ATE209207T1 - Androgen rezeptor modulator verbindungen und verfahren - Google Patents

Androgen rezeptor modulator verbindungen und verfahren

Info

Publication number
ATE209207T1
ATE209207T1 AT97931460T AT97931460T ATE209207T1 AT E209207 T1 ATE209207 T1 AT E209207T1 AT 97931460 T AT97931460 T AT 97931460T AT 97931460 T AT97931460 T AT 97931460T AT E209207 T1 ATE209207 T1 AT E209207T1
Authority
AT
Austria
Prior art keywords
compounds
androgen receptor
methods
receptor modulator
disclosed
Prior art date
Application number
AT97931460T
Other languages
English (en)
Inventor
James P Edwards
Robert Higuchi
Todd Jones
Original Assignee
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Application granted granted Critical
Publication of ATE209207T1 publication Critical patent/ATE209207T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT97931460T 1996-06-27 1997-06-26 Androgen rezeptor modulator verbindungen und verfahren ATE209207T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2199796P 1996-06-27 1996-06-27
PCT/US1997/011222 WO1997049709A1 (en) 1996-06-27 1997-06-26 Androgen receptor modulator compounds and methods

Publications (1)

Publication Number Publication Date
ATE209207T1 true ATE209207T1 (de) 2001-12-15

Family

ID=21807289

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97931460T ATE209207T1 (de) 1996-06-27 1997-06-26 Androgen rezeptor modulator verbindungen und verfahren

Country Status (12)

Country Link
EP (1) EP0918774B9 (de)
JP (1) JP2000513362A (de)
AT (1) ATE209207T1 (de)
AU (1) AU728178B2 (de)
BR (1) BR9710988A (de)
DE (1) DE69709752T2 (de)
DK (1) DK0918774T3 (de)
ES (1) ES2168650T3 (de)
NO (1) NO311645B1 (de)
PT (1) PT918774E (de)
RU (1) RU2214412C2 (de)
WO (1) WO1997049709A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6636733B1 (en) 1997-09-19 2003-10-21 Thompson Trust Wireless messaging method
US7003304B1 (en) 1997-09-19 2006-02-21 Thompson Investment Group, Llc Paging transceivers and methods for selectively retrieving messages
US6253061B1 (en) 1997-09-19 2001-06-26 Richard J. Helferich Systems and methods for delivering information to a transmitting and receiving device
US6826407B1 (en) 1999-03-29 2004-11-30 Richard J. Helferich System and method for integrating audio and visual messaging
US6983138B1 (en) 1997-12-12 2006-01-03 Richard J. Helferich User interface for message access
US6472415B1 (en) * 1998-12-18 2002-10-29 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
BR0013597A (pt) * 1999-08-27 2002-07-16 Ligand Pharm Inc Compostos e métodos moduladores de receptor de androgênio
WO2001016133A2 (en) * 1999-08-27 2001-03-08 Ligand Pharmaceuticals Incorporated 8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators
JP2003529545A (ja) 1999-09-14 2003-10-07 リガンド・ファーマシューティカルズ・インコーポレイテッド 改善された薬理学的プロファイルを有するｒｘｒモジュレーター
WO2001023405A2 (en) 1999-09-30 2001-04-05 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment of androgen receptor driven conditions
US20030175817A1 (en) * 2000-02-10 2003-09-18 Kyoji Ikeda Method of screening for antiandrogen agent
NZ523802A (en) * 2000-06-28 2005-11-25 Bristol Myers Squibb Co Fused cyclic compounds as modulators of nuclear hormone receptor function
JP3908162B2 (ja) 2000-06-30 2007-04-25 中外製薬株式会社 新規な抗アンドロゲン剤
IL155019A0 (en) * 2000-09-19 2003-10-31 Bristol Myers Squibb Co Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7214690B2 (en) 2001-02-23 2007-05-08 Ligand Pharmaceuticals Incorporated Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
US7026484B2 (en) 2001-02-23 2006-04-11 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
EP1439841B1 (de) * 2001-10-19 2007-09-19 Merck & Co., Inc. Androgen-rezeptor-modulatoren und verwendungsverfahren dafür
AU2002367424A1 (en) * 2001-12-28 2003-07-24 Takeda Chemical Industries, Ltd. Androgen receptor antagonists
US7705182B2 (en) 2002-02-28 2010-04-27 University Of Tennessee Research Foundation Multi-substituted selective androgen receptor modulators and methods of use thereof
WO2003090672A2 (en) * 2002-04-26 2003-11-06 Ortho-Mcneil Pharmaceutical, Inc. 2-(quinolonyl)-fused heterocycles as androgen receptor modulators
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
DE20301728U1 (de) 2002-10-11 2004-03-11 Ligand Pharmaceuticals, Inc., San Diego 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen
WO2004045518A2 (en) 2002-11-15 2004-06-03 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
CA2511089A1 (en) * 2003-01-17 2004-08-05 Warner-Lambert Company Llc Androgen receptor antagonists
MXPA06001751A (es) 2003-08-22 2006-05-12 Ligand Pharm Inc Derivados de 6-cicloamino-2-quinolinona como compuestos moduladores de receptor de androgeno.
US7256208B2 (en) 2003-11-13 2007-08-14 Bristol-Myers Squibb Company Monocyclic N-Aryl hydantoin modulators of androgen receptor function
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7388027B2 (en) 2004-03-04 2008-06-17 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
WO2005090282A1 (en) 2004-03-12 2005-09-29 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
JP5230448B2 (ja) * 2006-02-10 2013-07-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドローゲン受容体モジュレーターとして有用な新イミダゾロピラゾール誘導体
US8067448B2 (en) 2008-02-22 2011-11-29 Radius Health, Inc. Selective androgen receptor modulators
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
EP2130831A1 (de) 2008-06-06 2009-12-09 InterMed Discovery GmbH CDC25-Hemmer
NZ596060A (en) * 2009-04-30 2012-12-21 Nissan Chemical Ind Ltd NOVEL CRYSTAL FORMS OF TRICYCLIC BENZOPYRAN COMPOUND AND PROCESSES FOR PRODUCING SAME; (3R,4S)-7-hydroxymethyl-2,2,9-trimethyl-4-(phenethylamino)-3,4-dihydro-2H-pyrano[2,3g]quinolin-3-ol
AU2011212813B2 (en) 2010-02-04 2014-10-23 Radius Health, Inc. Selective androgen receptor modulators
WO2011143469A1 (en) 2010-05-12 2011-11-17 Radius Health,Inc Therapeutic regimens
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
WO2012047617A1 (en) 2010-09-28 2012-04-12 Radius Health, Inc. Selective androgen receptor modulators
US8846006B2 (en) 2011-01-20 2014-09-30 Board Of Regents, The University Of Texas System MRI markers, delivery and extraction systems, and methods of manufacture and use thereof
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
EP3122426B1 (de) 2014-03-28 2023-01-18 Duke University Brustkrebsbehandlung mit selektiven östrogenrezeptormodulatoren
IL292659A (en) 2016-06-22 2022-07-01 Ellipses Pharma Ltd Methods for treating breast cancer ar plus
CN106397317B (zh) * 2016-09-26 2019-03-22 天津师范大学 1,2,3,4-四氢喹啉化合物及其合成方法与应用
CN106565723B (zh) * 2016-11-04 2019-08-27 江苏师范大学 一种呋喃并吡啶、苯并吡啶类衍生化合物的制备方法
KR102557321B1 (ko) 2017-01-05 2023-07-18 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0181264B1 (ko) * 1989-07-07 1999-03-20 라브리 페르낭 성스테로이드 활성 억제용 안드로겐 유도체
US5677336A (en) * 1993-10-21 1997-10-14 Ligand Pharmaceuticals Incorporated Non-steroid androgen receptor antagonist compounds and methods
HUT78117A (hu) * 1994-12-22 1999-11-29 Ligand Pharmaceuticals Incorporated Szteroid receptor modulátor kinolin- és kondenzált kinolinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények

Also Published As

Publication number Publication date
DE69709752T2 (de) 2002-07-18
NO311645B1 (no) 2001-12-27
DK0918774T3 (da) 2002-05-21
NO986100L (no) 1998-12-23
DE69709752D1 (de) 2002-02-21
EP0918774A1 (de) 1999-06-02
AU3508497A (en) 1998-01-14
EP0918774B9 (de) 2002-04-10
PT918774E (pt) 2002-05-31
RU2214412C2 (ru) 2003-10-20
AU728178B2 (en) 2001-01-04
WO1997049709A1 (en) 1997-12-31
BR9710988A (pt) 2002-01-15
NO986100D0 (no) 1998-12-23
ES2168650T3 (es) 2002-06-16
JP2000513362A (ja) 2000-10-10
EP0918774B1 (de) 2001-11-21

Similar Documents

Publication Publication Date Title
ATE209207T1 (de) Androgen rezeptor modulator verbindungen und verfahren
DE69533180D1 (de) Steroidrezeptor-Modulator Verbindungen und Methoden
MX9704640A (es) Compuesto moduladores de los receptores de los esteroides y metodos para su preparacion.
WO2000066590A3 (en) Tetracyclic progesterone receptor modulator compounds and methods
MY129189A (en) Prostaglandin agonists and their use to treat bone disorders
YU7797A (sh) Kombinovana terapija za osteoporozu
DK0873295T3 (da) Dimer-selektive RXR-modulatorer og fremgangsmåder til deres anvendelse
YU38801A (sh) Azabicikloalkani kao modulatori ccr5
DE69728585D1 (de) Mittel gegen Juckreiz
EP0911321A3 (de) Verbindungen zur Behandlung von Osteoporose
DE69531403D1 (de) Allosterische modulatoren des nmda-rezeptors
AP9801269A0 (en) Prostaglandin agonists.
EA199900912A1 (ru) Фармацевтические средства
BR9708347A (pt) Compostos de tetrahidorbeta-carbonila
DK0996435T3 (da) Aminosyrederivater anvendelige til behandling af slagtilfælde
DE59809283D1 (de) Inhibitoren für den urokinaserezeptor
BR0206844A (pt) Uso de antagonistas do receptor gal3 para o tratamento de depressão e/ou ansiedade e compostos usados em tais métodos
CA2259031A1 (en) Androgen receptor modulator compounds and methods

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee