AU2002236768B2 - Use of thrombin-derived peptides for the therapy of chronic dermal ulcers - Google Patents

Use of thrombin-derived peptides for the therapy of chronic dermal ulcers Download PDF

Info

Publication number
AU2002236768B2
AU2002236768B2 AU2002236768A AU2002236768A AU2002236768B2 AU 2002236768 B2 AU2002236768 B2 AU 2002236768B2 AU 2002236768 A AU2002236768 A AU 2002236768A AU 2002236768 A AU2002236768 A AU 2002236768A AU 2002236768 B2 AU2002236768 B2 AU 2002236768B2
Authority
AU
Australia
Prior art keywords
gly
asp
peptide derivative
thrombin peptide
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002236768A
Other languages
English (en)
Other versions
AU2002236768A1 (en
Inventor
Darrell H. Carney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of AU2002236768A1 publication Critical patent/AU2002236768A1/en
Assigned to ORTHOLOGIC CORP. reassignment ORTHOLOGIC CORP. Request for Assignment Assignors: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Application granted granted Critical
Publication of AU2002236768B2 publication Critical patent/AU2002236768B2/en
Assigned to THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM reassignment THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM Request for Assignment Assignors: ORTHOLOGIC CORP.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2002236768A 2001-07-27 2002-01-16 Use of thrombin-derived peptides for the therapy of chronic dermal ulcers Ceased AU2002236768B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30819801P 2001-07-27 2001-07-27
US60/308,198 2001-07-27
PCT/US2002/001151 WO2003013569A2 (en) 2001-07-27 2002-01-16 Use of thrombin-derived peptides for the therapy of chronic dermal ulcers

Publications (2)

Publication Number Publication Date
AU2002236768A1 AU2002236768A1 (en) 2003-06-19
AU2002236768B2 true AU2002236768B2 (en) 2006-06-08

Family

ID=23192964

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002236768A Ceased AU2002236768B2 (en) 2001-07-27 2002-01-16 Use of thrombin-derived peptides for the therapy of chronic dermal ulcers

Country Status (11)

Country Link
US (3) US7049294B2 (enExample)
EP (1) EP1414487B1 (enExample)
JP (1) JP4192093B2 (enExample)
CN (1) CN100509055C (enExample)
AT (1) ATE328606T1 (enExample)
AU (1) AU2002236768B2 (enExample)
CA (1) CA2455756C (enExample)
DE (1) DE60212143T2 (enExample)
DK (1) DK1414487T3 (enExample)
ES (1) ES2271216T3 (enExample)
WO (1) WO2003013569A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100509055C (zh) * 2001-07-27 2009-07-08 奥索洛吉艾斯有限公司 使用凝血酶衍生的缩氨酸治疗慢性真皮溃疡
EP1539800B1 (en) * 2002-07-02 2007-05-23 Orthologic Corp. Thrombin peptide derivative dimers
AU2003256343B2 (en) * 2002-07-02 2006-12-21 Orthologic Corp. Thrombin peptide derivatives
DE602004005564T2 (de) 2003-12-31 2007-12-13 Orthologic Corp., Tempe Pharmazeutische Zusammensetzung für Thrombinpeptidderivaten
WO2007035406A1 (en) * 2005-09-16 2007-03-29 Orthologic Corp. Antibodies to complementary peptides of thrombin or portions thereof
WO2008124172A1 (en) * 2007-04-10 2008-10-16 The Board Of Regents, The University Of Texas System Combination therapy for chronic dermal ulcers
WO2009120307A2 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Method of treating peripheral arterial disease
EP2268304A2 (en) * 2008-03-26 2011-01-05 Orthologic Corp. Methods for treating acute myocardial infarction
AU2009229395A1 (en) * 2008-03-26 2009-10-01 The Board Of Regents, The University Of Texas System Method of treating degenerative diseases
US20110117075A1 (en) * 2008-03-26 2011-05-19 Orthologic Corp. Thrombin derived peptides for smooth muscle relaxation
GB0916576D0 (en) 2009-09-22 2009-10-28 Malmsten Nils M Polypeptides and uses thereof
EP2538874A4 (en) * 2010-02-24 2017-06-21 Syneron Medical Ltd. A body contouring apparatus
US8806615B2 (en) 2010-11-04 2014-08-12 Mcafee, Inc. System and method for protecting specified data combinations
US10220078B2 (en) 2014-06-11 2019-03-05 The Board Of Regents Of The University Of Texas System Methods of using thrombin derivatives to treat medulloblastoma
CZ308845B6 (cs) * 2019-01-21 2021-07-07 Globetech Innovation S.R.O Farmaceutická směs topicky hojivých peptidových složek pro použití k topické léčbě kožních defektů a/nebo k topickému hojení ran

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352664A (en) 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
AU5638096A (en) 1995-06-07 1996-12-30 Clarion Pharmaceuticals, Inc. Non-biological patch for hemostasis
GB9930768D0 (en) * 1999-12-29 2000-02-16 Pfizer Ltd Composition
IL156233A0 (en) * 2000-12-01 2004-01-04 Response Genetics Inc Method of determining epidermal growth factor receptor and her2-neu gene expression and correlation of levels thereof with survival rates
CN100509055C (zh) * 2001-07-27 2009-07-08 奥索洛吉艾斯有限公司 使用凝血酶衍生的缩氨酸治疗慢性真皮溃疡

Also Published As

Publication number Publication date
WO2003013569A3 (en) 2003-12-11
DE60212143D1 (de) 2006-07-20
ES2271216T3 (es) 2007-04-16
EP1414487A2 (en) 2004-05-06
JP2004538320A (ja) 2004-12-24
WO2003013569A2 (en) 2003-02-20
HK1065719A1 (en) 2005-03-24
US7833982B2 (en) 2010-11-16
CN100509055C (zh) 2009-07-08
US7049294B2 (en) 2006-05-23
CN1556711A (zh) 2004-12-22
US20060241049A1 (en) 2006-10-26
CA2455756A1 (en) 2003-02-20
DK1414487T3 (da) 2006-10-09
DE60212143T2 (de) 2007-04-12
US7378500B2 (en) 2008-05-27
ATE328606T1 (de) 2006-06-15
EP1414487B1 (en) 2006-06-07
US20090029923A1 (en) 2009-01-29
CA2455756C (en) 2013-04-02
JP4192093B2 (ja) 2008-12-03
US20040209819A1 (en) 2004-10-21

Similar Documents

Publication Publication Date Title
US7833982B2 (en) Methods of treating dermal ulcers with thrombin derived peptides
Demidova-Rice et al. Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 1: normal and chronic wounds: biology, causes, and approaches to care
Reiss et al. Matrix metalloproteinase-9 delays wound healing in a murine wound model
Steed Clinical evaluation of recombinant human platelet–derived growth factor for the treatment of lower extremity diabetic ulcers
AU2002236768A1 (en) Use of thrombin-derived peptides for the therapy of chronic dermal ulcers
JP3150338B2 (ja) プロテアーゼ ネキシン―ｉの創傷治▲ゆ▼を仲介することへの使用
CN101297033B (zh) 由菠萝蛋白酶获得的清创组合物及其制备方法
KR20010041408A (ko) 상처 치유용 매트릭스 단백질 조성물
JPH04211019A (ja) 創傷治癒促進のためのトロンボスポンデインの使用
Fujimoto et al. The wound/burn guidelines–4: Guidelines for the management of skin ulcers associated with connective tissue disease/vasculitis
JP4351041B2 (ja) 傷治癒のための処置および組成物
JP7026050B2 (ja) 慢性創傷を治療するための組成物及び方法
JP2025125558A (ja) 皮膚科障害の処置のための薬剤
JP2004532892A6 (ja) 傷治癒のための処置および組成物
Goncharuk et al. Matrix Metalloproteinase-9 is involved in the fibrotic process in denervated muscles after sciatic nerve trauma and recovery
JP2020100648A (ja) 創傷治癒に対するａｐｃ類似体の使用
Téot et al. Surgery in wounds
Mizokami et al. Iodoform gauze removes necrotic tissue from pressure ulcer wounds by fibrinolytic activity
US20130101574A1 (en) Methods of using thrombin peptide derivatives
JP2002526382A (ja) 皮膚創傷の治療へのプロテアーゼ阻害剤の使用
HK1065719B (en) Use of thrombin-derived peptides for the therapy of chronic dermal ulcers
MXPA05007227A (es) Metodo para incrementar la fibronectina.
JP2021506985A (ja) 瘢痕を最小化することにおける使用のための神経毒
Rao et al. Recombinant human epidermal growth factor in healing of pressure ulcers
Rattan et al. Management of ocular adnexal trauma

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: ORTHOLOGIC CORP.

Free format text: FORMER APPLICANT(S): THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYST

Free format text: FORMER OWNER WAS: ORTHOLOGIC CORP.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired