CA2460055A1 - Insulin and igf-1 receptor agonists and antagonists - Google Patents

Insulin and igf-1 receptor agonists and antagonists Download PDF

Info

Publication number
CA2460055A1
CA2460055A1 CA002460055A CA2460055A CA2460055A1 CA 2460055 A1 CA2460055 A1 CA 2460055A1 CA 002460055 A CA002460055 A CA 002460055A CA 2460055 A CA2460055 A CA 2460055A CA 2460055 A1 CA2460055 A1 CA 2460055A1
Authority
CA
Canada
Prior art keywords
seq
nos
amino acid
sequence
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002460055A
Other languages
English (en)
French (fr)
Inventor
Renuka Pillutla
Renee Brissette
Arthur J. Blume
Lauge Schaffer
Jakob Brandt
Neil I. Goldstein
Jane Spetzler
Soren Ostergaard
Per Hertz Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Antyra Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2460055A1 publication Critical patent/CA2460055A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/65Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA002460055A 2001-09-24 2002-09-24 Insulin and igf-1 receptor agonists and antagonists Abandoned CA2460055A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/962,756 2001-09-24
US09/962,756 US6875741B2 (en) 1998-09-02 2001-09-24 Insulin and IGF-1 receptor agonists and antagonists
PCT/US2002/030312 WO2003070747A2 (en) 2001-09-24 2002-09-24 Insulin and igf-1 receptor agonists and antagonists

Publications (1)

Publication Number Publication Date
CA2460055A1 true CA2460055A1 (en) 2003-08-28

Family

ID=25506313

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002460055A Abandoned CA2460055A1 (en) 2001-09-24 2002-09-24 Insulin and igf-1 receptor agonists and antagonists
CA002459999A Abandoned CA2459999A1 (en) 2001-09-24 2002-09-24 Antagonists_and agonists of igf-1 receptor

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002459999A Abandoned CA2459999A1 (en) 2001-09-24 2002-09-24 Antagonists_and agonists of igf-1 receptor

Country Status (6)

Country Link
US (1) US6875741B2 (enExample)
EP (2) EP1496935A4 (enExample)
JP (2) JP2005505579A (enExample)
AU (2) AU2002366384A1 (enExample)
CA (2) CA2460055A1 (enExample)
WO (2) WO2003027246A2 (enExample)

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US20090197805A1 (en) * 2005-10-05 2009-08-06 Novo Nordisk A/S Insulin receptor antagonists and related compositions, uses and methods
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WO2007095113A2 (en) * 2006-02-10 2007-08-23 Massachusetts Institute Of Technology Cpg15 and cpg15-2 compounds and inhibitors as insulin receptor and insulin-like growth factor receptor agonists and antagonists
EP2468766B1 (en) 2006-06-22 2014-09-17 Walter and Eliza Hall Institute of Medical Research Structure of the insulin receptor ectodomain
EP2044246A4 (en) * 2006-07-06 2009-12-16 Molecular Logix Inc LIGAND DRUG DISCOVERY SYSTEM DOMINANT NEGATIVE
WO2008133961A2 (en) 2007-04-24 2008-11-06 Antyra Inc. Igf-1r binding proteins and antagonists
US8557242B2 (en) * 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
US8557243B2 (en) * 2008-01-03 2013-10-15 The Scripps Research Institute EFGR antibodies comprising modular recognition domains
US8574577B2 (en) * 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
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EP2376099A4 (en) * 2008-12-19 2012-04-25 Univ Indiana Res & Tech Corp INSULIN AGAIN YL-BASED GROWTH FACTORS WITH HIGH ACTIVITY AT THE INSULIN RECEPTOR
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EP2717924A4 (en) * 2011-06-10 2015-04-22 Harvard College MODULATION OF BETA CELL PROLIFERATION IN THE PANCREATIC GLAND
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BR112014015156A2 (pt) 2011-12-20 2020-10-27 Indiana University Research And Technology Corporation análogos de insulina à base de ctp, seus métodos de produção e uso no tratamento de hiperglicemia, bem como sequência de ácido nucleico e célula hospedeira
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Also Published As

Publication number Publication date
US20030195147A1 (en) 2003-10-16
AU2002366384A8 (en) 2003-09-09
WO2003027246A2 (en) 2003-04-03
EP1432433A4 (en) 2006-08-30
EP1496935A2 (en) 2005-01-19
WO2003027246A3 (en) 2003-07-31
JP2005505579A (ja) 2005-02-24
WO2003070747A3 (en) 2004-11-11
WO2003070747A2 (en) 2003-08-28
AU2002341834A1 (en) 2003-04-07
EP1496935A4 (en) 2006-06-07
US6875741B2 (en) 2005-04-05
EP1432433A2 (en) 2004-06-30
JP2005517741A (ja) 2005-06-16
AU2002366384A1 (en) 2003-09-09
CA2459999A1 (en) 2003-04-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued