CA2460055A1 - Insulin and igf-1 receptor agonists and antagonists - Google Patents
Insulin and igf-1 receptor agonists and antagonists Download PDFInfo
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- CA2460055A1 CA2460055A1 CA002460055A CA2460055A CA2460055A1 CA 2460055 A1 CA2460055 A1 CA 2460055A1 CA 002460055 A CA002460055 A CA 002460055A CA 2460055 A CA2460055 A CA 2460055A CA 2460055 A1 CA2460055 A1 CA 2460055A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/962,756 US6875741B2 (en) | 1998-09-02 | 2001-09-24 | Insulin and IGF-1 receptor agonists and antagonists |
| US09/962,756 | 2001-09-24 | ||
| PCT/US2002/030312 WO2003070747A2 (en) | 2001-09-24 | 2002-09-24 | Insulin and igf-1 receptor agonists and antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2460055A1 true CA2460055A1 (en) | 2003-08-28 |
Family
ID=25506313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002460055A Abandoned CA2460055A1 (en) | 2001-09-24 | 2002-09-24 | Insulin and igf-1 receptor agonists and antagonists |
| CA002459999A Abandoned CA2459999A1 (en) | 2001-09-24 | 2002-09-24 | Antagonists_and agonists of igf-1 receptor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002459999A Abandoned CA2459999A1 (en) | 2001-09-24 | 2002-09-24 | Antagonists_and agonists of igf-1 receptor |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6875741B2 (enExample) |
| EP (2) | EP1496935A4 (enExample) |
| JP (2) | JP2005505579A (enExample) |
| AU (2) | AU2002341834A1 (enExample) |
| CA (2) | CA2460055A1 (enExample) |
| WO (2) | WO2003070747A2 (enExample) |
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| WO2003020201A2 (en) | 2001-08-28 | 2003-03-13 | Eli Lilly And Company | Pre-mixes of glp-1 and basal insulin |
| US20070105778A1 (en) | 2002-01-23 | 2007-05-10 | El-Gewely Mohamed R | Methods of screening molecular libraries and active molecules identified thereby |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| US8623822B2 (en) * | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US7261876B2 (en) * | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US7794693B2 (en) * | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
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| US7538195B2 (en) * | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US8034904B2 (en) * | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| AU2003278212B2 (en) * | 2002-07-31 | 2009-07-09 | Centre National De La Recherche Scientifique | Stem cells derived from adipous tissue and differentiated cells derived from said cells |
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| WO2005016970A2 (en) * | 2003-05-01 | 2005-02-24 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| US20050187175A1 (en) * | 2003-09-30 | 2005-08-25 | Elly Nedivi | Methods and compositions for CPG15-2 |
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| US7326567B2 (en) | 2003-11-12 | 2008-02-05 | Schering Corporation | Plasmid system for multigene expression |
| TW200526684A (en) * | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
| EP1737493B1 (en) | 2004-02-25 | 2011-06-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of insulin-like growth factor receptor -1 for inhibiting tumor cell growth |
| US8187595B2 (en) | 2004-05-07 | 2012-05-29 | The University Of North Carolina At Chapel Hill | Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I |
| ATE461708T1 (de) | 2004-05-07 | 2010-04-15 | Univ North Carolina | Verfahren zur verstärkung oder hemmung des insulinähnlichen wachstumsfaktors-i |
| US20100298213A1 (en) * | 2004-08-20 | 2010-11-25 | Novo Nordisk A/S | Pharmaceutically Active Insulin Receptor-Modulating Molecules |
| WO2006052468A2 (en) * | 2004-10-27 | 2006-05-18 | University Of Denver | Adrenocorticotropic hormone analogs and related methods |
| US20090197800A1 (en) * | 2004-10-27 | 2009-08-06 | Novo Nordisk A/S | Insulin Receptor Binding Peptides with Non-Insulin Gene Activation Profiles and Uses Thereof |
| MX2007006640A (es) * | 2004-12-03 | 2007-06-19 | Schering Corp | Biomarcadores para la preseleccion de pacientes para la terapia con anti-receptor 1 del factor de crecimiento similar a la insulina. |
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| WO2006072625A2 (en) | 2005-01-06 | 2006-07-13 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
| EP3312196B1 (en) | 2005-03-23 | 2019-07-17 | Genmab A/S | Antibodies against cd38 for treatment of multiple myeloma |
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| CN101287761A (zh) * | 2005-06-15 | 2008-10-15 | 先灵公司 | 抗-igf1r抗体制剂 |
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| JP2009511446A (ja) * | 2005-10-05 | 2009-03-19 | ノボ・ノルデイスク・エー／エス | インスリンレセプターアンタゴニストと、関連した組成物、使用及び方法 |
| AU2007212447B2 (en) * | 2006-02-03 | 2013-02-21 | Imclone Llc | IGF-IR antagonists as adjuvants for treatment of prostate cancer |
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| EP2044246A4 (en) * | 2006-07-06 | 2009-12-16 | Molecular Logix Inc | LIGAND DRUG DISCOVERY SYSTEM DOMINANT NEGATIVE |
| EP2152742B1 (en) | 2007-04-24 | 2013-01-23 | Antyra, Inc. | IGF-1R binding proteins and antagonists |
| US8574577B2 (en) * | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
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| EP2249853A4 (en) | 2008-01-30 | 2012-12-26 | Univ Indiana Res & Tech Corp | ESTER BASED PEPTIDE PRODRUGS |
| CN102245624B (zh) | 2008-12-19 | 2016-08-10 | 印第安纳大学研究及科技有限公司 | 基于酰胺的胰岛素前药 |
| WO2010080606A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Insulin analogs |
| EP2376099A4 (en) * | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | INSULIN AGAIN YL-BASED GROWTH FACTORS WITH HIGH ACTIVITY AT THE INSULIN RECEPTOR |
| CA2799608C (en) * | 2009-05-28 | 2023-02-28 | Richard H. Weisbart | Amino acid sequences which enhance peptide conjugate solubility |
| WO2011026000A1 (en) * | 2009-08-28 | 2011-03-03 | Bayer Healthcare Llc | Cofactors for thrombin activation of factor vii and uses thereof |
| WO2011159895A2 (en) | 2010-06-16 | 2011-12-22 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| US8946147B2 (en) | 2010-06-24 | 2015-02-03 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| US20140037642A1 (en) | 2011-02-02 | 2014-02-06 | Amgen Inc. | Methods and compositions relating to inhibition of igf-1r |
| EP2712423A4 (en) * | 2011-02-25 | 2015-06-10 | Wellstat Diagnostics Llc | Assays for detecting enzymatic activity |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| AU2012267492A1 (en) * | 2011-06-10 | 2014-01-09 | President And Fellows Of Harvard College | Modulation of pancreatic beta cell proliferation |
| CA2852127C (en) | 2011-11-11 | 2020-10-27 | Duke University | Combination drug therapy for the treatment of solid tumors |
| US9573987B2 (en) | 2011-12-20 | 2017-02-21 | Indiana University Research And Technology Corporation | CTP-based insulin analogs for treatment of diabetes |
| US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
| CN104768975A (zh) | 2012-08-31 | 2015-07-08 | 北卡罗来纳大学教堂山分校 | 用于增强或抑制胰岛素-样生长因子1(igf-1)的单克隆抗体 |
| CN108383902A (zh) | 2012-09-26 | 2018-08-10 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物二聚体 |
| WO2014158900A1 (en) | 2013-03-14 | 2014-10-02 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
| EP3424530A1 (en) | 2013-03-15 | 2019-01-09 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| MY192824A (en) | 2014-09-03 | 2022-09-12 | Boehringer Ingelheim Int | Compound targeting il-23a and tnf-alpha and uses thereof |
| ES2822994T3 (es) | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
| EP3197912B1 (en) | 2014-09-24 | 2023-01-04 | Indiana University Research & Technology Corporation | Lipidated amide-based insulin prodrugs |
| CN108699110B (zh) | 2015-10-23 | 2023-04-28 | 特温特大学 | 整合素结合肽及其用途 |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| CA3120327A1 (en) * | 2018-12-06 | 2020-06-11 | Cytomx Therapeutics, Inc. | Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof |
| US20230055519A1 (en) * | 2020-01-16 | 2023-02-23 | The Translational Genomics Research Institute | Methods of identifying synthetic molecular binding agents |
| WO2022020246A1 (en) * | 2020-07-23 | 2022-01-27 | The Scripps Research Institute | Insulin receptor-mediated enhancement of gene transfer |
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| US4876242A (en) | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| JPH03501487A (ja) * | 1988-06-30 | 1991-04-04 | シティ・オブ・ホープ | インシュリン模倣物およびインシュリンリセプター結合部位ペプチド |
| US5652214A (en) | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
| US6310040B1 (en) | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
| JPH07508025A (ja) | 1992-05-08 | 1995-09-07 | トーマス・ジェファーソン・ユニバーシティ | インスリン様増殖因子（ｉｇｆ−１）類似体 |
| DE4432943A1 (de) | 1994-09-15 | 1996-03-21 | Radulescu Razvan T Dr Med M D | Numerical Mirror Image Strategy (NUMIS) |
| RU2078769C1 (ru) | 1995-08-18 | 1997-05-10 | Научно-исследовательский институт биомедицинской химии РАМН | Пептидный фрагмент, обладающий биологической активностью инсулина |
| US5912160A (en) | 1995-08-22 | 1999-06-15 | Thomas Jefferson University | Gab1, Grb2 binding protein, and compositions for making and methods of using the same |
| US6028053A (en) * | 1995-10-27 | 2000-02-22 | Mount Sinai Hospital Corporation | Peptide inhibitors of a phosphotyrosine-binding domain containing protein |
| AU3568697A (en) | 1996-06-07 | 1998-01-05 | Genetics Institute Inc. | Polynucleotides from human adult pbmc endocing secreted proteins |
| ES2242995T3 (es) * | 1997-01-15 | 2005-11-16 | Telik, Inc. | Moduladores de la actividad del receptor de la insulina. |
| EP1034188B1 (en) | 1997-11-27 | 2006-06-07 | Commonwealth Scientific And Industrial Research Organisation | Method of designing agonists and antagonists to igf receptor (1-462) |
| PT1141014E (pt) | 1999-01-06 | 2005-04-29 | Genentech Inc | Variante mutante do factor de crescimento semelhante a insulina (igf-i) |
| JP2004512010A (ja) * | 2000-03-29 | 2004-04-22 | ディージーアイ・バイオテクノロジーズ・エル・エル・シー | インスリン及びｉｇｆ−１受容体のアゴニスト及びアンタゴニスト |
-
2001
- 2001-09-24 US US09/962,756 patent/US6875741B2/en not_active Expired - Fee Related
-
2002
- 2002-09-24 EP EP02806867A patent/EP1496935A4/en not_active Withdrawn
- 2002-09-24 JP JP2003530818A patent/JP2005505579A/ja active Pending
- 2002-09-24 EP EP02775987A patent/EP1432433A4/en not_active Withdrawn
- 2002-09-24 CA CA002460055A patent/CA2460055A1/en not_active Abandoned
- 2002-09-24 AU AU2002341834A patent/AU2002341834A1/en not_active Abandoned
- 2002-09-24 WO PCT/US2002/030312 patent/WO2003070747A2/en not_active Ceased
- 2002-09-24 CA CA002459999A patent/CA2459999A1/en not_active Abandoned
- 2002-09-24 JP JP2003569654A patent/JP2005517741A/ja active Pending
- 2002-09-24 AU AU2002366384A patent/AU2002366384A1/en not_active Abandoned
- 2002-09-24 WO PCT/US2002/030412 patent/WO2003027246A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002341834A1 (en) | 2003-04-07 |
| WO2003070747A2 (en) | 2003-08-28 |
| AU2002366384A8 (en) | 2003-09-09 |
| EP1432433A2 (en) | 2004-06-30 |
| CA2459999A1 (en) | 2003-04-03 |
| EP1432433A4 (en) | 2006-08-30 |
| US6875741B2 (en) | 2005-04-05 |
| WO2003027246A3 (en) | 2003-07-31 |
| JP2005517741A (ja) | 2005-06-16 |
| WO2003027246A2 (en) | 2003-04-03 |
| AU2002366384A1 (en) | 2003-09-09 |
| EP1496935A2 (en) | 2005-01-19 |
| WO2003070747A3 (en) | 2004-11-11 |
| JP2005505579A (ja) | 2005-02-24 |
| EP1496935A4 (en) | 2006-06-07 |
| US20030195147A1 (en) | 2003-10-16 |
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| EEER | Examination request | ||
| FZDE | Discontinued |