IL134719A0 - FRACTURE HEALING USING PTHrP ANALOGS - Google Patents

FRACTURE HEALING USING PTHrP ANALOGS

Info

Publication number
IL134719A0
IL134719A0 IL13471998A IL13471998A IL134719A0 IL 134719 A0 IL134719 A0 IL 134719A0 IL 13471998 A IL13471998 A IL 13471998A IL 13471998 A IL13471998 A IL 13471998A IL 134719 A0 IL134719 A0 IL 134719A0
Authority
IL
Israel
Prior art keywords
fracture healing
pthrp analogs
pthrp
analogs
healing
Prior art date
Application number
IL13471998A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL134719A0 publication Critical patent/IL134719A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL13471998A 1997-09-09 1998-09-02 FRACTURE HEALING USING PTHrP ANALOGS IL134719A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09
PCT/EP1998/005550 WO1999012561A2 (en) 1997-09-09 1998-09-02 FRACTURE HEALING USING PTHrP ANALOGS

Publications (1)

Publication Number Publication Date
IL134719A0 true IL134719A0 (en) 2001-04-30

Family

ID=22016113

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13471998A IL134719A0 (en) 1997-09-09 1998-09-02 FRACTURE HEALING USING PTHrP ANALOGS
IL134719A IL134719A (en) 1997-09-09 2000-02-24 USE OF PTHrP ANALOGS IN THE PREPARATION OF MEDICAMENTS FOR BONE FRACTURE REPAIR

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL134719A IL134719A (en) 1997-09-09 2000-02-24 USE OF PTHrP ANALOGS IN THE PREPARATION OF MEDICAMENTS FOR BONE FRACTURE REPAIR

Country Status (31)

Country Link
US (1) US6583114B2 (enExample)
EP (1) EP1005359B1 (enExample)
JP (1) JP2002509854A (enExample)
KR (1) KR100679778B1 (enExample)
CN (1) CN1210059C (enExample)
AR (1) AR015435A1 (enExample)
AT (1) ATE297754T1 (enExample)
AU (1) AU752925B2 (enExample)
BR (1) BR9812068A (enExample)
CA (1) CA2302255C (enExample)
CO (1) CO4890856A1 (enExample)
CZ (1) CZ298701B6 (enExample)
DE (1) DE69830591T2 (enExample)
ES (1) ES2244090T3 (enExample)
HR (1) HRP20000109A2 (enExample)
HU (1) HU226866B1 (enExample)
IL (2) IL134719A0 (enExample)
MA (1) MA26545A1 (enExample)
MY (1) MY121291A (enExample)
NO (1) NO323740B1 (enExample)
NZ (1) NZ502970A (enExample)
PE (1) PE117399A1 (enExample)
PL (1) PL195703B1 (enExample)
RS (1) RS49707B (enExample)
RU (1) RU2224539C2 (enExample)
SA (1) SA98190565B1 (enExample)
TR (1) TR200000649T2 (enExample)
TW (1) TW552139B (enExample)
UY (1) UY25172A1 (enExample)
WO (1) WO1999012561A2 (enExample)
ZA (1) ZA988030B (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1059933T1 (en) * 1998-08-19 2003-04-30 Eli Lilly & Company Use of parathyroide hormone consisting of aminoacid sequence 1-34 of human parathyroid hormone for reducing the risk of both vertebral and non vertebral bone fracture
AR033639A1 (es) 1998-08-19 2004-01-07 Lilly Co Eli Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
EP1769804B1 (en) * 1998-08-19 2012-09-19 Eli Lilly And Company hPTH(1-34) for use in preventing or reducing the incidence or severity of vertebral and / or non vertebral fracture in a male human
CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
NZ513825A (en) 1999-03-05 2001-09-28 Procter & Gamble C 16 unsaturated FP-selective prostaglandins analogs
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US6560487B1 (en) * 2000-05-08 2003-05-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6393328B1 (en) * 2000-05-08 2002-05-21 International Rehabilitative Sciences, Inc. Multi-functional portable electro-medical device
US6675048B2 (en) * 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US7015195B2 (en) 2002-01-10 2006-03-21 Osteotrophin, Llc Treatment of bone disorders with skeletal anabolic drugs
US7399826B1 (en) 2003-10-02 2008-07-15 Ali Sadat M Peptide for promoting healing of fractures
AU2005294125A1 (en) * 2004-10-08 2006-04-20 Transition Therapeutics Inc. Vasoactive intestinal polypeptide pharmaceuticals
CN101355959B (zh) * 2005-11-10 2013-02-27 密歇根理工大学管理委员会 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法
WO2007133580A2 (en) * 2006-05-09 2007-11-22 Zelos Therapeutics, Inc. Use of pth (1-31) and optionally g-csf for hematopoietic stimulation
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
BRPI0719821B8 (pt) 2006-10-03 2021-05-25 Ipsen Pharma Sas composição estável na armazenagem apropriada para administração a pacientes
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8563513B2 (en) 2009-03-27 2013-10-22 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
WO2011071480A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
FI3834824T3 (fi) 2014-03-28 2025-12-05 Univ Duke Estrogeenireseptoripositiivisen rintasyövän hoito selektiivisellä estrogeenireseptorin modulaattorilla
CN104146961B (zh) * 2014-07-04 2018-02-27 深圳职业技术学院 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法
MX393599B (es) 2015-04-29 2025-03-19 Radius Pharmaceuticals Inc Rad1901 para usarse en el tratamiento de cancer en sujetos con cancer positivo a receptor de estrogeno alfa resistente a farmaco
CN108025042A (zh) * 2015-07-06 2018-05-11 董正欣 PTHrP类似物的新型制剂
EP3481414B1 (en) 2016-04-18 2021-11-03 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
KR102881465B1 (ko) 2017-01-05 2025-11-04 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
KR20210127961A (ko) 2019-02-12 2021-10-25 래디어스 파마슈티컬스, 인코포레이티드 방법 및 화합물
MX2022002979A (es) 2019-09-12 2022-06-16 Radius Health Inc Metodos para mejorar la fusion vertebral con abaloparatida.
CN112646042A (zh) * 2019-10-10 2021-04-13 陕西麦科奥特科技有限公司 活性多肽化合物
AU2022205801A1 (en) * 2021-01-05 2023-07-13 Radius Health, Inc. Treatment of long bone fractures with abaloparatide

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
GB9308033D0 (en) * 1993-04-19 1993-06-02 Sandoz Ltd Organic compounds
CN1070500C (zh) * 1993-07-13 2001-09-05 森德克斯(美国)股份有限公司 甲状旁腺激素类似物和甲状旁腺激素相关肽：合成和治疗骨质疏松症的用途
WO1995011697A1 (en) * 1993-10-27 1995-05-04 Chugai Seiyaku Kabushiki Kaisha Cure accelerator in chondroplasty
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
NO20001195D0 (no) 2000-03-08
UY25172A1 (es) 2001-01-31
PL339449A1 (en) 2000-12-18
WO1999012561A3 (en) 1999-05-14
NO323740B1 (no) 2007-07-02
HUP0004560A2 (hu) 2001-04-28
NZ502970A (en) 2002-03-01
PL195703B1 (pl) 2007-10-31
DE69830591D1 (de) 2005-07-21
HU226866B1 (en) 2009-12-28
WO1999012561A2 (en) 1999-03-18
CZ2000862A3 (cs) 2000-09-13
IL134719A (en) 2010-04-29
TR200000649T2 (tr) 2000-09-21
AU752925B2 (en) 2002-10-03
AU9740698A (en) 1999-03-29
PE117399A1 (es) 1999-11-20
ZA988030B (en) 1999-03-09
TW552139B (en) 2003-09-11
CA2302255A1 (en) 1999-03-18
RU2224539C2 (ru) 2004-02-27
CO4890856A1 (es) 2000-02-28
ATE297754T1 (de) 2005-07-15
CZ298701B6 (cs) 2007-12-27
EP1005359A2 (en) 2000-06-07
MY121291A (en) 2006-01-28
KR20010023795A (ko) 2001-03-26
BR9812068A (pt) 2000-09-26
RS49707B (sr) 2007-12-31
CN1210059C (zh) 2005-07-13
AR015435A1 (es) 2001-05-02
KR100679778B1 (ko) 2007-02-07
HK1030753A1 (zh) 2001-05-18
EP1005359B1 (en) 2005-06-15
SA98190565B1 (ar) 2006-07-30
US6583114B2 (en) 2003-06-24
YU12700A (sh) 2004-09-03
HUP0004560A3 (en) 2005-11-28
CN1269726A (zh) 2000-10-11
US20020077281A1 (en) 2002-06-20
MA26545A1 (fr) 2004-12-20
DE69830591T2 (de) 2006-05-04
CA2302255C (en) 2011-11-08
WO1999012561A9 (en) 2000-03-16
NO20001195L (no) 2000-03-08
ES2244090T3 (es) 2005-12-01
JP2002509854A (ja) 2002-04-02
HRP20000109A2 (en) 2001-02-28

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