ATE453660T1 - 17-phosphor-steroid-derivate als progesteron- rezeptormodulatoren - Google Patents

17-phosphor-steroid-derivate als progesteron- rezeptormodulatoren

Info

Publication number
ATE453660T1
ATE453660T1 AT07757086T AT07757086T ATE453660T1 AT E453660 T1 ATE453660 T1 AT E453660T1 AT 07757086 T AT07757086 T AT 07757086T AT 07757086 T AT07757086 T AT 07757086T AT E453660 T1 ATE453660 T1 AT E453660T1
Authority
AT
Austria
Prior art keywords
phosphorus
steroid derivatives
receptor modulators
progesterone receptor
progesterone
Prior art date
Application number
AT07757086T
Other languages
English (en)
Inventor
Weiqin Jiang
Zhihua Sui
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE453660T1 publication Critical patent/ATE453660T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT07757086T 2006-02-17 2007-02-16 17-phosphor-steroid-derivate als progesteron- rezeptormodulatoren ATE453660T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77504306P 2006-02-17 2006-02-17
PCT/US2007/062274 WO2007098382A2 (en) 2006-02-17 2007-02-16 17-phosphorous steroid derivatives useful as progesterone receptor modulators

Publications (1)

Publication Number Publication Date
ATE453660T1 true ATE453660T1 (de) 2010-01-15

Family

ID=38330971

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07757086T ATE453660T1 (de) 2006-02-17 2007-02-16 17-phosphor-steroid-derivate als progesteron- rezeptormodulatoren

Country Status (15)

Country Link
US (1) US7671045B2 (de)
EP (1) EP1989218B1 (de)
JP (1) JP5230450B2 (de)
CN (1) CN101421290B (de)
AT (1) ATE453660T1 (de)
AU (1) AU2007217095B2 (de)
CA (1) CA2642566C (de)
CY (1) CY1111128T1 (de)
DE (1) DE602007004081D1 (de)
DK (1) DK1989218T3 (de)
ES (1) ES2337521T3 (de)
PL (1) PL1989218T3 (de)
PT (1) PT1989218E (de)
SI (1) SI1989218T1 (de)
WO (1) WO2007098382A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0501132A2 (en) * 2005-12-05 2007-06-28 Richter Gedeon Nyrt 17-alpha-cyanomethyl-17betha-hydroxyestra-4,9-diene-3-one of high purity and process for its production
EP1989217B1 (de) * 2006-02-17 2012-06-27 Janssen Pharmaceutica N.V. 11-phosphor-steroid-derivate als progesteron-rezeptormodulatoren
JP5583976B2 (ja) 2007-03-07 2014-09-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的プロゲステロン受容体モジュレーターとしてのステロイド誘導体
CN102617691B (zh) * 2012-01-18 2014-05-14 上海新华联制药有限公司 一种改进的米非司酮中间体制备方法
WO2014060888A1 (en) 2012-10-18 2014-04-24 Lupin Limited Novel process and intermediate for preparation of ulipristal
JP6906525B2 (ja) * 2015-12-23 2021-07-21 オリック ファーマシューティカルズ，インク． グルココルチコイド受容体の阻害剤
WO2017112904A1 (en) 2015-12-23 2017-06-29 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
JP6995757B2 (ja) 2015-12-23 2022-01-17 オリック ファーマシューティカルズ，インク． グルココルチコイド受容体の阻害剤
PL3523315T3 (pl) 2016-10-07 2021-10-18 Oric Pharmaceuticals, Inc. Inhibitor receptora glukokortykoidowego
CN106810584A (zh) * 2016-12-28 2017-06-09 宁波第二激素厂 烯丙孕素的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
GB9003939D0 (en) * 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
CA2100514C (en) 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
JPH0995496A (ja) * 1995-09-28 1997-04-08 Kaken Pharmaceut Co Ltd ウルソデオキシコール酸誘導体
PT1448592E (pt) * 2001-10-18 2006-07-31 Sterix Ltd Compostos esteroides para inibicao da esteroide sulfatase

Also Published As

Publication number Publication date
SI1989218T1 (sl) 2010-04-30
EP1989218A2 (de) 2008-11-12
JP2009527490A (ja) 2009-07-30
US20070207982A1 (en) 2007-09-06
JP5230450B2 (ja) 2013-07-10
DE602007004081D1 (de) 2010-02-11
CA2642566C (en) 2014-04-15
WO2007098382A3 (en) 2007-11-01
CY1111128T1 (el) 2015-06-11
CN101421290B (zh) 2012-09-19
US7671045B2 (en) 2010-03-02
PL1989218T3 (pl) 2010-06-30
DK1989218T3 (da) 2010-04-26
CA2642566A1 (en) 2007-08-30
AU2007217095A1 (en) 2007-08-30
EP1989218B1 (de) 2009-12-30
AU2007217095B2 (en) 2012-05-03
CN101421290A (zh) 2009-04-29
PT1989218E (pt) 2010-02-01
ES2337521T3 (es) 2010-04-26
WO2007098382A2 (en) 2007-08-30

Similar Documents

Publication Publication Date Title
ATE453660T1 (de) 17-phosphor-steroid-derivate als progesteron- rezeptormodulatoren
WO2010054158A3 (en) Steroid modulators of glucocorticoid receptor
MY147985A (en) Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
MY142048A (en) Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms)
TW200606146A (en) Novel indole derivatives as selective androgen receptor modulators (SARMS)
WO2007098381A3 (en) 11-phosphorous steroid derivatives useful as progesterone receptor modulators
ATE514700T1 (de) Neues tetrazyklisches heteroatom mit als sexualsteroidhormon-rezeptormodulatoren geeigneten derivaten
UA94600C2 (en) Indole sulfonamide modulators of progesterone receptors
TW200624424A (en) Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
ECSP088648A (es) Nuevos bencimidazoles 2-sustituidos como moduladores de receptor de androgeno selectivos (sarms)
MY143211A (en) Novel indole derivatives as selective androgen receptor modulators (sarms)
TW200604170A (en) Novel indole derivatives as selective androgen receptor modulators (SARMs)
WO2006130416A3 (en) Novel 3-spirocyclic indolyl derivatives useful as orl-1 receptor modulators
EA200970662A1 (ru) Трициклические соединения и их применение в качестве модуляторов глюкокортикоидного рецептора
ATE473741T1 (de) Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren
WO2008109719A3 (en) Steroids derivatives as selective progesterone receptor modulators
ATE485286T1 (de) Tetracyclische steroidderivate als progesteron- rezeptormodulatoren
WO2009140225A3 (en) Anti-inflammatory and immunosuppresive glucocorticoid steroids
WO2007098388A3 (en) Oxa-steroids derivatives as selective progesterone receptor modulators
DE602005010735D1 (de) Neue 2h-chromenderivate als selektive östrogenrezeptor-modulatoren
ATE540953T1 (de) Bizyklische imidazol- oder thiadiazol- heterozyklen als selektive androgen-rezeptor- modulatoren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1989218

Country of ref document: EP