DE69709752T2 - Androgen rezeptor modulator verbindungen und verfahren - Google Patents

Androgen rezeptor modulator verbindungen und verfahren

Info

Publication number
DE69709752T2
DE69709752T2 DE69709752T DE69709752T DE69709752T2 DE 69709752 T2 DE69709752 T2 DE 69709752T2 DE 69709752 T DE69709752 T DE 69709752T DE 69709752 T DE69709752 T DE 69709752T DE 69709752 T2 DE69709752 T2 DE 69709752T2
Authority
DE
Germany
Prior art keywords
compounds
androgen receptor
disclosed
receptor modulator
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69709752T
Other languages
English (en)
Other versions
DE69709752D1 (de
Inventor
P Edwards
Robert Higuchi
Todd Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand Pharmaceuticals Inc
Original Assignee
Ligand Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharmaceuticals Inc filed Critical Ligand Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69709752D1 publication Critical patent/DE69709752D1/de
Publication of DE69709752T2 publication Critical patent/DE69709752T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
DE69709752T 1996-06-27 1997-06-26 Androgen rezeptor modulator verbindungen und verfahren Expired - Fee Related DE69709752T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2199796P 1996-06-27 1996-06-27
PCT/US1997/011222 WO1997049709A1 (en) 1996-06-27 1997-06-26 Androgen receptor modulator compounds and methods

Publications (2)

Publication Number Publication Date
DE69709752D1 DE69709752D1 (de) 2002-02-21
DE69709752T2 true DE69709752T2 (de) 2002-07-18

Family

ID=21807289

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69709752T Expired - Fee Related DE69709752T2 (de) 1996-06-27 1997-06-26 Androgen rezeptor modulator verbindungen und verfahren

Country Status (12)

Country Link
EP (1) EP0918774B9 (de)
JP (1) JP2000513362A (de)
AT (1) ATE209207T1 (de)
AU (1) AU728178B2 (de)
BR (1) BR9710988A (de)
DE (1) DE69709752T2 (de)
DK (1) DK0918774T3 (de)
ES (1) ES2168650T3 (de)
NO (1) NO311645B1 (de)
PT (1) PT918774E (de)
RU (1) RU2214412C2 (de)
WO (1) WO1997049709A1 (de)

