BR0206844A - Uso de antagonistas do receptor gal3 para o tratamento de depressão e/ou ansiedade e compostos usados em tais métodos - Google Patents

Uso de antagonistas do receptor gal3 para o tratamento de depressão e/ou ansiedade e compostos usados em tais métodos

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Publication number
BR0206844A
BR0206844A BR0206844-3A BR0206844A BR0206844A BR 0206844 A BR0206844 A BR 0206844A BR 0206844 A BR0206844 A BR 0206844A BR 0206844 A BR0206844 A BR 0206844A
Authority
BR
Brazil
Prior art keywords
anxiety
depression
subject
receptor antagonists
provides
Prior art date
Application number
BR0206844-3A
Other languages
English (en)
Inventor
Thomas P Blackburn
Michael Konkel
Lakmal W Boteju
Ian Jamie Talisman
John M Wetzel
Mathivanan Packiarajan
Heidi Chen
Hermo Jimenez
Bharat Lagu
Kitae Lim
Stewart Noble
Original Assignee
Synaptic Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synaptic Pharma Corp filed Critical Synaptic Pharma Corp
Priority claimed from PCT/US2002/004608 external-priority patent/WO2002060392A2/en
Publication of BR0206844A publication Critical patent/BR0206844A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"USO DE ANTAGONISTAS DO RECEPTOR GAL3 PARA O TRATAMENTO DE DEPRESSãO E/OU ANSIEDADE E COMPOSTOS USADOS EM TAIS MéTODOS". Esta invenção diz respeito a derivados de pirimidina e indolona que são antagonistas seletivos para o receptor GAL3. A invenção fornece uma composição farmacêutica que compreende uma quantidade terapeuticamente efetiva de um composto da invenção e um carreador farmaceuticamente aceitável. Esta invenção também fornece uma composição farmacêutica feita pela combinação de uma quantidade terapeuticamente efetiva de um composto da invenção e um carreador farmaceuticamente aceitável. Esta invenção fornece ainda um processo para fazer uma composição farmacêutica, que compreende combinar uma quantidade terapeuticamente efetiva de um composto da invenção e um carreador farmaceuticamente aceitável. Esta invenção também fornece um método de tratamento de um sujeito que sofre de depressão e/o ansiedade, que compreende administrar ao sujeito uma quantidade de um composto da invenção efetiva para tratar depressão e/ou ansiedade do sujeito. A invenção também fornece um método de tratar depressão e/ou ansiedade em um sujeito, que compreende administrar ao sujeito uma composição que compreende um carreador farmaceuticamente aceitável e uma quantidade terapeuticamente efetiva de um antagonista do receptor GAL3.
BR0206844-3A 2001-01-31 2002-01-31 Uso de antagonistas do receptor gal3 para o tratamento de depressão e/ou ansiedade e compostos usados em tais métodos BR0206844A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77534101A 2001-01-31 2001-01-31
PCT/US2002/004608 WO2002060392A2 (en) 2001-01-31 2002-01-31 Use of gal3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods

Publications (1)

Publication Number Publication Date
BR0206844A true BR0206844A (pt) 2005-07-12

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EP (3) EP1363638A4 (pt)
JP (3) JP4739650B2 (pt)
KR (1) KR20040041092A (pt)
CN (2) CN101406469B (pt)
AU (2) AU2002247149B2 (pt)
BG (1) BG108114A (pt)
BR (1) BR0206844A (pt)
CA (3) CA2672805A1 (pt)
CZ (1) CZ20032341A3 (pt)
EA (1) EA006486B1 (pt)
HR (1) HRP20030608A2 (pt)
HU (1) HUP0401858A3 (pt)
IL (2) IL157102A0 (pt)
IS (1) IS6880A (pt)
MX (1) MXPA03006812A (pt)
NO (1) NO20033388L (pt)
NZ (1) NZ527163A (pt)
PL (1) PL369270A1 (pt)
SK (1) SK9562003A3 (pt)
UA (1) UA74421C2 (pt)
YU (1) YU60803A (pt)
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Publication number Priority date Publication date Assignee Title
BR0206844A (pt) * 2001-01-31 2005-07-12 Synaptic Pharma Corp Uso de antagonistas do receptor gal3 para o tratamento de depressão e/ou ansiedade e compostos usados em tais métodos
BR0307429A (pt) * 2002-02-05 2004-12-28 Novo Nordisk As Composto, uso do mesmo, composição farmacêutica, e, método para o tratamento de distúrbios ou doenças relacionadas com receptor de histamina h3
CN101973925B (zh) * 2010-10-15 2012-03-28 中国药科大学 具有抗炎活性的2-吲哚酮类化合物、其制备方法及医药用途
CN104903312B (zh) * 2013-10-07 2019-01-29 卡德门企业有限公司 Rho激酶抑制剂
CA3048357A1 (en) * 2016-12-29 2018-07-05 Minoryx Therapeutics S.L. Heteroaryl compounds and their use
CA3127113A1 (en) * 2019-01-30 2020-08-06 Dongxu Sun Anti-gal3 antibodies and uses thereof
CN113317221B (zh) * 2021-06-18 2023-01-31 青岛百宜电器有限公司 自动梳毛机

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MXPA03006812A (es) 2004-10-15
EA006486B1 (ru) 2005-12-29
AU2008200385B2 (en) 2010-09-09
ZA200305686B (en) 2004-10-25
JP2010006813A (ja) 2010-01-14
IS6880A (is) 2003-07-21
NO20033388L (no) 2003-09-24
JP4739650B2 (ja) 2011-08-03
SK9562003A3 (en) 2004-04-06
EA200300850A1 (ru) 2004-06-24
IL198759A (en) 2013-06-27
AU2002247149B2 (en) 2007-10-25
CZ20032341A3 (cs) 2004-12-15
JP2004529089A (ja) 2004-09-24
EP1363638A2 (en) 2003-11-26
EP2140862A2 (en) 2010-01-06
EP1363638A4 (en) 2010-01-06
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EP2140862A3 (en) 2010-02-17
JP2009173657A (ja) 2009-08-06
CA2438582A1 (en) 2002-08-08
CA2671776A1 (en) 2002-08-08
KR20040041092A (ko) 2004-05-13
CN101406469B (zh) 2012-06-13
CN100446767C (zh) 2008-12-31
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HRP20030608A2 (en) 2005-06-30
CA2671776C (en) 2012-12-18
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HUP0401858A3 (en) 2009-06-29
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BG108114A (bg) 2005-03-31
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