RS49707B - Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu i njegovih soli za proizvodnju medikamenata za lečenje preloma kostiju - Google Patents

Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu i njegovih soli za proizvodnju medikamenata za lečenje preloma kostiju

Info

Publication number
RS49707B
RS49707B YUP-127/00A YU12700A RS49707B RS 49707 B RS49707 B RS 49707B YU 12700 A YU12700 A YU 12700A RS 49707 B RS49707 B RS 49707B
Authority
RS
Serbia
Prior art keywords
pthrp
salts
preparation
parathyroid hormone
related peptide
Prior art date
Application number
YUP-127/00A
Other languages
English (en)
Inventor
Brian Henry Vickery
Original Assignee
F.Hoffmann-La Roche Ag.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag., filed Critical F.Hoffmann-La Roche Ag.,
Publication of YU12700A publication Critical patent/YU12700A/sh
Publication of RS49707B publication Critical patent/RS49707B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu (PTHrP) i njihovih soli, pri čemu su amino kiseline na pozicijama 22-31 naznačenog PTHrP analoga u formi amfipatičnog α-heliksa Glu Leu Leu Glu Xaa Leu Leu Glu Lys Leu, gde je Xaa neki pozitivno naelektrisani amino kiselinski ostatak, za pripremu medikamenata za zaceljivanje kostiju i srastanje preloma. Prijava sadrži još 8 zavisnih patentnih zahteva.
YUP-127/00A 1997-09-09 1998-09-02 Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu i njegovih soli za proizvodnju medikamenata za lečenje preloma kostiju RS49707B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09

Publications (2)

Publication Number Publication Date
YU12700A YU12700A (sh) 2004-09-03
RS49707B true RS49707B (sr) 2007-12-31

Family

ID=22016113

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-127/00A RS49707B (sr) 1997-09-09 1998-09-02 Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu i njegovih soli za proizvodnju medikamenata za lečenje preloma kostiju

Country Status (32)

Country Link
US (1) US6583114B2 (sr)
EP (1) EP1005359B1 (sr)
JP (1) JP2002509854A (sr)
KR (1) KR100679778B1 (sr)
CN (1) CN1210059C (sr)
AR (1) AR015435A1 (sr)
AT (1) ATE297754T1 (sr)
AU (1) AU752925B2 (sr)
BR (1) BR9812068A (sr)
CA (1) CA2302255C (sr)
CO (1) CO4890856A1 (sr)
CZ (1) CZ298701B6 (sr)
DE (1) DE69830591T2 (sr)
ES (1) ES2244090T3 (sr)
HK (1) HK1030753A1 (sr)
HR (1) HRP20000109A2 (sr)
HU (1) HU226866B1 (sr)
IL (2) IL134719A0 (sr)
MA (1) MA26545A1 (sr)
MY (1) MY121291A (sr)
NO (1) NO323740B1 (sr)
NZ (1) NZ502970A (sr)
PE (1) PE117399A1 (sr)
PL (1) PL195703B1 (sr)
RS (1) RS49707B (sr)
RU (1) RU2224539C2 (sr)
SA (1) SA98190565B1 (sr)
TR (1) TR200000649T2 (sr)
TW (1) TW552139B (sr)
UY (1) UY25172A1 (sr)
WO (1) WO1999012561A2 (sr)
ZA (1) ZA988030B (sr)

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US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
JP4834224B2 (ja) 1999-03-05 2011-12-14 デューク ユニバーシティ Ｃ１６不飽和ｆｐ−選択的プロスタグランジン類縁体
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US6560487B1 (en) 2000-05-08 2003-05-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6393328B1 (en) * 2000-05-08 2002-05-21 International Rehabilitative Sciences, Inc. Multi-functional portable electro-medical device
US6675048B2 (en) * 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
AU2003207512B2 (en) 2002-01-10 2008-06-12 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
US7399826B1 (en) 2003-10-02 2008-07-15 Ali Sadat M Peptide for promoting healing of fractures
MX2007004116A (es) * 2004-10-08 2007-10-05 Forbes Medi Tech Res Inc Composiciones farmaceuticas de polipeptidos intestinales vasoactivos.
EP1945245A2 (en) * 2005-11-10 2008-07-23 The Board of Control of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
WO2007133580A2 (en) * 2006-05-09 2007-11-22 Zelos Therapeutics, Inc. Use of pth (1-31) and optionally g-csf for hematopoietic stimulation
UA98776C2 (ru) 2006-10-03 2012-06-25 Радиус Хелс, Инк. СПОСОБ ДОСТАВКИ лекарственного ПРЕПАРАТА ДЛЯ УСИЛЕНИЯ СИНТЕЗА БЕЛКА В КОСТЯХ
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
EP2411038B1 (en) 2009-03-27 2016-12-28 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
US8987201B2 (en) 2009-12-07 2015-03-24 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
CN104146961B (zh) * 2014-07-04 2018-02-27 深圳职业技术学院 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法
CA2984357A1 (en) 2015-04-29 2016-11-03 Radius Pharmaceuticals, Inc. Methods for treating cancer
CN108025042A (zh) * 2015-07-06 2018-05-11 董正欣 PTHrP类似物的新型制剂
WO2017184355A1 (en) 2016-04-18 2017-10-26 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
CN117417263A (zh) 2017-01-05 2024-01-19 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
WO2021051082A1 (en) * 2019-09-12 2021-03-18 Radius Health, Inc. Methods of improving spinal fusion with abaloparatide
CN112646042A (zh) * 2019-10-10 2021-04-13 陕西麦科奥特科技有限公司 活性多肽化合物
WO2022149066A1 (en) * 2021-01-05 2022-07-14 Radius Health, Inc. Treatment of long bone fractures with abaloparatide

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JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
US20020077281A1 (en) 2002-06-20
CZ298701B6 (cs) 2007-12-27
BR9812068A (pt) 2000-09-26
CA2302255A1 (en) 1999-03-18
CN1269726A (zh) 2000-10-11
RU2224539C2 (ru) 2004-02-27
HRP20000109A2 (en) 2001-02-28
AR015435A1 (es) 2001-05-02
PL195703B1 (pl) 2007-10-31
HK1030753A1 (en) 2001-05-18
KR20010023795A (ko) 2001-03-26
JP2002509854A (ja) 2002-04-02
EP1005359B1 (en) 2005-06-15
CN1210059C (zh) 2005-07-13
AU9740698A (en) 1999-03-29
IL134719A (en) 2010-04-29
YU12700A (sh) 2004-09-03
EP1005359A2 (en) 2000-06-07
KR100679778B1 (ko) 2007-02-07
TW552139B (en) 2003-09-11
UY25172A1 (es) 2001-01-31
WO1999012561A2 (en) 1999-03-18
NO20001195D0 (no) 2000-03-08
IL134719A0 (en) 2001-04-30
CZ2000862A3 (cs) 2000-09-13
CO4890856A1 (es) 2000-02-28
NZ502970A (en) 2002-03-01
DE69830591T2 (de) 2006-05-04
HU226866B1 (en) 2009-12-28
DE69830591D1 (de) 2005-07-21
ZA988030B (en) 1999-03-09
CA2302255C (en) 2011-11-08
US6583114B2 (en) 2003-06-24
WO1999012561A3 (en) 1999-05-14
ES2244090T3 (es) 2005-12-01
TR200000649T2 (tr) 2000-09-21
HUP0004560A3 (en) 2005-11-28
MY121291A (en) 2006-01-28
NO323740B1 (no) 2007-07-02
PL339449A1 (en) 2000-12-18
PE117399A1 (es) 1999-11-20
HUP0004560A2 (hu) 2001-04-28
WO1999012561A9 (en) 2000-03-16
NO20001195L (no) 2000-03-08
ATE297754T1 (de) 2005-07-15
MA26545A1 (fr) 2004-12-20
AU752925B2 (en) 2002-10-03
SA98190565B1 (ar) 2006-07-30

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