HK1254258A1 - 使用阿吡莫德治療癌症的方法 - Google Patents
使用阿吡莫德治療癌症的方法Info
- Publication number
- HK1254258A1 HK1254258A1 HK18113402.5A HK18113402A HK1254258A1 HK 1254258 A1 HK1254258 A1 HK 1254258A1 HK 18113402 A HK18113402 A HK 18113402A HK 1254258 A1 HK1254258 A1 HK 1254258A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- apilimod
- methods
- treating cancer
- cancer
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562194367P | 2015-07-20 | 2015-07-20 | |
PCT/US2016/042905 WO2017015262A1 (en) | 2015-07-20 | 2016-07-19 | Methods for treating cancer using apilimod |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1254258A1 true HK1254258A1 (zh) | 2019-07-12 |
Family
ID=56551023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18113402.5A HK1254258A1 (zh) | 2015-07-20 | 2018-10-18 | 使用阿吡莫德治療癌症的方法 |
Country Status (14)
Country | Link |
---|---|
US (1) | US10350213B2 (zh) |
EP (1) | EP3325014B1 (zh) |
JP (2) | JP2018525358A (zh) |
KR (1) | KR20180030630A (zh) |
CN (1) | CN108025076A (zh) |
AU (1) | AU2016297555B2 (zh) |
BR (1) | BR112018000776A2 (zh) |
CA (1) | CA2991779A1 (zh) |
HK (1) | HK1254258A1 (zh) |
IL (1) | IL256836B (zh) |
MX (1) | MX2018000715A (zh) |
RU (1) | RU2738934C2 (zh) |
TW (1) | TWI746449B (zh) |
WO (1) | WO2017015262A1 (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102320190B1 (ko) | 2014-01-24 | 2021-11-03 | 에이아이 테라퓨틱스, 인코포레이티드 | 아필리모드 조성물 및 이를 사용하기 위한 방법 |
PT3215157T (pt) * | 2014-11-07 | 2019-07-12 | Ai Therapeutics Inc | Apilimod para utilização no tratamento de melanoma |
PL3215158T3 (pl) | 2014-11-07 | 2019-11-29 | Ai Therapeutics Inc | Apilimod do zastosowania do leczenia raka nerki |
TWI746449B (zh) | 2015-07-20 | 2021-11-21 | 美商Ai治療公司 | 使用阿吡莫德治療癌症之方法 |
BR112018009738A2 (pt) * | 2016-01-21 | 2018-12-04 | Lam Therapeutics Inc | biomarcadores para tratamento contra o câncer com apilimod |
WO2019051387A1 (en) | 2017-09-08 | 2019-03-14 | Mingbao Zhang | METHODS OF USING DIPIVECHINE |
AU2019223014A1 (en) | 2018-02-21 | 2020-08-20 | AI Therapeutics, Inc. | Combination therapy with apilimod and glutamatergic agents |
US20230364084A1 (en) * | 2020-10-28 | 2023-11-16 | The Regents Of The University Of Michigan | Methods for preventing or treating conditions related to pikfyve activity |
WO2023108110A2 (en) * | 2021-12-10 | 2023-06-15 | Verastem, Inc. | Combination therapy for treating abnormal cell growth |
US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6693097B2 (en) | 2001-11-30 | 2004-02-17 | Synta Pharmaceuticals Corp. | Pyrimidine compounds |
CU23475A1 (es) * | 2004-07-08 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Composición farmacéutica conteniendo fragmentos polipeptídicos de serralisinas |
TW200630363A (en) | 2004-11-10 | 2006-09-01 | Synta Pharmaceuticals Corp | Process for preparing trisubstituted pyrimidine compounds |
TW200720256A (en) | 2005-05-13 | 2007-06-01 | Synta Pharmaceuticals Corp | IL-12 modulatory compounds |
WO2006128129A2 (en) * | 2005-05-26 | 2006-11-30 | Synta Pharmaceuticals Corp. | Method for treating cancer |
RU2350338C2 (ru) * | 2007-05-14 | 2009-03-27 | ФГУ Ростовский научно-исследовательский онкологический институт Росздрава | Способ лечения поверхностного рака мочевого пузыря |
RU2421217C2 (ru) * | 2009-09-03 | 2011-06-20 | Учреждение Российской академии медицинских наук Гематологический научный центр РАМН (ГНЦ РАМН) | Способ дифференцированного лечения диффузных в-крупноклеточных лимфосарком лимфоидных органов взрослых |
JP6267638B2 (ja) * | 2011-09-26 | 2018-01-24 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーGalera Labs, Llc | 疾患の治療方法 |
DK2914296T4 (da) * | 2012-11-01 | 2022-01-03 | Infinity Pharmaceuticals Inc | Behandling af cancere under anvendelse af PI3-kinase-isoform-modulatorer |
JP2016512549A (ja) * | 2013-03-14 | 2016-04-28 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼ阻害剤及びcyp3a4阻害剤の組み合わせ |
CA2899577C (en) * | 2013-04-03 | 2023-10-17 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
SG11201604875PA (en) * | 2013-12-17 | 2016-07-28 | Genentech Inc | Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody |
BR112016014410A2 (pt) * | 2013-12-20 | 2018-02-20 | The Broad Institute Inc. | terapia de combinação com vacina de neoantígeno |
KR102320190B1 (ko) * | 2014-01-24 | 2021-11-03 | 에이아이 테라퓨틱스, 인코포레이티드 | 아필리모드 조성물 및 이를 사용하기 위한 방법 |
TWI746449B (zh) | 2015-07-20 | 2021-11-21 | 美商Ai治療公司 | 使用阿吡莫德治療癌症之方法 |
-
2016
- 2016-07-15 TW TW105122406A patent/TWI746449B/zh not_active IP Right Cessation
- 2016-07-19 CN CN201680054093.3A patent/CN108025076A/zh active Pending
- 2016-07-19 WO PCT/US2016/042905 patent/WO2017015262A1/en active Application Filing
- 2016-07-19 BR BR112018000776A patent/BR112018000776A2/pt not_active Application Discontinuation
- 2016-07-19 CA CA2991779A patent/CA2991779A1/en not_active Abandoned
- 2016-07-19 RU RU2018105923A patent/RU2738934C2/ru active
- 2016-07-19 EP EP16744650.9A patent/EP3325014B1/en active Active
- 2016-07-19 AU AU2016297555A patent/AU2016297555B2/en not_active Ceased
- 2016-07-19 KR KR1020187004110A patent/KR20180030630A/ko not_active Application Discontinuation
- 2016-07-19 JP JP2018502669A patent/JP2018525358A/ja active Pending
- 2016-07-19 MX MX2018000715A patent/MX2018000715A/es unknown
- 2016-07-19 US US15/213,829 patent/US10350213B2/en not_active Expired - Fee Related
-
2018
- 2018-01-10 IL IL256836A patent/IL256836B/en active IP Right Grant
- 2018-10-18 HK HK18113402.5A patent/HK1254258A1/zh unknown
-
2021
- 2021-05-19 JP JP2021084241A patent/JP2021121611A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2016297555B2 (en) | 2021-08-19 |
TW201717957A (zh) | 2017-06-01 |
EP3325014A1 (en) | 2018-05-30 |
CA2991779A1 (en) | 2017-01-26 |
MX2018000715A (es) | 2018-06-06 |
IL256836B (en) | 2021-04-29 |
AU2016297555A1 (en) | 2018-03-01 |
KR20180030630A (ko) | 2018-03-23 |
RU2018105923A3 (zh) | 2019-12-20 |
JP2018525358A (ja) | 2018-09-06 |
WO2017015262A1 (en) | 2017-01-26 |
US10350213B2 (en) | 2019-07-16 |
BR112018000776A2 (pt) | 2018-09-04 |
RU2018105923A (ru) | 2019-08-20 |
US20170020884A1 (en) | 2017-01-26 |
IL256836A (en) | 2018-03-29 |
TWI746449B (zh) | 2021-11-21 |
JP2021121611A (ja) | 2021-08-26 |
CN108025076A (zh) | 2018-05-11 |
EP3325014B1 (en) | 2021-05-19 |
RU2738934C2 (ru) | 2020-12-18 |
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