WO2000066590A3 - Tetracyclic progesterone receptor modulator compounds and methods - Google Patents
Tetracyclic progesterone receptor modulator compounds and methods Download PDFInfo
- Publication number
- WO2000066590A3 WO2000066590A3 PCT/US2000/011750 US0011750W WO0066590A3 WO 2000066590 A3 WO2000066590 A3 WO 2000066590A3 US 0011750 W US0011750 W US 0011750W WO 0066590 A3 WO0066590 A3 WO 0066590A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- progesterone receptor
- methods
- receptor modulator
- tetracyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000615620A JP2002543204A (en) | 1999-05-04 | 2000-05-01 | Tetracyclic progesterone receptor modulatory compounds and methods |
AU45018/00A AU4501800A (en) | 1999-05-04 | 2000-05-01 | Tetracyclic progesterone receptor modulator compounds and methods |
EP00926495A EP1175422A2 (en) | 1999-05-04 | 2000-05-01 | Tetracyclic progesterone receptor modulator compounds and methods |
CA002371273A CA2371273A1 (en) | 1999-05-04 | 2000-05-01 | Tetracyclic progesterone receptor modulator compounds and methods |
MXPA01011294A MXPA01011294A (en) | 1999-05-04 | 2000-05-01 | Tetracyclic progesterone receptor modulator compounds and methods. |
HK02104861.6A HK1043788A1 (en) | 1999-05-04 | 2002-06-28 | Tetracyclic progesterone receptor modulator compounds and methods |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30461499A | 1999-05-04 | 1999-05-04 | |
US09/552,353 | 2000-04-19 | ||
US09/552,353 US6358947B1 (en) | 1999-05-04 | 2000-04-19 | Tetracyclic progesterone receptor modulator compounds and methods |
US60/183,044 | 2000-04-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000066590A2 WO2000066590A2 (en) | 2000-11-09 |
WO2000066590A3 true WO2000066590A3 (en) | 2001-02-08 |
Family
ID=26974128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/011750 WO2000066590A2 (en) | 1999-05-04 | 2000-05-01 | Tetracyclic progesterone receptor modulator compounds and methods |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1175422A2 (en) |
CN (1) | CN1353717A (en) |
AU (1) | AU4501800A (en) |
CA (1) | CA2371273A1 (en) |
HK (1) | HK1043788A1 (en) |
WO (1) | WO2000066590A2 (en) |
Families Citing this family (61)
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ES2295050T3 (en) * | 1999-08-31 | 2008-04-16 | Bayer Schering Pharma Aktiengesellschaft | MESOPROGESTINES FOR THE TREATMENT AND PREVENTION OF BENEFIT DEPENDENT GYNECOLOGICAL DISORDERS OF HORMONES. |
CN1384748A (en) * | 1999-08-31 | 2002-12-11 | 耶拿制药两合公司 | Mesoprogestins (progesterone receptor modulators) as component of female contraceptives |
US8193252B1 (en) | 1999-08-31 | 2012-06-05 | Bayer Pharma AG | Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders |
HK1055058A2 (en) | 2002-10-11 | 2003-12-05 | Ligand Pharm Inc | 5-CYCLOALKENYL 5H-CHROMENO[3,4-f]QUINOLINE DERIVATIVES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS |
AR040783A1 (en) | 2002-10-11 | 2005-04-20 | Ligand Pharm Inc | 5- (1 ', 1'-CYCLOAQUIL / ALQUENIL) METHYLIDEN-1,2-DIHYDRO-5-H-CHROMENE [3,4- F] CHIINOLINES AS SELECTING MODULATING COMPOUNDS OF PROGESTERONE RECEPTORS |
GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
US8519158B2 (en) | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
PE20060272A1 (en) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2R, 3R, 4S, 5R, 2'R, 3'R, 4'S, 5'S) -2.2 '- {TRANS-1,4-CYCLOHEXANODIYLBIS- [IMINO (2 - {[2- (1-METHYL- 1H-IMIDAZOL-4-IL) ETHYL] AMINO} -9H-PURIN-6,9-DIYL)]} BIS [5- (2-ETHYL-2H-TETRAZOLE-5-IL) TETRAHYDRO-3,4-FURANODIOL] AS AN A2A AGONIST |
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DE102005030294A1 (en) * | 2005-06-24 | 2007-01-04 | Schering Ag | Nonsteroidal progesterone receptor modulators |
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EP2408458A1 (en) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (STAT6) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
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WO2010111464A1 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
EP2411520A2 (en) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE THYMIC STROMAL LYMPHOPOIETIN (TSLP) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US20120004281A1 (en) | 2009-03-27 | 2012-01-05 | Merck Sharp & Dohme Corp | RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
WO2010111471A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US20100273744A1 (en) | 2009-04-24 | 2010-10-28 | Paul Martin Gore | Compounds |
WO2010122088A1 (en) | 2009-04-24 | 2010-10-28 | Glaxo Group Limited | Pyrazole and triazole carboxamides as crac channel inhibitors |
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JP2013512879A (en) | 2009-12-03 | 2013-04-18 | グラクソ グループ リミテッド | Benzpyrazole derivatives as inhibitors of PI3 kinase |
EP2512438B1 (en) | 2009-12-16 | 2017-01-25 | 3M Innovative Properties Company | Formulations and methods for controlling mdi particle size delivery |
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KR20160062178A (en) | 2013-10-17 | 2016-06-01 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Pi3k inhibitor for treatment of respiratory disease |
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EP3122730B1 (en) | 2014-03-28 | 2020-03-25 | Calitor Sciences, LLC | Substituted heteroaryl compounds and methods of use |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996019458A2 (en) * | 1994-12-22 | 1996-06-27 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
US5688808A (en) * | 1994-12-22 | 1997-11-18 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
-
2000
- 2000-05-01 CA CA002371273A patent/CA2371273A1/en not_active Abandoned
- 2000-05-01 EP EP00926495A patent/EP1175422A2/en not_active Ceased
- 2000-05-01 CN CN00808438A patent/CN1353717A/en active Pending
- 2000-05-01 WO PCT/US2000/011750 patent/WO2000066590A2/en not_active Application Discontinuation
- 2000-05-01 AU AU45018/00A patent/AU4501800A/en not_active Abandoned
-
2002
- 2002-06-28 HK HK02104861.6A patent/HK1043788A1/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996019458A2 (en) * | 1994-12-22 | 1996-06-27 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
US5688808A (en) * | 1994-12-22 | 1997-11-18 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
US5693646A (en) * | 1994-12-22 | 1997-12-02 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
US5693647A (en) * | 1994-12-22 | 1997-12-02 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
Also Published As
Publication number | Publication date |
---|---|
CN1353717A (en) | 2002-06-12 |
WO2000066590A2 (en) | 2000-11-09 |
HK1043788A1 (en) | 2002-09-27 |
EP1175422A2 (en) | 2002-01-30 |
CA2371273A1 (en) | 2000-11-09 |
AU4501800A (en) | 2000-11-17 |
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