CA2460055A1 - Insulin and igf-1 receptor agonists and antagonists - Google Patents
Insulin and igf-1 receptor agonists and antagonists Download PDFInfo
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- CA2460055A1 CA2460055A1 CA002460055A CA2460055A CA2460055A1 CA 2460055 A1 CA2460055 A1 CA 2460055A1 CA 002460055 A CA002460055 A CA 002460055A CA 2460055 A CA2460055 A CA 2460055A CA 2460055 A1 CA2460055 A1 CA 2460055A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
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- Peptides Or Proteins (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/962,756 | 2001-09-24 | ||
| US09/962,756 US6875741B2 (en) | 1998-09-02 | 2001-09-24 | Insulin and IGF-1 receptor agonists and antagonists |
| PCT/US2002/030312 WO2003070747A2 (en) | 2001-09-24 | 2002-09-24 | Insulin and igf-1 receptor agonists and antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2460055A1 true CA2460055A1 (en) | 2003-08-28 |
Family
ID=25506313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002460055A Abandoned CA2460055A1 (en) | 2001-09-24 | 2002-09-24 | Insulin and igf-1 receptor agonists and antagonists |
| CA002459999A Abandoned CA2459999A1 (en) | 2001-09-24 | 2002-09-24 | Antagonists_and agonists of igf-1 receptor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002459999A Abandoned CA2459999A1 (en) | 2001-09-24 | 2002-09-24 | Antagonists_and agonists of igf-1 receptor |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6875741B2 (enExample) |
| EP (2) | EP1496935A4 (enExample) |
| JP (2) | JP2005505579A (enExample) |
| AU (2) | AU2002366384A1 (enExample) |
| CA (2) | CA2460055A1 (enExample) |
| WO (2) | WO2003027246A2 (enExample) |
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| CN1635900A (zh) | 2001-08-28 | 2005-07-06 | 伊莱利利公司 | Glp-1和基础胰岛素的预混合物 |
| US20070128657A1 (en) * | 2002-01-23 | 2007-06-07 | El-Gewely Mohamed R | Molecular libraries |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| EP1587944A4 (en) | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| US7794693B2 (en) * | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
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| US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US8034904B2 (en) * | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| CA2493532C (fr) * | 2002-07-31 | 2014-05-27 | Yves Saint-Laurent Parfums | Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules |
| WO2004031347A2 (en) * | 2002-09-24 | 2004-04-15 | Massachusetts Institute Of Technology | Methods and compositions for soluble cpg15 |
| US7638605B2 (en) * | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| US20050187175A1 (en) * | 2003-09-30 | 2005-08-25 | Elly Nedivi | Methods and compositions for CPG15-2 |
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| US8187595B2 (en) | 2004-05-07 | 2012-05-29 | The University Of North Carolina At Chapel Hill | Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I |
| ATE461708T1 (de) | 2004-05-07 | 2010-04-15 | Univ North Carolina | Verfahren zur verstärkung oder hemmung des insulinähnlichen wachstumsfaktors-i |
| JP2008510692A (ja) * | 2004-08-20 | 2008-04-10 | ノボ ノルディスク アクティーゼルスカブ | 薬学的に活性なインスリン受容体調節分子 |
| US20090197800A1 (en) * | 2004-10-27 | 2009-08-06 | Novo Nordisk A/S | Insulin Receptor Binding Peptides with Non-Insulin Gene Activation Profiles and Uses Thereof |
| CN101947310A (zh) * | 2004-10-27 | 2011-01-19 | 丹佛大学 | 促肾上腺皮质激素类似物以及相关方法 |
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| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| US20090196850A1 (en) | 2005-01-06 | 2009-08-06 | Novo Nordisk A/S | Anti-Kir Combination Treatments and Methods |
| EA015584B1 (ru) | 2005-03-23 | 2011-10-31 | Генмаб А/С | Антитело к cd38 человека и его применение |
| BRPI0608777A2 (pt) * | 2005-04-15 | 2010-01-26 | Schering Corp | métodos para tratamento ou prevenção de cáncer, bem como uso de inibidores de igf1r na preparação de composições farmacêuticas |
| MX2007016306A (es) * | 2005-06-15 | 2008-03-07 | Schering Corp | Formulaciones de anticuerpo anti-igf1r. |
| PT2100614E (pt) * | 2005-06-17 | 2013-12-16 | Imclone Llc | Antagonistas de receptor para tratamento de cancro ósseo metastático |
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| US20090197805A1 (en) * | 2005-10-05 | 2009-08-06 | Novo Nordisk A/S | Insulin receptor antagonists and related compositions, uses and methods |
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| WO2007095113A2 (en) * | 2006-02-10 | 2007-08-23 | Massachusetts Institute Of Technology | Cpg15 and cpg15-2 compounds and inhibitors as insulin receptor and insulin-like growth factor receptor agonists and antagonists |
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| US8557242B2 (en) * | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
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| US8574577B2 (en) * | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
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| JP2011511778A (ja) | 2008-01-30 | 2011-04-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | エステルに基づいたペプチドプロドラッグ |
| EP2376099A4 (en) * | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | INSULIN AGAIN YL-BASED GROWTH FACTORS WITH HIGH ACTIVITY AT THE INSULIN RECEPTOR |
| AU2009335715B2 (en) | 2008-12-19 | 2016-09-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| US8481485B2 (en) | 2008-12-19 | 2013-07-09 | Indiana University Research And Technology Corporation | Insulin analogs |
| CA2799608C (en) * | 2009-05-28 | 2023-02-28 | Richard H. Weisbart | Amino acid sequences which enhance peptide conjugate solubility |
| WO2011026000A1 (en) * | 2009-08-28 | 2011-03-03 | Bayer Healthcare Llc | Cofactors for thrombin activation of factor vii and uses thereof |
| AU2011268327B2 (en) | 2010-06-16 | 2016-02-25 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| US8946147B2 (en) | 2010-06-24 | 2015-02-03 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
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| EP2717924A4 (en) * | 2011-06-10 | 2015-04-22 | Harvard College | MODULATION OF BETA CELL PROLIFERATION IN THE PANCREATIC GLAND |
| US9700619B2 (en) | 2011-11-11 | 2017-07-11 | Duke University | Combination drug therapy for the treatment of solid tumors |
| BR112014015156A2 (pt) | 2011-12-20 | 2020-10-27 | Indiana University Research And Technology Corporation | análogos de insulina à base de ctp, seus métodos de produção e uso no tratamento de hiperglicemia, bem como sequência de ácido nucleico e célula hospedeira |
| US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
| EP2890716A4 (en) | 2012-08-31 | 2016-06-08 | Univ North Carolina | MONOCLONAL ANTIBODIES FOR THE REINFORCEMENT OR INHIBITION OF INSULINARY FACTOR 1 (IGF-1) |
| CN108383902A (zh) | 2012-09-26 | 2018-08-10 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物二聚体 |
| WO2014158900A1 (en) | 2013-03-14 | 2014-10-02 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
| EP3424530A1 (en) | 2013-03-15 | 2019-01-09 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| WO2016036918A1 (en) * | 2014-09-03 | 2016-03-10 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
| ES2947409T3 (es) | 2014-09-24 | 2023-08-08 | Univ Indiana Res & Tech Corp | Profármacos de insulina a base de amida lipídica |
| JP6657230B2 (ja) | 2014-09-24 | 2020-03-04 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | インクレチン−インスリンコンジュゲート |
| JP7174627B2 (ja) | 2015-10-23 | 2022-11-17 | ウニフェルシタイト・トゥヴェンテ | インテグリン結合ペプチド及びその使用 |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| US20230055519A1 (en) * | 2020-01-16 | 2023-02-23 | The Translational Genomics Research Institute | Methods of identifying synthetic molecular binding agents |
| EP4185608A4 (en) * | 2020-07-23 | 2024-08-21 | University of Florida Research Foundation, Inc. | INSULIN RECEPTOR-MEDIATED ENHANCEMENT OF GENE TRANSFER |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4876242A (en) | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| DE68927854T2 (de) * | 1988-06-30 | 1997-10-16 | Hope City | Insulinomimetrische eigenschaften und insulin-rezeptor-bindestellen-peptide |
| US5652214A (en) | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
| US6310040B1 (en) | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
| JPH07508025A (ja) | 1992-05-08 | 1995-09-07 | トーマス・ジェファーソン・ユニバーシティ | インスリン様増殖因子(igf−1)類似体 |
| DE4432943A1 (de) | 1994-09-15 | 1996-03-21 | Radulescu Razvan T Dr Med M D | Numerical Mirror Image Strategy (NUMIS) |
| RU2078769C1 (ru) | 1995-08-18 | 1997-05-10 | Научно-исследовательский институт биомедицинской химии РАМН | Пептидный фрагмент, обладающий биологической активностью инсулина |
| WO1997007827A1 (en) | 1995-08-22 | 1997-03-06 | Thomas Jefferson University | Gab1, A Grb2 BINDING PROTEIN, AND COMPOSITIONS FOR MAKING AND METHODS OF USING THE SAME |
| US6028053A (en) * | 1995-10-27 | 2000-02-22 | Mount Sinai Hospital Corporation | Peptide inhibitors of a phosphotyrosine-binding domain containing protein |
| JP2000515726A (ja) | 1996-06-07 | 2000-11-28 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌蛋白をコードする成人pbmc由来のポリヌクレオチド |
| EP0960335B1 (en) * | 1997-01-15 | 2005-05-25 | Telik, Inc. | Modulators of insulin receptor activity |
| EP1034188B1 (en) | 1997-11-27 | 2006-06-07 | Commonwealth Scientific And Industrial Research Organisation | Method of designing agonists and antagonists to igf receptor (1-462) |
| DK1141014T3 (da) | 1999-01-06 | 2005-04-11 | Genentech Inc | Insulinlignende vækstfaktor (IGF) i mutantvariant |
| EP1383793B1 (en) * | 2000-03-29 | 2011-10-19 | DGI BioTechnologies, L.L.C. | Insulin and igf-1 receptor agonists and antagonists |
-
2001
- 2001-09-24 US US09/962,756 patent/US6875741B2/en not_active Expired - Fee Related
-
2002
- 2002-09-24 CA CA002460055A patent/CA2460055A1/en not_active Abandoned
- 2002-09-24 CA CA002459999A patent/CA2459999A1/en not_active Abandoned
- 2002-09-24 AU AU2002366384A patent/AU2002366384A1/en not_active Abandoned
- 2002-09-24 EP EP02806867A patent/EP1496935A4/en not_active Withdrawn
- 2002-09-24 JP JP2003530818A patent/JP2005505579A/ja active Pending
- 2002-09-24 AU AU2002341834A patent/AU2002341834A1/en not_active Abandoned
- 2002-09-24 WO PCT/US2002/030412 patent/WO2003027246A2/en not_active Ceased
- 2002-09-24 WO PCT/US2002/030312 patent/WO2003070747A2/en not_active Ceased
- 2002-09-24 EP EP02775987A patent/EP1432433A4/en not_active Withdrawn
- 2002-09-24 JP JP2003569654A patent/JP2005517741A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20030195147A1 (en) | 2003-10-16 |
| AU2002366384A8 (en) | 2003-09-09 |
| WO2003027246A2 (en) | 2003-04-03 |
| EP1432433A4 (en) | 2006-08-30 |
| EP1496935A2 (en) | 2005-01-19 |
| WO2003027246A3 (en) | 2003-07-31 |
| JP2005505579A (ja) | 2005-02-24 |
| WO2003070747A3 (en) | 2004-11-11 |
| WO2003070747A2 (en) | 2003-08-28 |
| AU2002341834A1 (en) | 2003-04-07 |
| EP1496935A4 (en) | 2006-06-07 |
| US6875741B2 (en) | 2005-04-05 |
| EP1432433A2 (en) | 2004-06-30 |
| JP2005517741A (ja) | 2005-06-16 |
| AU2002366384A1 (en) | 2003-09-09 |
| CA2459999A1 (en) | 2003-04-03 |
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| EEER | Examination request | ||
| FZDE | Discontinued |