MX9703642A - Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana. - Google Patents

Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana.

Info

Publication number
MX9703642A
MX9703642A MX9703642A MX9703642A MX9703642A MX 9703642 A MX9703642 A MX 9703642A MX 9703642 A MX9703642 A MX 9703642A MX 9703642 A MX9703642 A MX 9703642A MX 9703642 A MX9703642 A MX 9703642A
Authority
MX
Mexico
Prior art keywords
peptide analogues
multiple sclerosis
myelin basic
basic protein
treatment
Prior art date
Application number
MX9703642A
Other languages
English (en)
Inventor
Nicholas Ling
Paul J Conlon
Amitabh Gaur
Lawrence Steinman
Original Assignee
Neurocrine Biosciences Inc
Trustees Of The Leland Board O
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc, Trustees Of The Leland Board O, Univ Leland Stanford Junior filed Critical Neurocrine Biosciences Inc
Publication of MX9703642A publication Critical patent/MX9703642A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Se proveen análogos de péptido de proteína básica de mielina humana que contienen los residuos 87-99. El residuo 91 de los análogos de péptido es alterado del residuo de L-lisina encontrado en la proteína nativa a cualquier otro aminoácido. Se proveen composiciones farmacéuticas de los análogos de péptido. Además, los análogos de péptido se administran a pacientes con esclerosis multiple.
MX9703642A 1994-11-18 1997-05-16 Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana. MX9703642A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34207894A 1994-11-18 1994-11-18

Publications (1)

Publication Number Publication Date
MX9703642A true MX9703642A (es) 1998-11-29

Family

ID=23340234

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9703642A MX9703642A (es) 1994-11-18 1997-05-16 Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana.

Country Status (9)

Country Link
US (4) US6369033B1 (es)
EP (2) EP1172376A1 (es)
JP (1) JPH10509714A (es)
AT (1) ATE213499T1 (es)
AU (1) AU721898B2 (es)
CA (1) CA2205532A1 (es)
DE (1) DE69525544T2 (es)
MX (1) MX9703642A (es)
WO (1) WO1996016085A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7090982B2 (en) 1991-10-22 2006-08-15 The Governors Of The University Of Alberta Methods of predicting therapeutic efficacy of treatment of a multiple sclerosis patient
US6252040B1 (en) 1991-10-22 2001-06-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
IL105347A0 (en) * 1992-04-09 1993-08-18 Autoimmune Corp Multiple sclerosis t-cell receptor
BR9509438A (pt) * 1994-10-25 1997-12-23 Immulogic Pharma Corp Composições e tratamento para a esclerose múltipla
US6379670B1 (en) 1994-11-18 2002-04-30 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US6251396B1 (en) * 1994-11-18 2001-06-26 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
EP1172376A1 (en) * 1994-11-18 2002-01-16 Neurocrine Biosciences, Inc. Peptide analogues at position 91 of human myelin basic protein for treatment of multiple sclerosis
US6329499B1 (en) 1994-11-18 2001-12-11 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
AU5360796A (en) * 1995-03-09 1996-10-02 Neurocrine Biosciences, Inc. Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
WO1997030150A2 (en) * 1996-02-15 1997-08-21 Pangenetics B.V. Molecules for the induction of immunological tolerance
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
US6541608B1 (en) * 1999-02-23 2003-04-01 Baylor College Of Medicine T cell receptor Vβ-Dβ-Jβ sequence and methods for its detection
US20040072222A1 (en) * 2001-03-23 2004-04-15 John Matsoukas Peptide analogues of myelin basic protein epitopes in the treatment of experimental autoimmune encephalomyelitis (eae) and multiple sclerosis (ms)
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
CN100567987C (zh) * 2002-08-08 2009-12-09 贝勒医学院 T细胞疫苗及其制备方法
CA2605321A1 (en) 2005-04-19 2006-10-26 Eli Lilly And Company Monovalent and polyvalent synthetic polysaccharide antigens for immunological intervention in disease
DK2420833T3 (en) * 2006-05-05 2015-12-07 Opexa Therapeutics T-cell vaccine
JP5810413B2 (ja) 2008-12-19 2015-11-11 バイオジェン インターナショナル ニューロサイエンス ゲーエムベーハー ヒト抗アルファシヌクレイン自己抗体
US20140348861A1 (en) 2011-05-05 2014-11-27 National Institute Of Immunology Synthetic peptides and random copolymers for the treatment of autoimmune disorders
MX357193B (es) 2011-06-23 2018-06-29 Univ Zuerich Moleculas de union anti-alfa sinucleina.
CN103102393B (zh) * 2013-01-30 2015-01-07 北京大学 一种多肽及其在制备抑郁症治疗药物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468481A (en) * 1988-06-23 1995-11-21 Amergen, Inc. MHC class II-peptide conjugates useful in ameliorating autoimmunity
AU651097B2 (en) * 1990-03-02 1994-07-14 Autoimmune, Inc. Enhancement of the down-regulation of autoimmune diseases by oral administration of autoantigens
US6077509A (en) * 1990-03-30 2000-06-20 Autoimmune, Inc. Peptide fragments of myelin basic protein
JPH07502977A (ja) * 1991-05-31 1995-03-30 ゾーマ・コーポレーション 免疫関連疾患用治療薬としてのｔ細胞レセプターペプチド
CA2053799C (en) * 1991-10-22 2002-03-12 Kenneth G. Warren Synthetic peptide specificity of anti-myelin basic protein from multiple sclerosis cerebrospinal fluid
IL105347A0 (en) * 1992-04-09 1993-08-18 Autoimmune Corp Multiple sclerosis t-cell receptor
JPH09502981A (ja) * 1993-09-22 1997-03-25 ザ ボード オブ トラスティーズ フォー ザ リーランド スタンフォード ジュニア ユニバーシティ 自己免疫疾患におけるｔ−細胞レセプターと抗原の相互作用
EP1172376A1 (en) * 1994-11-18 2002-01-16 Neurocrine Biosciences, Inc. Peptide analogues at position 91 of human myelin basic protein for treatment of multiple sclerosis
US6329499B1 (en) * 1994-11-18 2001-12-11 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein

Also Published As

Publication number Publication date
US6489299B2 (en) 2002-12-03
EP1172376A1 (en) 2002-01-16
ATE213499T1 (de) 2002-03-15
US6740638B2 (en) 2004-05-25
US6369033B1 (en) 2002-04-09
WO1996016085A1 (en) 1996-05-30
US20020058627A1 (en) 2002-05-16
JPH10509714A (ja) 1998-09-22
AU721898B2 (en) 2000-07-20
DE69525544D1 (de) 2002-03-28
US20040214775A1 (en) 2004-10-28
EP0792286A1 (en) 1997-09-03
US20030114380A1 (en) 2003-06-19
AU4405796A (en) 1996-06-17
EP0792286B1 (en) 2002-02-20
CA2205532A1 (en) 1996-05-30
DE69525544T2 (de) 2002-08-22

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Legal Events

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