BR112012030641A2 - métodos e composições para terapia farmacêutica oral - Google Patents
métodos e composições para terapia farmacêutica oralInfo
- Publication number
- BR112012030641A2 BR112012030641A2 BR112012030641A BR112012030641A BR112012030641A2 BR 112012030641 A2 BR112012030641 A2 BR 112012030641A2 BR 112012030641 A BR112012030641 A BR 112012030641A BR 112012030641 A BR112012030641 A BR 112012030641A BR 112012030641 A2 BR112012030641 A2 BR 112012030641A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- oral pharmaceutical
- agents
- pharmaceutical therapy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 210000001630 jejunum Anatomy 0.000 abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000001198 duodenum Anatomy 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 abstract 1
- 229960004267 taurolidine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Abstract
metodos e composições para terapia farmacêutica oral. descobriu-se agora que a administração oral de agentes farmacêuticos, incluindo os agentes de transferência de n-metilol, tais como taurolidina, pode ser utilizada para proporcionar uma concentração eficaz no plasma sanguineo dos agentes para o tratamento de doenças através da liberação do agente ativo no duodemo ou jejuno de um paciente e/ou a um ph de cerca de 5,4 a cerca de 6,5. modalidades da invenção, por conseguinte, proporcionam formas de dosagem oral, composições e métodos para a administração de agentes farmacêuticos ao duodeno ou ao jejuno de um paciente, e/ou a liberação a um ph de cerca de 5,4 a cerca de 6,5.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35018310P | 2010-06-01 | 2010-06-01 | |
US61/350,183 | 2010-06-01 | ||
US37031510P | 2010-08-03 | 2010-08-03 | |
US61/370,315 | 2010-08-03 | ||
PCT/IB2011/001539 WO2011151722A2 (en) | 2010-06-01 | 2011-06-01 | Methods and compositions for oral pharmaceutical therapy |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112012030641A2 true BR112012030641A2 (pt) | 2016-08-16 |
BR112012030641B1 BR112012030641B1 (pt) | 2022-05-24 |
BR112012030641B8 BR112012030641B8 (pt) | 2022-06-14 |
Family
ID=45067142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012030641A BR112012030641B8 (pt) | 2010-06-01 | 2011-06-01 | Usos e composições para terapia farmacêutica oral |
Country Status (10)
Country | Link |
---|---|
US (1) | US9028866B2 (pt) |
EP (1) | EP2575783B1 (pt) |
JP (2) | JP5926243B2 (pt) |
CN (1) | CN103118669B (pt) |
AU (1) | AU2011262308B2 (pt) |
BR (1) | BR112012030641B8 (pt) |
CA (1) | CA2801309C (pt) |
ES (1) | ES2614878T3 (pt) |
HK (1) | HK1183228A1 (pt) |
WO (1) | WO2011151722A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2850453B1 (en) * | 2012-05-15 | 2019-09-25 | Signify Holding B.V. | Control of lighting devices |
AU2017206750B2 (en) * | 2016-01-11 | 2022-10-13 | Cormedix Inc. | Therapeutic nanoparticles for the treatment of neuroblastoma and other cancers |
US11541061B2 (en) | 2016-01-11 | 2023-01-03 | Cormedix Inc. | Neuroblastoma treatment with taurolidine hydrolysis products |
US20190381058A1 (en) * | 2016-01-11 | 2019-12-19 | Cormedix Inc. | Methods and compositions for treating neuroblastoma in a juvenile mammalian body |
CN111936121A (zh) | 2017-11-17 | 2020-11-13 | 赢创运营有限公司 | 制备包衣硬壳胶囊的方法 |
JP2021535167A (ja) * | 2018-08-31 | 2021-12-16 | コーメディクス・インコーポレーテッド | 哺乳動物の身体におけるmyc発現腫瘍のタウロリジン治療 |
WO2020234833A1 (en) | 2019-05-22 | 2020-11-26 | Geistlich Pharma Ag | Method for treating, preventing, inhibiting or reducing cytokine release |
US20220323452A1 (en) | 2019-05-22 | 2022-10-13 | Geistlich Pharma Ag | Methods and compositions for inhibiting gapdh |
CN111671758A (zh) * | 2020-07-06 | 2020-09-18 | 长春迈灵生物工程有限公司 | 牛磺罗定在制备抗hiv病毒药物中的应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5210083A (en) | 1986-07-17 | 1993-05-11 | Ed. Geistlich Sohne A.G. Fur Chemische Industrie | Pharmaceutical compositions |
IE66933B1 (en) * | 1990-01-15 | 1996-02-07 | Elan Corp Plc | Controlled absorption naproxen formulation for once-daily administration |
US20030027818A1 (en) * | 2001-04-03 | 2003-02-06 | Redmond H. Paul | Treatment of cancers |
US5972933A (en) * | 1998-01-08 | 1999-10-26 | Ed. Geistlich Sohne Ag Fur Chemische Industrie | Method of treating microbial infections |
US6555534B1 (en) * | 1998-09-11 | 2003-04-29 | Medpointe Healthcare Inc. | Method and compositions for the control or eradication of Helicobacter pylori |
US6251896B1 (en) * | 1999-03-24 | 2001-06-26 | Carter-Wallace, Inc. | Compositions and methods for the management of Crohn's disease |
US20020098164A1 (en) * | 2000-10-27 | 2002-07-25 | Redmond H. Paul | Treatment of tumor metastases and cancer |
JP2003507438A (ja) * | 1999-08-24 | 2003-02-25 | セルゲイト, インコーポレイテッド | オリゴアルギニン部分を使用する上皮組織を横切るおよび上皮組織内への薬物送達の増強 |
WO2001039763A2 (en) * | 1999-12-06 | 2001-06-07 | Rhode Island Hospital, A Lifespan Partner | Use of methylol-containing compounds for the manufacture of a medicament for the treatment of tumors |
US20020004502A1 (en) * | 2000-01-05 | 2002-01-10 | Redmond H. Paul | Treatment of inflammatory bowel disease |
US20040170617A1 (en) * | 2000-06-05 | 2004-09-02 | Finegold Sydney M. | Method of treating diseases associated with abnormal gastrointestinal flora |
JP5502254B2 (ja) * | 2001-01-31 | 2014-05-28 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | 少なくとも2種類の異なる被覆ペレット形から成る多粒子剤形 |
US20030092707A1 (en) * | 2001-10-19 | 2003-05-15 | Redmond H. Paul | Treatment of breast cancer |
MXPA04012641A (es) | 2002-06-21 | 2005-08-15 | Oreal | Uso de tarurina o derivados de la misma para el tratamiento de alopecia. |
US20060198886A1 (en) * | 2005-03-01 | 2006-09-07 | Jenkins Richard B | Medicament having coated methenamine combined with acidifier |
US20100166872A1 (en) * | 2005-10-21 | 2010-07-01 | Amarjit Singh | Novel improved compositions for cancer therapy |
ES2318628T3 (es) * | 2006-07-25 | 2009-05-01 | Claus Herdeis | Preparacion de formulaciones antimicrobianas que comprenden 7-oxa-2-tia-1,5 diazabiciclo(3.3.1)-nonan-2,2-diona. |
-
2011
- 2011-06-01 JP JP2013513002A patent/JP5926243B2/ja active Active
- 2011-06-01 BR BR112012030641A patent/BR112012030641B8/pt not_active IP Right Cessation
- 2011-06-01 AU AU2011262308A patent/AU2011262308B2/en active Active
- 2011-06-01 EP EP11758551.3A patent/EP2575783B1/en active Active
- 2011-06-01 ES ES11758551.3T patent/ES2614878T3/es active Active
- 2011-06-01 WO PCT/IB2011/001539 patent/WO2011151722A2/en active Application Filing
- 2011-06-01 CN CN201180036488.8A patent/CN103118669B/zh active Active
- 2011-06-01 CA CA2801309A patent/CA2801309C/en active Active
- 2011-06-01 US US13/701,372 patent/US9028866B2/en active Active
-
2013
- 2013-09-12 HK HK13110554.2A patent/HK1183228A1/zh unknown
-
2016
- 2016-02-29 JP JP2016037487A patent/JP2016155826A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
BR112012030641B1 (pt) | 2022-05-24 |
CN103118669B (zh) | 2016-01-13 |
HK1183228A1 (zh) | 2013-12-20 |
JP5926243B2 (ja) | 2016-05-25 |
AU2011262308A1 (en) | 2013-01-10 |
EP2575783B1 (en) | 2017-01-11 |
AU2011262308B2 (en) | 2014-07-31 |
US20130089606A1 (en) | 2013-04-11 |
JP2016155826A (ja) | 2016-09-01 |
ES2614878T3 (es) | 2017-06-02 |
CA2801309C (en) | 2018-07-17 |
EP2575783A2 (en) | 2013-04-10 |
BR112012030641B8 (pt) | 2022-06-14 |
CA2801309A1 (en) | 2011-12-08 |
JP2013527224A (ja) | 2013-06-27 |
WO2011151722A2 (en) | 2011-12-08 |
US9028866B2 (en) | 2015-05-12 |
WO2011151722A3 (en) | 2012-05-24 |
CN103118669A (zh) | 2013-05-22 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
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B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B09X | Republication of the decision to grant [chapter 9.1.3 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
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