JP2004520395A5 - - Google Patents
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- Publication number
- JP2004520395A5 JP2004520395A5 JP2002563196A JP2002563196A JP2004520395A5 JP 2004520395 A5 JP2004520395 A5 JP 2004520395A5 JP 2002563196 A JP2002563196 A JP 2002563196A JP 2002563196 A JP2002563196 A JP 2002563196A JP 2004520395 A5 JP2004520395 A5 JP 2004520395A5
- Authority
- JP
- Japan
- Prior art keywords
- lys
- ala
- derivative
- leu
- administering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims 21
- 238000004519 manufacturing process Methods 0.000 claims 12
- 239000003937 drug carrier Substances 0.000 claims 11
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 9
- 230000002159 abnormal effect Effects 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 239000012503 blood component Substances 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 230000001737 promoting effect Effects 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 3
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims 3
- 102000018997 Growth Hormone Human genes 0.000 claims 3
- 108010051696 Growth Hormone Proteins 0.000 claims 3
- 101710142969 Somatoliberin Proteins 0.000 claims 3
- 102100022831 Somatoliberin Human genes 0.000 claims 3
- 239000000122 growth hormone Substances 0.000 claims 3
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000003578 releasing effect Effects 0.000 claims 2
- GDFAOVXKHJXLEI-GSVOUGTGSA-N (2r)-2-(methylamino)propanoic acid Chemical compound CN[C@H](C)C(O)=O GDFAOVXKHJXLEI-GSVOUGTGSA-N 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 101000825768 Bos taurus Somatoliberin Proteins 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 101000825742 Homo sapiens Somatoliberin Proteins 0.000 claims 1
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 claims 1
- IGRMTQMIDNDFAA-UWVGGRQHSA-N Lys-His Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 IGRMTQMIDNDFAA-UWVGGRQHSA-N 0.000 claims 1
- MYTOTTSMVMWVJN-STQMWFEESA-N Lys-Tyr Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 MYTOTTSMVMWVJN-STQMWFEESA-N 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 239000003325 growth hormone releasing factor derivative Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26642401P | 2001-02-02 | 2001-02-02 | |
| PCT/CA2002/000123 WO2002062844A2 (en) | 2001-02-02 | 2002-02-01 | Long lasting growth hormone releasing factor derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007341449A Division JP2008106073A (ja) | 2001-02-02 | 2007-12-28 | 長期持続性成長ホルモン放出因子誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004520395A JP2004520395A (ja) | 2004-07-08 |
| JP2004520395A5 true JP2004520395A5 (enExample) | 2006-01-05 |
Family
ID=23014533
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002563196A Withdrawn JP2004520395A (ja) | 2001-02-02 | 2002-02-01 | 長期持続性成長ホルモン放出因子誘導体 |
| JP2007341449A Pending JP2008106073A (ja) | 2001-02-02 | 2007-12-28 | 長期持続性成長ホルモン放出因子誘導体 |
| JP2008208279A Pending JP2009024017A (ja) | 2001-02-02 | 2008-08-12 | 長期持続性成長ホルモン放出因子誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007341449A Pending JP2008106073A (ja) | 2001-02-02 | 2007-12-28 | 長期持続性成長ホルモン放出因子誘導体 |
| JP2008208279A Pending JP2009024017A (ja) | 2001-02-02 | 2008-08-12 | 長期持続性成長ホルモン放出因子誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7268113B2 (enExample) |
| EP (1) | EP1355941A2 (enExample) |
| JP (3) | JP2004520395A (enExample) |
| CN (2) | CN101696240A (enExample) |
| AU (1) | AU2002233082B2 (enExample) |
| BR (1) | BR0206919A (enExample) |
| CA (1) | CA2435563A1 (enExample) |
| EA (1) | EA006484B1 (enExample) |
| WO (1) | WO2002062844A2 (enExample) |
| ZA (1) | ZA200305641B (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425729D0 (en) * | 1994-09-14 | 1995-02-22 | British Telecomm | Otical device |
| US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
| US6329336B1 (en) * | 1999-05-17 | 2001-12-11 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
| WO2002066511A2 (en) * | 2001-02-16 | 2002-08-29 | Conjuchem Inc. | Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders |
| WO2004027064A2 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
| PT1745078E (pt) * | 2004-04-23 | 2009-09-17 | Conjuchem Biotechnologies Inc | Método para a purificação de conjugados de albumina |
| WO2007053946A1 (en) * | 2005-11-09 | 2007-05-18 | Conjuchem Biotechnologies Inc. | Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin |
| AU2006329215A1 (en) * | 2005-12-22 | 2007-06-28 | Conjuchem Biotechnologies Inc. | Process for the production of preformed conjugates of albumin and a therapeutic agent |
| US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
| EP2118123B1 (en) | 2007-01-31 | 2015-10-14 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| EP3159352B1 (en) | 2007-03-28 | 2023-08-02 | President and Fellows of Harvard College | Stitched polypeptides |
| WO2009009727A2 (en) * | 2007-07-12 | 2009-01-15 | Akela Pharma Srl | Ghrh analogs and therapeutic uses thereof |
| EP2231191A2 (en) * | 2007-12-11 | 2010-09-29 | ConjuChem Biotechnologies Inc. | Formulation of insulinotropic peptide conjugates |
| US20100267636A1 (en) * | 2009-04-20 | 2010-10-21 | Theratechnologies Inc. | Use of cytochrome p450-metabolized drugs and grf molecules in combination therapy |
| WO2010121351A1 (en) * | 2009-04-20 | 2010-10-28 | Theratechnologies Inc. | Use of (hexenoyl trans-3)hgrf(1-44)nh2 and ritonavir in combination therapy |
| BR112012015597A2 (pt) * | 2009-12-21 | 2017-01-31 | Ambrx Inc | peptídeos de somatotropina suínos modificados e seus usos |
| WO2011153491A2 (en) | 2010-06-03 | 2011-12-08 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| KR20140027284A (ko) * | 2011-04-21 | 2014-03-06 | 쎄러테크놀로지스 인코포레이티드 | 성장 호르몬 방출 인자(grf) 유사체 및 이의 용도 |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| NZ627528A (en) | 2012-02-15 | 2016-05-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| CN108524919A (zh) | 2012-05-17 | 2018-09-14 | 延伸生物科学股份有限公司 | 用于改进的药物递送的载体 |
| WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| EP2934565B1 (en) | 2012-12-21 | 2019-03-13 | University of Miami | Ghrh agonists for the treatment of ischemic disorders |
| WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
| CN103897053B (zh) * | 2012-12-25 | 2019-01-15 | 深圳先进技术研究院 | 化学修饰的胸腺肽α1及其合成方法 |
| CN103665147A (zh) * | 2013-11-26 | 2014-03-26 | 深圳翰宇药业股份有限公司 | 一种生长激素释放因子衍生物的合成方法 |
| KR20170058424A (ko) | 2014-09-24 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| US10519239B2 (en) | 2015-05-28 | 2019-12-31 | Institut National De La Recherche Scientifique | Inhibitors of prototypic galectin dimerization and uses thereof |
| US20190046604A1 (en) | 2015-11-18 | 2019-02-14 | Helmholtz-Zentrum für Infektionsforschung GmbH | Labyrinthopeptins as anti-viral agents |
| WO2017223207A1 (en) | 2016-06-22 | 2017-12-28 | University Of Rochester | Cyclic peptide inhibitors of hedgehog proteins |
| WO2018085460A2 (en) * | 2016-11-02 | 2018-05-11 | Flagship Pioneering, Inc. | Compositions and methods for cell delivery |
| CN108623694B (zh) * | 2017-03-24 | 2021-09-17 | 北京市肿瘤防治研究所 | 血管内皮细胞生长因子受体拮抗肽f56的衍生物及应用 |
| ES3036928T3 (en) | 2019-12-19 | 2025-09-25 | Transfert Plus Soc En Commandite | Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies |
| AR124707A1 (es) | 2021-01-28 | 2023-04-26 | Talem Therapeutics Llc | Anticuerpos antiglicoproteína de espiga y su uso terapéutico |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
| WO2024081918A1 (en) | 2022-10-14 | 2024-04-18 | Talem Therapeutics Llc | Anti-trkb/cd3 antibodies and uses thereof |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4462941A (en) * | 1982-06-10 | 1984-07-31 | The Regents Of The University Of California | Dynorphin amide analogs |
| US4517181A (en) * | 1982-09-15 | 1985-05-14 | The Salk Institute For Biological Studies | Mammalian PGRF |
| US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| US4595676A (en) * | 1983-04-26 | 1986-06-17 | The Salk Institute For Biological Studies | Rat hypothalamic GRF |
| US4529595A (en) * | 1983-01-13 | 1985-07-16 | The Salk Institute For Biological Studies | GRF Analogs |
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| US4628043A (en) * | 1983-04-26 | 1986-12-09 | The Salk Institute For Biological Studies | Hypothalamic GRF agonists |
| US5416073A (en) * | 1983-08-10 | 1995-05-16 | The Adminstrators Of The Tulane Educational Fund | Growth hormone-releasing peptides and method of treating animals, therewith |
| US4610976A (en) * | 1983-08-29 | 1986-09-09 | The Salk Institute For Biological Studies | Porcine GRF |
| US4605643A (en) * | 1984-03-02 | 1986-08-12 | The Salk Institute For Biological Studies | Ovine GRF |
| US4585756A (en) * | 1983-10-12 | 1986-04-29 | The Salk Institute For Biological Studies | Bovine GRF |
| US4626523A (en) * | 1983-09-13 | 1986-12-02 | The Salk Institute For Biological Studies | GRF analogs II |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| EP0189673B1 (en) * | 1984-12-24 | 1990-09-26 | Sumitomo Pharmaceuticals Company, Limited | Stable growth hormone releasing factor preparation |
| CA1271600A (en) | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| US4784987A (en) * | 1987-01-13 | 1988-11-15 | The Salk Institute For Biological Studies | GRF analogs VI |
| US4843064A (en) * | 1987-01-13 | 1989-06-27 | The Salk Institute For Biological Studies | GRF analogs V |
| JPH03502326A (ja) | 1988-01-28 | 1991-05-30 | ポリゲン ホールディング コーポレイション | 成長ホルモン放出活性を有するポリペプチド化合物類 |
| ATE122357T1 (de) | 1988-01-28 | 1995-05-15 | Polygen Holding Corp | Polypeptide mit hormonwachstumsbefreiender wirkung. |
| US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
| DK608589D0 (da) | 1989-12-01 | 1989-12-01 | Holm Arne | Kemisk fremgangsmaade |
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| AU662731B2 (en) | 1991-04-09 | 1995-09-14 | F. Hoffmann-La Roche Ag | Growth hormone releasing factor analogs |
| DE4122210C2 (de) | 1991-07-04 | 1999-04-01 | Deutsches Krebsforsch | Konjugate aus tumoraktiver Verbindung und Serumalbumin sowie Verfahren zu deren Herstellung und ihre Verwendung |
| US5663146A (en) | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
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| US5580853A (en) * | 1994-03-22 | 1996-12-03 | New England Deaconess Hospital | Modified polypeptides with increased biological activity |
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| US6184201B1 (en) * | 1995-04-14 | 2001-02-06 | Nps Allelix Corp. | Intestinotrophic glucagon-like peptide-2 analogs |
| US5654276A (en) * | 1995-06-07 | 1997-08-05 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
| EP0851767A1 (en) * | 1995-09-21 | 1998-07-08 | Quadrant Healthcare (UK) Limited | Transcytosis vehicles and enhancers for drug delivery |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| CN1130222C (zh) * | 1996-01-11 | 2003-12-10 | 法玛西雅厄普约翰美国公司 | 水性延长释放配剂 |
| WO1998008872A1 (en) | 1996-08-30 | 1998-03-05 | Novo Nordisk A/S | Glp-2 derivatives |
| CA2309205A1 (en) | 1997-11-07 | 1999-05-20 | Conjuchem, Inc. | Novel conjugates of rgd-containing peptides and endogenous carriers |
| DE69839946D1 (de) | 1997-11-07 | 2008-10-09 | Conjuchem Biotechnologies Inc | Methoden zum Screening von Affinitätsmarker-Bibliotheken |
| IL133053A0 (en) | 1998-03-23 | 2001-03-19 | Conjuchem Inc | Local delivery of long lasting therapeutic agents |
| US6329336B1 (en) | 1999-05-17 | 2001-12-11 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
| EP2100901A1 (en) * | 1999-05-17 | 2009-09-16 | ConjuChem Biotechnologies Inc. | Modified Insulin and conjugates thereof |
| DE19926154A1 (de) | 1999-06-09 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
| DE19926475A1 (de) | 1999-06-10 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Träger-Pharmaka-Konjugate |
| DE10012120A1 (de) | 2000-03-13 | 2001-09-27 | Ktb Tumorforschungs Gmbh | Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel |
| ES2741524T3 (es) | 2004-03-23 | 2020-02-11 | Ascendis Pharma Gmbh | Profármaco polimérico con un enlazador autoinmolador |
-
2002
- 2002-02-01 CN CN200910163485A patent/CN101696240A/zh active Pending
- 2002-02-01 AU AU2002233082A patent/AU2002233082B2/en not_active Ceased
- 2002-02-01 BR BR0206919-9A patent/BR0206919A/pt not_active Application Discontinuation
- 2002-02-01 CA CA002435563A patent/CA2435563A1/en not_active Abandoned
- 2002-02-01 US US10/203,809 patent/US7268113B2/en not_active Expired - Fee Related
- 2002-02-01 WO PCT/CA2002/000123 patent/WO2002062844A2/en not_active Ceased
- 2002-02-01 CN CNA028044975A patent/CN1491233A/zh active Pending
- 2002-02-01 EP EP02700072A patent/EP1355941A2/en not_active Withdrawn
- 2002-02-01 EA EA200300856A patent/EA006484B1/ru not_active IP Right Cessation
- 2002-02-01 JP JP2002563196A patent/JP2004520395A/ja not_active Withdrawn
-
2003
- 2003-07-22 ZA ZA200305641A patent/ZA200305641B/en unknown
-
2007
- 2007-12-28 JP JP2007341449A patent/JP2008106073A/ja active Pending
-
2008
- 2008-08-12 JP JP2008208279A patent/JP2009024017A/ja active Pending
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