EA006484B1 - Долгоживущие производные рилизинг-фактора гормона роста - Google Patents
Долгоживущие производные рилизинг-фактора гормона роста Download PDFInfo
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- EA006484B1 EA006484B1 EA200300856A EA200300856A EA006484B1 EA 006484 B1 EA006484 B1 EA 006484B1 EA 200300856 A EA200300856 A EA 200300856A EA 200300856 A EA200300856 A EA 200300856A EA 006484 B1 EA006484 B1 EA 006484B1
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- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
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- 239000007929 subcutaneous injection Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
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- 230000002483 superagonistic effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
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- 238000001308 synthesis method Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Child & Adolescent Psychology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26642401P | 2001-02-02 | 2001-02-02 | |
| PCT/CA2002/000123 WO2002062844A2 (en) | 2001-02-02 | 2002-02-01 | Long lasting growth hormone releasing factor derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200300856A1 EA200300856A1 (ru) | 2004-08-26 |
| EA006484B1 true EA006484B1 (ru) | 2005-12-29 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200300856A EA006484B1 (ru) | 2001-02-02 | 2002-02-01 | Долгоживущие производные рилизинг-фактора гормона роста |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7268113B2 (enExample) |
| EP (1) | EP1355941A2 (enExample) |
| JP (3) | JP2004520395A (enExample) |
| CN (2) | CN1491233A (enExample) |
| AU (1) | AU2002233082B2 (enExample) |
| BR (1) | BR0206919A (enExample) |
| CA (1) | CA2435563A1 (enExample) |
| EA (1) | EA006484B1 (enExample) |
| WO (1) | WO2002062844A2 (enExample) |
| ZA (1) | ZA200305641B (enExample) |
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| GB9425729D0 (en) * | 1994-09-14 | 1995-02-22 | British Telecomm | Otical device |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| PT1180121E (pt) * | 1999-05-17 | 2004-03-31 | Conjuchem Inc | Peptidos insulinotropicos de longa duracao |
| US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
| US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
| DK1360202T3 (da) * | 2001-02-16 | 2008-09-22 | Conjuchem Biotechnologies Inc | Langvarigt glucagon-lignende peptid 2 (GLP-2) til behandling af gastrointestinale sygdomme og lidelser |
| EP1539959A2 (en) * | 2002-09-18 | 2005-06-15 | Centre Hospitalier de l'Université de Montréal (CHUM) | Ghrh analogues |
| ES2347902T3 (es) * | 2004-04-23 | 2010-11-22 | Conjuchem Biotechnologies Inc. Canadian Corporation 4528590 | Fase solida para uso en un procedimiento para la purificacion de conjugados de albumina. |
| US8039432B2 (en) * | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
| AU2006329215A1 (en) * | 2005-12-22 | 2007-06-28 | Conjuchem Biotechnologies Inc. | Process for the production of preformed conjugates of albumin and a therapeutic agent |
| US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| US20090088380A1 (en) * | 2007-07-12 | 2009-04-02 | Pierrette Gaudreau | Ghrh analogs and therapeutic uses thereof |
| JP2011506442A (ja) * | 2007-12-11 | 2011-03-03 | コンジュケム バイオテクノロジーズ インコーポレイテッド | インスリン分泌性ペプチド結合体の製剤 |
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| EP2421548A4 (en) * | 2009-04-20 | 2012-09-26 | Theratechnologies Inc | USE OF (HEXENOYL TRANS-3) HGRF (1-44) NH2 AND SIMVASTATIN IN COMBINED TREATMENT |
| JP2013515081A (ja) * | 2009-12-21 | 2013-05-02 | アンブルックス，インコーポレイテッド | 修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用 |
| WO2011153491A2 (en) | 2010-06-03 | 2011-12-08 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
| SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
| BR112013027150A2 (pt) | 2011-04-21 | 2017-06-06 | Theratechnologies Inc | thera |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
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| KR102112373B1 (ko) | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
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| EP2934565B1 (en) | 2012-12-21 | 2019-03-13 | University of Miami | Ghrh agonists for the treatment of ischemic disorders |
| EP2935317B1 (en) | 2012-12-21 | 2019-03-27 | University of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
| CN103897053B (zh) * | 2012-12-25 | 2019-01-15 | 深圳先进技术研究院 | 化学修饰的胸腺肽α1及其合成方法 |
| CN103665147A (zh) * | 2013-11-26 | 2014-03-26 | 深圳翰宇药业股份有限公司 | 一种生长激素释放因子衍生物的合成方法 |
| BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
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| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| EP3303378B1 (en) | 2015-05-28 | 2021-04-21 | Institut National de la Recherche Scientifique | Inhibitors of prototypic galectin dimerization and uses thereof |
| JP7185874B2 (ja) | 2015-11-18 | 2022-12-08 | ヘルムホルツ－ツェントルン フュル インフェクティオンスフォルシュング ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗ウイルス剤としてのラビリントペプチン |
| EP3475294A1 (en) | 2016-06-22 | 2019-05-01 | The University of Rochester | Cyclic peptide inhibitors of hedgehog proteins |
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| CN108623694B (zh) * | 2017-03-24 | 2021-09-17 | 北京市肿瘤防治研究所 | 血管内皮细胞生长因子受体拮抗肽f56的衍生物及应用 |
| US20230022970A1 (en) | 2019-12-19 | 2023-01-26 | Transfert Plus, Société En Commandite | Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies |
| PY2204506A (es) | 2021-01-28 | 2022-08-30 | Talem Therapeutics Llc | Anticuerpos antiglicoproteína de espiga y su uso terapéutico |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
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2002
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- 2002-02-01 AU AU2002233082A patent/AU2002233082B2/en not_active Ceased
- 2002-02-01 BR BR0206919-9A patent/BR0206919A/pt not_active Application Discontinuation
- 2002-02-01 EA EA200300856A patent/EA006484B1/ru not_active IP Right Cessation
- 2002-02-01 WO PCT/CA2002/000123 patent/WO2002062844A2/en not_active Ceased
- 2002-02-01 CN CNA028044975A patent/CN1491233A/zh active Pending
- 2002-02-01 US US10/203,809 patent/US7268113B2/en not_active Expired - Fee Related
- 2002-02-01 CN CN200910163485A patent/CN101696240A/zh active Pending
- 2002-02-01 JP JP2002563196A patent/JP2004520395A/ja not_active Withdrawn
- 2002-02-01 EP EP02700072A patent/EP1355941A2/en not_active Withdrawn
-
2003
- 2003-07-22 ZA ZA200305641A patent/ZA200305641B/en unknown
-
2007
- 2007-12-28 JP JP2007341449A patent/JP2008106073A/ja active Pending
-
2008
- 2008-08-12 JP JP2008208279A patent/JP2009024017A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EA200300856A1 (ru) | 2004-08-26 |
| ZA200305641B (en) | 2004-05-25 |
| JP2008106073A (ja) | 2008-05-08 |
| JP2009024017A (ja) | 2009-02-05 |
| CA2435563A1 (en) | 2002-08-15 |
| BR0206919A (pt) | 2004-07-06 |
| US7268113B2 (en) | 2007-09-11 |
| CN1491233A (zh) | 2004-04-21 |
| WO2002062844A2 (en) | 2002-08-15 |
| EP1355941A2 (en) | 2003-10-29 |
| US20030073630A1 (en) | 2003-04-17 |
| CN101696240A (zh) | 2010-04-21 |
| WO2002062844A3 (en) | 2003-08-21 |
| AU2002233082B2 (en) | 2005-11-10 |
| JP2004520395A (ja) | 2004-07-08 |
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| PC4A | Registration of transfer of a eurasian patent by assignment | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM BY KZ KG MD TM |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ TJ RU |