DE602007007734D1 - Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren - Google Patents

Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren

Info

Publication number
DE602007007734D1
DE602007007734D1 DE602007007734T DE602007007734T DE602007007734D1 DE 602007007734 D1 DE602007007734 D1 DE 602007007734D1 DE 602007007734 T DE602007007734 T DE 602007007734T DE 602007007734 T DE602007007734 T DE 602007007734T DE 602007007734 D1 DE602007007734 D1 DE 602007007734D1
Authority
DE
Germany
Prior art keywords
derivatives
androgen receptor
imidazolopyrazol
new
receptor modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007007734T
Other languages
English (en)
Inventor
Xuqing Zhang
Zhihua Sui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602007007734D1 publication Critical patent/DE602007007734D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DE602007007734T 2006-02-10 2007-02-01 Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren Active DE602007007734D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77202606P 2006-02-10 2006-02-10
PCT/US2007/061436 WO2007092727A1 (en) 2006-02-10 2007-02-01 Novel imidazolopyrazole derivatives useful as selective androgen receptor modulators

Publications (1)

Publication Number Publication Date
DE602007007734D1 true DE602007007734D1 (de) 2010-08-26

Family

ID=38002066

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007007734T Active DE602007007734D1 (de) 2006-02-10 2007-02-01 Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren

Country Status (9)

Country Link
US (1) US7655683B2 (de)
EP (1) EP1991223B1 (de)
JP (1) JP5230448B2 (de)
CN (1) CN101415419B (de)
AT (1) ATE473741T1 (de)
AU (1) AU2007212191B2 (de)
CA (1) CA2642154A1 (de)
DE (1) DE602007007734D1 (de)
WO (1) WO2007092727A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092371A1 (en) 2009-02-10 2010-08-19 Astrazeneca Ab Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer
CN101671336B (zh) * 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
CN103857678A (zh) * 2011-07-27 2014-06-11 诺华股份有限公司 吡唑啉衍生物及其用作选择性雄激素受体调节剂的用途
TW201534586A (zh) * 2013-06-11 2015-09-16 Orion Corp 新穎ｃｙｐ１７抑制劑／抗雄激素劑
CN107737125A (zh) * 2016-11-26 2018-02-27 王玉美 一种治疗药物流产后子宫出血的药物
CN112876391A (zh) * 2021-01-15 2021-06-01 山东铂源药业有限公司 一种4-异硫氰基-2-（三氟甲基）苯甲腈的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69709752T2 (de) * 1996-06-27 2002-07-18 Ligand Pharm Inc Androgen rezeptor modulator verbindungen und verfahren
BR0014651A (pt) 1999-10-20 2002-06-18 Tanabe Seiyaku Co Inibidores de adesão de célula mediada por "alfa" l beta2
PT1334106E (pt) * 2000-11-17 2006-08-31 Takeda Pharmaceutical Derivados de imidazole, seu metodo de producao e sua utilizacao
TW200407324A (en) * 2002-05-17 2004-05-16 Bristol Myers Squibb Co Bicyclic modulators of androgen receptor function
JP4745616B2 (ja) * 2003-02-26 2011-08-10 武田薬品工業株式会社 安定化されたイミダゾール誘導体含有医薬組成物、イミダゾール誘導体の安定化方法
US7625923B2 (en) * 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7388027B2 (en) * 2004-03-04 2008-06-17 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
JP4969451B2 (ja) * 2004-11-16 2012-07-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）として有用な新規な複素環誘導体

Also Published As

Publication number Publication date
JP2009526077A (ja) 2009-07-16
AU2007212191B2 (en) 2011-12-22
US20070197616A1 (en) 2007-08-23
US7655683B2 (en) 2010-02-02
CN101415419B (zh) 2012-06-13
JP5230448B2 (ja) 2013-07-10
CA2642154A1 (en) 2007-08-16
CN101415419A (zh) 2009-04-22
EP1991223A1 (de) 2008-11-19
EP1991223B1 (de) 2010-07-14
WO2007092727A1 (en) 2007-08-16
AU2007212191A1 (en) 2007-08-16
ATE473741T1 (de) 2010-07-15

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