CN1916025B - 甲状旁腺素类似物 - Google Patents
甲状旁腺素类似物 Download PDFInfo
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- CN1916025B CN1916025B CN2006101001134A CN200610100113A CN1916025B CN 1916025 B CN1916025 B CN 1916025B CN 2006101001134 A CN2006101001134 A CN 2006101001134A CN 200610100113 A CN200610100113 A CN 200610100113A CN 1916025 B CN1916025 B CN 1916025B
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Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
肽 | Kd(μM) | EC<sub>50</sub>(nM) |
[Cha<sup>7,11</sup>]hPTH(1-34)NH<sub>2</sub> | 0.01 | 0.6 |
[Cha<sup>23</sup>]hPTH(1-34)NH<sub>2</sub> | 0.2 | 20 |
[Cha<sup>24</sup>]hPTH(1-34)NH<sub>2</sub> | 0.1 | 10 |
[Nle<sup>8,28</sup>,Cha<sup>27</sup>]hPTH(1-34)NH<sub>2</sub>; | 0.05 | 2 |
肽 | Kd(μM) | EC<sub>50</sub>(nM) |
[Cha<sup>28</sup>]hPTH(1-34)NH<sub>2</sub> | 0.05 | 2.5 |
[Cha<sup>31</sup>]hPTH(1-34)NH<sub>2</sub> | 0.03 | 4 |
[Aib<sup>16</sup>]hPTH(1-34)NH<sub>2</sub>; | 0.004 | 0.7 |
[Aib<sup>19</sup>]hPTH(1-34)NH<sub>2</sub>; | 0.005 | 0.6 |
[Aib<sup>34</sup>]hPTH(1-34)NH<sub>2</sub>; | 0.007 | 3 |
[Nle<sup>31</sup>]hPTH(1-34)NH<sub>2</sub>; | 0.004 | 0.7 |
[hArg<sup>27</sup>]hPTH(1-34)NH<sub>2</sub> | 0.007 | 1 |
[Dap,Nle<sup>8,18</sup>,Tyr<sup>34</sup>]hPTH(1-34)NH<sub>2</sub> | 0.150 | 10 |
[Cha<sup>24,28,31</sup>,Lys<sup>30</sup>]hPTH(1-34)NH<sub>2</sub>; | 0.5 | 7 |
[Cha<sup>7,11</sup>,Nle<sup>8,18</sup>,Tyr<sup>34</sup>]hPTH(1-34)NH<sub>2</sub> | 0.006 | 0.6 |
[Cha<sup>7,11</sup>,Nle<sup>8,18</sup>,Aib<sup>16,19</sup>,Tyr<sup>34</sup>]hPTH(1-34)NH<sub>2</sub> | 0.005 | 1.5 |
[Cha<sup>7,11</sup>,Nle<sup>8,18,31</sup>,Aib<sup>16,19</sup>,Tyr<sup>34</sup>]hPTH(1-34)NH<sub>2</sub> | 0.04 | 4 |
[Cha<sup>11</sup>]hPTH(1-34)NH<sub>2</sub> | 0.005 | 2 |
[Cha<sup>28,31</sup>]hPTH(1-34)NH<sub>2</sub> | 0.06 | 7 |
[Cha<sup>7,11</sup>,Nle<sup>8,18</sup>,Aib<sup>34</sup>]hPTH(1-34)NH<sub>2</sub> | 0.03 | 1.5 |
[Cha<sup>15</sup>]hPTH(1-34)NH<sub>2</sub> | 0.005 | 1.3 |
[Cha<sup>7,11</sup>,Aib<sup>19</sup>]hPTH(1-34)NH<sub>2</sub> | 0.007 | 0.5 |
[Cha<sup>7,11</sup>,Aib<sup>16</sup>]hPTH(1-34)NH<sub>2</sub> | 0.004 | 1.1 |
[Aib<sup>16,19</sup>]hPTH(1-34)NH<sub>2</sub> | 0.004 | 0.6 |
肽 | Kd(μM) | EC<sub>50</sub>(nM) |
[Aib<sup>12</sup>]hPTH(1-34)NH<sub>2</sub> | 0.005 | 2 |
[Aib<sup>3</sup>]hPTH(1-34)NH<sub>2</sub> | 0.004 | 1.1 |
[Cha<sup>7,11</sup>,Aib<sup>19</sup>,Lys<sup>30</sup>]hPTH(1-34)NH<sub>2</sub> | 0.004 | 2 |
[Cha<sup>7</sup>]hPTH(1-34)NH<sub>2</sub> | 0.02 | 2.3 |
[Cha<sup>24,28,31</sup>]hPTH(1-34)NH<sub>2</sub> | 1.0 | 30 |
[Aib<sup>17</sup>]hPTH(1-34) | 0.05 | 3 |
[Cha<sup>7,11,15</sup>]hPTH(1-34) | 0.01 | 1.4 |
Claims (1)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US110595P | 1995-07-13 | 1995-07-13 | |
US60/001105 | 1995-07-13 | ||
US330595P | 1995-09-06 | 1995-09-06 | |
US60/003305 | 1995-09-06 | ||
US08/626,186 US5723577A (en) | 1995-07-13 | 1996-03-29 | Analogs of parathyroid hormone |
US08/626186 | 1996-03-29 |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100054277A Division CN100412091C (zh) | 1995-07-13 | 1996-07-03 | 甲状旁腺素类似物 |
CNB961969261A Division CN1247260C (zh) | 1995-07-13 | 1996-07-03 | 甲状旁腺素类似物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1916025A CN1916025A (zh) | 2007-02-21 |
CN1916025B true CN1916025B (zh) | 2010-05-12 |
Family
ID=21694392
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200510113898 Pending CN1803839A (zh) | 1995-07-13 | 1996-07-03 | 甲状旁腺素类似物 |
CN2006101001134A Expired - Lifetime CN1916025B (zh) | 1995-07-13 | 1996-07-03 | 甲状旁腺素类似物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200510113898 Pending CN1803839A (zh) | 1995-07-13 | 1996-07-03 | 甲状旁腺素类似物 |
Country Status (2)
Country | Link |
---|---|
CN (2) | CN1803839A (zh) |
ZA (1) | ZA965886B (zh) |
-
1996
- 1996-07-03 CN CN 200510113898 patent/CN1803839A/zh active Pending
- 1996-07-03 CN CN2006101001134A patent/CN1916025B/zh not_active Expired - Lifetime
- 1996-07-11 ZA ZA965886A patent/ZA965886B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN1803839A (zh) | 2006-07-19 |
ZA965886B (en) | 1997-01-29 |
CN1916025A (zh) | 2007-02-21 |
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