CA2259031A1 - Androgen receptor modulator compounds and methods - Google Patents

Androgen receptor modulator compounds and methods

Info

Publication number
CA2259031A1
CA2259031A1 CA002259031A CA2259031A CA2259031A1 CA 2259031 A1 CA2259031 A1 CA 2259031A1 CA 002259031 A CA002259031 A CA 002259031A CA 2259031 A CA2259031 A CA 2259031A CA 2259031 A1 CA2259031 A1 CA 2259031A1
Authority
CA
Canada
Prior art keywords
compounds
androgen receptor
methods
receptor modulator
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002259031A
Other languages
French (fr)
Other versions
CA2259031C (en
Inventor
James P. Edwards
Robert Higuchi
Todd Jones
Lawrence G. Hamann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1997/011222 external-priority patent/WO1997049709A1/en
Publication of CA2259031A1 publication Critical patent/CA2259031A1/en
Application granted granted Critical
Publication of CA2259031C publication Critical patent/CA2259031C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Non-steroidal compounds which are high affinity, high selectivity modulators for androgen receptors are disclosed, having the formula:
(see formula I, III, IV, V) (see formula VI) Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring androgen receptor agonist, partial agonist or antagonist therapy, intermediates usefully in the preparation of the compounds and processes for the preparation of the androgen receptor modulator compounds.
CA002259031A 1996-06-27 1997-06-26 Androgen receptor modulator compounds and methods Expired - Fee Related CA2259031C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2199796P 1996-06-27 1996-06-27
US60/021,997 1996-06-27
PCT/US1997/011222 WO1997049709A1 (en) 1996-06-27 1997-06-26 Androgen receptor modulator compounds and methods

Publications (2)

Publication Number Publication Date
CA2259031A1 true CA2259031A1 (en) 1997-12-31
CA2259031C CA2259031C (en) 2006-10-24

Family

ID=37388423

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002259031A Expired - Fee Related CA2259031C (en) 1996-06-27 1997-06-26 Androgen receptor modulator compounds and methods

Country Status (1)

Country Link
CA (1) CA2259031C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727980B2 (en) 2001-02-23 2010-06-01 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727980B2 (en) 2001-02-23 2010-06-01 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods

Also Published As

Publication number Publication date
CA2259031C (en) 2006-10-24

Similar Documents

Publication Publication Date Title
AU3508497A (en) Androgen receptor modulator compounds and methods
AU4597796A (en) Steroid receptor modulator compounds and methods
MX9704640A (en) Steroid receptor modulator compounds and methods.
WO2000066590A3 (en) Tetracyclic progesterone receptor modulator compounds and methods
AU7362496A (en) Dimer-selective rxr modulators and methods for their use
CA2164689A1 (en) NK-1 Receptor Antagonists and 5HT3 Receptor Antagonists for the Treatment of Emesis
CA2202513A1 (en) Allosteric modulators of the nmda receptor
HUP9901244A3 (en) 3-pyrazolecarboxamide derivatives having cannabinoid receptor affinity, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds
UA66750C2 (en) Substituted 1-phenylpirazole 3-carboxamides, a method for the preparation thereof and intermediary compounds, pharmaceutical composition having affinity to neurotensin receptors
CA2237582A1 (en) Use of 5ht4 receptor antagonists for overcoming gastrointestinal effects of serotonin reuptake inhibitors
WO1998058911A3 (en) Prostaglandin agonists
CA2325739A1 (en) Combination for the treatment of alcohol and drug dependence containing an opioid antagonist and a nmda receptor complex modulator
CA2338066A1 (en) Treatment of dyskinesia
BG102229A (en) Endothelium receptor antagonists
CA2259031A1 (en) Androgen receptor modulator compounds and methods
HUP0000489A3 (en) Sulfonamide compounds having 5-ht receptor activity, process for their preparation and pharmaceutical compositions containing the same
AU3476599A (en) Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression (5-ht1 receptor antagonists)
AU1356299A (en) New compounds which are p2-purinoceptor 7-transmembrane (tm) g-protein coupled receptor antagonists
WO2001071346A3 (en) Binding compounds for cc chemokine receptor 5 and methods for identifying them
AU4448497A (en) Novel 6 or 7 substituted analogues of swainsonine, processes for their preparation and their use as therapeutic agents
NO924190L (en) PROCEDURE FOR THE PREPARATION OF HOMOGENEOUS, FINE, POWDER-SHEET SOLID DISPERSIONS WHICH MAY INCLUDE EFFECTIVE SUBSTANCES
HUP9802040A3 (en) Phenoxyethylamine derivatives having high affinity for the 5-ht1a receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said compounds
MX9707832A (en) 1-phenylpyrazole-3-carboxamides acting on neurotensin receptors.
RU93046495A (en) HETEROCYCLIC COMPOUNDS, INTERMEDIATE COMPOUNDS, METHOD OF OBTAINING AND PHARMACEUTICAL COMPOSITION

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed