
AR (1) AR015435A1 (enExample)
AT (1) ATE297754T1 (enExample)
AU (1) AU752925B2 (enExample)
BR (1) BR9812068A (enExample)
CA (1) CA2302255C (enExample)
CO (1) CO4890856A1 (enExample)
CZ (1) CZ298701B6 (enExample)
DE (1) DE69830591T2 (enExample)
ES (1) ES2244090T3 (enExample)
HR (1) HRP20000109A2 (enExample)
HU (1) HU226866B1 (enExample)
IL (2) IL134719A0 (enExample)
MA (1) MA26545A1 (enExample)
MY (1) MY121291A (enExample)
NO (1) NO323740B1 (enExample)
NZ (1) NZ502970A (enExample)
PE (1) PE117399A1 (enExample)
PL (1) PL195703B1 (enExample)
RS (1) RS49707B (enExample)
RU (1) RU2224539C2 (enExample)
SA (1) SA98190565B1 (enExample)
TR (1) TR200000649T2 (enExample)
TW (1) TW552139B (enExample)
UY (1) UY25172A1 (enExample)
WO (1) WO1999012561A2 (enExample)
ZA (1) ZA988030B (enExample)

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SI1059933T1 (en) * 1998-08-19 2003-04-30 Eli Lilly & Company Use of parathyroide hormone consisting of aminoacid sequence 1-34 of human parathyroid hormone for reducing the risk of both vertebral and non vertebral bone fracture
EP1769804B1 (en) * 1998-08-19 2012-09-19 Eli Lilly And Company hPTH(1-34) for use in preventing or reducing the incidence or severity of vertebral and / or non vertebral fracture in a male human
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
DZ2873A1 (fr) * 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
ES2232434T3 (es) 1999-03-05 2005-06-01 Duke University Analogos de prostaglandinas c-16 fp selectivas insaturadas.
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US6560487B1 (en) * 2000-05-08 2003-05-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6675048B2 (en) * 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6393328B1 (en) * 2000-05-08 2002-05-21 International Rehabilitative Sciences, Inc. Multi-functional portable electro-medical device
EP1531855A4 (en) * 2002-01-10 2009-07-22 Osteotrophin Llc TREATMENT OF BONE DISEASES WITH SKELETTAL ANABOLIKA
US7399826B1 (en) 2003-10-02 2008-07-15 Ali Sadat M Peptide for promoting healing of fractures
WO2006042152A2 (en) * 2004-10-08 2006-04-20 Forbes Medi-Tech (Research) Inc. Vasoactive intestinal polypeptide pharmaceuticals
CN101355959B (zh) * 2005-11-10 2013-02-27 密歇根理工大学管理委员会 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法
US20090022684A1 (en) * 2006-05-09 2009-01-22 Paul Morley Methods for hematopoietic stimulation
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
SI2957278T1 (sl) 2006-10-03 2017-09-29 Radius Health, Inc. Stabilni sestavek, ki obsega PTHrP, in njegova uporaba
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8563513B2 (en) 2009-03-27 2013-10-22 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
EP2509996A1 (en) 2009-12-07 2012-10-17 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
PL3122426T3 (pl) 2014-03-28 2023-05-15 Duke University Leczenie raka sutka z zastosowaniem selektywnych modulatorów receptora estrogenowego
CN104146961B (zh) * 2014-07-04 2018-02-27 深圳职业技术学院 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法
WO2016176665A1 (en) 2015-04-29 2016-11-03 Radius Health, Inc. Methods of treating cancer
WO2017007777A2 (en) * 2015-07-06 2017-01-12 Zhengxin Dong NOVEL FORMULATIONS OF PTHrP ANALOGUE
AU2017253674B2 (en) 2016-04-18 2021-07-29 Kindeva Drug Delivery L.P. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
EP4374925A3 (en) 2017-01-05 2025-01-15 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
CN112423844B (zh) 2018-07-04 2024-08-13 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
CN119390714A (zh) 2019-02-12 2025-02-07 雷迪厄斯制药公司 方法和化合物
EP4027899A4 (en) * 2019-09-12 2023-08-16 Radius Health, Inc. METHODS OF ENHANCING SPINE FUSION USING ABALOPARATIDE
CN112646042A (zh) * 2019-10-10 2021-04-13 陕西麦科奥特科技有限公司 活性多肽化合物
WO2022149066A1 (en) * 2021-01-05 2022-07-14 Radius Health, Inc. Treatment of long bone fractures with abaloparatide

Family Cites Families (12)

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DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
GB9308033D0 (en) * 1993-04-19 1993-06-02 Sandoz Ltd Organic compounds
CN1070500C (zh) * 1993-07-13 2001-09-05 森德克斯(美国)股份有限公司 甲状旁腺激素类似物和甲状旁腺激素相关肽：合成和治疗骨质疏松症的用途
TW273513B (enExample) * 1993-10-27 1996-04-01 Chugai Pharmaceutical Co Ltd
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
AR015435A1 (es) 2001-05-02
DE69830591T2 (de) 2006-05-04
MA26545A1 (fr) 2004-12-20
ES2244090T3 (es) 2005-12-01
CZ2000862A3 (cs) 2000-09-13
CZ298701B6 (cs) 2007-12-27
NZ502970A (en) 2002-03-01
RU2224539C2 (ru) 2004-02-27
SA98190565B1 (ar) 2006-07-30
RS49707B (sr) 2007-12-31
NO20001195L (no) 2000-03-08
AU752925B2 (en) 2002-10-03
NO323740B1 (no) 2007-07-02
JP2002509854A (ja) 2002-04-02
HUP0004560A3 (en) 2005-11-28
KR20010023795A (ko) 2001-03-26
PE117399A1 (es) 1999-11-20
DE69830591D1 (de) 2005-07-21
HK1030753A1 (zh) 2001-05-18
TW552139B (en) 2003-09-11
UY25172A1 (es) 2001-01-31
HU226866B1 (en) 2009-12-28
BR9812068A (pt) 2000-09-26
HRP20000109A2 (en) 2001-02-28
CN1210059C (zh) 2005-07-13
NO20001195D0 (no) 2000-03-08
EP1005359B1 (en) 2005-06-15
US6583114B2 (en) 2003-06-24
WO1999012561A2 (en) 1999-03-18
PL195703B1 (pl) 2007-10-31
HUP0004560A2 (hu) 2001-04-28
IL134719A0 (en) 2001-04-30
CA2302255A1 (en) 1999-03-18
WO1999012561A9 (en) 2000-03-16
CA2302255C (en) 2011-11-08
TR200000649T2 (tr) 2000-09-21
CN1269726A (zh) 2000-10-11
US20020077281A1 (en) 2002-06-20
ATE297754T1 (de) 2005-07-15
CO4890856A1 (es) 2000-02-28
PL339449A1 (en) 2000-12-18
KR100679778B1 (ko) 2007-02-07
IL134719A (en) 2010-04-29
EP1005359A2 (en) 2000-06-07
YU12700A (sh) 2004-09-03
WO1999012561A3 (en) 1999-05-14
AU9740698A (en) 1999-03-29
MY121291A (en) 2006-01-28

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