HUP0105134A2 - Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents - Google Patents

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

Info

Publication number
HUP0105134A2
HUP0105134A2 HU0105134A HUP0105134A HUP0105134A2 HU P0105134 A2 HUP0105134 A2 HU P0105134A2 HU 0105134 A HU0105134 A HU 0105134A HU P0105134 A HUP0105134 A HU P0105134A HU P0105134 A2 HUP0105134 A2 HU P0105134A2
Authority
HU
Hungary
Prior art keywords
arylimino
substituted
compositions containing
receptor binding
binding agents
Prior art date
Application number
HU0105134A
Other languages
Hungarian (hu)
Inventor
Cedo M. Bagi
Catherine R. Brennan
David R. Brittelli
William H. Bullock
Jinshan Chen
William L. Collibee
Robert Dally
Brian R. Dixon
Jeffrey S. Johnson
Harold C. E. Kluender
William F. Lathrop
Peiying Liu
Carol Ann Mase
Aniko M. Redman
William J. Scott
Klaus Urbahns
Donald J. Wolanin
Original Assignee
Bayer Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corporation filed Critical Bayer Corporation
Publication of HUP0105134A2 publication Critical patent/HUP0105134A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Abstract

A tal lm ny 2-amino-heterociklusos vegyületekre, k"ztük 2-arilimino-1,3-tiazolidinok, 2-arilimino-2,3,4,5-tetrahidro-1,3-tiazinok, 2-arilimino-1,3-tiazolidin-4-onok, 2-arilimino-tiazolidin-5-onok és 2-arilamino-1,3-oxazolidinokra vonatkozik, valamint ezek alkalmaz s raprogeszteron receptor medi lt folyamatok modul l s ra. A tal lm nyk"rébe tartoznak tov bb az ilyen vegyületeket tartalmazó gyógy szatikészítmények is. ÓThese include 2-amino-heterocyclic compounds, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1, It applies to 3-thiazolidin-4-ones, 2-arylimino-thiazolidin-5-ones and 2-arylamino-1,3-oxazolidines, and they are used to modulate raprogesterone receptor-mediated processes. bb also medicinal preparations containing such compounds. HE

HU0105134A 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents HUP0105134A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23190699A 1999-01-14 1999-01-14
PCT/US1999/029601 WO2000042031A2 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

Publications (1)

Publication Number Publication Date
HUP0105134A2 true HUP0105134A2 (en) 2002-04-29

Family

ID=22871101

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105134A HUP0105134A2 (en) 1999-01-14 1999-12-14 Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

Country Status (21)

Country Link
EP (1) EP1144396A2 (en)
JP (1) JP2002534517A (en)
KR (1) KR20010089831A (en)
CN (1) CN1337955A (en)
AR (1) AR022214A1 (en)
AU (1) AU2708700A (en)
BG (1) BG105761A (en)
BR (1) BR9916999A (en)
CA (1) CA2359562A1 (en)
CO (1) CO5160338A1 (en)
CZ (1) CZ20012530A3 (en)
GT (1) GT200000003A (en)
HU (1) HUP0105134A2 (en)
ID (1) ID30514A (en)
IL (1) IL144031A0 (en)
NO (1) NO20013318L (en)
SK (1) SK10032001A3 (en)
SV (1) SV2002000005A (en)
TR (1) TR200102041T2 (en)
WO (1) WO2000042031A2 (en)
ZA (1) ZA200105253B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2295050T3 (en) * 1999-08-31 2008-04-16 Bayer Schering Pharma Aktiengesellschaft MESOPROGESTINES FOR THE TREATMENT AND PREVENTION OF BENEFIT DEPENDENT GYNECOLOGICAL DISORDERS OF HORMONES.
US8193252B1 (en) 1999-08-31 2012-06-05 Bayer Pharma AG Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
RS50396B (en) * 1999-08-31 2009-12-31 Bayer Schering Pharma Aktiengesellschaft, Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
KR100509401B1 (en) * 1999-09-14 2005-08-22 시오노기세이야쿠가부시키가이샤 2-imino-1,3-thiazine derivatives
WO2001072723A1 (en) * 2000-03-28 2001-10-04 Nippon Soda Co.,Ltd. Oxa(thia)zolidine derivative and anti-inflammatory drug
US20030229072A1 (en) * 2000-09-07 2003-12-11 Bullock William H Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binning agents
JP4188694B2 (en) 2001-03-08 2008-11-26 塩野義製薬株式会社 Pharmaceutical composition containing a 1,3-thiazine derivative
EP1410822A4 (en) 2001-06-25 2007-06-20 Nippon Soda Co Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents
ES2367539T3 (en) 2001-12-21 2011-11-04 X-Ceptor Therapeutics, Inc. HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS.
US20060142387A1 (en) * 2003-06-10 2006-06-29 Rodolfo Cadilla Chemical compounds
CN103382158B (en) * 2013-07-29 2015-11-18 张家港市大伟助剂有限公司 A kind of preparation method of 2-clopentylamino ethanol
MX2022000427A (en) * 2019-07-10 2022-02-10 Bayer Ag Process of preparing 2-(phenylimino)-1,3-thiazolidin-4-ones.
CN114507143A (en) * 2022-02-26 2022-05-17 江苏壹药新材料有限公司 Synthesis method of 2-ethyl-1-fluoro-4-nitrobenzene
CN114671828A (en) * 2022-04-28 2022-06-28 蔚林新材料科技股份有限公司 Preparation method of 3-methyl-2-thiazolethione
CN114957288B (en) * 2022-06-07 2024-02-13 苏州华道生物药业股份有限公司 Synthesis method of tetramisole hydrochloride
CN115925559A (en) * 2022-11-11 2023-04-07 上海泰坦科技股份有限公司 Preparation method of 1-amino-1-cyclopentyl methanol

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670754A1 (en) * 1966-09-27 1970-12-23 Bayer Ag Process for the preparation of 2-phenylimino-oxazolidines
FR1510015A (en) * 1966-12-05 1968-01-19 Aquitaine Petrole Preparation of imino-thiazolidines
DE1767335A1 (en) * 1968-04-27 1971-09-02 Bayer Ag Anesthetic for animals
DE1963193A1 (en) * 1969-12-17 1971-06-24 Bayer Ag N-substituted 2-arylimino-oxazolidines, process for their preparation and their use as ectoparasiticides
FR2117337A5 (en) * 1970-12-04 1972-07-21 Eastman Kodak Co Merocyanine dye sensitisers - contg basic and acidic gps for silver halide emulsions
US3787575A (en) * 1970-12-17 1974-01-22 Bayer Ag N-substituted-2-arylimino-oxazolidines used as acaricides
GB1342232A (en) * 1971-07-29 1974-01-03 Bayer Ag Aryliminothiazolidines a process for their preparation and their use as acaricides
CH614946A5 (en) * 1975-05-07 1979-12-28 Ciba Geigy Ag
DE2658138A1 (en) * 1976-12-22 1978-07-06 Bayer Ag 2-Phenyl-imino-4-hydroxy-thiazolidine derivs. - useful as ectoparasiticides, esp. against acarids
DE2926771A1 (en) * 1979-07-03 1981-01-15 Hoechst Ag THIAZOLIDE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
DE3049460A1 (en) * 1980-12-30 1982-07-29 Hoechst Ag, 6000 Frankfurt "THIAZOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS
DE3505432A1 (en) * 1985-02-16 1986-08-21 Hoechst Ag, 6230 Frankfurt Crop protection agents and pesticides based on thiazolidine derivatives, novel thiazolidine derivatives, and their preparation
US4806653A (en) * 1986-10-17 1989-02-21 Stauffer Chemical Company Process for preparation of iminooxazolidines
DE3768416D1 (en) * 1986-10-17 1991-04-11 Stauffer Chemical Co IMINOOXAZOLIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF.
DE3770419D1 (en) * 1986-11-04 1991-07-04 Duphar Int Res SUBSTITUTED 2-PHENYLIMINO-OXAZOLIDIN DERIVATIVES WITH HERBICIDAL EFFECT.
WO1989004595A2 (en) * 1987-11-19 1989-06-01 The Upjohn Company Ectoparasiticides

Also Published As

Publication number Publication date
BG105761A (en) 2002-03-29
NO20013318L (en) 2001-08-30
TR200102041T2 (en) 2001-12-21
GT200000003A (en) 2001-07-06
CN1337955A (en) 2002-02-27
CZ20012530A3 (en) 2002-02-13
AU2708700A (en) 2000-08-01
IL144031A0 (en) 2002-04-21
ID30514A (en) 2001-12-13
KR20010089831A (en) 2001-10-08
ZA200105253B (en) 2002-09-05
AR022214A1 (en) 2002-09-04
CO5160338A1 (en) 2002-05-30
JP2002534517A (en) 2002-10-15
WO2000042031A3 (en) 2000-11-09
EP1144396A2 (en) 2001-10-17
SV2002000005A (en) 2002-07-16
CA2359562A1 (en) 2000-07-20
SK10032001A3 (en) 2002-05-09
BR9916999A (en) 2001-10-30
WO2000042031A2 (en) 2000-07-20
NO20013318D0 (en) 2001-07-04

Similar Documents

Publication Publication Date Title
HUP0105134A2 (en) Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
ATE429210T1 (en) ORAL LIQUID COMPOSITIONS
GEP20033025B (en) 4,4-Biarylpiperidine Derivatives with Opioid Receptor Activity
PT73879B (en) 1-CARBOXYALKANOYLINDOLINE-2-CARBONIC ACIDS PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINED THESE COMPOUNDS AND THERAPEUTIC USE THEREOF
DE69327536D1 (en) FIBRINOGEN RECEPTOR ANTAGONISTS
MY125651A (en) Eplerenone compositions
TR199901411T2 (en) New compositions with analgesic effect.
SE9504661D0 (en) New compounds
ATE330959T1 (en) ALLOSTERIC ADENOSINE RECEPTOR MODULATORS
BR9709062A (en) Compound, pharmaceutical composition, and, use of a compound.
SE0102843D0 (en) Stabilized oral pharmaceutical composition containing lodide and lodate and method
BG104930A (en) 2-phenyl-1-[2-(-aminoethoxy)-benzyl]-indole in combination with estrogens
HUP9802865A3 (en) N-(substituted phenyl)-pyrazole-derivatives, preparation and use thereof, parasiticidal compositions containing these compounds as active ingredients
HK1032542A1 (en) Combination for the treatment of alcohol dependence containing an opioid antagonist and nmda receptor complex modulator
AU2797695A (en) Thiazolidine derivatives, their preparation and drugs containing same
TNSN98113A1 (en) PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL FOR THE TREATMENT OF INSULIN RESISTANCE.
YU59400A (en) Azabicyclic 5ht1 receptor ligands
HUP0200055A2 (en) 16-hydroxyestrienes and pharmaceutical compositions containing the same
AU1366802A (en) 3-oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives
DE69612056D1 (en) TERPEN DERIVATIVES (SARCODICTYINE) AS AN ANTICRECELLENT
SE9504662D0 (en) New compounds
EE200900049A (en) Ethin 1 "Pharmaceutical Composition Containing Stradiol and Drospirenone for Use as a Contraceptive
CA2204475A1 (en) Pharmaceutical composition containing stabilized lipophilic matrices for the controlled release of active substances
GEP20043377B (en) Pharmaceutical Complex
DK0981363T3 (en) Somatostatin agonists for reducing body weight