HUP0004560A2 - Törést gyógyító PTHrP analógok - Google Patents

Törést gyógyító PTHrP analógok

Info

Publication number
HUP0004560A2
HUP0004560A2 HU0004560A HUP0004560A HUP0004560A2 HU P0004560 A2 HUP0004560 A2 HU P0004560A2 HU 0004560 A HU0004560 A HU 0004560A HU P0004560 A HUP0004560 A HU P0004560A HU P0004560 A2 HUP0004560 A2 HU P0004560A2
Authority
HU
Hungary
Prior art keywords
pthrp
fracture healing
bone healing
pthrp analogs
fracture repair
Prior art date
Application number
HU0004560A
Other languages
English (en)
Inventor
Brian Henry Vickery
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of HUP0004560A2 publication Critical patent/HUP0004560A2/hu
Publication of HUP0004560A3 publication Critical patent/HUP0004560A3/hu
Publication of HU226866B1 publication Critical patent/HU226866B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya eljárás csontgyógyításra és törés-helyreállításra,azzal jellemezve, hogy a fenti kezelésre rászoruló betegnek hatékonymennyiségben a parathiroid hormonnal rokon peptid (PTHrP) olyanpolipeptidanalógját vagy sóját adják be, amelyben a PTHrP-analóg 22-31aminosavmaradéka amfipatikus alfa-hélixet képez. A találmány továbbá afenti polipeptideknek csontgyógyulás vagy törés-helyreállításkezelésére szolgáló gyógyászati készítmények előállítására történőfelhasználására vonatkozik. Ó
HU0004560A 1997-09-09 1998-09-02 Fracture healing using pthrp analogs HU226866B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09
PCT/EP1998/005550 WO1999012561A2 (en) 1997-09-09 1998-09-02 FRACTURE HEALING USING PTHrP ANALOGS

Publications (3)

Publication Number Publication Date
HUP0004560A2 true HUP0004560A2 (hu) 2001-04-28
HUP0004560A3 HUP0004560A3 (en) 2005-11-28
HU226866B1 HU226866B1 (en) 2009-12-28

Family

ID=22016113

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004560A HU226866B1 (en) 1997-09-09 1998-09-02 Fracture healing using pthrp analogs

Country Status (32)

Country Link
US (1) US6583114B2 (hu)
EP (1) EP1005359B1 (hu)
JP (1) JP2002509854A (hu)
KR (1) KR100679778B1 (hu)
CN (1) CN1210059C (hu)
AR (1) AR015435A1 (hu)
AT (1) ATE297754T1 (hu)
AU (1) AU752925B2 (hu)
BR (1) BR9812068A (hu)
CA (1) CA2302255C (hu)
CO (1) CO4890856A1 (hu)
CZ (1) CZ298701B6 (hu)
DE (1) DE69830591T2 (hu)
ES (1) ES2244090T3 (hu)
HK (1) HK1030753A1 (hu)
HR (1) HRP20000109A2 (hu)
HU (1) HU226866B1 (hu)
IL (2) IL134719A0 (hu)
MA (1) MA26545A1 (hu)
MY (1) MY121291A (hu)
NO (1) NO323740B1 (hu)
NZ (1) NZ502970A (hu)
PE (1) PE117399A1 (hu)
PL (1) PL195703B1 (hu)
RS (1) RS49707B (hu)
RU (1) RU2224539C2 (hu)
SA (1) SA98190565B1 (hu)
TR (1) TR200000649T2 (hu)
TW (1) TW552139B (hu)
UY (1) UY25172A1 (hu)
WO (1) WO1999012561A2 (hu)
ZA (1) ZA988030B (hu)

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DZ2873A1 (fr) 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
EP1295605A3 (en) * 1998-08-19 2003-10-29 Eli Lilly And Company Method of increasing bone toughness and stiffness and reducing fractures
EP1769804B1 (en) * 1998-08-19 2012-09-19 Eli Lilly And Company hPTH(1-34) for use in preventing or reducing the incidence or severity of vertebral and / or non vertebral fracture in a male human
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
PL350917A1 (en) 1999-03-05 2003-02-10 Procter & Gamble C16 unsaturated fp-selective prostaglandins analogs
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US6675048B2 (en) * 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6393328B1 (en) * 2000-05-08 2002-05-21 International Rehabilitative Sciences, Inc. Multi-functional portable electro-medical device
US6560487B1 (en) 2000-05-08 2003-05-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
EP1531855A4 (en) * 2002-01-10 2009-07-22 Osteotrophin Llc TREATMENT OF BONE DISEASES WITH SKELETTAL ANABOLIKA
AU2003272814A1 (en) 2003-10-02 2005-05-19 Ibrahim Al-Habdan Peptide for promoting healing of fractures
KR20070067136A (ko) * 2004-10-08 2007-06-27 포베스 메디-테크 (리서치) 인코포레이티드 혈관작용성 장내 폴리펩티드 제약
CA2628945A1 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
WO2007133580A2 (en) * 2006-05-09 2007-11-22 Zelos Therapeutics, Inc. Use of pth (1-31) and optionally g-csf for hematopoietic stimulation
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
CN102274492B (zh) 2006-10-03 2014-11-26 半径健康公司 骨合成代谢蛋白质的药物递送方法
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
EP2411038B1 (en) 2009-03-27 2016-12-28 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
AU2009356227A1 (en) 2009-12-07 2012-06-21 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
CN104146961B (zh) * 2014-07-04 2018-02-27 深圳职业技术学院 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法
EP4039253A1 (en) 2015-04-29 2022-08-10 Radius Pharmaceuticals, Inc. Methods of treating cancer
WO2017007777A2 (en) * 2015-07-06 2017-01-12 Zhengxin Dong NOVEL FORMULATIONS OF PTHrP ANALOGUE
EP3998061A1 (en) 2016-04-18 2022-05-18 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
EP3565542B1 (en) 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
JP7473486B2 (ja) 2018-07-04 2024-04-23 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形形態
EP4027899A4 (en) * 2019-09-12 2023-08-16 Radius Health, Inc. METHODS OF ENHANCING SPINE FUSION USING ABALOPARATIDE
CN112646042A (zh) * 2019-10-10 2021-04-13 陕西麦科奥特科技有限公司 活性多肽化合物
WO2022149066A1 (en) * 2021-01-05 2022-07-14 Radius Health, Inc. Treatment of long bone fractures with abaloparatide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU8002994A (en) * 1993-10-27 1995-05-22 Chugai Seiyaku Kabushiki Kaisha Cure accelerator in chondroplasty
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
KR100679778B1 (ko) 2007-02-07
ZA988030B (en) 1999-03-09
NZ502970A (en) 2002-03-01
AR015435A1 (es) 2001-05-02
RU2224539C2 (ru) 2004-02-27
KR20010023795A (ko) 2001-03-26
HU226866B1 (en) 2009-12-28
EP1005359A2 (en) 2000-06-07
HRP20000109A2 (en) 2001-02-28
HK1030753A1 (en) 2001-05-18
NO20001195L (no) 2000-03-08
RS49707B (sr) 2007-12-31
DE69830591D1 (de) 2005-07-21
TR200000649T2 (tr) 2000-09-21
PE117399A1 (es) 1999-11-20
WO1999012561A9 (en) 2000-03-16
CN1210059C (zh) 2005-07-13
IL134719A (en) 2010-04-29
MY121291A (en) 2006-01-28
SA98190565B1 (ar) 2006-07-30
CA2302255C (en) 2011-11-08
CZ298701B6 (cs) 2007-12-27
NO323740B1 (no) 2007-07-02
ES2244090T3 (es) 2005-12-01
US20020077281A1 (en) 2002-06-20
CZ2000862A3 (cs) 2000-09-13
AU9740698A (en) 1999-03-29
CA2302255A1 (en) 1999-03-18
NO20001195D0 (no) 2000-03-08
CN1269726A (zh) 2000-10-11
ATE297754T1 (de) 2005-07-15
US6583114B2 (en) 2003-06-24
IL134719A0 (en) 2001-04-30
PL195703B1 (pl) 2007-10-31
WO1999012561A2 (en) 1999-03-18
WO1999012561A3 (en) 1999-05-14
EP1005359B1 (en) 2005-06-15
DE69830591T2 (de) 2006-05-04
PL339449A1 (en) 2000-12-18
CO4890856A1 (es) 2000-02-28
JP2002509854A (ja) 2002-04-02
AU752925B2 (en) 2002-10-03
MA26545A1 (fr) 2004-12-20
YU12700A (sh) 2004-09-03
UY25172A1 (es) 2001-01-31
TW552139B (en) 2003-09-11
HUP0004560A3 (en) 2005-11-28
BR9812068A (pt) 2000-09-26

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