SV2002000005A - 2-ARILIMINE HETEROCICLES SUBSTITUTED AND COMPOSITIONS THAT CONTAIN THEM TO USE AS AGENTS THAT BIND THE PROGESTERONE RECEIVER REF. 5048P1-SV - Google Patents

2-ARILIMINE HETEROCICLES SUBSTITUTED AND COMPOSITIONS THAT CONTAIN THEM TO USE AS AGENTS THAT BIND THE PROGESTERONE RECEIVER REF. 5048P1-SV

Info

Publication number
SV2002000005A
SV2002000005A SV2000000005A SV2000000005A SV2002000005A SV 2002000005 A SV2002000005 A SV 2002000005A SV 2000000005 A SV2000000005 A SV 2000000005A SV 2000000005 A SV2000000005 A SV 2000000005A SV 2002000005 A SV2002000005 A SV 2002000005A
Authority
SV
El Salvador
Prior art keywords
heterocicles
arilimine
bind
compositions
substituted
Prior art date
Application number
SV2000000005A
Other languages
Spanish (es)
Inventor
Brian R Dixon
Catherine Brennan
David R Brittelli
William H Bullock
Jinshan Chen
William L Collibee
Robert Dally
Jeffrey S Johnson
Harold C E Kluender
William F Lathrop
Peiying Liu
Carol Ann Mase
Aniko M Redman
William J Scott
Klaus Urbahns
Donald J Wolanin
Cedo M Bagi
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of SV2002000005A publication Critical patent/SV2002000005A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A HETEROCICLOS 2-ARILIMINO, INCLUYENDO 2-ARILIMINO-1,3-TIAZOLIDINAS, 2-ARILIMINO-2,3,4,5- TETRAHIDRO-1,3-TIAZINAS, 2-ARILIMINO-1,3-TIAZOLIDINA-4-ONAS, 2ARILIMINO-1,3-TIAZOLIDIN-5-ONAS, Y 2-ARILIMINO-1,3-OXAZOLIDINAS, Y SU USO EN LA MODULACION EN LOS PROCESOS MEDIADOS DEL RECEPTOR DE PROGESTERONA, Y PARA USAR EN COMPOSICIONES FARMACEUTICAS EN TALES TERAPIAS.THE INVENTION REFERS TO 2-ARILIMINO HETEROCICLES, INCLUDING 2-ARILIMINO-1,3-TIAZOLIDINS, 2-ARILIMINO-2,3,4,5- TETRAHYDRO-1,3-THIAZINES, 2-ARILIMINO-1,3-THIAZOLIDINE -4-ONAS, 2ARILIMINO-1,3-TIAZOLIDIN-5-ONAS, and 2-ARILIMINO-1,3-OXAZOLIDINAS, AND ITS USE IN THE MODULATION IN THE PROCESSES MEASURED OF THE PROGESTERONE RECEPTOR, AND FOR USE IN PHARMACEUTICAL COMPOSITIONS IN SUCH THERAPIES.

SV2000000005A 1999-01-14 2000-01-13 2-ARILIMINE HETEROCICLES SUBSTITUTED AND COMPOSITIONS THAT CONTAIN THEM TO USE AS AGENTS THAT BIND THE PROGESTERONE RECEIVER REF. 5048P1-SV SV2002000005A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23190699A 1999-01-14 1999-01-14

Publications (1)

Publication Number Publication Date
SV2002000005A true SV2002000005A (en) 2002-07-16

Family

ID=22871101

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2000000005A SV2002000005A (en) 1999-01-14 2000-01-13 2-ARILIMINE HETEROCICLES SUBSTITUTED AND COMPOSITIONS THAT CONTAIN THEM TO USE AS AGENTS THAT BIND THE PROGESTERONE RECEIVER REF. 5048P1-SV

Country Status (21)

Country Link
EP (1) EP1144396A2 (en)
JP (1) JP2002534517A (en)
KR (1) KR20010089831A (en)
CN (1) CN1337955A (en)
AR (1) AR022214A1 (en)
AU (1) AU2708700A (en)
BG (1) BG105761A (en)
BR (1) BR9916999A (en)
CA (1) CA2359562A1 (en)
CO (1) CO5160338A1 (en)
CZ (1) CZ20012530A3 (en)
GT (1) GT200000003A (en)
HU (1) HUP0105134A2 (en)
ID (1) ID30514A (en)
IL (1) IL144031A0 (en)
NO (1) NO20013318L (en)
SK (1) SK10032001A3 (en)
SV (1) SV2002000005A (en)
TR (1) TR200102041T2 (en)
WO (1) WO2000042031A2 (en)
ZA (1) ZA200105253B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2383659C (en) * 1999-08-31 2009-02-10 Jenapharm Gmbh & Co. Kg Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
RO122179B1 (en) * 1999-08-31 2009-02-27 Schering Aktiengesellschaft Use of mesoprogestins for the treatment and prevention of benign hormone-dependent gynecological disorders
US8193252B1 (en) 1999-08-31 2012-06-05 Bayer Pharma AG Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
ATE393150T1 (en) * 1999-09-14 2008-05-15 Shionogi & Co 2-IMINO-1,3-THIAZINE DERIVATIVES
WO2001072723A1 (en) * 2000-03-28 2001-10-04 Nippon Soda Co.,Ltd. Oxa(thia)zolidine derivative and anti-inflammatory drug
CN1395467A (en) * 2000-09-07 2003-02-05 美国拜尔公司 Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents
JP4188694B2 (en) * 2001-03-08 2008-11-26 塩野義製薬株式会社 Pharmaceutical composition containing a 1,3-thiazine derivative
JPWO2003000668A1 (en) 2001-06-25 2004-10-07 日本曹達株式会社 Oxa (thia) zolidine compound, production method and anti-inflammatory drug
WO2003060078A2 (en) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Heterocyclic modulators of nuclear receptors
JP2007505164A (en) * 2003-06-10 2007-03-08 スミスクライン ビーチャム コーポレーション 1-aminonaphthalenes as modulators of androgens, glucocorticoids, mineralocorticoids and progesterone receptors
CN103382158B (en) * 2013-07-29 2015-11-18 张家港市大伟助剂有限公司 A kind of preparation method of 2-clopentylamino ethanol
US20220251053A1 (en) * 2019-07-10 2022-08-11 Bayer Aktiengesellschaft Process of preparing 2-(phenylimino)-1,3-thiazolidin-4-ones
CN114507143A (en) * 2022-02-26 2022-05-17 江苏壹药新材料有限公司 Synthesis method of 2-ethyl-1-fluoro-4-nitrobenzene
CN114671828B (en) * 2022-04-28 2024-05-31 蔚林新材料科技股份有限公司 Preparation method of 3-methyl-2-thiazole thioketone
CN114957288B (en) * 2022-06-07 2024-02-13 苏州华道生物药业股份有限公司 Synthesis method of tetramisole hydrochloride
CN115925559A (en) * 2022-11-11 2023-04-07 上海泰坦科技股份有限公司 Preparation method of 1-amino-1-cyclopentyl methanol

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DE1670754A1 (en) * 1966-09-27 1970-12-23 Bayer Ag Process for the preparation of 2-phenylimino-oxazolidines
FR1510015A (en) * 1966-12-05 1968-01-19 Aquitaine Petrole Preparation of imino-thiazolidines
DE1767335A1 (en) * 1968-04-27 1971-09-02 Bayer Ag Anesthetic for animals
DE1963193A1 (en) * 1969-12-17 1971-06-24 Bayer Ag N-substituted 2-arylimino-oxazolidines, process for their preparation and their use as ectoparasiticides
FR2117337A5 (en) * 1970-12-04 1972-07-21 Eastman Kodak Co Merocyanine dye sensitisers - contg basic and acidic gps for silver halide emulsions
US3787575A (en) * 1970-12-17 1974-01-22 Bayer Ag N-substituted-2-arylimino-oxazolidines used as acaricides
GB1342232A (en) * 1971-07-29 1974-01-03 Bayer Ag Aryliminothiazolidines a process for their preparation and their use as acaricides
CH614946A5 (en) * 1975-05-07 1979-12-28 Ciba Geigy Ag
DE2658138A1 (en) * 1976-12-22 1978-07-06 Bayer Ag 2-Phenyl-imino-4-hydroxy-thiazolidine derivs. - useful as ectoparasiticides, esp. against acarids
DE2926771A1 (en) * 1979-07-03 1981-01-15 Hoechst Ag THIAZOLIDE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
DE3049460A1 (en) * 1980-12-30 1982-07-29 Hoechst Ag, 6000 Frankfurt "THIAZOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS
DE3505432A1 (en) * 1985-02-16 1986-08-21 Hoechst Ag, 6230 Frankfurt Crop protection agents and pesticides based on thiazolidine derivatives, novel thiazolidine derivatives, and their preparation
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AU2717488A (en) * 1987-11-19 1989-06-14 Chevron Research Company Ectoparasiticides

Also Published As

Publication number Publication date
KR20010089831A (en) 2001-10-08
NO20013318D0 (en) 2001-07-04
WO2000042031A2 (en) 2000-07-20
AU2708700A (en) 2000-08-01
HUP0105134A2 (en) 2002-04-29
BG105761A (en) 2002-03-29
BR9916999A (en) 2001-10-30
CO5160338A1 (en) 2002-05-30
SK10032001A3 (en) 2002-05-09
CN1337955A (en) 2002-02-27
EP1144396A2 (en) 2001-10-17
NO20013318L (en) 2001-08-30
AR022214A1 (en) 2002-09-04
TR200102041T2 (en) 2001-12-21
IL144031A0 (en) 2002-04-21
CA2359562A1 (en) 2000-07-20
ID30514A (en) 2001-12-13
CZ20012530A3 (en) 2002-02-13
ZA200105253B (en) 2002-09-05
JP2002534517A (en) 2002-10-15
WO2000042031A3 (en) 2000-11-09
GT200000003A (en) 2001-07-06

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