JP2005505579A - アンタゴニスト - Google Patents
アンタゴニスト Download PDFInfo
- Publication number
- JP2005505579A JP2005505579A JP2003530818A JP2003530818A JP2005505579A JP 2005505579 A JP2005505579 A JP 2005505579A JP 2003530818 A JP2003530818 A JP 2003530818A JP 2003530818 A JP2003530818 A JP 2003530818A JP 2005505579 A JP2005505579 A JP 2005505579A
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- seq
- growth factor
- amino acid
- factor receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/962,756 US6875741B2 (en) | 1998-09-02 | 2001-09-24 | Insulin and IGF-1 receptor agonists and antagonists |
| PCT/US2002/030412 WO2003027246A2 (en) | 2001-09-24 | 2002-09-24 | Antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005505579A true JP2005505579A (ja) | 2005-02-24 |
| JP2005505579A5 JP2005505579A5 (enExample) | 2006-01-05 |
Family
ID=25506313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530818A Pending JP2005505579A (ja) | 2001-09-24 | 2002-09-24 | アンタゴニスト |
| JP2003569654A Pending JP2005517741A (ja) | 2001-09-24 | 2002-09-24 | インシュリン及びigf−1レセプターのアゴニスト及びアンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569654A Pending JP2005517741A (ja) | 2001-09-24 | 2002-09-24 | インシュリン及びigf−1レセプターのアゴニスト及びアンタゴニスト |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6875741B2 (enExample) |
| EP (2) | EP1496935A4 (enExample) |
| JP (2) | JP2005505579A (enExample) |
| AU (2) | AU2002341834A1 (enExample) |
| CA (2) | CA2459999A1 (enExample) |
| WO (2) | WO2003027246A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019501664A (ja) * | 2015-10-23 | 2019-01-24 | ウニフェルシタイト・トゥヴェンテ | インテグリン結合ペプチド及びその使用 |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7625859B1 (en) | 2000-02-16 | 2009-12-01 | Oregon Health & Science University | HER-2 binding antagonists |
| US6521738B2 (en) * | 1999-12-29 | 2003-02-18 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
| EP1432430A4 (en) | 2001-08-28 | 2006-05-10 | Lilly Co Eli | PREMIXTURES OF GLP-1 AND BASALINSULIN |
| AU2003205830A1 (en) | 2002-01-23 | 2003-09-02 | Mohamed Raafat El-Gewely | Molecular libraries |
| US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| AU2003278807A1 (en) | 2002-03-01 | 2004-08-13 | Bracco International B.V. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US8623822B2 (en) * | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US7794693B2 (en) * | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| AU2003228525A1 (en) * | 2002-04-22 | 2003-11-03 | Greenville Hospital System | Multimeric ligands with enhanced stability |
| JP4563171B2 (ja) * | 2002-05-24 | 2010-10-13 | シェーリング コーポレイション | 中和ヒト抗igfr抗体 |
| US8034904B2 (en) * | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US8334135B2 (en) * | 2002-07-31 | 2012-12-18 | Yves Saint Laurent Parfums | Stem cells from adipose tissue, and differentiated cells from said cells |
| US20040176291A1 (en) * | 2002-09-24 | 2004-09-09 | Elly Nedivi | Methods and compositions for soluble CPG15 |
| JP2007535895A (ja) * | 2003-05-01 | 2007-12-13 | イムクローン システムズ インコーポレイティド | ヒトインシュリン様成長因子−1受容体に対する完全ヒト抗体 |
| US20050187175A1 (en) * | 2003-09-30 | 2005-08-25 | Elly Nedivi | Methods and compositions for CPG15-2 |
| US7605120B2 (en) * | 2003-10-22 | 2009-10-20 | Amgen Inc. | Antagonists of the brandykinin B1 receptor |
| ATE514783T1 (de) | 2003-11-12 | 2011-07-15 | Schering Corp | Plasmidsystem zur expression mehrerer gene |
| TW200526684A (en) * | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
| US7781393B2 (en) | 2004-02-25 | 2010-08-24 | Dana-Farber Cancer Institute, Inc. | Methods for inhibiting tumor cell growth |
| DK1755660T3 (da) * | 2004-05-07 | 2010-07-19 | Univ North Carolina | Fremgangsmåde til forbedring eller hæmning af insulin-lignende vækstfaktor-I |
| US8187595B2 (en) | 2004-05-07 | 2012-05-29 | The University Of North Carolina At Chapel Hill | Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I |
| US20100298213A1 (en) * | 2004-08-20 | 2010-11-25 | Novo Nordisk A/S | Pharmaceutically Active Insulin Receptor-Modulating Molecules |
| WO2006052468A2 (en) * | 2004-10-27 | 2006-05-18 | University Of Denver | Adrenocorticotropic hormone analogs and related methods |
| WO2006045710A2 (en) * | 2004-10-27 | 2006-05-04 | Novo Nordisk A/S | Insulin receptor binding peptides with non-insulin gene activation profiles and uses thereof |
| EP1828249B1 (en) * | 2004-12-03 | 2010-12-29 | Schering Corporation | Biomarkers for pre-selection of patients for anti-igf1r therapy |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| EP3072522B1 (en) | 2005-01-06 | 2019-04-24 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
| MX2007011064A (es) | 2005-03-23 | 2008-02-19 | Genmab As | Anticuerpos contra cd38 para tratamiento de mieloma multiple. |
| NZ561648A (en) * | 2005-04-15 | 2009-11-27 | Schering Corp | Methods and composition of IGF1R inhibitors for treating or preventing cancer |
| KR20080019249A (ko) * | 2005-06-15 | 2008-03-03 | 쉐링 코포레이션 | 안정한 항체 제형 |
| PL2100618T3 (pl) * | 2005-06-17 | 2014-07-31 | Imclone Llc | Przeciwciało anty-PDGFR alfa do zastosowania w leczeniu przerzutowego raka kości |
| US7622438B1 (en) | 2005-07-18 | 2009-11-24 | Acologix, Inc. | Protein formulation for promoting hard tissue formation |
| JP2009511446A (ja) * | 2005-10-05 | 2009-03-19 | ノボ・ノルデイスク・エー/エス | インスリンレセプターアンタゴニストと、関連した組成物、使用及び方法 |
| AP2008004569A0 (en) * | 2006-02-03 | 2008-08-31 | Imclone Systems Inc | IGR-IR antagonists as adjuvants for treatment of prostrate cancer |
| WO2007095113A2 (en) * | 2006-02-10 | 2007-08-23 | Massachusetts Institute Of Technology | Cpg15 and cpg15-2 compounds and inhibitors as insulin receptor and insulin-like growth factor receptor agonists and antagonists |
| EP2468766B1 (en) | 2006-06-22 | 2014-09-17 | Walter and Eliza Hall Institute of Medical Research | Structure of the insulin receptor ectodomain |
| WO2008005992A2 (en) * | 2006-07-06 | 2008-01-10 | Molecular Logix, Inc. | Dominant negative ligand drug discovery system |
| WO2008133961A2 (en) | 2007-04-24 | 2008-11-06 | Antyra Inc. | Igf-1r binding proteins and antagonists |
| US8574577B2 (en) * | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| EA201500156A3 (ru) | 2008-01-03 | 2017-09-29 | Дзе Скриппс Рисерч Инститьют | Доставка антител посредством модульного домена распознавания |
| US8557242B2 (en) * | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| US8557243B2 (en) * | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| AU2009210570B2 (en) | 2008-01-30 | 2014-11-20 | Indiana University Research And Technology Corporation | Ester-based insulin prodrugs |
| US8697632B2 (en) | 2008-12-19 | 2014-04-15 | Indiana University Research And Technology Corporation | Amide based insulin prodrugs |
| EP2376099A4 (en) * | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | INSULIN AGAIN YL-BASED GROWTH FACTORS WITH HIGH ACTIVITY AT THE INSULIN RECEPTOR |
| US8481485B2 (en) | 2008-12-19 | 2013-07-09 | Indiana University Research And Technology Corporation | Insulin analogs |
| EP2438090B1 (en) * | 2009-05-28 | 2016-07-06 | The United States Government as Represented by the Department of Veterans Affairs | Amino acid sequences which enhance peptide conjugate solubility |
| US20120178693A1 (en) * | 2009-08-28 | 2012-07-12 | Bayer Healthcare Llc | Cofactors for Thrombin Activation of Factor VII and Uses Thereof |
| AU2011268327B2 (en) | 2010-06-16 | 2016-02-25 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| JP5912112B2 (ja) | 2010-06-24 | 2016-04-27 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | アミド系インスリンプロドラッグ |
| US20140037642A1 (en) | 2011-02-02 | 2014-02-06 | Amgen Inc. | Methods and compositions relating to inhibition of igf-1r |
| US9244073B2 (en) | 2011-02-25 | 2016-01-26 | Wellstat Diagnostics, Llc | Assays for detecting enzymatic activity |
| WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| CA2838824A1 (en) * | 2011-06-10 | 2012-12-13 | President And Fellows Of Harvard College | Modulation of pancreatic beta cell proliferation |
| WO2013071056A2 (en) | 2011-11-11 | 2013-05-16 | Duke University | Combination drug therapy for the treatment of solid tumors |
| CN104114183A (zh) | 2011-12-20 | 2014-10-22 | 印第安纳大学研究及科技有限公司 | 用于治疗糖尿病的基于ctp的胰岛素类似物 |
| US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
| RU2015106333A (ru) | 2012-08-31 | 2016-10-27 | Зэ Юниверсити Оф Норз Каролина Эт Чапел Хилл | Моноклональные антитела для стимуляции или ингибирования инсулиноподобного фактора роста 1 (igf-1) |
| CN104981251B (zh) | 2012-09-26 | 2018-03-20 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物二聚体 |
| BR112015023071A2 (pt) | 2013-03-14 | 2017-07-18 | Univ Indiana Res & Tech Corp | conjugados de insulina-incretina |
| WO2014144600A2 (en) | 2013-03-15 | 2014-09-18 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
| CA2959629C (en) * | 2014-09-03 | 2023-10-31 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
| US10232020B2 (en) | 2014-09-24 | 2019-03-19 | Indiana University Research And Technology Corporation | Incretin-insulin conjugates |
| CN107001441A (zh) | 2014-09-24 | 2017-08-01 | 印第安纳大学研究及科技有限公司 | 脂质化的基于酰胺的胰岛素前药 |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| MY205459A (en) * | 2018-12-06 | 2024-10-22 | Cytomx Therapeutics Inc | Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof |
| WO2021146657A1 (en) * | 2020-01-16 | 2021-07-22 | The Translational Genomics Research Institute | Methods of identifying synthetic molecular binding agents |
| WO2022020246A1 (en) * | 2020-07-23 | 2022-01-27 | The Scripps Research Institute | Insulin receptor-mediated enhancement of gene transfer |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876242A (en) | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| EP0378671B1 (en) * | 1988-06-30 | 1997-03-12 | City Of Hope | Insulinomimetic and insulin receptor binding site peptides |
| US5652214A (en) | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
| US6310040B1 (en) | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
| EP0639981A4 (en) | 1992-05-08 | 1995-06-28 | Univ Jefferson | ANALOGS OF THE IGF FACTOR (01/18/94). |
| DE4432943A1 (de) | 1994-09-15 | 1996-03-21 | Radulescu Razvan T Dr Med M D | Numerical Mirror Image Strategy (NUMIS) |
| RU2078769C1 (ru) | 1995-08-18 | 1997-05-10 | Научно-исследовательский институт биомедицинской химии РАМН | Пептидный фрагмент, обладающий биологической активностью инсулина |
| WO1997007827A1 (en) | 1995-08-22 | 1997-03-06 | Thomas Jefferson University | Gab1, A Grb2 BINDING PROTEIN, AND COMPOSITIONS FOR MAKING AND METHODS OF USING THE SAME |
| US6028053A (en) * | 1995-10-27 | 2000-02-22 | Mount Sinai Hospital Corporation | Peptide inhibitors of a phosphotyrosine-binding domain containing protein |
| WO1997046682A2 (en) | 1996-06-07 | 1997-12-11 | Genetics Institute, Inc. | Polynucleotides from human adult pbmc encoding secreted proteins |
| JP2002512685A (ja) * | 1997-01-15 | 2002-04-23 | テリック・インコーポレイテッド | インスリン受容体活性のモジュレーター |
| JP2001525339A (ja) | 1997-11-27 | 2001-12-11 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション | Igf受容体に対するアゴニストおよびアンタゴニストの設計方法 |
| CA2356109C (en) | 1999-01-06 | 2008-04-22 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
| WO2001072771A2 (en) * | 2000-03-29 | 2001-10-04 | Dgi Biotechnologies, L.L.C. | Insulin and igf-1 receptor agonists and antagonists |
-
2001
- 2001-09-24 US US09/962,756 patent/US6875741B2/en not_active Expired - Fee Related
-
2002
- 2002-09-24 CA CA002459999A patent/CA2459999A1/en not_active Abandoned
- 2002-09-24 EP EP02806867A patent/EP1496935A4/en not_active Withdrawn
- 2002-09-24 EP EP02775987A patent/EP1432433A4/en not_active Withdrawn
- 2002-09-24 JP JP2003530818A patent/JP2005505579A/ja active Pending
- 2002-09-24 WO PCT/US2002/030412 patent/WO2003027246A2/en not_active Ceased
- 2002-09-24 AU AU2002341834A patent/AU2002341834A1/en not_active Abandoned
- 2002-09-24 WO PCT/US2002/030312 patent/WO2003070747A2/en not_active Ceased
- 2002-09-24 JP JP2003569654A patent/JP2005517741A/ja active Pending
- 2002-09-24 CA CA002460055A patent/CA2460055A1/en not_active Abandoned
- 2002-09-24 AU AU2002366384A patent/AU2002366384A1/en not_active Abandoned
Non-Patent Citations (4)
| Title |
|---|
| JPN6010017698, J. Am. Soc. Nephrol. (2000) vol.11, no.11, p.2027−2035 * |
| JPN6010017699, Biopolymers (2000) vol.55, no.4, p.347−356 * |
| JPN6010017701, EMBO J. (2000) vol.19, no.7, p.1525−1533 * |
| JPN6010017704, Gene (1993) vol.128, no.1, p.37−42 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019501664A (ja) * | 2015-10-23 | 2019-01-24 | ウニフェルシタイト・トゥヴェンテ | インテグリン結合ペプチド及びその使用 |
| JP7174627B2 (ja) | 2015-10-23 | 2022-11-17 | ウニフェルシタイト・トゥヴェンテ | インテグリン結合ペプチド及びその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005517741A (ja) | 2005-06-16 |
| WO2003070747A3 (en) | 2004-11-11 |
| CA2459999A1 (en) | 2003-04-03 |
| AU2002341834A1 (en) | 2003-04-07 |
| WO2003070747A2 (en) | 2003-08-28 |
| WO2003027246A3 (en) | 2003-07-31 |
| EP1432433A2 (en) | 2004-06-30 |
| AU2002366384A8 (en) | 2003-09-09 |
| US20030195147A1 (en) | 2003-10-16 |
| EP1496935A2 (en) | 2005-01-19 |
| WO2003027246A2 (en) | 2003-04-03 |
| AU2002366384A1 (en) | 2003-09-09 |
| CA2460055A1 (en) | 2003-08-28 |
| US6875741B2 (en) | 2005-04-05 |
| EP1432433A4 (en) | 2006-08-30 |
| EP1496935A4 (en) | 2006-06-07 |
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