UY25172A1 - Curación de fracturas utilizando análogos pthrp - Google Patents
Curación de fracturas utilizando análogos pthrpInfo
- Publication number
- UY25172A1 UY25172A1 UY25172A UY25172A UY25172A1 UY 25172 A1 UY25172 A1 UY 25172A1 UY 25172 A UY25172 A UY 25172A UY 25172 A UY25172 A UY 25172A UY 25172 A1 UY25172 A1 UY 25172A1
- Authority
- UY
- Uruguay
- Prior art keywords
- pthrp
- amino acid
- xaa
- pth
- analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invención proporciona métodos de cicatrización de hueso y reparación de fracturas que comprenden la administración a un paciente que lo necesite de una cantidad eficaz de un análogo polipeptídico del péptido relacionado con la hormona paratiroidea (PTHrP) y de sales del mismo, en el cual los residuos aminoacídicos 22-31 forman una hélice alfa anfipática, en la cual dicha hélice es GLU LEU LEU GLU Xaa LEU LEU GLU LYS donde Xaa es un residuo aminoacídico cargado positivamente para la preparación de un medicamento para el tratamiento de dichos trastornos. Se demostró que los análogos monocíclicos y bicíclicos de PTHrP (1-34) y PTHrP (7-34) se unen fuertemente con el receptor de PTH y estimulan (o antagonizan) la actividad adenilciclasa estimulada por PTH en las células similares a osteoblastos. Deberá tenerse en cuenta que pueden estar presentes en lo análogos de PTHrP empleados en la presente invenció aminoácidos tanto naturales como no naturales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5832497P | 1997-09-09 | 1997-09-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25172A1 true UY25172A1 (es) | 2001-01-31 |
Family
ID=22016113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25172A UY25172A1 (es) | 1997-09-09 | 1998-09-07 | Curación de fracturas utilizando análogos pthrp |
Country Status (32)
Country | Link |
---|---|
US (1) | US6583114B2 (es) |
EP (1) | EP1005359B1 (es) |
JP (1) | JP2002509854A (es) |
KR (1) | KR100679778B1 (es) |
CN (1) | CN1210059C (es) |
AR (1) | AR015435A1 (es) |
AT (1) | ATE297754T1 (es) |
AU (1) | AU752925B2 (es) |
BR (1) | BR9812068A (es) |
CA (1) | CA2302255C (es) |
CO (1) | CO4890856A1 (es) |
CZ (1) | CZ298701B6 (es) |
DE (1) | DE69830591T2 (es) |
ES (1) | ES2244090T3 (es) |
HK (1) | HK1030753A1 (es) |
HR (1) | HRP20000109A2 (es) |
HU (1) | HU226866B1 (es) |
IL (2) | IL134719A0 (es) |
MA (1) | MA26545A1 (es) |
MY (1) | MY121291A (es) |
NO (1) | NO323740B1 (es) |
NZ (1) | NZ502970A (es) |
PE (1) | PE117399A1 (es) |
PL (1) | PL195703B1 (es) |
RS (1) | RS49707B (es) |
RU (1) | RU2224539C2 (es) |
SA (1) | SA98190565B1 (es) |
TR (1) | TR200000649T2 (es) |
TW (1) | TW552139B (es) |
UY (1) | UY25172A1 (es) |
WO (1) | WO1999012561A2 (es) |
ZA (1) | ZA988030B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040033950A1 (en) | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
EP1769804B1 (en) * | 1998-08-19 | 2012-09-19 | Eli Lilly And Company | hPTH(1-34) for use in preventing or reducing the incidence or severity of vertebral and / or non vertebral fracture in a male human |
EP1136076A1 (en) * | 1998-08-19 | 2001-09-26 | Eli Lilly And Company | Method of increasing bone toughness and stiffness and reducing fractures |
DZ2873A1 (fr) | 1998-08-19 | 2003-12-15 | Lilly Co Eli | Procédé pour augmenter la dureté et la rigidité osseuse. |
CA2245903A1 (en) * | 1998-09-28 | 2000-03-28 | Mcgill University | Use of pex in the treatment of metabolic bone diseases |
PL350917A1 (en) | 1999-03-05 | 2003-02-10 | Procter & Gamble | C16 unsaturated fp-selective prostaglandins analogs |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
US6675048B2 (en) * | 2000-05-08 | 2004-01-06 | International Rehabilitative Sciences, Inc. | Electro-medical device for use with biologics |
US6560487B1 (en) | 2000-05-08 | 2003-05-06 | International Rehabilitative Sciences, Inc. | Electro-medical device for use with biologics |
US6393328B1 (en) * | 2000-05-08 | 2002-05-21 | International Rehabilitative Sciences, Inc. | Multi-functional portable electro-medical device |
CA2472472A1 (en) | 2002-01-10 | 2003-07-24 | Osteotrophin Llc | Treatment of bone disorders with skeletal anabolic drugs |
US7399826B1 (en) | 2003-10-02 | 2008-07-15 | Ali Sadat M | Peptide for promoting healing of fractures |
AU2005294125A1 (en) * | 2004-10-08 | 2006-04-20 | Transition Therapeutics Inc. | Vasoactive intestinal polypeptide pharmaceuticals |
BRPI0618469A2 (pt) * | 2005-11-10 | 2011-08-30 | Univ Michigan Tech | hormÈnio paratiróide de urso preto e métodos de uso de hormÈnio paratiróide de urso preto |
US20090022684A1 (en) * | 2006-05-09 | 2009-01-22 | Paul Morley | Methods for hematopoietic stimulation |
US7803770B2 (en) | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
ES2637283T3 (es) | 2006-10-03 | 2017-10-11 | Radius Health, Inc. | Una composición estable que comprende PTHrP y usos de la misma |
EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
JP5564167B2 (ja) * | 2008-05-22 | 2014-07-30 | 日本たばこ産業株式会社 | 苦味マスキング剤及び苦味低減方法 |
US8870876B2 (en) | 2009-02-13 | 2014-10-28 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
CN102448482A (zh) | 2009-03-27 | 2012-05-09 | 范安德尔研究所 | 甲状旁腺素肽和甲状旁腺素相关蛋白肽及使用方法 |
US8277459B2 (en) | 2009-09-25 | 2012-10-02 | Tarsus Medical Inc. | Methods and devices for treating a structural bone and joint deformity |
CA2782640A1 (en) | 2009-12-07 | 2011-06-16 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
US8652141B2 (en) | 2010-01-21 | 2014-02-18 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
US8696719B2 (en) | 2010-06-03 | 2014-04-15 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
CN104146961B (zh) * | 2014-07-04 | 2018-02-27 | 深圳职业技术学院 | 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法 |
CN113288887A (zh) | 2015-04-29 | 2021-08-24 | 雷迪厄斯制药公司 | 用于治疗癌症的方法 |
CN108025042A (zh) * | 2015-07-06 | 2018-05-11 | 董正欣 | PTHrP类似物的新型制剂 |
EP3481414B1 (en) | 2016-04-18 | 2021-11-03 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
EP3565542B1 (en) | 2017-01-05 | 2024-04-10 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
AU2019297421A1 (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals, Inc. | Polymorphic forms of RAD 1901-2HCL |
WO2021051082A1 (en) * | 2019-09-12 | 2021-03-18 | Radius Health, Inc. | Methods of improving spinal fusion with abaloparatide |
CN112646042A (zh) * | 2019-10-10 | 2021-04-13 | 陕西麦科奥特科技有限公司 | 活性多肽化合物 |
EP4274556A1 (en) * | 2021-01-05 | 2023-11-15 | Radius Health, Inc. | Treatment of long bone fractures with abaloparatide |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3935738A1 (de) * | 1989-10-27 | 1991-05-08 | Forssmann Wolf Georg | Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff |
US5977070A (en) * | 1992-07-14 | 1999-11-02 | Piazza; Christin Teresa | Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis |
US5821225A (en) * | 1992-07-14 | 1998-10-13 | Syntex (U.S.A.) Inc. | Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp |
US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
CN1070500C (zh) * | 1993-07-13 | 2001-09-05 | 森德克斯(美国)股份有限公司 | 甲状旁腺激素类似物和甲状旁腺激素相关肽:合成和治疗骨质疏松症的用途 |
WO1995011697A1 (fr) * | 1993-10-27 | 1995-05-04 | Chugai Seiyaku Kabushiki Kaisha | Accelerateur de guerison utilise en chondroplastie |
JPH08310965A (ja) * | 1995-05-16 | 1996-11-26 | Chugai Pharmaceut Co Ltd | 骨癒合促進剤 |
US5717062A (en) * | 1995-06-07 | 1998-02-10 | Beth Israel Hospital Association | Cyclic analogs of PTH and PTHrP |
US5723577A (en) * | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
US5955574A (en) * | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
-
1998
- 1998-09-02 AU AU97406/98A patent/AU752925B2/en not_active Expired
- 1998-09-02 WO PCT/EP1998/005550 patent/WO1999012561A2/en active IP Right Grant
- 1998-09-02 PL PL98339449A patent/PL195703B1/pl unknown
- 1998-09-02 EP EP98951341A patent/EP1005359B1/en not_active Expired - Lifetime
- 1998-09-02 IL IL13471998A patent/IL134719A0/xx unknown
- 1998-09-02 KR KR1020007002454A patent/KR100679778B1/ko not_active IP Right Cessation
- 1998-09-02 DE DE69830591T patent/DE69830591T2/de not_active Expired - Lifetime
- 1998-09-02 RU RU2000109305/15A patent/RU2224539C2/ru active
- 1998-09-02 CN CNB988089696A patent/CN1210059C/zh not_active Expired - Lifetime
- 1998-09-02 CA CA2302255A patent/CA2302255C/en not_active Expired - Lifetime
- 1998-09-02 AT AT98951341T patent/ATE297754T1/de active
- 1998-09-02 ZA ZA988030A patent/ZA988030B/xx unknown
- 1998-09-02 CZ CZ20000862A patent/CZ298701B6/cs not_active IP Right Cessation
- 1998-09-02 BR BR9812068-9A patent/BR9812068A/pt not_active IP Right Cessation
- 1998-09-02 JP JP2000510458A patent/JP2002509854A/ja active Pending
- 1998-09-02 RS YUP-127/00A patent/RS49707B/sr unknown
- 1998-09-02 NZ NZ502970A patent/NZ502970A/en not_active IP Right Cessation
- 1998-09-02 HU HU0004560A patent/HU226866B1/hu unknown
- 1998-09-02 ES ES98951341T patent/ES2244090T3/es not_active Expired - Lifetime
- 1998-09-02 TR TR2000/00649T patent/TR200000649T2/xx unknown
- 1998-09-03 US US09/146,802 patent/US6583114B2/en not_active Expired - Lifetime
- 1998-09-07 UY UY25172A patent/UY25172A1/es not_active Application Discontinuation
- 1998-09-07 MY MYPI98004075A patent/MY121291A/en unknown
- 1998-09-07 AR ARP980104456A patent/AR015435A1/es unknown
- 1998-09-07 PE PE1998000838A patent/PE117399A1/es not_active Application Discontinuation
- 1998-09-07 CO CO98051174A patent/CO4890856A1/es unknown
- 1998-09-07 TW TW087114825A patent/TW552139B/zh not_active IP Right Cessation
- 1998-09-08 MA MA25247A patent/MA26545A1/fr unknown
- 1998-09-21 SA SA98190565A patent/SA98190565B1/ar unknown
-
2000
- 2000-02-24 IL IL134719A patent/IL134719A/en not_active IP Right Cessation
- 2000-02-29 HR HR20000109A patent/HRP20000109A2/hr not_active Application Discontinuation
- 2000-03-08 NO NO20001195A patent/NO323740B1/no not_active IP Right Cessation
-
2001
- 2001-03-12 HK HK01101739A patent/HK1030753A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20121219 |