PT3122426T - Tratamento de cancro da mama utilizando moduladores seletivos do recetor de estrogénio - Google Patents
Tratamento de cancro da mama utilizando moduladores seletivos do recetor de estrogénioInfo
- Publication number
- PT3122426T PT3122426T PT157693946T PT15769394T PT3122426T PT 3122426 T PT3122426 T PT 3122426T PT 157693946 T PT157693946 T PT 157693946T PT 15769394 T PT15769394 T PT 15769394T PT 3122426 T PT3122426 T PT 3122426T
- Authority
- PT
- Portugal
- Prior art keywords
- treating cancer
- estrogen receptor
- receptor modulators
- selective estrogen
- selective
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461971627P | 2014-03-28 | 2014-03-28 | |
US14/512,061 US9421264B2 (en) | 2014-03-28 | 2014-10-10 | Method of treating cancer using selective estrogen receptor modulators |
US201562129379P | 2015-03-06 | 2015-03-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3122426T true PT3122426T (pt) | 2023-02-28 |
Family
ID=54196487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT157693946T PT3122426T (pt) | 2014-03-28 | 2015-03-28 | Tratamento de cancro da mama utilizando moduladores seletivos do recetor de estrogénio |
Country Status (16)
Country | Link |
---|---|
US (4) | US10420734B2 (pt) |
EP (3) | EP4035664A3 (pt) |
CA (1) | CA2943611A1 (pt) |
DK (1) | DK3122426T3 (pt) |
ES (1) | ES2939940T3 (pt) |
FI (2) | FI3122426T3 (pt) |
FR (1) | FR24C1007I1 (pt) |
HR (1) | HRP20230365T1 (pt) |
HU (2) | HUE061499T2 (pt) |
LT (1) | LT3122426T (pt) |
NO (1) | NO2024007I1 (pt) |
PL (1) | PL3122426T3 (pt) |
PT (1) | PT3122426T (pt) |
RS (1) | RS64115B1 (pt) |
SI (1) | SI3122426T1 (pt) |
WO (1) | WO2015149045A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4035664A3 (en) | 2014-03-28 | 2022-11-30 | Duke University | Treating cancer using selective estrogen receptor modulators |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
IL297369B1 (en) * | 2015-04-29 | 2024-02-01 | Radius Pharmaceuticals Inc | RAD for use in a method to treat mutant estrogen receptor positive breast cancer or mutant estrogen receptor positive ovarian cancer |
CN108699024B (zh) | 2015-12-09 | 2022-03-11 | 伊利诺伊大学评议会 | 苯并噻吩基选择性雌激素受体下调剂化合物 |
BR112019007254A2 (pt) | 2016-10-11 | 2019-07-02 | Univ Duke | tratamento lasofoxifeno de câncer de mama er+ |
WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
KR102576011B1 (ko) | 2017-01-06 | 2023-09-06 | 쥐원 쎄라퓨틱스, 인크. | 암의 치료를 위한 조합 요법 |
WO2018148576A1 (en) | 2017-02-10 | 2018-08-16 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
CN112261937B (zh) | 2018-04-10 | 2023-11-14 | 杜克大学 | 乳腺癌的拉索昔芬治疗 |
KR20220151616A (ko) * | 2020-03-06 | 2022-11-15 | 올레마 파마슈티컬스 인코포레이티드 | 에스트로겐 수용체-연관 질환의 치료 방법 |
WO2022020605A1 (en) * | 2020-07-23 | 2022-01-27 | The Board Of Trustees Of The University Of Illinois | Treatment of metastasized estrogen receptor positive breast cancer |
WO2023172909A1 (en) * | 2022-03-08 | 2023-09-14 | Context Biopharma Inc. | Compositions comprising anti-progestins and selective estrogen receptor modulators and methods of using the same |
WO2023224961A1 (en) | 2022-05-16 | 2023-11-23 | Exelixis, Inc. | Cancer therapy using a combination of a cdk7 inhibitor with an oral serd |
Family Cites Families (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274213A (en) | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
GB1547758A (en) | 1975-07-29 | 1979-06-27 | Shell Int Research | Herbicidal composition |
US4133814A (en) | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
DE2909754A1 (de) | 1979-03-13 | 1980-09-18 | Thomae Gmbh Dr K | Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel |
US4418068A (en) | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
EP0226508A1 (fr) | 1985-12-02 | 1987-06-24 | Sanofi | Dérivés de l'indolo(3,2-c)quinoléine, leur procédé de préparation et leur activité antitumorale |
US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
JPH07121931B2 (ja) | 1989-06-22 | 1995-12-25 | キッセイ薬品工業株式会社 | ベンゾ〔b〕フラン誘導体 |
US5166170A (en) | 1989-07-03 | 1992-11-24 | Hoechst-Roussel Pharmaceuticals Incorporated | 2-(aminoaryl) indoles and indolines as topical antiinflammatory agents for the treatment of skin disorders |
FR2693461B1 (fr) | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
GB9310635D0 (en) | 1993-05-21 | 1993-07-07 | Glaxo Group Ltd | Chemical compounds |
US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
DE4420644A1 (de) | 1994-06-14 | 1995-12-21 | Basf Ag | Farbige Metalloxidpigmente enthaltende Kugelschreiberpasten |
US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
UA51652C2 (uk) | 1995-06-08 | 2002-12-16 | Новартіс Аг | Спосіб гідрування імінів |
PT802183E (pt) | 1996-04-19 | 2002-03-28 | American Home Prod | Agentes estrogenicos |
DE69709752T2 (de) | 1996-06-27 | 2002-07-18 | Ligand Pharm Inc | Androgen rezeptor modulator verbindungen und verfahren |
FR2770842B1 (fr) | 1997-11-13 | 1999-12-17 | Oreal | Nouveaux composes derives de n-aryl 2-hydroxy alkylamides |
EP1228045A2 (en) | 1999-10-29 | 2002-08-07 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
US6544553B1 (en) | 1999-12-28 | 2003-04-08 | Watson Pharmaceuticals, Inc. | Dosage forms and methods for oral delivery of progesterone |
ES2238034T3 (es) | 1999-12-30 | 2005-08-16 | Signal Pharmaceuticals Llc | Compuestos y metodos para la modulacion de receptores estrogenicos. |
WO2001054699A1 (en) | 2000-01-28 | 2001-08-02 | Endorecherche, Inc. | Selective estrogen receptor modulators in combination with estrogens |
US20010044431A1 (en) | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
CA2420289A1 (en) | 2000-08-23 | 2002-02-28 | Akzo Nobel N.V. | 10-aryl-11-hbenzo [b]fluorene derivatives and analogs for medicinal use |
SI1401801T1 (sl) | 2000-08-24 | 2007-04-30 | Univ Tennessee Res Foundation | Selektivni modulatorji androgenskega receptorja in postopki za njihovo uporabo |
IL145838A (en) | 2000-10-16 | 2008-11-03 | Pfizer Prod Inc | Use of an estrogen agonist / antagonist to produce a drug for the treatment of vaginitis |
US6670386B2 (en) | 2001-07-31 | 2003-12-30 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
CA2456150A1 (en) | 2001-08-13 | 2003-02-27 | Merck & Co., Inc. | Selective estrogen receptor modulators |
US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
EP1465619A1 (en) | 2002-01-14 | 2004-10-13 | Nordic Bioscience A/S | Suppression of cartilage degradation via the estrogen receptor |
MXPA04007870A (es) | 2002-02-15 | 2005-06-20 | Endorech Inc | Derivados de bifenilo y su uso como agentes antiandrogenicos. |
JP4554219B2 (ja) | 2002-04-24 | 2010-09-29 | メルク・シャープ・エンド・ドーム・コーポレイション | エストロゲン受容体調節剤 |
TW200407324A (en) | 2002-05-17 | 2004-05-16 | Bristol Myers Squibb Co | Bicyclic modulators of androgen receptor function |
TW200307553A (en) | 2002-05-24 | 2003-12-16 | Akzo Nobel Nv | Treatment of post-menopausal complaints in breast cancer patients |
US7622592B2 (en) | 2002-11-01 | 2009-11-24 | Merck & Co., Inc. | Carbonylamino-benzimidazole derivatives as androgen receptor modulators |
UA79504C2 (en) | 2002-11-07 | 2007-06-25 | Organon Nv | Indols for treating diseases associated with androgen receptors |
EP1567487A4 (en) | 2002-11-15 | 2005-11-16 | Bristol Myers Squibb Co | OPEN-CHAINED, PROLYL-FROSTED MODULATORS OF ANDROGEN RECEPTOR FUNCTION |
JP4500689B2 (ja) | 2002-12-26 | 2010-07-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 選択的エストロゲン受容体モジュレーター |
US7741352B2 (en) | 2003-03-11 | 2010-06-22 | Neurosearch A/S | KCNQ channel modulating compounds and their pharmaceutical use |
WO2005000795A2 (en) | 2003-06-10 | 2005-01-06 | Smithkline Beecham Corporation | Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators |
JP2007505164A (ja) | 2003-06-10 | 2007-03-08 | スミスクライン ビーチャム コーポレーション | アンドロゲン、グルココルチコイド、ミネラルコルチコイドおよびプロゲステロン受容体のモジュレーターとしての1−アミノナフタレン類 |
FI20030958A0 (fi) | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
WO2005002549A1 (en) | 2003-07-04 | 2005-01-13 | Nycomed Danmark Aps | Parathyroid hormone (pth) containing pharmaceutical compositions for oral use |
US20050124625A1 (en) | 2003-10-21 | 2005-06-09 | Salvati Mark E. | Piperazine derivatives and their use as modulators of nuclear hormone receptor function |
GB0324551D0 (en) | 2003-10-21 | 2003-11-26 | Karobio Ab | Novel compounds |
US7256208B2 (en) | 2003-11-13 | 2007-08-14 | Bristol-Myers Squibb Company | Monocyclic N-Aryl hydantoin modulators of androgen receptor function |
JP2007521328A (ja) | 2003-11-20 | 2007-08-02 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲン受容体モジュレーター |
WO2005060956A1 (en) | 2003-12-12 | 2005-07-07 | University Of Maryland, Baltimore | IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN |
ATE476428T1 (de) | 2004-01-22 | 2010-08-15 | Lilly Co Eli | Selektive modulatoren des östrogenrezeptors zur behandlung von vasomotorischen symptomen |
US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
EP1725522B1 (en) | 2004-03-03 | 2014-09-10 | GlaxoSmithKline LLC | Aniline derivatives as selective androgen receptor modulators |
US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
US7388027B2 (en) | 2004-03-04 | 2008-06-17 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
GB0405033D0 (en) | 2004-03-05 | 2004-04-07 | Karobio Ab | Novel pharmaceutical compositions |
US8519158B2 (en) | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
CA2562132A1 (en) | 2004-04-08 | 2005-10-27 | Merck & Co., Inc. | 17 beta-acetamide-4-azasteroids as androgen receptor modulators |
TW200602317A (en) | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
US7282507B2 (en) | 2004-05-03 | 2007-10-16 | Janssen Pharmaceutica N.V. | Indole derivatives as selective androgen receptor modulators (SARMS) |
US20080045504A1 (en) | 2004-05-11 | 2008-02-21 | Pfizer Products Inc. | Benzonitrile Derivatives to Treat Musculoskeletal Frailty |
CA2580777A1 (en) | 2004-09-20 | 2006-03-30 | Janssen Pharmaceutica N.V. | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators |
US7566733B2 (en) | 2004-09-30 | 2009-07-28 | Janssen Pharmaceutica N.V. | Benzimidazole derivatives useful as selective androgen receptor modulators (sarms) |
US8143425B2 (en) | 2004-10-12 | 2012-03-27 | Bristol-Myers Squibb Company | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
US7834063B2 (en) | 2004-10-13 | 2010-11-16 | Glaxosmithkline Llc | Benzonitryl and nitrobenzyl derivatives that modulate androgen receptors |
EP1807076A4 (en) | 2004-10-29 | 2010-06-02 | Merck Sharp & Dohme | N- (PYRIDIN-3-YL) -2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS |
CA2587678C (en) | 2004-11-16 | 2013-05-21 | Janssen Pharmaceutica N.V. | Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms) |
AU2006205066B2 (en) | 2005-01-10 | 2012-05-17 | Acadia Pharmaceuticals Inc. | Aminophenyl derivatives as selective androgen receptor modulators |
JP2008536868A (ja) | 2005-04-15 | 2008-09-11 | スミスクライン・ビーチャム・コーポレイション | シアノアリールアミン |
ES2314922T3 (es) | 2005-05-13 | 2009-03-16 | Eli Lilly And Company | N-arilpirrolidinas sustituidas como moduladores selectivos del receptor de androgenos. |
WO2006133216A2 (en) | 2005-06-06 | 2006-12-14 | Smithkline Beecham Corporation | 4-substituted arylamine derivatives and their use in pharmaceutical compositions |
US7829589B2 (en) | 2005-06-10 | 2010-11-09 | Elixir Pharmaceuticals, Inc. | Sulfonamide compounds and uses thereof |
BRPI0611705A2 (pt) | 2005-06-24 | 2016-11-16 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto |
AR057656A1 (es) | 2005-07-01 | 2007-12-12 | Ligand Pharm Inc | Compuestos moduladores de receptores de androgeno y metodods relacionados |
US8592452B2 (en) | 2005-08-01 | 2013-11-26 | Takeda Pharmaceutical Company Limited | Cyclic amine compound |
JP2008303145A (ja) | 2005-09-22 | 2008-12-18 | Takeda Chem Ind Ltd | Grk阻害剤からなる強心薬 |
TW200730505A (en) | 2005-12-07 | 2007-08-16 | Merck & Co Inc | Polymorphs of an androgen receptor modulator |
US7932399B2 (en) | 2006-01-24 | 2011-04-26 | Janssen Pharmaceutica Nv | 2-substituted benzimidazoles as selective androgen receptor modulators (SARMS) |
AU2007220419B2 (en) | 2006-03-03 | 2012-03-15 | Orion Corporation | Selective androgen receptor modulators |
EP2037905B1 (en) | 2006-06-23 | 2013-05-01 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
KR101460999B1 (ko) | 2006-07-12 | 2014-11-17 | 유니버시티 오브 테네시 리서치 파운데이션 | 치환된 아실아닐리드 및 그의 사용 방법 |
CA2658098A1 (en) | 2006-07-19 | 2008-01-24 | Osurf | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof |
BRPI0714526A2 (pt) | 2006-08-24 | 2013-04-30 | Univ Tennessee Res Foundation | acilanilidas substituÍdas e seus mÉtodos de uso |
JP5275236B2 (ja) | 2006-09-29 | 2013-08-28 | スミスクライン ビーチャム コーポレーション | 置換されたインドール化合物 |
WO2008044033A1 (en) | 2006-10-11 | 2008-04-17 | Astrazeneca Ab | Amide derivatives |
UA98777C2 (en) | 2006-11-20 | 2012-06-25 | Эли Лилли Энд Компани | Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators |
WO2008121602A1 (en) | 2007-03-29 | 2008-10-09 | Smithkline Beecham Corporation | Chemical compounds |
WO2008124000A2 (en) | 2007-04-02 | 2008-10-16 | Ligand Pharmaceuticals Incorporated | Thiazole derivatives as androgen receptor modulator compounds |
US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
US7696227B2 (en) | 2007-04-13 | 2010-04-13 | Regents Of The University Of California | Small-molecule inhibitors of the androgen receptor |
US20110009387A1 (en) | 2007-06-12 | 2011-01-13 | Andrea Dawn Basso-Porcaro | Histone h2ax (hh2ax) biomarker for fti sensitivity |
KR101089045B1 (ko) | 2007-06-28 | 2011-12-02 | (주)바이오니아 | 핵산증폭반응 산물의 실시간 모니터링장치 |
KR20100049644A (ko) | 2007-08-07 | 2010-05-12 | 다케다 야쿠힌 고교 가부시키가이샤 | 안드로겐 수용체 조절제로서의 피롤리딘-2-온 유도체 |
EP2222636B1 (en) | 2007-12-21 | 2013-04-10 | Ligand Pharmaceuticals Inc. | Selective androgen receptor modulators (sarms) and uses thereof |
MX2010009162A (es) | 2008-02-22 | 2010-12-21 | Radius Health Inc | Moduladores selectivos del receptor de androgeno. |
WO2009133861A1 (ja) | 2008-04-28 | 2009-11-05 | 武田薬品工業株式会社 | 環状アミン化合物 |
WO2009137104A1 (en) * | 2008-05-09 | 2009-11-12 | Radius Health, Inc. | Combination therapy for breastcancer comprising an antiestrogenic agent |
JP5603327B2 (ja) | 2008-05-16 | 2014-10-08 | イーライ リリー アンド カンパニー | テトラヒドロシクロペンタ[b]インドールアンドロゲン受容体調節物質 |
GB2460672B (en) | 2008-06-04 | 2012-01-04 | Gw Pharma Ltd | Cannabinoids in combination with non-cannabinoid chemotherapeutic agents that are alkylating agents |
WO2010118287A1 (en) | 2009-04-10 | 2010-10-14 | Radius Health, Inc. | Selective androgen receptor modulators |
KR101933841B1 (ko) | 2009-10-16 | 2018-12-28 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 액정 표시 장치 및 이를 구비한 전자 장치 |
EP2531029B1 (en) | 2010-02-04 | 2016-10-19 | Radius Health, Inc. | Selective androgen receptor modulators |
ME02474B (me) | 2010-05-12 | 2017-02-20 | Radius Health Inc | Terapijski režimi |
BR112013007685B1 (pt) | 2010-09-28 | 2021-11-09 | Radius Pharmaceuticals, Inc | Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto |
GB201217439D0 (en) | 2012-09-28 | 2012-11-14 | Topotarget As | Combination therapy |
CN104812414A (zh) | 2012-11-28 | 2015-07-29 | 诺华股份有限公司 | 联合治疗 |
WO2014203129A1 (en) | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Combinations of benzopyran compounds, compositions and uses thereof |
EP4035664A3 (en) | 2014-03-28 | 2022-11-30 | Duke University | Treating cancer using selective estrogen receptor modulators |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
IL297369B1 (en) | 2015-04-29 | 2024-02-01 | Radius Pharmaceuticals Inc | RAD for use in a method to treat mutant estrogen receptor positive breast cancer or mutant estrogen receptor positive ovarian cancer |
-
2015
- 2015-03-28 EP EP21215140.1A patent/EP4035664A3/en active Pending
- 2015-03-28 RS RS20230271A patent/RS64115B1/sr unknown
- 2015-03-28 EP EP15769394.6A patent/EP3122426B1/en active Active
- 2015-03-28 LT LTEPPCT/US2015/023216T patent/LT3122426T/lt unknown
- 2015-03-28 FI FIEP15769394.6T patent/FI3122426T3/fi active
- 2015-03-28 CA CA2943611A patent/CA2943611A1/en active Pending
- 2015-03-28 ES ES15769394T patent/ES2939940T3/es active Active
- 2015-03-28 HU HUE15769394A patent/HUE061499T2/hu unknown
- 2015-03-28 DK DK15769394.6T patent/DK3122426T3/da active
- 2015-03-28 EP EP21151737.0A patent/EP3834824A1/en active Pending
- 2015-03-28 HR HRP20230365TT patent/HRP20230365T1/hr unknown
- 2015-03-28 SI SI201531925T patent/SI3122426T1/sl unknown
- 2015-03-28 PT PT157693946T patent/PT3122426T/pt unknown
- 2015-03-28 PL PL15769394.6T patent/PL3122426T3/pl unknown
- 2015-03-28 WO PCT/US2015/023216 patent/WO2015149045A1/en active Application Filing
- 2015-03-28 US US15/129,197 patent/US10420734B2/en active Active
-
2019
- 2019-08-23 US US16/549,828 patent/US20200009084A1/en not_active Abandoned
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2021
- 2021-12-22 US US17/558,731 patent/US11779552B2/en active Active
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2023
- 2023-08-29 US US18/457,567 patent/US20230398085A1/en active Pending
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2024
- 2024-02-20 HU HUS2400002C patent/HUS2400002I1/hu unknown
- 2024-02-21 NO NO2024007C patent/NO2024007I1/no unknown
- 2024-02-26 FR FR24C1007C patent/FR24C1007I1/fr active Active
- 2024-03-06 FI FIC20240005C patent/FIC20240005I1/fi unknown
Also Published As
Publication number | Publication date |
---|---|
EP4035664A2 (en) | 2022-08-03 |
FR24C1007I1 (fr) | 2024-04-19 |
LT3122426T (lt) | 2023-03-10 |
CA2943611A1 (en) | 2015-10-01 |
ES2939940T3 (es) | 2023-04-28 |
US20230398085A1 (en) | 2023-12-14 |
HRP20230365T1 (hr) | 2023-06-23 |
EP3834824A1 (en) | 2021-06-16 |
EP3122426A4 (en) | 2017-11-29 |
DK3122426T3 (da) | 2023-04-03 |
US10420734B2 (en) | 2019-09-24 |
WO2015149045A1 (en) | 2015-10-01 |
FI3122426T3 (fi) | 2023-03-31 |
RS64115B1 (sr) | 2023-04-28 |
EP4035664A3 (en) | 2022-11-30 |
US20220110893A1 (en) | 2022-04-14 |
EP3122426B1 (en) | 2023-01-18 |
US20200009084A1 (en) | 2020-01-09 |
US20170202823A1 (en) | 2017-07-20 |
HUE061499T2 (hu) | 2023-07-28 |
HUS2400002I1 (hu) | 2024-03-28 |
SI3122426T1 (sl) | 2023-04-28 |
US11779552B2 (en) | 2023-10-10 |
EP3122426A1 (en) | 2017-02-01 |
NO2024007I1 (no) | 2024-02-21 |
FIC20240005I1 (fi) | 2024-03-06 |
PL3122426T3 (pl) | 2023-05-15 |
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