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US7003304B1 (en) 1997-09-19 2006-02-21 Thompson Investment Group, Llc Paging transceivers and methods for selectively retrieving messages
US6636733B1 (en) 1997-09-19 2003-10-21 Thompson Trust Wireless messaging method
US6253061B1 (en) 1997-09-19 2001-06-26 Richard J. Helferich Systems and methods for delivering information to a transmitting and receiving device
US6826407B1 (en) 1999-03-29 2004-11-30 Richard J. Helferich System and method for integrating audio and visual messaging
US6983138B1 (en) 1997-12-12 2006-01-03 Richard J. Helferich User interface for message access
US6472415B1 (en) * 1998-12-18 2002-10-29 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
WO2001016133A2 (en) * 1999-08-27 2001-03-08 Ligand Pharmaceuticals Incorporated 8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators
JP2003508402A (ja) * 1999-08-27 2003-03-04 リガンド・ファーマシューティカルズ・インコーポレイテッド アンドロゲン受容体モジュレーター化合物および方法
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
JP2003529545A (ja) 1999-09-14 2003-10-07 リガンド・ファーマシューティカルズ・インコーポレイテッド 改善された薬理学的プロファイルを有するｒｘｒモジュレーター
EP1832598A3 (de) 1999-09-30 2008-01-02 Hollis-Eden Pharmaceuticals Inc. Therapeutische Behandlung von androgenrezeptorbedingten Leiden
WO2001059448A1 (fr) * 2000-02-10 2001-08-16 Chugai Seiyaku Kabushiki Kaisha Procede de criblage d'un agent antiandrogene
BR0111869A (pt) * 2000-06-28 2003-09-23 Bristol Myers Squibb Co Compostos cìclicos fundidos como moduladores da função do receptor para homÈnio nuclear
US7018993B2 (en) 2000-06-30 2006-03-28 Chugai Seiyaku Kabushiki Kaisha Antiandrogenic agent
AU2001269943B2 (en) * 2000-09-19 2006-11-09 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7214690B2 (en) 2001-02-23 2007-05-08 Ligand Pharmaceuticals Incorporated Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
US7026484B2 (en) 2001-02-23 2006-04-11 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
JP2005509629A (ja) * 2001-10-19 2005-04-14 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレーターおよびその使用方法
WO2003057669A1 (fr) * 2001-12-28 2003-07-17 Takeda Chemical Industries, Ltd. Antagonistes du recepteur androgene
EP1487458B1 (de) 2002-02-28 2011-11-16 University Of Tennessee Research Foundation Mehrfach substituierte selektive androgen-rezeptor-modulatoren und anwendungsverfahren dafür
CA2484340C (en) 2002-04-26 2011-05-03 Ortho-Mcneil Pharmaceutical, Inc. 2-(quinolonyl)-fused heterocycles as androgen receptor modulators
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
DE20301728U1 (de) 2002-10-11 2004-03-11 Ligand Pharmaceuticals, Inc., San Diego 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen
EP1567487A4 (de) 2002-11-15 2005-11-16 Bristol Myers Squibb Co Offenkettige, mit prolylharnstoff verwandtemodulatoren der androgenrezeptorfunktion
CA2511089A1 (en) * 2003-01-17 2004-08-05 Warner-Lambert Company Llc Androgen receptor antagonists
BRPI0413820A (pt) 2003-08-22 2006-10-24 Ligand Pharm Inc derivados de 6-cicloamino-2-quinolinona como compostos moduladores de receptor de androgênio
US7256208B2 (en) 2003-11-13 2007-08-14 Bristol-Myers Squibb Company Monocyclic N-Aryl hydantoin modulators of androgen receptor function
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7388027B2 (en) 2004-03-04 2008-06-17 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
WO2005090282A1 (en) 2004-03-12 2005-09-29 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
CA2642154A1 (en) * 2006-02-10 2007-08-16 Janssen Pharmaceutica N.V. Novel imidazolopyrazole derivatives useful as selective androgen receptor modulators
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
ES2488990T3 (es) 2008-02-22 2014-09-01 Radius Health, Inc. Moduladores selectivos del receptor de andrógenos
EP2130831A1 (de) 2008-06-06 2009-12-09 InterMed Discovery GmbH CDC25-Hemmer
JP5664870B2 (ja) * 2009-04-30 2015-02-04 日産化学工業株式会社 ３環性ベンゾピラン化合物の新規な結晶形態及びその製造方法
MX338831B (es) 2010-02-04 2016-05-03 Radius Health Inc Moduladores selectivos de receptores de androgenos.
PT2568806T (pt) 2010-05-12 2016-08-05 Radius Health Inc Regimes terapêuticos
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
WO2012047617A1 (en) 2010-09-28 2012-04-12 Radius Health, Inc. Selective androgen receptor modulators
CN103442737B (zh) 2011-01-20 2017-03-29 得克萨斯系统大学董事会 Mri标记、递送和提取系统及其制造方法和用途
FI3122426T3 (fi) 2014-03-28 2023-03-31 Univ Duke Rintasyövän hoitaminen käyttäen selektiivisiä estrogeenin reseptorin modulaattoreita
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
EP4066827A1 (de) 2016-06-22 2022-10-05 Ellipses Pharma Ltd Verfahren zur behandlung von ar+-brustkrebs
CN106397317B (zh) * 2016-09-26 2019-03-22 天津师范大学 1,2,3,4-四氢喹啉化合物及其合成方法与应用
CN106565723B (zh) * 2016-11-04 2019-08-27 江苏师范大学 一种呋喃并吡啶、苯并吡啶类衍生化合物的制备方法
EP3565542B1 (de) 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Polymorphe formen von rad1901-2hcl

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0181264B1 (ko) * 1989-07-07 1999-03-20 라브리 페르낭 성스테로이드 활성 억제용 안드로겐 유도체
US5677336A (en) * 1993-10-21 1997-10-14 Ligand Pharmaceuticals Incorporated Non-steroid androgen receptor antagonist compounds and methods
HUT78117A (hu) * 1994-12-22 1999-11-29 Ligand Pharmaceuticals Incorporated Szteroid receptor modulátor kinolin- és kondenzált kinolinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények

Also Published As

Publication number Publication date
EP0918774A1 (de) 1999-06-02
NO986100L (no) 1998-12-23
WO1997049709A1 (en) 1997-12-31
NO986100D0 (no) 1998-12-23
DK0918774T3 (da) 2002-05-21
ATE209207T1 (de) 2001-12-15
JP2000513362A (ja) 2000-10-10
EP0918774B9 (de) 2002-04-10
AU728178B2 (en) 2001-01-04
RU2214412C2 (ru) 2003-10-20
ES2168650T3 (es) 2002-06-16
AU3508497A (en) 1998-01-14
PT918774E (pt) 2002-05-31
EP0918774B1 (de) 2001-11-21
BR9710988A (pt) 2002-01-15
DE69709752D1 (de) 2002-02-21
NO311645B1 (no) 2001-12-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee