DE69812727D1 - Opioid-konjugate mit endogenen Trägerproteinen - Google Patents
Opioid-konjugate mit endogenen TrägerproteinenInfo
- Publication number
- DE69812727D1 DE69812727D1 DE69812727T DE69812727T DE69812727D1 DE 69812727 D1 DE69812727 D1 DE 69812727D1 DE 69812727 T DE69812727 T DE 69812727T DE 69812727 T DE69812727 T DE 69812727T DE 69812727 D1 DE69812727 D1 DE 69812727D1
- Authority
- DE
- Germany
- Prior art keywords
- patient
- conjugates
- antinociceptive
- conjugate
- vivo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6470597P | 1997-11-07 | 1997-11-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69812727D1 true DE69812727D1 (de) | 2003-04-30 |
Family
ID=22057753
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69812727T Expired - Lifetime DE69812727D1 (de) | 1997-11-07 | 1998-11-06 | Opioid-konjugate mit endogenen Trägerproteinen |
DE69804974T Expired - Lifetime DE69804974T2 (de) | 1997-11-07 | 1998-11-06 | Opioid-konjugate mit endogenen trägerproteinen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69804974T Expired - Lifetime DE69804974T2 (de) | 1997-11-07 | 1998-11-06 | Opioid-konjugate mit endogenen trägerproteinen |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP1007561B1 (de) |
JP (2) | JP2001522817A (de) |
AT (2) | ATE235513T1 (de) |
AU (3) | AU750387B2 (de) |
CA (2) | CA2301799C (de) |
DE (2) | DE69812727D1 (de) |
ES (1) | ES2173641T3 (de) |
IL (1) | IL135835A0 (de) |
WO (3) | WO1999024462A2 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6437092B1 (en) | 1998-11-06 | 2002-08-20 | Conjuchem, Inc. | Conjugates of opioids and endogenous carriers |
WO1999048536A2 (en) * | 1998-03-23 | 1999-09-30 | Conjuchem, Inc. | Delivery of long lasting therapeutic agents by forming covalent attachments in vivo |
US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
CN1810832B (zh) | 1998-10-23 | 2012-12-12 | 麒麟-安姆根有限公司 | 与MPl受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽 |
US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
DK1105409T3 (da) * | 1999-05-17 | 2006-07-03 | Conjuchem Inc | Beskyttelse af endogene terapeutiske peptider fra peptidaseaktivitet ved konjugering med blodkomponenter |
US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
US7144854B1 (en) | 1999-09-10 | 2006-12-05 | Conjuchem, Inc. | Long lasting anti-angiogenic peptides |
CN1698881A (zh) * | 1999-05-17 | 2005-11-23 | 康久化学公司 | 病毒感染的长效融合肽抑制剂 |
US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
ATE252601T1 (de) | 1999-05-17 | 2003-11-15 | Conjuchem Inc | Lang wirkende insulinotrope peptide |
ATE443714T1 (de) * | 1999-05-17 | 2009-10-15 | Conjuchem Biotechnologies Inc | Lang wirkende peptidinhibitoren der virusfusion mit körperzellen bei viralen infektionen |
US6706892B1 (en) | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
US7090851B1 (en) | 1999-09-10 | 2006-08-15 | Conjuchem Inc. | Long lasting fusion peptide inhibitors of viral infection |
AU2002233082B2 (en) | 2001-02-02 | 2005-11-10 | Conjuchem Biotechnologies Inc. | Long lasting growth hormone releasing factor derivatives |
JP4280070B2 (ja) | 2001-02-16 | 2009-06-17 | コンジュケム バイオテクノロジーズ インコーポレイテッド | 胃腸疾患および胃腸障害の処置のための長期持続性グルカゴン様ペプチド2(glp−2) |
DE60216151T2 (de) | 2001-05-31 | 2007-09-27 | ConjuChem Biotechnologies Inc., Montreal | Langwirkende Fusionspeptidinhibitoren gegen HIV-Infektion |
WO2004066917A2 (en) | 2003-01-17 | 2004-08-12 | Advanced Proteome Therapeutics, Inc | Tandem analyses of noncovalently driven effectors for modulatory mapping of activities of protein sites |
ES2347902T3 (es) | 2004-04-23 | 2010-11-22 | Conjuchem Biotechnologies Inc. Canadian Corporation 4528590 | Fase solida para uso en un procedimiento para la purificacion de conjugados de albumina. |
MX2007000216A (es) | 2004-07-08 | 2007-03-15 | Amgen Inc | Peptidos terapeuticos. |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
JO3324B1 (ar) | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
US7982018B2 (en) | 2006-10-16 | 2011-07-19 | Conjuchem, Llc | Modified corticotropin releasing factor peptides and uses thereof |
GB201204868D0 (en) | 2012-03-20 | 2012-05-02 | San Raffaele Centro Fond | Peptides |
CA2955408A1 (en) * | 2014-07-18 | 2016-01-21 | Biocogent, Llc | Compositions and methods comprising salicylates and polysalicylates |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59138958A (ja) * | 1983-01-31 | 1984-08-09 | Mitsubishi Chem Ind Ltd | 抗血清 |
US4784955A (en) * | 1984-09-21 | 1988-11-15 | Miles Inc. | Immunogen conjugates and the use thereof in a dihydropyridine assay |
IE901736L (en) * | 1989-05-17 | 1990-11-17 | Fuller H B Licensing Financ | Polypeptide-antibody conjugate for inhibiting cell adhesion |
DK608589D0 (da) * | 1989-12-01 | 1989-12-01 | Holm Arne | Kemisk fremgangsmaade |
US5292362A (en) * | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
JPH04364200A (ja) * | 1991-06-10 | 1992-12-16 | Unitika Ltd | 細胞接着性アルブミン |
US5399671A (en) * | 1992-11-18 | 1995-03-21 | Kluger; Ronald | Specifically crosslinked hemoglobin with free functionality |
US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
-
1998
- 1998-11-06 JP JP2000520159A patent/JP2001522817A/ja active Pending
- 1998-11-06 EP EP98956656A patent/EP1007561B1/de not_active Expired - Lifetime
- 1998-11-06 DE DE69812727T patent/DE69812727D1/de not_active Expired - Lifetime
- 1998-11-06 WO PCT/US1998/023702 patent/WO1999024462A2/en not_active Application Discontinuation
- 1998-11-06 AU AU13127/99A patent/AU750387B2/en not_active Ceased
- 1998-11-06 CA CA002301799A patent/CA2301799C/en not_active Expired - Fee Related
- 1998-11-06 WO PCT/US1998/023704 patent/WO1999024074A2/en active IP Right Grant
- 1998-11-06 AU AU15197/99A patent/AU1519799A/en not_active Abandoned
- 1998-11-06 EP EP98957648A patent/EP1028971A2/de not_active Withdrawn
- 1998-11-06 ES ES98956656T patent/ES2173641T3/es not_active Expired - Lifetime
- 1998-11-06 AT AT01121557T patent/ATE235513T1/de not_active IP Right Cessation
- 1998-11-06 JP JP2000520470A patent/JP2001522863A/ja active Pending
- 1998-11-06 IL IL13583598A patent/IL135835A0/xx unknown
- 1998-11-06 AU AU13856/99A patent/AU1385699A/en not_active Abandoned
- 1998-11-06 WO PCT/US1998/023706 patent/WO1999024076A2/en active Application Filing
- 1998-11-06 DE DE69804974T patent/DE69804974T2/de not_active Expired - Lifetime
- 1998-11-06 CA CA002309205A patent/CA2309205A1/en not_active Abandoned
- 1998-11-06 AT AT98956656T patent/ATE216402T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1007561A2 (de) | 2000-06-14 |
ATE216402T1 (de) | 2002-05-15 |
WO1999024076A9 (en) | 2000-06-08 |
JP2001522863A (ja) | 2001-11-20 |
CA2301799A1 (en) | 1999-05-20 |
AU1312799A (en) | 1999-05-31 |
WO1999024074A3 (en) | 1999-08-19 |
CA2301799C (en) | 2007-08-07 |
WO1999024076A3 (en) | 1999-08-19 |
AU750387B2 (en) | 2002-07-18 |
EP1007561B1 (de) | 2002-04-17 |
EP1028971A2 (de) | 2000-08-23 |
ES2173641T3 (es) | 2002-10-16 |
AU1519799A (en) | 1999-05-31 |
IL135835A0 (en) | 2001-05-20 |
CA2309205A1 (en) | 1999-05-20 |
WO1999024462A3 (en) | 1999-08-26 |
DE69804974D1 (de) | 2002-05-23 |
WO1999024462A2 (en) | 1999-05-20 |
DE69804974T2 (de) | 2002-11-07 |
ATE235513T1 (de) | 2003-04-15 |
JP2001522817A (ja) | 2001-11-20 |
WO1999024076A2 (en) | 1999-05-20 |
WO1999024074A2 (en) | 1999-05-20 |
AU1385699A (en) | 1999-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |