JP2005505579A5 - - Google Patents
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- Publication number
- JP2005505579A5 JP2005505579A5 JP2003530818A JP2003530818A JP2005505579A5 JP 2005505579 A5 JP2005505579 A5 JP 2005505579A5 JP 2003530818 A JP2003530818 A JP 2003530818A JP 2003530818 A JP2003530818 A JP 2003530818A JP 2005505579 A5 JP2005505579 A5 JP 2005505579A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- formula
- igf receptor
- receptor antagonist
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 12
- 239000002464 receptor antagonist Substances 0.000 claims 8
- 229940044551 receptor antagonist Drugs 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 5
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 4
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 3
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 239000005557 antagonist Substances 0.000 claims 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- FSXRLASFHBWESK-HOTGVXAUSA-N Phe-Tyr Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C1=CC=CC=C1 FSXRLASFHBWESK-HOTGVXAUSA-N 0.000 claims 1
- 108010017622 Somatomedin Receptors Proteins 0.000 claims 1
- 102000004584 Somatomedin Receptors Human genes 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- FSXRLASFHBWESK-UHFFFAOYSA-N dipeptide phenylalanyl-tyrosine Natural products C=1C=C(O)C=CC=1CC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FSXRLASFHBWESK-UHFFFAOYSA-N 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/962,756 US6875741B2 (en) | 1998-09-02 | 2001-09-24 | Insulin and IGF-1 receptor agonists and antagonists |
| PCT/US2002/030412 WO2003027246A2 (en) | 2001-09-24 | 2002-09-24 | Antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005505579A JP2005505579A (ja) | 2005-02-24 |
| JP2005505579A5 true JP2005505579A5 (enExample) | 2006-01-05 |
Family
ID=25506313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530818A Pending JP2005505579A (ja) | 2001-09-24 | 2002-09-24 | アンタゴニスト |
| JP2003569654A Pending JP2005517741A (ja) | 2001-09-24 | 2002-09-24 | インシュリン及びigf−1レセプターのアゴニスト及びアンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569654A Pending JP2005517741A (ja) | 2001-09-24 | 2002-09-24 | インシュリン及びigf−1レセプターのアゴニスト及びアンタゴニスト |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6875741B2 (enExample) |
| EP (2) | EP1496935A4 (enExample) |
| JP (2) | JP2005505579A (enExample) |
| AU (2) | AU2002366384A1 (enExample) |
| CA (2) | CA2460055A1 (enExample) |
| WO (2) | WO2003070747A2 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7625859B1 (en) | 2000-02-16 | 2009-12-01 | Oregon Health & Science University | HER-2 binding antagonists |
| US6521738B2 (en) * | 1999-12-29 | 2003-02-18 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
| CA2452044A1 (en) | 2001-08-28 | 2003-03-13 | Eli Lilly And Company | Pre-mixes of glp-1 and basal insulin |
| AU2003205830A1 (en) * | 2002-01-23 | 2003-09-02 | Mohamed Raafat El-Gewely | Molecular libraries |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| US8623822B2 (en) * | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| EP1587944A4 (en) * | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US7632809B2 (en) * | 2002-04-22 | 2009-12-15 | Oncolix, Inc. | Multimeric ligands with enhanced stability |
| NZ536475A (en) * | 2002-05-24 | 2008-06-30 | Schering Corp | Neutralizing human anti-igfr antibody |
| US8034904B2 (en) * | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US7538195B2 (en) * | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| ES2560847T3 (es) * | 2002-07-31 | 2016-02-23 | Yves Saint-Laurent Parfums | Células madre procedentes de tejido adiposo y células diferenciadas procedentes de estas células |
| AU2003275240A1 (en) * | 2002-09-24 | 2004-04-23 | Massachusetts Institute Of Technology | Methods and compositions for soluble cpg15 |
| CA2524305C (en) * | 2003-05-01 | 2015-12-08 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| WO2005032476A2 (en) * | 2003-09-30 | 2005-04-14 | Massachusetts Institute Of Technology | Methods and compositions for cpg15-2 |
| US7605120B2 (en) * | 2003-10-22 | 2009-10-20 | Amgen Inc. | Antagonists of the brandykinin B1 receptor |
| ATE514783T1 (de) | 2003-11-12 | 2011-07-15 | Schering Corp | Plasmidsystem zur expression mehrerer gene |
| PE20050928A1 (es) * | 2003-11-21 | 2005-11-08 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti-igfr1 |
| ES2368741T3 (es) | 2004-02-25 | 2011-11-21 | Dana-Farber Cancer Institute, Inc. | Inhibidores del receptor 1 del factor de crecimiento de tipo insulina para inhibir el crecimiento de células tumorales. |
| US8187595B2 (en) | 2004-05-07 | 2012-05-29 | The University Of North Carolina At Chapel Hill | Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I |
| JP4928443B2 (ja) | 2004-05-07 | 2012-05-09 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | インスリン様成長因子iを増強または阻害するための方法 |
| US20100298213A1 (en) * | 2004-08-20 | 2010-11-25 | Novo Nordisk A/S | Pharmaceutically Active Insulin Receptor-Modulating Molecules |
| EP1807105A2 (en) * | 2004-10-27 | 2007-07-18 | Novo Nordisk A/S | Insulin receptor binding peptides with non-insulin gene activation profiles and uses thereof |
| EP1814574A4 (en) * | 2004-10-27 | 2009-08-05 | Univ Denver | ANALOGUE OF ADRENOCORTICOTROPEN HORMON AND CORRESPONDING METHODS |
| DE602005025685D1 (de) * | 2004-12-03 | 2011-02-10 | Schering Corp | Biologische marker zur vorauswahl von patienten für die anti-igf1r-therapie |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| WO2006072625A2 (en) | 2005-01-06 | 2006-07-13 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
| EP3312196B1 (en) | 2005-03-23 | 2019-07-17 | Genmab A/S | Antibodies against cd38 for treatment of multiple myeloma |
| US20060233810A1 (en) * | 2005-04-15 | 2006-10-19 | Yaolin Wang | Methods and compositions for treating or preventing cancer |
| AU2006259536A1 (en) | 2005-06-15 | 2006-12-28 | Schering Corporation | Anti-IGF1R antibody formulations |
| KR101246504B1 (ko) * | 2005-06-17 | 2013-03-26 | 임클론 엘엘씨 | 항-PDGFRα 항체 |
| US7622438B1 (en) | 2005-07-18 | 2009-11-24 | Acologix, Inc. | Protein formulation for promoting hard tissue formation |
| CN101321780A (zh) * | 2005-10-05 | 2008-12-10 | 诺沃-诺迪斯克有限公司 | 胰岛素受体拮抗剂及相关组合物、用途和方法 |
| KR101353706B1 (ko) * | 2006-02-03 | 2014-02-18 | 유니버시티 오브 워싱톤 | 전립선 암 치료용 보강제로서의 ⅰgf-ⅰr 길항제 |
| WO2007095113A2 (en) * | 2006-02-10 | 2007-08-23 | Massachusetts Institute Of Technology | Cpg15 and cpg15-2 compounds and inhibitors as insulin receptor and insulin-like growth factor receptor agonists and antagonists |
| EP2468767B1 (en) | 2006-06-22 | 2015-10-28 | Walter and Eliza Hall Institute of Medical Research | Structure of the insulin receptor ectodomain |
| WO2008005992A2 (en) * | 2006-07-06 | 2008-01-10 | Molecular Logix, Inc. | Dominant negative ligand drug discovery system |
| WO2008133961A2 (en) | 2007-04-24 | 2008-11-06 | Antyra Inc. | Igf-1r binding proteins and antagonists |
| US8557242B2 (en) * | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| KR101658247B1 (ko) | 2008-01-03 | 2016-09-22 | 더 스크립스 리서치 인스티튜트 | 모듈 인식 도메인을 통한 항체 표적화 |
| US8557243B2 (en) * | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8574577B2 (en) * | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| WO2009099763A1 (en) | 2008-01-30 | 2009-08-13 | Indiana University Research And Technology Corporation | Ester-based peptide prodrugs |
| EP2376099A4 (en) * | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | INSULIN AGAIN YL-BASED GROWTH FACTORS WITH HIGH ACTIVITY AT THE INSULIN RECEPTOR |
| CN102245624B (zh) | 2008-12-19 | 2016-08-10 | 印第安纳大学研究及科技有限公司 | 基于酰胺的胰岛素前药 |
| JP5789515B2 (ja) | 2008-12-19 | 2015-10-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | インスリン類似体 |
| US9155801B2 (en) | 2009-05-28 | 2015-10-13 | The United States Government As Represented By The Department Of Veterans Affairs | Amino acid sequences which enhance peptide conjugate solubility |
| EP2470201A4 (en) * | 2009-08-28 | 2013-01-30 | Bayer Healthcare Llc | COFACTORS ENABLING THE THROMBINIC ACTIVATION OF FACTOR VII AND THEIR USES |
| EP2582719B1 (en) | 2010-06-16 | 2016-08-10 | Indiana University Research and Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| CA2803164C (en) | 2010-06-24 | 2018-08-21 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| AU2012212075A1 (en) | 2011-02-02 | 2013-07-18 | Amgen Inc. | Methods and compositons relating to inhibition of IGF-1R |
| WO2012154272A1 (en) * | 2011-02-25 | 2012-11-15 | Wellstat Diagnostics, Llc | Assays for detecting enzymatic activity |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| CN104039357A (zh) * | 2011-06-10 | 2014-09-10 | 哈佛学院校长同事会 | 胰腺β-细胞增殖的调节 |
| US9700619B2 (en) | 2011-11-11 | 2017-07-11 | Duke University | Combination drug therapy for the treatment of solid tumors |
| CN104114183A (zh) | 2011-12-20 | 2014-10-22 | 印第安纳大学研究及科技有限公司 | 用于治疗糖尿病的基于ctp的胰岛素类似物 |
| US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
| HK1213904A1 (zh) | 2012-08-31 | 2016-07-15 | The University Of North Carolina At Chapel Hill | 用於增强或抑制胰島素樣生長因子1(igf-1)的單克隆抗體 |
| CN108383902A (zh) | 2012-09-26 | 2018-08-10 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物二聚体 |
| JP6538645B2 (ja) | 2013-03-14 | 2019-07-03 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | インスリン‐インクレチン複合物 |
| MX2015013163A (es) | 2013-03-15 | 2016-04-04 | Zyngenia Inc | Complejos multiespecificos multivalente y monovalentes y sus usos. |
| AR101753A1 (es) | 2014-09-03 | 2017-01-11 | Boehringer Ingelheim Int | COMPUESTO DE OBJETIVO A IL-23A Y TNF-a Y USO DEL MISMO |
| CN107001441A (zh) | 2014-09-24 | 2017-08-01 | 印第安纳大学研究及科技有限公司 | 脂质化的基于酰胺的胰岛素前药 |
| US10232020B2 (en) | 2014-09-24 | 2019-03-19 | Indiana University Research And Technology Corporation | Incretin-insulin conjugates |
| KR20180100302A (ko) * | 2015-10-23 | 2018-09-10 | 우니베르지태트 트벤테 | 인테그린 결합 펩티드 및 그의 용도 |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| SG11202105476XA (en) * | 2018-12-06 | 2021-06-29 | Cytomx Therapeutics Inc | Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof |
| US20230055519A1 (en) * | 2020-01-16 | 2023-02-23 | The Translational Genomics Research Institute | Methods of identifying synthetic molecular binding agents |
| EP4185608A4 (en) * | 2020-07-23 | 2024-08-21 | University of Florida Research Foundation, Inc. | INSULIN RECEPTOR-MEDIATED ENHANCEMENT OF GENE TRANSFER |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876242A (en) | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| JPH03501487A (ja) * | 1988-06-30 | 1991-04-04 | シティ・オブ・ホープ | インシュリン模倣物およびインシュリンリセプター結合部位ペプチド |
| US5652214A (en) | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
| US6310040B1 (en) | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
| AU4238493A (en) | 1992-05-08 | 1993-12-13 | Thomas Jefferson University | IGF-1 analogs |
| DE4432943A1 (de) | 1994-09-15 | 1996-03-21 | Radulescu Razvan T Dr Med M D | Numerical Mirror Image Strategy (NUMIS) |
| RU2078769C1 (ru) | 1995-08-18 | 1997-05-10 | Научно-исследовательский институт биомедицинской химии РАМН | Пептидный фрагмент, обладающий биологической активностью инсулина |
| US5912160A (en) | 1995-08-22 | 1999-06-15 | Thomas Jefferson University | Gab1, Grb2 binding protein, and compositions for making and methods of using the same |
| US6028053A (en) * | 1995-10-27 | 2000-02-22 | Mount Sinai Hospital Corporation | Peptide inhibitors of a phosphotyrosine-binding domain containing protein |
| JP2000515726A (ja) | 1996-06-07 | 2000-11-28 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌蛋白をコードする成人pbmc由来のポリヌクレオチド |
| DE69830301T2 (de) * | 1997-01-15 | 2006-02-02 | Telik Inc., South San Francisco | Modulatoren von insulinrezeptor-aktivität |
| JP2001525339A (ja) | 1997-11-27 | 2001-12-11 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション | Igf受容体に対するアゴニストおよびアンタゴニストの設計方法 |
| CA2356109C (en) | 1999-01-06 | 2008-04-22 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
| EP2368902A3 (en) * | 2000-03-29 | 2011-12-21 | DGI Bio Technologies LLC | Insulin and IGF-1 receptor agonists and antagonists |
-
2001
- 2001-09-24 US US09/962,756 patent/US6875741B2/en not_active Expired - Fee Related
-
2002
- 2002-09-24 AU AU2002366384A patent/AU2002366384A1/en not_active Abandoned
- 2002-09-24 EP EP02806867A patent/EP1496935A4/en not_active Withdrawn
- 2002-09-24 JP JP2003530818A patent/JP2005505579A/ja active Pending
- 2002-09-24 WO PCT/US2002/030312 patent/WO2003070747A2/en not_active Ceased
- 2002-09-24 AU AU2002341834A patent/AU2002341834A1/en not_active Abandoned
- 2002-09-24 CA CA002460055A patent/CA2460055A1/en not_active Abandoned
- 2002-09-24 WO PCT/US2002/030412 patent/WO2003027246A2/en not_active Ceased
- 2002-09-24 CA CA002459999A patent/CA2459999A1/en not_active Abandoned
- 2002-09-24 JP JP2003569654A patent/JP2005517741A/ja active Pending
- 2002-09-24 EP EP02775987A patent/EP1432433A4/en not_active Withdrawn
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