AU2002233082B2 - Long lasting growth hormone releasing factor derivatives - Google Patents
Long lasting growth hormone releasing factor derivatives Download PDFInfo
- Publication number
- AU2002233082B2 AU2002233082B2 AU2002233082A AU2002233082A AU2002233082B2 AU 2002233082 B2 AU2002233082 B2 AU 2002233082B2 AU 2002233082 A AU2002233082 A AU 2002233082A AU 2002233082 A AU2002233082 A AU 2002233082A AU 2002233082 B2 AU2002233082 B2 AU 2002233082B2
- Authority
- AU
- Australia
- Prior art keywords
- fmoc
- leu
- ala
- lys
- grf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003325 growth hormone releasing factor derivative Substances 0.000 title 1
- 230000005923 long-lasting effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 6
- 230000005856 abnormality Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000001737 promoting effect Effects 0.000 claims 3
- 239000012503 blood component Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2005218012A AU2005218012A1 (en) | 2001-02-02 | 2005-09-28 | Long lasting growth hormone releasing factor derivatives |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26642401P | 2001-02-02 | 2001-02-02 | |
| US60/266,424 | 2001-02-02 | ||
| PCT/CA2002/000123 WO2002062844A2 (en) | 2001-02-02 | 2002-02-01 | Long lasting growth hormone releasing factor derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005218012A Division AU2005218012A1 (en) | 2001-02-02 | 2005-09-28 | Long lasting growth hormone releasing factor derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002233082A1 AU2002233082A1 (en) | 2003-02-13 |
| AU2002233082B2 true AU2002233082B2 (en) | 2005-11-10 |
Family
ID=23014533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002233082A Ceased AU2002233082B2 (en) | 2001-02-02 | 2002-02-01 | Long lasting growth hormone releasing factor derivatives |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7268113B2 (enExample) |
| EP (1) | EP1355941A2 (enExample) |
| JP (3) | JP2004520395A (enExample) |
| CN (2) | CN101696240A (enExample) |
| AU (1) | AU2002233082B2 (enExample) |
| BR (1) | BR0206919A (enExample) |
| CA (1) | CA2435563A1 (enExample) |
| EA (1) | EA006484B1 (enExample) |
| WO (1) | WO2002062844A2 (enExample) |
| ZA (1) | ZA200305641B (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425729D0 (en) * | 1994-09-14 | 1995-02-22 | British Telecomm | Otical device |
| US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
| US7601691B2 (en) * | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
| DK1180121T3 (da) * | 1999-05-17 | 2004-03-01 | Conjuchem Inc | Langtidsvirkende insulinotrope peptider |
| US7112567B2 (en) * | 2001-02-16 | 2006-09-26 | Conjuchem Inc. | Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders |
| CN1688696A (zh) * | 2002-09-18 | 2005-10-26 | 蒙特利尔大学医疗中心 | Ghrh类似物 |
| AU2005235634B2 (en) * | 2004-04-23 | 2011-10-20 | Conjuchem Biotechnologies Inc. | Method for the purification of albumin conjugates |
| US8039432B2 (en) * | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
| MX2008008076A (es) * | 2005-12-22 | 2008-11-28 | Conjuchem Biotechnologies Inc | Procesos para la produccion de conjugados preformados de albumina y un agente terapeutico. |
| US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
| PT2118123E (pt) | 2007-01-31 | 2016-02-10 | Harvard College | Péptidos de p53 estabilizados e suas utilizações |
| JP5631201B2 (ja) | 2007-03-28 | 2014-11-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ステッチングされたポリペプチド |
| WO2009009727A2 (en) * | 2007-07-12 | 2009-01-15 | Akela Pharma Srl | Ghrh analogs and therapeutic uses thereof |
| CN102026666B (zh) * | 2007-12-11 | 2013-10-16 | 常山凯捷健生物药物研发(河北)有限公司 | 促胰岛素肽缀合物制剂 |
| WO2010121351A1 (en) * | 2009-04-20 | 2010-10-28 | Theratechnologies Inc. | Use of (hexenoyl trans-3)hgrf(1-44)nh2 and ritonavir in combination therapy |
| WO2010121352A1 (en) * | 2009-04-20 | 2010-10-28 | Theratechnologies Inc. | Use of (hexenoyl trans-3)hgrf(l-44)nh2 and simvastatin in combination therapy |
| WO2011087810A1 (en) * | 2009-12-21 | 2011-07-21 | Ambrx, Inc. | Modified porcine somatotropin polypeptides and their uses |
| WO2011153491A2 (en) | 2010-06-03 | 2011-12-08 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
| MX355543B (es) | 2010-08-13 | 2018-04-20 | Aileron Therapeutics Inc Star | Macrociclos peptidomiméticos. |
| WO2012142706A1 (en) | 2011-04-21 | 2012-10-26 | Theratechnologies Inc. | Growth hormone releasing factor (grf) analogs and uses thereof |
| TWI643868B (zh) | 2011-10-18 | 2018-12-11 | 艾利倫治療公司 | 擬肽巨環化合物 |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER |
| SG11201404648PA (en) | 2012-02-15 | 2014-09-26 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| AU2013263349B2 (en) | 2012-05-17 | 2016-09-08 | Extend Biosciences, Inc | Carriers for improved drug delivery |
| WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
| KR20150082307A (ko) | 2012-11-01 | 2015-07-15 | 에일러론 테라퓨틱스 인코포레이티드 | 이치환 아미노산 및 이의 제조 및 사용 방법 |
| WO2014100809A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for the treatment of ischemic disorders |
| EP2935317B1 (en) | 2012-12-21 | 2019-03-27 | University of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
| CN103897053B (zh) * | 2012-12-25 | 2019-01-15 | 深圳先进技术研究院 | 化学修饰的胸腺肽α1及其合成方法 |
| CN103665147A (zh) * | 2013-11-26 | 2014-03-26 | 深圳翰宇药业股份有限公司 | 一种生长激素释放因子衍生物的合成方法 |
| SG11201702223UA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| KR20170129879A (ko) | 2015-03-20 | 2017-11-27 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
| EP3303378B1 (en) | 2015-05-28 | 2021-04-21 | Institut National de la Recherche Scientifique | Inhibitors of prototypic galectin dimerization and uses thereof |
| CA3004805A1 (en) | 2015-11-18 | 2017-05-26 | Helmholtz-Zentrum Fur Infektionsforschung Gmbh | Labyrinthopeptins as anti-viral agents |
| WO2017223207A1 (en) | 2016-06-22 | 2017-12-28 | University Of Rochester | Cyclic peptide inhibitors of hedgehog proteins |
| WO2018085460A2 (en) * | 2016-11-02 | 2018-05-11 | Flagship Pioneering, Inc. | Compositions and methods for cell delivery |
| CN108623694B (zh) * | 2017-03-24 | 2021-09-17 | 北京市肿瘤防治研究所 | 血管内皮细胞生长因子受体拮抗肽f56的衍生物及应用 |
| US20230022970A1 (en) | 2019-12-19 | 2023-01-26 | Transfert Plus, Société En Commandite | Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies |
| EP4284828A1 (en) | 2021-01-28 | 2023-12-06 | Talem Therapeutics LLC | Anti-sars-cov-2 spike glycoprotein antibodies and the therapeutic use thereof |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| EP4601691A1 (en) | 2022-10-14 | 2025-08-20 | Talem Therapeutics LLC | Anti-trkb/cd3 antibodies and uses thereof |
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|---|---|---|---|---|
| US4411890A (en) | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4462941A (en) | 1982-06-10 | 1984-07-31 | The Regents Of The University Of California | Dynorphin amide analogs |
| US4517181A (en) | 1982-09-15 | 1985-05-14 | The Salk Institute For Biological Studies | Mammalian PGRF |
| US4529595A (en) | 1983-01-13 | 1985-07-16 | The Salk Institute For Biological Studies | GRF Analogs |
| US4563352A (en) | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| US4595676A (en) | 1983-04-26 | 1986-06-17 | The Salk Institute For Biological Studies | Rat hypothalamic GRF |
| US4518586A (en) | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| US4628043A (en) | 1983-04-26 | 1986-12-09 | The Salk Institute For Biological Studies | Hypothalamic GRF agonists |
| US5416073A (en) * | 1983-08-10 | 1995-05-16 | The Adminstrators Of The Tulane Educational Fund | Growth hormone-releasing peptides and method of treating animals, therewith |
| US4585756A (en) | 1983-10-12 | 1986-04-29 | The Salk Institute For Biological Studies | Bovine GRF |
| US4605643A (en) | 1984-03-02 | 1986-08-12 | The Salk Institute For Biological Studies | Ovine GRF |
| US4610976A (en) | 1983-08-29 | 1986-09-09 | The Salk Institute For Biological Studies | Porcine GRF |
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| US4528190A (en) | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| EP0189673B1 (en) | 1984-12-24 | 1990-09-26 | Sumitomo Pharmaceuticals Company, Limited | Stable growth hormone releasing factor preparation |
| CA1271600A (en) | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
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| JPH03502326A (ja) | 1988-01-28 | 1991-05-30 | ポリゲン ホールディング コーポレイション | 成長ホルモン放出活性を有するポリペプチド化合物類 |
| WO1989007110A1 (en) | 1988-01-28 | 1989-08-10 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
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| NZ318472A (en) | 1995-09-21 | 1999-10-28 | Quadrant Healthcare Uk Ltd | Composition or conjugate containing a gp60 receptor and a transcytosis enhancer (typically albumin) |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| CN1130222C (zh) * | 1996-01-11 | 2003-12-10 | 法玛西雅厄普约翰美国公司 | 水性延长释放配剂 |
| JP2000517308A (ja) | 1996-08-30 | 2000-12-26 | ノボ ノルディスク アクティーゼルスカブ | Glp―2誘導体 |
| ATE218892T1 (de) | 1997-11-07 | 2002-06-15 | Conjuchem Inc | Affinitätsmarkierer für menschliches serum albumin |
| IL135835A0 (en) | 1997-11-07 | 2001-05-20 | Conjuchem Inc | Novel conjugates of opioids and endogenous carriers |
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| EP1105409B1 (en) * | 1999-05-17 | 2006-03-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| DK1180121T3 (da) | 1999-05-17 | 2004-03-01 | Conjuchem Inc | Langtidsvirkende insulinotrope peptider |
| DE19926154A1 (de) | 1999-06-09 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
| DE19926475A1 (de) | 1999-06-10 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Träger-Pharmaka-Konjugate |
| DE10012120A1 (de) | 2000-03-13 | 2001-09-27 | Ktb Tumorforschungs Gmbh | Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel |
| HUE045882T2 (hu) | 2004-03-23 | 2020-01-28 | Ascendis Pharma Gmbh | Polimer prodrug önmagát lehasító linkerrel |
-
2002
- 2002-02-01 BR BR0206919-9A patent/BR0206919A/pt not_active Application Discontinuation
- 2002-02-01 AU AU2002233082A patent/AU2002233082B2/en not_active Ceased
- 2002-02-01 JP JP2002563196A patent/JP2004520395A/ja not_active Withdrawn
- 2002-02-01 CA CA002435563A patent/CA2435563A1/en not_active Abandoned
- 2002-02-01 EA EA200300856A patent/EA006484B1/ru not_active IP Right Cessation
- 2002-02-01 CN CN200910163485A patent/CN101696240A/zh active Pending
- 2002-02-01 US US10/203,809 patent/US7268113B2/en not_active Expired - Fee Related
- 2002-02-01 CN CNA028044975A patent/CN1491233A/zh active Pending
- 2002-02-01 WO PCT/CA2002/000123 patent/WO2002062844A2/en not_active Ceased
- 2002-02-01 EP EP02700072A patent/EP1355941A2/en not_active Withdrawn
-
2003
- 2003-07-22 ZA ZA200305641A patent/ZA200305641B/en unknown
-
2007
- 2007-12-28 JP JP2007341449A patent/JP2008106073A/ja active Pending
-
2008
- 2008-08-12 JP JP2008208279A patent/JP2009024017A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200305641B (en) | 2004-05-25 |
| US20030073630A1 (en) | 2003-04-17 |
| WO2002062844A2 (en) | 2002-08-15 |
| JP2004520395A (ja) | 2004-07-08 |
| EP1355941A2 (en) | 2003-10-29 |
| EA200300856A1 (ru) | 2004-08-26 |
| BR0206919A (pt) | 2004-07-06 |
| JP2009024017A (ja) | 2009-02-05 |
| JP2008106073A (ja) | 2008-05-08 |
| CA2435563A1 (en) | 2002-08-15 |
| US7268113B2 (en) | 2007-09-11 |
| CN1491233A (zh) | 2004-04-21 |
| CN101696240A (zh) | 2010-04-21 |
| WO2002062844A3 (en) | 2003-08-21 |
| EA006484B1 (ru) | 2005-12-29 |
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