WO2000042031A3 - Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents - Google Patents

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents Download PDF

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Publication number
WO2000042031A3
WO2000042031A3 PCT/US1999/029601 US9929601W WO0042031A3 WO 2000042031 A3 WO2000042031 A3 WO 2000042031A3 US 9929601 W US9929601 W US 9929601W WO 0042031 A3 WO0042031 A3 WO 0042031A3
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WO
WIPO (PCT)
Prior art keywords
arylimino
progesterone receptor
substituted
compositions containing
receptor binding
Prior art date
Application number
PCT/US1999/029601
Other languages
French (fr)
Other versions
WO2000042031A2 (en
Inventor
Brian R Dixon
Cedo M Bagi
Catherine R Brennan
David R Brittelli
William H Bullock
Jinshan Chen
William L Collibee
Robert Dally
Jeffrey S Johnson
Harold C E Kluender
William F Lathrop
Peiying Liu
Carol Ann Mase
Aniko M Redman
William J Scott
Klaus Urbahns
John J Wolanin
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2000593599A priority Critical patent/JP2002534517A/en
Application filed by Bayer Ag filed Critical Bayer Ag
Priority to BR9916999-1A priority patent/BR9916999A/en
Priority to AU27087/00A priority patent/AU2708700A/en
Priority to SK1003-2001A priority patent/SK10032001A3/en
Priority to CA002359562A priority patent/CA2359562A1/en
Priority to KR1020017008891A priority patent/KR20010089831A/en
Priority to HU0105134A priority patent/HUP0105134A2/en
Priority to EP99968883A priority patent/EP1144396A2/en
Priority to IL14403199A priority patent/IL144031A0/en
Publication of WO2000042031A2 publication Critical patent/WO2000042031A2/en
Publication of WO2000042031A3 publication Critical patent/WO2000042031A3/en
Priority to NO20013318A priority patent/NO20013318L/en
Priority to BG105761A priority patent/BG105761A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Abstract

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1, 3-thiazolidines, 2-arylimino-2, 3, 4, 5-tetrahydro-1, 3-thiazines, 2-arylimino-1, 3-thiazolidin-4-ones, 2-arylimino-1, 3-thiazolidin-5-ones, and 2-arylimino-1, 3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.
PCT/US1999/029601 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents WO2000042031A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
KR1020017008891A KR20010089831A (en) 1999-01-14 1999-12-14 Substituted 2-Arylimino Heterocycles and Compositions Containing Them, for Use as Progesterone Receptor Binding Agents
BR9916999-1A BR9916999A (en) 1999-01-14 1999-12-14 Substituted 2-arylimine heterocycles and compositions containing them, for use as progesterone receptor binding agents
AU27087/00A AU2708700A (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
SK1003-2001A SK10032001A3 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
CA002359562A CA2359562A1 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
JP2000593599A JP2002534517A (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles for use as progesterone receptor binders and compositions containing them
HU0105134A HUP0105134A2 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
EP99968883A EP1144396A2 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
IL14403199A IL144031A0 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
NO20013318A NO20013318L (en) 1999-01-14 2001-07-04 Substituted 2-arylimino heterocyclic compounds and preparations containing them for use
BG105761A BG105761A (en) 1999-01-14 2001-08-01 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23190699A 1999-01-14 1999-01-14
US09/231,906 1999-01-14

Publications (2)

Publication Number Publication Date
WO2000042031A2 WO2000042031A2 (en) 2000-07-20
WO2000042031A3 true WO2000042031A3 (en) 2000-11-09

Family

ID=22871101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/029601 WO2000042031A2 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

Country Status (21)

Country Link
EP (1) EP1144396A2 (en)
JP (1) JP2002534517A (en)
KR (1) KR20010089831A (en)
CN (1) CN1337955A (en)
AR (1) AR022214A1 (en)
AU (1) AU2708700A (en)
BG (1) BG105761A (en)
BR (1) BR9916999A (en)
CA (1) CA2359562A1 (en)
CO (1) CO5160338A1 (en)
CZ (1) CZ20012530A3 (en)
GT (1) GT200000003A (en)
HU (1) HUP0105134A2 (en)
ID (1) ID30514A (en)
IL (1) IL144031A0 (en)
NO (1) NO20013318L (en)
SK (1) SK10032001A3 (en)
SV (1) SV2002000005A (en)
TR (1) TR200102041T2 (en)
WO (1) WO2000042031A2 (en)
ZA (1) ZA200105253B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2295050T3 (en) * 1999-08-31 2008-04-16 Bayer Schering Pharma Aktiengesellschaft MESOPROGESTINES FOR THE TREATMENT AND PREVENTION OF BENEFIT DEPENDENT GYNECOLOGICAL DISORDERS OF HORMONES.
US8193252B1 (en) 1999-08-31 2012-06-05 Bayer Pharma AG Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
RS50396B (en) * 1999-08-31 2009-12-31 Bayer Schering Pharma Aktiengesellschaft, Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
KR100509401B1 (en) * 1999-09-14 2005-08-22 시오노기세이야쿠가부시키가이샤 2-imino-1,3-thiazine derivatives
WO2001072723A1 (en) * 2000-03-28 2001-10-04 Nippon Soda Co.,Ltd. Oxa(thia)zolidine derivative and anti-inflammatory drug
US20030229072A1 (en) * 2000-09-07 2003-12-11 Bullock William H Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binning agents
JP4188694B2 (en) 2001-03-08 2008-11-26 塩野義製薬株式会社 Pharmaceutical composition containing a 1,3-thiazine derivative
EP1410822A4 (en) 2001-06-25 2007-06-20 Nippon Soda Co Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents
ES2367539T3 (en) 2001-12-21 2011-11-04 X-Ceptor Therapeutics, Inc. HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS.
US20060142387A1 (en) * 2003-06-10 2006-06-29 Rodolfo Cadilla Chemical compounds
CN103382158B (en) * 2013-07-29 2015-11-18 张家港市大伟助剂有限公司 A kind of preparation method of 2-clopentylamino ethanol
MX2022000427A (en) * 2019-07-10 2022-02-10 Bayer Ag Process of preparing 2-(phenylimino)-1,3-thiazolidin-4-ones.
CN114507143A (en) * 2022-02-26 2022-05-17 江苏壹药新材料有限公司 Synthesis method of 2-ethyl-1-fluoro-4-nitrobenzene
CN114671828A (en) * 2022-04-28 2022-06-28 蔚林新材料科技股份有限公司 Preparation method of 3-methyl-2-thiazolethione
CN114957288B (en) * 2022-06-07 2024-02-13 苏州华道生物药业股份有限公司 Synthesis method of tetramisole hydrochloride
CN115925559A (en) * 2022-11-11 2023-04-07 上海泰坦科技股份有限公司 Preparation method of 1-amino-1-cyclopentyl methanol

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FR1510015A (en) * 1966-12-05 1968-01-19 Aquitaine Petrole Preparation of imino-thiazolidines
GB1140776A (en) * 1966-09-27 1969-01-22 Bayer Ag 2-phenylimino-2-oxazolidines and their production
US3651053A (en) * 1968-04-27 1972-03-21 Bayer Ag 1 3-thiazines
FR2117337A5 (en) * 1970-12-04 1972-07-21 Eastman Kodak Co Merocyanine dye sensitisers - contg basic and acidic gps for silver halide emulsions
US3686199A (en) * 1969-12-17 1972-08-22 Bayer Ag N-substituted-2-arylimino oxazolidines
GB1342232A (en) * 1971-07-29 1974-01-03 Bayer Ag Aryliminothiazolidines a process for their preparation and their use as acaricides
US3787575A (en) * 1970-12-17 1974-01-22 Bayer Ag N-substituted-2-arylimino-oxazolidines used as acaricides
US4079144A (en) * 1975-05-07 1978-03-14 Ciba-Geigy Corporation Phenylimino-thiazolines and their use as acaricides
DE2658138A1 (en) * 1976-12-22 1978-07-06 Bayer Ag 2-Phenyl-imino-4-hydroxy-thiazolidine derivs. - useful as ectoparasiticides, esp. against acarids
EP0055458A2 (en) * 1980-12-30 1982-07-07 Hoechst Aktiengesellschaft Thiazoline derivatives, their preparation and use and pharmaceutical preparations containing them
US4346088A (en) * 1979-07-03 1982-08-24 Hoechst Aktiengesellschaft Thiazoline derivatives
DE3505432A1 (en) * 1985-02-16 1986-08-21 Hoechst Ag, 6230 Frankfurt Crop protection agents and pesticides based on thiazolidine derivatives, novel thiazolidine derivatives, and their preparation
EP0265162A1 (en) * 1986-10-17 1988-04-27 Stauffer Chemical Company Iminooxazolidines, process of preparation and method of use
EP0270138A1 (en) * 1986-11-04 1988-06-08 Duphar International Research B.V Substituted 2-phenylimino-oxazolidine compounds having herbicidal activity
US4806653A (en) * 1986-10-17 1989-02-21 Stauffer Chemical Company Process for preparation of iminooxazolidines
WO1989004595A2 (en) * 1987-11-19 1989-06-01 The Upjohn Company Ectoparasiticides

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Publication number Priority date Publication date Assignee Title
GB1140776A (en) * 1966-09-27 1969-01-22 Bayer Ag 2-phenylimino-2-oxazolidines and their production
FR1510015A (en) * 1966-12-05 1968-01-19 Aquitaine Petrole Preparation of imino-thiazolidines
US3651053A (en) * 1968-04-27 1972-03-21 Bayer Ag 1 3-thiazines
US3737536A (en) * 1968-04-27 1973-06-05 Bayer Ag Anaesthetic compositions for and use in animals
US3686199A (en) * 1969-12-17 1972-08-22 Bayer Ag N-substituted-2-arylimino oxazolidines
FR2117337A5 (en) * 1970-12-04 1972-07-21 Eastman Kodak Co Merocyanine dye sensitisers - contg basic and acidic gps for silver halide emulsions
US3787575A (en) * 1970-12-17 1974-01-22 Bayer Ag N-substituted-2-arylimino-oxazolidines used as acaricides
GB1342232A (en) * 1971-07-29 1974-01-03 Bayer Ag Aryliminothiazolidines a process for their preparation and their use as acaricides
US4079144A (en) * 1975-05-07 1978-03-14 Ciba-Geigy Corporation Phenylimino-thiazolines and their use as acaricides
DE2658138A1 (en) * 1976-12-22 1978-07-06 Bayer Ag 2-Phenyl-imino-4-hydroxy-thiazolidine derivs. - useful as ectoparasiticides, esp. against acarids
US4346088A (en) * 1979-07-03 1982-08-24 Hoechst Aktiengesellschaft Thiazoline derivatives
EP0055458A2 (en) * 1980-12-30 1982-07-07 Hoechst Aktiengesellschaft Thiazoline derivatives, their preparation and use and pharmaceutical preparations containing them
DE3505432A1 (en) * 1985-02-16 1986-08-21 Hoechst Ag, 6230 Frankfurt Crop protection agents and pesticides based on thiazolidine derivatives, novel thiazolidine derivatives, and their preparation
EP0265162A1 (en) * 1986-10-17 1988-04-27 Stauffer Chemical Company Iminooxazolidines, process of preparation and method of use
US4806653A (en) * 1986-10-17 1989-02-21 Stauffer Chemical Company Process for preparation of iminooxazolidines
EP0270138A1 (en) * 1986-11-04 1988-06-08 Duphar International Research B.V Substituted 2-phenylimino-oxazolidine compounds having herbicidal activity
WO1989004595A2 (en) * 1987-11-19 1989-06-01 The Upjohn Company Ectoparasiticides

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BG105761A (en) 2002-03-29
NO20013318L (en) 2001-08-30
TR200102041T2 (en) 2001-12-21
GT200000003A (en) 2001-07-06
CN1337955A (en) 2002-02-27
CZ20012530A3 (en) 2002-02-13
AU2708700A (en) 2000-08-01
IL144031A0 (en) 2002-04-21
ID30514A (en) 2001-12-13
KR20010089831A (en) 2001-10-08
HUP0105134A2 (en) 2002-04-29
ZA200105253B (en) 2002-09-05
AR022214A1 (en) 2002-09-04
CO5160338A1 (en) 2002-05-30
JP2002534517A (en) 2002-10-15
EP1144396A2 (en) 2001-10-17
SV2002000005A (en) 2002-07-16
CA2359562A1 (en) 2000-07-20
SK10032001A3 (en) 2002-05-09
BR9916999A (en) 2001-10-30
WO2000042031A2 (en) 2000-07-20
NO20013318D0 (en) 2001-07-04

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