ATE297754T1 - Heilung von bruchverletzungen unter verwendung von pthrp analogen - Google Patents

Heilung von bruchverletzungen unter verwendung von pthrp analogen

Info

Publication number
ATE297754T1
ATE297754T1 AT98951341T AT98951341T ATE297754T1 AT E297754 T1 ATE297754 T1 AT E297754T1 AT 98951341 T AT98951341 T AT 98951341T AT 98951341 T AT98951341 T AT 98951341T AT E297754 T1 ATE297754 T1 AT E297754T1
Authority
AT
Austria
Prior art keywords
healing
pthrp analogue
fracture injuries
injuries
fracture
Prior art date
Application number
AT98951341T
Other languages
English (en)
Inventor
Brian Henry Vickery
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE297754T1 publication Critical patent/ATE297754T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98951341T 1997-09-09 1998-09-02 Heilung von bruchverletzungen unter verwendung von pthrp analogen ATE297754T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09
PCT/EP1998/005550 WO1999012561A2 (en) 1997-09-09 1998-09-02 FRACTURE HEALING USING PTHrP ANALOGS

Publications (1)

Publication Number Publication Date
ATE297754T1 true ATE297754T1 (de) 2005-07-15

Family

ID=22016113

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98951341T ATE297754T1 (de) 1997-09-09 1998-09-02 Heilung von bruchverletzungen unter verwendung von pthrp analogen

Country Status (31)

Country Link
US (1) US6583114B2 (de)
EP (1) EP1005359B1 (de)
JP (1) JP2002509854A (de)
KR (1) KR100679778B1 (de)
CN (1) CN1210059C (de)
AR (1) AR015435A1 (de)
AT (1) ATE297754T1 (de)
AU (1) AU752925B2 (de)
BR (1) BR9812068A (de)
CA (1) CA2302255C (de)
CO (1) CO4890856A1 (de)
CZ (1) CZ298701B6 (de)
DE (1) DE69830591T2 (de)
ES (1) ES2244090T3 (de)
HR (1) HRP20000109A2 (de)
HU (1) HU226866B1 (de)
IL (2) IL134719A0 (de)
MA (1) MA26545A1 (de)
MY (1) MY121291A (de)
NO (1) NO323740B1 (de)
NZ (1) NZ502970A (de)
PE (1) PE117399A1 (de)
PL (1) PL195703B1 (de)
RS (1) RS49707B (de)
RU (1) RU2224539C2 (de)
SA (1) SA98190565B1 (de)
TR (1) TR200000649T2 (de)
TW (1) TW552139B (de)
UY (1) UY25172A1 (de)
WO (1) WO1999012561A2 (de)
ZA (1) ZA988030B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
EP1769804B1 (de) * 1998-08-19 2012-09-19 Eli Lilly And Company hPTH(1-34) zur Verwendung in der Vorbeugung und Reduzierung des Auftretens oder der Schwere von Knochenbrüchen bei Männern
SI1059933T1 (en) * 1998-08-19 2003-04-30 Eli Lilly & Company Use of parathyroide hormone consisting of aminoacid sequence 1-34 of human parathyroid hormone for reducing the risk of both vertebral and non vertebral bone fracture
AR033639A1 (es) * 1998-08-19 2004-01-07 Lilly Co Eli Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis
CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
WO2000051980A1 (en) 1999-03-05 2000-09-08 The Procter & Gamble Company C16 unsaturated fp-selective prostaglandins analogs
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US6675048B2 (en) * 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6393328B1 (en) * 2000-05-08 2002-05-21 International Rehabilitative Sciences, Inc. Multi-functional portable electro-medical device
US6560487B1 (en) * 2000-05-08 2003-05-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
JP2005525312A (ja) * 2002-01-10 2005-08-25 オステオトロフィン エルエルシー 骨同化物質を用いた骨疾患の治療方法
WO2005041998A1 (en) 2003-10-02 2005-05-12 Ali Sadat M Peptide for promoting healing of fractures
MX2007004116A (es) * 2004-10-08 2007-10-05 Forbes Medi Tech Res Inc Composiciones farmaceuticas de polipeptidos intestinales vasoactivos.
CN101355959B (zh) * 2005-11-10 2013-02-27 密歇根理工大学管理委员会 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法
US20090022684A1 (en) * 2006-05-09 2009-01-22 Paul Morley Methods for hematopoietic stimulation
EP2073789B8 (de) 2006-10-03 2023-02-08 Radius Health, Inc. Stabile zusammensetzung mit anabolischem knochenprotein, und zwar einem pthrp-analogon, sowie deren verwendung
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
EP1961765A1 (de) * 2006-12-08 2008-08-27 Zealand Pharma A/S Verkürzte PTH-Peptide mit zyklischer Konformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
WO2010111617A2 (en) 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
CA2782640A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
EP4035664A3 (de) 2014-03-28 2022-11-30 Duke University Behandlung von krebs unter verwendung von selektiven östrogenrezeptormodulatoren
CN104146961B (zh) * 2014-07-04 2018-02-27 深圳职业技术学院 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法
MX393599B (es) 2015-04-29 2025-03-19 Radius Pharmaceuticals Inc Rad1901 para usarse en el tratamiento de cancer en sujetos con cancer positivo a receptor de estrogeno alfa resistente a farmaco
CN108025042A (zh) * 2015-07-06 2018-05-11 董正欣 PTHrP类似物的新型制剂
AU2017253674B2 (en) 2016-04-18 2021-07-29 Kindeva Drug Delivery L.P. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
DK3565542T3 (da) 2017-01-05 2024-07-01 Radius Pharmaceuticals Inc Polymorphic forms of rad1901-2hcl
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
KR102792490B1 (ko) 2018-07-04 2025-04-04 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
MX2021009569A (es) 2019-02-12 2021-09-08 Radius Pharmaceuticals Inc Procesos y compuestos.
MX2022002979A (es) 2019-09-12 2022-06-16 Radius Health Inc Metodos para mejorar la fusion vertebral con abaloparatida.
CN112646042A (zh) * 2019-10-10 2021-04-13 陕西麦科奥特科技有限公司 活性多肽化合物
AU2022205801A1 (en) * 2021-01-05 2023-07-13 Radius Health, Inc. Treatment of long bone fractures with abaloparatide

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
GB9308033D0 (en) * 1993-04-19 1993-06-02 Sandoz Ltd Organic compounds
CN1070500C (zh) * 1993-07-13 2001-09-05 森德克斯(美国)股份有限公司 甲状旁腺激素类似物和甲状旁腺激素相关肽：合成和治疗骨质疏松症的用途
TW273513B (de) * 1993-10-27 1996-04-01 Chugai Pharmaceutical Co Ltd
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
ZA988030B (en) 1999-03-09
IL134719A (en) 2010-04-29
CN1269726A (zh) 2000-10-11
KR100679778B1 (ko) 2007-02-07
RS49707B (sr) 2007-12-31
HRP20000109A2 (en) 2001-02-28
MA26545A1 (fr) 2004-12-20
HUP0004560A2 (hu) 2001-04-28
SA98190565B1 (ar) 2006-07-30
US6583114B2 (en) 2003-06-24
KR20010023795A (ko) 2001-03-26
HU226866B1 (en) 2009-12-28
NO323740B1 (no) 2007-07-02
AU9740698A (en) 1999-03-29
WO1999012561A3 (en) 1999-05-14
AU752925B2 (en) 2002-10-03
CZ2000862A3 (cs) 2000-09-13
DE69830591T2 (de) 2006-05-04
ES2244090T3 (es) 2005-12-01
WO1999012561A2 (en) 1999-03-18
EP1005359B1 (de) 2005-06-15
NO20001195L (no) 2000-03-08
IL134719A0 (en) 2001-04-30
DE69830591D1 (de) 2005-07-21
CN1210059C (zh) 2005-07-13
US20020077281A1 (en) 2002-06-20
AR015435A1 (es) 2001-05-02
WO1999012561A9 (en) 2000-03-16
TW552139B (en) 2003-09-11
PL339449A1 (en) 2000-12-18
YU12700A (sh) 2004-09-03
PE117399A1 (es) 1999-11-20
MY121291A (en) 2006-01-28
HUP0004560A3 (en) 2005-11-28
EP1005359A2 (de) 2000-06-07
CO4890856A1 (es) 2000-02-28
CZ298701B6 (cs) 2007-12-27
UY25172A1 (es) 2001-01-31
RU2224539C2 (ru) 2004-02-27
HK1030753A1 (zh) 2001-05-18
TR200000649T2 (tr) 2000-09-21
JP2002509854A (ja) 2002-04-02
PL195703B1 (pl) 2007-10-31
NZ502970A (en) 2002-03-01
CA2302255A1 (en) 1999-03-18
BR9812068A (pt) 2000-09-26
NO20001195D0 (no) 2000-03-08
CA2302255C (en) 2011-11-08

Similar Documents

Publication Publication Date Title
ATE297754T1 (de) Heilung von bruchverletzungen unter verwendung von pthrp analogen
ATE271393T1 (de) Zusammensetzungen zur erhöhung des hautdurchtritts von arzneistoffen unter verwendung von permeationsbeschleunigern
ATE327976T1 (de) Vorbeugung des verlustes und wiederherstellung von knochenmasse unter verwendung von prostaglandin-analogen
DE69838338D1 (de) Verwendung von antimykotica zur topischen behandlung von pilz-induzierten schleimhautentzündungen
DE69837906D1 (de) Insektizides proteintoxin von xenorhabus
DE69605669D1 (de) Bestimmung der Oligonucleotid-Länge unter Verwendung von spaltbaren Primern
DE59101613D1 (de) Knochennagel zur Versorgung von Oberarmfrakturen.
ATE239011T1 (de) Neuartige form von s-omeprazol
FI972681A0 (fi) Kynsien sientenvastainen käsittely
DE69903655D1 (de) Verwendung von menthyl-2-pyrrolidon-5-carboxylat zur insektenabwehr
DE69630603D1 (de) Mittel zur gesteuerten freisetzung von paroxetin
DE69902898D1 (de) Vielschichtiges inkrementales aktualisieren von software
DE69811054D1 (de) Verpackung von folienartigen pflaster
ATE211634T1 (de) Orthopädische vorrichtung zur allmählichen korrektur von gliedern
DE69905906D1 (de) Kombination von zwei oder mehreren wirkstoffen unter verwendung von mikrokapsel-formulierungen
ATE244000T1 (de) Gesteuerte freisetzung von sublingual oder bukkal verabreichten arzneistoffen
DE50012379D1 (de) Verwendung von nanoskaligen antischuppenwirkstoffen
EP0996433A4 (de) Behandlungsverfahren von lactosylceramidbedingten zuständen
DE69831361T2 (de) Modularer Marknagel
DE69434777D1 (de) Verwendung von Relaxin zur Herstellung von therapeutischen Mitteln
DE69807466D1 (de) Triptolid-derivate nützlich zur behandlung von autoimmunkrankheiten
DE69801844D1 (de) Atmosphärische distillation von kohlenwasserstoffe enthaltenden flüssigen einsätzen
DE59600130D1 (de) Vorrichtung zur Versorgung von Knochenbrüchen
DE69818490D1 (de) Herstellung von zuckerrohr
DE69834937D1 (de) Antibiotika zur behandlung von magengeschwuren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1005359

Country of ref document: EP