DE69709752D1 - Androgen rezeptor modulator verbindungen und verfahren - Google Patents
Androgen rezeptor modulator verbindungen und verfahrenInfo
- Publication number
- DE69709752D1 DE69709752D1 DE69709752T DE69709752T DE69709752D1 DE 69709752 D1 DE69709752 D1 DE 69709752D1 DE 69709752 T DE69709752 T DE 69709752T DE 69709752 T DE69709752 T DE 69709752T DE 69709752 D1 DE69709752 D1 DE 69709752D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- androgen receptor
- disclosed
- receptor modulator
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2199796P | 1996-06-27 | 1996-06-27 | |
PCT/US1997/011222 WO1997049709A1 (en) | 1996-06-27 | 1997-06-26 | Androgen receptor modulator compounds and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69709752D1 true DE69709752D1 (de) | 2002-02-21 |
DE69709752T2 DE69709752T2 (de) | 2002-07-18 |
Family
ID=21807289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69709752T Expired - Fee Related DE69709752T2 (de) | 1996-06-27 | 1997-06-26 | Androgen rezeptor modulator verbindungen und verfahren |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0918774B9 (de) |
JP (1) | JP2000513362A (de) |
AT (1) | ATE209207T1 (de) |
AU (1) | AU728178B2 (de) |
BR (1) | BR9710988A (de) |
DE (1) | DE69709752T2 (de) |
DK (1) | DK0918774T3 (de) |
ES (1) | ES2168650T3 (de) |
NO (1) | NO311645B1 (de) |
PT (1) | PT918774E (de) |
RU (1) | RU2214412C2 (de) |
WO (1) | WO1997049709A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6253061B1 (en) | 1997-09-19 | 2001-06-26 | Richard J. Helferich | Systems and methods for delivering information to a transmitting and receiving device |
US6636733B1 (en) | 1997-09-19 | 2003-10-21 | Thompson Trust | Wireless messaging method |
US7003304B1 (en) | 1997-09-19 | 2006-02-21 | Thompson Investment Group, Llc | Paging transceivers and methods for selectively retrieving messages |
US6826407B1 (en) | 1999-03-29 | 2004-11-30 | Richard J. Helferich | System and method for integrating audio and visual messaging |
US6983138B1 (en) | 1997-12-12 | 2006-01-03 | Richard J. Helferich | User interface for message access |
US6472415B1 (en) * | 1998-12-18 | 2002-10-29 | Biophysica, Inc. | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
EP1212322A2 (de) * | 1999-08-27 | 2002-06-12 | Ligand Pharmaceuticals Incorporated | 8-substituierte-6-trifluoromethyl-9-pyrido[3,2-g]chiolinverbindungen als androgen rezeptormodulatoren |
MXPA02002032A (es) * | 1999-08-27 | 2003-05-19 | Ligand Pharm Inc | Compuestos moduladores del receptor de androgeno y metodos. |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
JP2003529545A (ja) | 1999-09-14 | 2003-10-07 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 改善された薬理学的プロファイルを有するrxrモジュレーター |
DE60045751D1 (de) | 1999-09-30 | 2011-04-28 | Harbor Biosciences Inc | Therapeutische Behandlung androgenrezeptorbedingter Leiden |
US20030175817A1 (en) * | 2000-02-10 | 2003-09-18 | Kyoji Ikeda | Method of screening for antiandrogen agent |
NZ523802A (en) * | 2000-06-28 | 2005-11-25 | Bristol Myers Squibb Co | Fused cyclic compounds as modulators of nuclear hormone receptor function |
JP3908162B2 (ja) | 2000-06-30 | 2007-04-25 | 中外製薬株式会社 | 新規な抗アンドロゲン剤 |
UA78686C2 (en) * | 2000-09-19 | 2007-04-25 | Bristol Myers Squibb Co | Fused heterocyclic succinamide compounds and their analogs as modulators of functions of nuclear receptors for hormones |
US7214690B2 (en) | 2001-02-23 | 2007-05-08 | Ligand Pharmaceuticals Incorporated | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods |
US7026484B2 (en) | 2001-02-23 | 2006-04-11 | Ligand Pharmaceuticals Incorporated | Tricyclic androgen receptor modulator compounds and methods |
AU2002340256B2 (en) * | 2001-10-19 | 2007-04-05 | Merck Sharp & Dohme Corp. | Androgen receptor modulators and methods of use thereof |
CA2471754A1 (en) * | 2001-12-28 | 2003-07-17 | Takeda Chemical Industries, Ltd. | Androgen receptor antagonist |
JP5113979B2 (ja) | 2002-02-28 | 2013-01-09 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 複数置換の選択的アンドロゲンレセプタ修飾因子及びその使用方法 |
EP1501835A2 (de) * | 2002-04-26 | 2005-02-02 | Ortho-Mcneil Pharmaceutical, Inc. | 2-(chinolonyl)-kondensierte heterocyclen als androgen rezeptor-modulatoren |
US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
DE20301728U1 (de) | 2002-10-11 | 2004-03-11 | Ligand Pharmaceuticals, Inc., San Diego | 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen |
AU2003302084A1 (en) | 2002-11-15 | 2004-06-15 | Bristol-Myers Squibb Company | Open chain prolyl urea-related modulators of androgen receptor function |
MXPA05007605A (es) * | 2003-01-17 | 2005-09-30 | Warner Lambert Co | Antagonista del receptor de androgenos. |
MXPA06001751A (es) | 2003-08-22 | 2006-05-12 | Ligand Pharm Inc | Derivados de 6-cicloamino-2-quinolinona como compuestos moduladores de receptor de androgeno. |
US7256208B2 (en) | 2003-11-13 | 2007-08-14 | Bristol-Myers Squibb Company | Monocyclic N-Aryl hydantoin modulators of androgen receptor function |
US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
US7388027B2 (en) | 2004-03-04 | 2008-06-17 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
WO2005090282A1 (en) | 2004-03-12 | 2005-09-29 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
CA2642154A1 (en) * | 2006-02-10 | 2007-08-16 | Janssen Pharmaceutica N.V. | Novel imidazolopyrazole derivatives useful as selective androgen receptor modulators |
US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
MX2010009162A (es) | 2008-02-22 | 2010-12-21 | Radius Health Inc | Moduladores selectivos del receptor de androgeno. |
EP2130831A1 (de) | 2008-06-06 | 2009-12-09 | InterMed Discovery GmbH | CDC25-Hemmer |
BRPI1007112A2 (pt) * | 2009-04-30 | 2015-08-18 | Nissan Chemical Ind Ltd | Formas cristalinas a,b,e,f,g e h compostos triciclicos benzopirano e metodo para produçao das mesmas |
CA2788907A1 (en) | 2010-02-04 | 2011-08-11 | Radius Health, Inc. | Selective androgen receptor modulators |
HUE030072T2 (en) | 2010-05-12 | 2017-04-28 | Radius Health Inc | Therapeutic prescriptions |
US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
US9133182B2 (en) | 2010-09-28 | 2015-09-15 | Radius Health, Inc. | Selective androgen receptor modulators |
CN103442737B (zh) | 2011-01-20 | 2017-03-29 | 得克萨斯系统大学董事会 | Mri标记、递送和提取系统及其制造方法和用途 |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
RS64115B1 (sr) | 2014-03-28 | 2023-04-28 | Univ Duke | Lečenje kancera dojke upotrebom selektivnih modulatora receptora estrogena |
KR20220035276A (ko) | 2016-06-22 | 2022-03-21 | 일립시스 파마 리미티드 | Ar+ 유방암 치료 방법 |
CN106397317B (zh) * | 2016-09-26 | 2019-03-22 | 天津师范大学 | 1,2,3,4-四氢喹啉化合物及其合成方法与应用 |
CN106565723B (zh) * | 2016-11-04 | 2019-08-27 | 江苏师范大学 | 一种呋喃并吡啶、苯并吡啶类衍生化合物的制备方法 |
CA3047411A1 (en) | 2017-01-05 | 2018-07-12 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR1001164B (el) * | 1989-07-07 | 1993-05-24 | Endorecherche Inc | Παραγωγα αρρενογονου ορμονης προς χρησιν εις την αναστολην δραστηριοτητος της στεροειδους ορμονης φυλου |
US5677336A (en) * | 1993-10-21 | 1997-10-14 | Ligand Pharmaceuticals Incorporated | Non-steroid androgen receptor antagonist compounds and methods |
CZ176197A3 (cs) * | 1994-12-22 | 1998-09-16 | Ligand Pharmaceuticals Incorporated | Modulátory steroidových receptorů a způsoby jejich přípravy a použití |
-
1997
- 1997-06-26 ES ES97931460T patent/ES2168650T3/es not_active Expired - Lifetime
- 1997-06-26 PT PT97931460T patent/PT918774E/pt unknown
- 1997-06-26 EP EP97931460A patent/EP0918774B9/de not_active Expired - Lifetime
- 1997-06-26 RU RU99101057/04A patent/RU2214412C2/ru not_active IP Right Cessation
- 1997-06-26 AU AU35084/97A patent/AU728178B2/en not_active Ceased
- 1997-06-26 WO PCT/US1997/011222 patent/WO1997049709A1/en active IP Right Grant
- 1997-06-26 DK DK97931460T patent/DK0918774T3/da active
- 1997-06-26 JP JP10503562A patent/JP2000513362A/ja not_active Ceased
- 1997-06-26 AT AT97931460T patent/ATE209207T1/de not_active IP Right Cessation
- 1997-06-26 BR BR9710988-6A patent/BR9710988A/pt not_active IP Right Cessation
- 1997-06-26 DE DE69709752T patent/DE69709752T2/de not_active Expired - Fee Related
-
1998
- 1998-12-23 NO NO19986100A patent/NO311645B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP0918774B1 (de) | 2001-11-21 |
JP2000513362A (ja) | 2000-10-10 |
PT918774E (pt) | 2002-05-31 |
RU2214412C2 (ru) | 2003-10-20 |
AU3508497A (en) | 1998-01-14 |
NO986100L (no) | 1998-12-23 |
EP0918774B9 (de) | 2002-04-10 |
ES2168650T3 (es) | 2002-06-16 |
NO311645B1 (no) | 2001-12-27 |
BR9710988A (pt) | 2002-01-15 |
AU728178B2 (en) | 2001-01-04 |
DK0918774T3 (da) | 2002-05-21 |
DE69709752T2 (de) | 2002-07-18 |
NO986100D0 (no) | 1998-12-23 |
WO1997049709A1 (en) | 1997-12-31 |
EP0918774A1 (de) | 1999-06-02 |
ATE209207T1 (de) | 2001-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |