BRPI0719821B8 - composição estável na armazenagem apropriada para administração a pacientes - Google Patents
composição estável na armazenagem apropriada para administração a pacientesInfo
- Publication number
- BRPI0719821B8 BRPI0719821B8 BRPI0719821A BRPI0719821A BRPI0719821B8 BR PI0719821 B8 BRPI0719821 B8 BR PI0719821B8 BR PI0719821 A BRPI0719821 A BR PI0719821A BR PI0719821 A BRPI0719821 A BR PI0719821A BR PI0719821 B8 BRPI0719821 B8 BR PI0719821B8
- Authority
- BR
- Brazil
- Prior art keywords
- storage stable
- patients
- administration
- pthrp
- stable composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 101150071808 PTHLH gene Proteins 0.000 abstract 3
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 102000043299 Parathyroid hormone-related Human genes 0.000 abstract 1
- 101710123753 Parathyroid hormone-related protein Proteins 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
composição estável na armazenagem apropriada para administração a pacientes, recipiente vedado, dispositivo de liberação de medicamento e uso da composição a presente invenção fornece uma composição estável em armazenagem que contém um análogo de proteína relativo a hormônio paratireóide (pthrp) e métodos de utilização de um análogo de pthrp e das composições de pthrp descritas no presente para tratar osteoporose, aumentar a massa óssea ou melhorar a qualidade dos ossos. a composição é estável na armazenagem, em forma estéril e, de forma geral, pode ser armazenada à temperatura ambiente por pelo menos várias semanas para permitir a administração parenteral conveniente a pacientes humanos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84896006P | 2006-10-03 | 2006-10-03 | |
US60/848,960 | 2006-10-03 | ||
PCT/US2007/021216 WO2008063279A2 (en) | 2006-10-03 | 2007-10-03 | A stable composition comprising a bone anabolic protein, namely a pthrp analogue, and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0719821A2 BRPI0719821A2 (pt) | 2013-05-07 |
BRPI0719821B1 BRPI0719821B1 (pt) | 2020-04-14 |
BRPI0719821B8 true BRPI0719821B8 (pt) | 2021-05-25 |
Family
ID=39430237
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0719821A BRPI0719821B8 (pt) | 2006-10-03 | 2007-10-03 | composição estável na armazenagem apropriada para administração a pacientes |
BRPI0722428-1A BRPI0722428A2 (pt) | 2006-10-03 | 2007-10-03 | Uso de composição estável no armazenamento |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0722428-1A BRPI0722428A2 (pt) | 2006-10-03 | 2007-10-03 | Uso de composição estável no armazenamento |
Country Status (28)
Country | Link |
---|---|
US (1) | US8148333B2 (pt) |
EP (2) | EP2957278B1 (pt) |
JP (1) | JP5375611B2 (pt) |
KR (4) | KR20150020289A (pt) |
CN (2) | CN101578093B (pt) |
AU (1) | AU2007322334B2 (pt) |
BR (2) | BRPI0719821B8 (pt) |
CA (1) | CA2664734C (pt) |
CY (1) | CY1119198T1 (pt) |
DK (2) | DK2957278T3 (pt) |
ES (2) | ES2739459T3 (pt) |
FR (1) | FR23C1024I1 (pt) |
HK (1) | HK1214181A1 (pt) |
HR (1) | HRP20171217T1 (pt) |
IL (1) | IL197926A (pt) |
LT (1) | LT2957278T (pt) |
MX (1) | MX2009003569A (pt) |
NL (1) | NL301235I2 (pt) |
NO (1) | NO344885B1 (pt) |
NZ (1) | NZ576682A (pt) |
PL (1) | PL2957278T3 (pt) |
PT (2) | PT2957278T (pt) |
RS (1) | RS56164B1 (pt) |
RU (1) | RU2506070C2 (pt) |
SG (1) | SG175580A1 (pt) |
SI (1) | SI2957278T1 (pt) |
UA (1) | UA98776C2 (pt) |
WO (1) | WO2008063279A2 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2957278T (pt) | 2006-10-03 | 2017-08-23 | Ipsen Pharma Sas | Uma composição estável compreendendo pthrp e utilizações da mesma |
USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
US7803770B2 (en) | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
ME02474B (me) | 2010-05-12 | 2017-02-20 | Radius Health Inc | Terapijski režimi |
BR112013007685B1 (pt) | 2010-09-28 | 2021-11-09 | Radius Pharmaceuticals, Inc | Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto |
EP2472329B1 (en) | 2010-12-31 | 2013-06-05 | Rohm and Haas Electronic Materials LLC | Coating compositions for use with an overcoated photoresist |
EP2472328B1 (en) | 2010-12-31 | 2013-06-19 | Rohm and Haas Electronic Materials LLC | Coating compositions for use with an overcoated photoresist |
WO2012145665A2 (en) * | 2011-04-22 | 2012-10-26 | Radius Health, Inc. | Method of drug delivery for pth, pthrp and related peptides |
CN108195965B (zh) | 2011-06-07 | 2021-02-23 | 旭化成制药株式会社 | 含pth肽冷冻干燥制剂的检査方法及包含该含pth肽冷冻干燥制剂的医药品的制造方法 |
AU2012345768B2 (en) * | 2011-11-30 | 2016-05-12 | Kindeva Drug Delivery L.P. | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
IL297369B1 (en) | 2015-04-29 | 2024-02-01 | Radius Pharmaceuticals Inc | RAD for use in a method to treat mutant estrogen receptor positive breast cancer or mutant estrogen receptor positive ovarian cancer |
US20180161401A1 (en) * | 2015-07-06 | 2018-06-14 | Zheng Xin Dong | Novel Formulations of PTHrP Analogue |
JP6525376B2 (ja) | 2015-08-31 | 2019-06-05 | ローム アンド ハース エレクトロニック マテリアルズ エルエルシーRohm and Haas Electronic Materials LLC | オーバーコートされたフォトレジストと共に使用するためのコーティング組成物 |
PL3359241T3 (pl) * | 2015-10-09 | 2021-12-20 | Radius Health, Inc. | Formulacje analogów pthrp, plastry przezskórne je zawierające i ich zastosowania |
US10568937B2 (en) | 2016-04-18 | 2020-02-25 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
RU2769527C2 (ru) | 2016-06-22 | 2022-04-01 | Эллипсес Фарма Лтд | Способы лечения ar+ рака молочной железы |
BR112019011070A2 (pt) * | 2016-11-30 | 2019-10-01 | Purdue Research Foundation | regeneração óssea direcionada à fratura através da estimulação do receptor de hormônio da paratireoide |
KR102322802B1 (ko) | 2017-01-05 | 2021-11-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
EP3765488A1 (en) * | 2018-03-12 | 2021-01-20 | Fresenius Kabi iPSUM S.r.l. | Process for the manufacture of pthrp analogue |
US11643385B2 (en) | 2018-07-04 | 2023-05-09 | Radius Pharmaceuticals, Inc. | Polymorphic forms of RAD1901-2HCl |
WO2021149012A1 (en) | 2020-01-24 | 2021-07-29 | Radius Health, Inc. | Methods of stimulating bone growth with abalopartide and denosumab |
WO2023281447A1 (en) | 2021-07-07 | 2023-01-12 | Radius Health, Inc. | Methods of treating a cardiovascular ischemic event |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5977070A (en) * | 1992-07-14 | 1999-11-02 | Piazza; Christin Teresa | Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis |
US5821225A (en) | 1992-07-14 | 1998-10-13 | Syntex (U.S.A.) Inc. | Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp |
US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
EP0679088B1 (en) | 1992-09-29 | 2002-07-10 | Inhale Therapeutic Systems | Pulmonary delivery of active fragments of parathyroid hormone |
CN1070500C (zh) | 1993-07-13 | 2001-09-05 | 森德克斯(美国)股份有限公司 | 甲状旁腺激素类似物和甲状旁腺激素相关肽:合成和治疗骨质疏松症的用途 |
US7410948B2 (en) * | 1995-07-13 | 2008-08-12 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Analogs of parathyroid hormone |
US5723577A (en) | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
US5969095A (en) * | 1995-07-13 | 1999-10-19 | Biomeasure, Inc. | Analogs of parathyroid hormone |
US5955574A (en) | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
US6544949B1 (en) | 1995-07-13 | 2003-04-08 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Analogs of parathyroid hormone |
CN1204262A (zh) * | 1995-10-17 | 1999-01-06 | 曼海姆泊灵格股份公司 | 稳定的含甲状旁腺激素的药物给药剂型 |
TW505654B (en) * | 1996-07-30 | 2002-10-11 | Hoffmann La Roche | Synthesis of analogs of PTH and PTHrP |
US6136784A (en) * | 1997-01-08 | 2000-10-24 | Amylin Pharmaceuticals, Inc. | Amylin agonist pharmaceutical compositions containing insulin |
RS49707B (sr) | 1997-09-09 | 2007-12-31 | F.Hoffmann-La Roche Ag., | Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu i njegovih soli za proizvodnju medikamenata za lečenje preloma kostiju |
US6770623B1 (en) | 1997-12-09 | 2004-08-03 | Eli Lilly And Company | Stabilized teriparatide solutions |
ZA9811127B (en) * | 1997-12-09 | 2000-07-11 | Lilly Co Eli | Stabilized teriparatide solutions. |
SE9801495D0 (sv) * | 1998-04-28 | 1998-04-28 | Astra Ab | Protein formulationa |
US6756480B2 (en) * | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
US20050124537A1 (en) * | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
US7371721B2 (en) * | 2000-09-18 | 2008-05-13 | Sanos Bioscience A/S | Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes |
US7799757B2 (en) * | 2002-06-13 | 2010-09-21 | Michael Chorev | Analogs of parathyroid hormone and PTH-related protein as bone anabolic agents |
AU2002359391A1 (en) | 2002-11-01 | 2004-07-29 | Amgen, Inc. | Modulators of receptors for parathyrois hormone and parathyroid hormone-related protein |
TWI359026B (en) * | 2004-02-12 | 2012-03-01 | Sankyo Co | Pharmaceutical composition for the osteoclast rela |
JP2007537274A (ja) * | 2004-05-10 | 2007-12-20 | ナステック ファーマスーティカル カンパニー インク. | 副甲状腺ホルモンの粘膜送達を増強するための組成物及び方法 |
US7803770B2 (en) | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
PT2957278T (pt) | 2006-10-03 | 2017-08-23 | Ipsen Pharma Sas | Uma composição estável compreendendo pthrp e utilizações da mesma |
-
2007
- 2007-10-03 PT PT151765484T patent/PT2957278T/pt unknown
- 2007-10-03 WO PCT/US2007/021216 patent/WO2008063279A2/en active Application Filing
- 2007-10-03 KR KR20147033817A patent/KR20150020289A/ko active Search and Examination
- 2007-10-03 KR KR1020187030530A patent/KR20180117738A/ko not_active Application Discontinuation
- 2007-10-03 UA UAA200904264A patent/UA98776C2/ru unknown
- 2007-10-03 DK DK15176548.4T patent/DK2957278T3/en active
- 2007-10-03 BR BRPI0719821A patent/BRPI0719821B8/pt active IP Right Grant
- 2007-10-03 EP EP15176548.4A patent/EP2957278B1/en not_active Revoked
- 2007-10-03 SG SG2011071784A patent/SG175580A1/en unknown
- 2007-10-03 CN CN2007800370219A patent/CN101578093B/zh active Active
- 2007-10-03 CN CN201110220104.XA patent/CN102274492B/zh active Active
- 2007-10-03 PT PT07870768T patent/PT2073789T/pt unknown
- 2007-10-03 NZ NZ576682A patent/NZ576682A/xx unknown
- 2007-10-03 LT LTEP15176548.4T patent/LT2957278T/lt unknown
- 2007-10-03 ES ES07870768T patent/ES2739459T3/es active Active
- 2007-10-03 RU RU2009116531/15A patent/RU2506070C2/ru not_active IP Right Cessation
- 2007-10-03 KR KR1020097008736A patent/KR101512377B1/ko active IP Right Grant
- 2007-10-03 CA CA2664734A patent/CA2664734C/en active Active
- 2007-10-03 ES ES15176548.4T patent/ES2637283T3/es active Active
- 2007-10-03 KR KR1020177015557A patent/KR20170067906A/ko not_active Application Discontinuation
- 2007-10-03 DK DK07870768.4T patent/DK2073789T3/da active
- 2007-10-03 US US12/311,418 patent/US8148333B2/en active Active
- 2007-10-03 EP EP07870768.4A patent/EP2073789B8/en active Active
- 2007-10-03 RS RS20170803A patent/RS56164B1/sr unknown
- 2007-10-03 SI SI200731956T patent/SI2957278T1/sl unknown
- 2007-10-03 JP JP2009531434A patent/JP5375611B2/ja active Active
- 2007-10-03 MX MX2009003569A patent/MX2009003569A/es active IP Right Grant
- 2007-10-03 AU AU2007322334A patent/AU2007322334B2/en active Active
- 2007-10-03 PL PL15176548T patent/PL2957278T3/pl unknown
- 2007-10-03 BR BRPI0722428-1A patent/BRPI0722428A2/pt not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL197926A patent/IL197926A/en active IP Right Grant
- 2009-04-20 NO NO20091545A patent/NO344885B1/no unknown
- 2009-10-02 HK HK16102423.5A patent/HK1214181A1/zh unknown
-
2017
- 2017-08-08 HR HRP20171217TT patent/HRP20171217T1/hr unknown
- 2017-08-10 CY CY20171100860T patent/CY1119198T1/el unknown
-
2023
- 2023-06-05 FR FR23C1024C patent/FR23C1024I1/fr active Active
- 2023-06-09 NL NL301235C patent/NL301235I2/nl unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0719821B8 (pt) | composição estável na armazenagem apropriada para administração a pacientes | |
BRPI0418029B8 (pt) | formulação farmacêutica líquida, estável, adequada para administração parentérica que compreende um anticorpo agonista de cd40 | |
CY1118059T1 (el) | Συνθεσεις αντιλοιμωδων βασει λιπιδιων για αγωγη πνευμονικων λοιμωξεων | |
BR112014008551A2 (pt) | conjunto de válvulas para uso com recipiente de líquido e frasco de medicamento | |
EP2392322A3 (en) | Dosing regimes for trans-clomiphene | |
BRPI0707235B8 (pt) | formulação de fentanil sublingual sem propelente, e, dispositivo de dose unitária para administração sublingual de uma formulação de fentanil sublingual | |
PH12013501790B1 (en) | Use of dpp iv inhibitors | |
BRPI0611705A2 (pt) | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto | |
BR0316906A (pt) | administração do capsaicinoides | |
BRPI0807453B8 (pt) | preparação sólida | |
BRPI0917315B8 (pt) | anticorpo monoclonal, seu uso e composição farmacêutica o compreendendo | |
EA201190127A1 (ru) | Фармацевтические составы нитазоксанида с контролируемым высвобождением | |
ATE543491T1 (de) | Kombinationspräparat enthaltend ibuprofen und paracetamol | |
Tosounidis et al. | Pain relief management following proximal femoral fractures: Options, issues and controversies | |
Bukata et al. | Short-term and long-term orthopaedic issues in patients with fragility fractures | |
BR112013010829B8 (pt) | Composição farmacêutica intravenosa para proporcionar alívio da dor e/ou da inflamação | |
BR112012030641A2 (pt) | métodos e composições para terapia farmacêutica oral | |
BR112012020377A2 (pt) | utilização de um ou mais selecionado do grupo constituído por um composto da fórmula (i), uma mistura racêmica-diastereomérica e um isômero óptico do referido composto, e um sal farmaceuticamente aceitável e uma pródroga do mesmo, método, composição farmacêutica e kit para tratamento de caquexia e embalagem comercial | |
CL2010001577A1 (es) | Uso de nifurtimox para preparar un medicamento util en el tratamiento de enfermedades causadas por giardias. | |
ECSP088285A (es) | 3-(2-dimetilaminometil ciclohexil) fenol formulación retardada. | |
GT200800235A (es) | Formulacion de medicamento liquida | |
AR086491A1 (es) | Composicion farmaceutica que comprende fexofenadina | |
CY1111361T1 (el) | Νεα προσδεματα συναγωνιστες των υποδοχεων rar, χρηση στην ανθρωπινη ιατρικη καθως και στην κοσμετολογια | |
BRPI0815280A2 (pt) | medicamento que compreende uma formulação líquida aquosa de g-csf, receptáculo para a administração de medicamentos líquidos, seringa ou ampola, kit para a administração parenteral de g-csf | |
MX2008015323A (es) | Composicion farmaceutica que comprende ciclobenzaprina y aceclofenac en asociacion. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 14/04/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/10/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |