ATE473741T1 - Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren - Google Patents

Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren

Info

Publication number
ATE473741T1
ATE473741T1 AT07763146T AT07763146T ATE473741T1 AT E473741 T1 ATE473741 T1 AT E473741T1 AT 07763146 T AT07763146 T AT 07763146T AT 07763146 T AT07763146 T AT 07763146T AT E473741 T1 ATE473741 T1 AT E473741T1
Authority
AT
Austria
Prior art keywords
androgen receptor
new
receptor modulators
selective androgen
imidazolopyrazole
Prior art date
Application number
AT07763146T
Other languages
English (en)
Inventor
Xuqing Zhang
Zhihua Sui
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE473741T1 publication Critical patent/ATE473741T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT07763146T 2006-02-10 2007-02-01 Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren ATE473741T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77202606P 2006-02-10 2006-02-10
PCT/US2007/061436 WO2007092727A1 (en) 2006-02-10 2007-02-01 Novel imidazolopyrazole derivatives useful as selective androgen receptor modulators

Publications (1)

Publication Number Publication Date
ATE473741T1 true ATE473741T1 (de) 2010-07-15

Family

ID=38002066

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07763146T ATE473741T1 (de) 2006-02-10 2007-02-01 Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren

Country Status (9)

Country Link
US (1) US7655683B2 (de)
EP (1) EP1991223B1 (de)
JP (1) JP5230448B2 (de)
CN (1) CN101415419B (de)
AT (1) ATE473741T1 (de)
AU (1) AU2007212191B2 (de)
CA (1) CA2642154A1 (de)
DE (1) DE602007007734D1 (de)
WO (1) WO2007092727A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102388048B (zh) 2009-02-10 2014-07-30 阿斯利康(瑞典)有限公司 三唑并[4，3-b]哒嗪衍生物及其用于前列腺癌的用途
CN101671336B (zh) * 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
ES2551923T3 (es) * 2011-07-27 2015-11-24 Novartis Ag Derivados de pirazolina y su uso como moduladores selectivos de receptores de andrógenos
TW201534586A (zh) * 2013-06-11 2015-09-16 Orion Corp 新穎ｃｙｐ１７抑制劑／抗雄激素劑
CN107737125A (zh) * 2016-11-26 2018-02-27 王玉美 一种治疗药物流产后子宫出血的药物
CN112876391A (zh) * 2021-01-15 2021-06-01 山东铂源药业有限公司 一种4-异硫氰基-2-（三氟甲基）苯甲腈的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0918774B9 (de) * 1996-06-27 2002-04-10 Ligand Pharmaceuticals Incorporated Androgen rezeptor modulator verbindungen und verfahren
CN1185232C (zh) 1999-10-20 2005-01-19 田边制药株式会社 αLβ2介导细胞粘连抑制剂
TWI306099B (en) * 2000-11-17 2009-02-11 Takeda Chemical Industries Ltd Novel imidazole derivatives, production method thereof and use thereof
TW200407324A (en) * 2002-05-17 2004-05-16 Bristol Myers Squibb Co Bicyclic modulators of androgen receptor function
JP4745616B2 (ja) * 2003-02-26 2011-08-10 武田薬品工業株式会社 安定化されたイミダゾール誘導体含有医薬組成物、イミダゾール誘導体の安定化方法
US7388027B2 (en) * 2004-03-04 2008-06-17 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) * 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
JP4969451B2 (ja) * 2004-11-16 2012-07-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）として有用な新規な複素環誘導体

Also Published As

Publication number Publication date
CN101415419A (zh) 2009-04-22
EP1991223B1 (de) 2010-07-14
JP5230448B2 (ja) 2013-07-10
US7655683B2 (en) 2010-02-02
CN101415419B (zh) 2012-06-13
WO2007092727A1 (en) 2007-08-16
EP1991223A1 (de) 2008-11-19
US20070197616A1 (en) 2007-08-23
AU2007212191B2 (en) 2011-12-22
AU2007212191A1 (en) 2007-08-16
CA2642154A1 (en) 2007-08-16
JP2009526077A (ja) 2009-07-16
DE602007007734D1 (de) 2010-08-26

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