JP2005505579A - アンタゴニスト - Google Patents

アンタゴニスト Download PDF

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Publication number
JP2005505579A
JP2005505579A JP2003530818A JP2003530818A JP2005505579A JP 2005505579 A JP2005505579 A JP 2005505579A JP 2003530818 A JP2003530818 A JP 2003530818A JP 2003530818 A JP2003530818 A JP 2003530818A JP 2005505579 A JP2005505579 A JP 2005505579A
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JP
Japan
Prior art keywords
insulin
seq
growth factor
amino acid
factor receptor
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Pending
Application number
JP2003530818A
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English (en)
Japanese (ja)
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JP2005505579A5 (enExample
Inventor
レヌーカ ピルートラ,
オルガ デドヴァ,
アーサー, ジェイ. ブルーム,
ニール, アイ. ゴールドスタイン,
レニー ブリセット,
ピンガー ワン,
ハオ リュー,
クー−チュアン シャオ,
マイケル レニック,
ポール フレッチャー,
Original Assignee
ノボ・ノルデイスク・エー/エス
ディージーアイ バイオテクノロジーズ
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Application filed by ノボ・ノルデイスク・エー/エス, ディージーアイ バイオテクノロジーズ filed Critical ノボ・ノルデイスク・エー/エス
Publication of JP2005505579A publication Critical patent/JP2005505579A/ja
Publication of JP2005505579A5 publication Critical patent/JP2005505579A5/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/65Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2003530818A 2001-09-24 2002-09-24 アンタゴニスト Pending JP2005505579A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/962,756 US6875741B2 (en) 1998-09-02 2001-09-24 Insulin and IGF-1 receptor agonists and antagonists
PCT/US2002/030412 WO2003027246A2 (en) 2001-09-24 2002-09-24 Antagonists

Publications (2)

Publication Number Publication Date
JP2005505579A true JP2005505579A (ja) 2005-02-24
JP2005505579A5 JP2005505579A5 (enExample) 2006-01-05

Family

ID=25506313

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003530818A Pending JP2005505579A (ja) 2001-09-24 2002-09-24 アンタゴニスト
JP2003569654A Pending JP2005517741A (ja) 2001-09-24 2002-09-24 インシュリン及びigf−1レセプターのアゴニスト及びアンタゴニスト

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2003569654A Pending JP2005517741A (ja) 2001-09-24 2002-09-24 インシュリン及びigf−1レセプターのアゴニスト及びアンタゴニスト

Country Status (6)

Country Link
US (1) US6875741B2 (enExample)
EP (2) EP1496935A4 (enExample)
JP (2) JP2005505579A (enExample)
AU (2) AU2002366384A1 (enExample)
CA (2) CA2460055A1 (enExample)
WO (2) WO2003070747A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019501664A (ja) * 2015-10-23 2019-01-24 ウニフェルシタイト・トゥヴェンテ インテグリン結合ペプチド及びその使用

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7625859B1 (en) 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
US6521738B2 (en) * 1999-12-29 2003-02-18 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
CA2452044A1 (en) 2001-08-28 2003-03-13 Eli Lilly And Company Pre-mixes of glp-1 and basal insulin
AU2003205830A1 (en) * 2002-01-23 2003-09-02 Mohamed Raafat El-Gewely Molecular libraries
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US20050250700A1 (en) * 2002-03-01 2005-11-10 Sato Aaron K KDR and VEGF/KDR binding peptides
US8623822B2 (en) * 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (en) * 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
US7666979B2 (en) * 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7985402B2 (en) * 2002-03-01 2011-07-26 Bracco Suisse Sa Targeting vector-phospholipid conjugates
US7632809B2 (en) * 2002-04-22 2009-12-15 Oncolix, Inc. Multimeric ligands with enhanced stability
NZ536475A (en) * 2002-05-24 2008-06-30 Schering Corp Neutralizing human anti-igfr antibody
US8034904B2 (en) * 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
US7538195B2 (en) * 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
ES2560847T3 (es) * 2002-07-31 2016-02-23 Yves Saint-Laurent Parfums Células madre procedentes de tejido adiposo y células diferenciadas procedentes de estas células
AU2003275240A1 (en) * 2002-09-24 2004-04-23 Massachusetts Institute Of Technology Methods and compositions for soluble cpg15
CA2524305C (en) * 2003-05-01 2015-12-08 Imclone Systems Incorporated Fully human antibodies directed against the human insulin-like growth factor-1 receptor
WO2005032476A2 (en) * 2003-09-30 2005-04-14 Massachusetts Institute Of Technology Methods and compositions for cpg15-2
US7605120B2 (en) * 2003-10-22 2009-10-20 Amgen Inc. Antagonists of the brandykinin B1 receptor
ATE514783T1 (de) 2003-11-12 2011-07-15 Schering Corp Plasmidsystem zur expression mehrerer gene
PE20050928A1 (es) * 2003-11-21 2005-11-08 Schering Corp Combinaciones terapeuticas de anticuerpo anti-igfr1
ES2368741T3 (es) 2004-02-25 2011-11-21 Dana-Farber Cancer Institute, Inc. Inhibidores del receptor 1 del factor de crecimiento de tipo insulina para inhibir el crecimiento de células tumorales.
US8187595B2 (en) 2004-05-07 2012-05-29 The University Of North Carolina At Chapel Hill Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I
JP4928443B2 (ja) 2004-05-07 2012-05-09 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル インスリン様成長因子iを増強または阻害するための方法
US20100298213A1 (en) * 2004-08-20 2010-11-25 Novo Nordisk A/S Pharmaceutically Active Insulin Receptor-Modulating Molecules
EP1807105A2 (en) * 2004-10-27 2007-07-18 Novo Nordisk A/S Insulin receptor binding peptides with non-insulin gene activation profiles and uses thereof
EP1814574A4 (en) * 2004-10-27 2009-08-05 Univ Denver ANALOGUE OF ADRENOCORTICOTROPEN HORMON AND CORRESPONDING METHODS
DE602005025685D1 (de) * 2004-12-03 2011-02-10 Schering Corp Biologische marker zur vorauswahl von patienten für die anti-igf1r-therapie
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
WO2006072625A2 (en) 2005-01-06 2006-07-13 Novo Nordisk A/S Anti-kir combination treatments and methods
EP3312196B1 (en) 2005-03-23 2019-07-17 Genmab A/S Antibodies against cd38 for treatment of multiple myeloma
US20060233810A1 (en) * 2005-04-15 2006-10-19 Yaolin Wang Methods and compositions for treating or preventing cancer
AU2006259536A1 (en) 2005-06-15 2006-12-28 Schering Corporation Anti-IGF1R antibody formulations
KR101246504B1 (ko) * 2005-06-17 2013-03-26 임클론 엘엘씨 항-PDGFRα 항체
US7622438B1 (en) 2005-07-18 2009-11-24 Acologix, Inc. Protein formulation for promoting hard tissue formation
CN101321780A (zh) * 2005-10-05 2008-12-10 诺沃-诺迪斯克有限公司 胰岛素受体拮抗剂及相关组合物、用途和方法
KR101353706B1 (ko) * 2006-02-03 2014-02-18 유니버시티 오브 워싱톤 전립선 암 치료용 보강제로서의 ⅰgf-ⅰr 길항제
WO2007095113A2 (en) * 2006-02-10 2007-08-23 Massachusetts Institute Of Technology Cpg15 and cpg15-2 compounds and inhibitors as insulin receptor and insulin-like growth factor receptor agonists and antagonists
EP2468767B1 (en) 2006-06-22 2015-10-28 Walter and Eliza Hall Institute of Medical Research Structure of the insulin receptor ectodomain
WO2008005992A2 (en) * 2006-07-06 2008-01-10 Molecular Logix, Inc. Dominant negative ligand drug discovery system
WO2008133961A2 (en) 2007-04-24 2008-11-06 Antyra Inc. Igf-1r binding proteins and antagonists
US8557242B2 (en) * 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
KR101658247B1 (ko) 2008-01-03 2016-09-22 더 스크립스 리서치 인스티튜트 모듈 인식 도메인을 통한 항체 표적화
US8557243B2 (en) * 2008-01-03 2013-10-15 The Scripps Research Institute EFGR antibodies comprising modular recognition domains
US8574577B2 (en) * 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
WO2009099763A1 (en) 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
EP2376099A4 (en) * 2008-12-19 2012-04-25 Univ Indiana Res & Tech Corp INSULIN AGAIN YL-BASED GROWTH FACTORS WITH HIGH ACTIVITY AT THE INSULIN RECEPTOR
CN102245624B (zh) 2008-12-19 2016-08-10 印第安纳大学研究及科技有限公司 基于酰胺的胰岛素前药
JP5789515B2 (ja) 2008-12-19 2015-10-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation インスリン類似体
US9155801B2 (en) 2009-05-28 2015-10-13 The United States Government As Represented By The Department Of Veterans Affairs Amino acid sequences which enhance peptide conjugate solubility
EP2470201A4 (en) * 2009-08-28 2013-01-30 Bayer Healthcare Llc COFACTORS ENABLING THE THROMBINIC ACTIVATION OF FACTOR VII AND THEIR USES
EP2582719B1 (en) 2010-06-16 2016-08-10 Indiana University Research and Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
CA2803164C (en) 2010-06-24 2018-08-21 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
AU2012212075A1 (en) 2011-02-02 2013-07-18 Amgen Inc. Methods and compositons relating to inhibition of IGF-1R
WO2012154272A1 (en) * 2011-02-25 2012-11-15 Wellstat Diagnostics, Llc Assays for detecting enzymatic activity
EP2714738B1 (en) 2011-05-24 2018-10-10 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
CN104039357A (zh) * 2011-06-10 2014-09-10 哈佛学院校长同事会 胰腺β-细胞增殖的调节
US9700619B2 (en) 2011-11-11 2017-07-11 Duke University Combination drug therapy for the treatment of solid tumors
CN104114183A (zh) 2011-12-20 2014-10-22 印第安纳大学研究及科技有限公司 用于治疗糖尿病的基于ctp的胰岛素类似物
US8980259B2 (en) 2012-07-20 2015-03-17 Novartis Ag Combination therapy
HK1213904A1 (zh) 2012-08-31 2016-07-15 The University Of North Carolina At Chapel Hill 用於增强或抑制胰島素樣生長因子1(igf-1)的單克隆抗體
CN108383902A (zh) 2012-09-26 2018-08-10 印第安纳大学研究及科技有限公司 胰岛素类似物二聚体
JP6538645B2 (ja) 2013-03-14 2019-07-03 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation インスリン‐インクレチン複合物
MX2015013163A (es) 2013-03-15 2016-04-04 Zyngenia Inc Complejos multiespecificos multivalente y monovalentes y sus usos.
AR101753A1 (es) 2014-09-03 2017-01-11 Boehringer Ingelheim Int COMPUESTO DE OBJETIVO A IL-23A Y TNF-a Y USO DEL MISMO
CN107001441A (zh) 2014-09-24 2017-08-01 印第安纳大学研究及科技有限公司 脂质化的基于酰胺的胰岛素前药
US10232020B2 (en) 2014-09-24 2019-03-19 Indiana University Research And Technology Corporation Incretin-insulin conjugates
WO2017129763A1 (en) 2016-01-28 2017-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer
SG11202105476XA (en) * 2018-12-06 2021-06-29 Cytomx Therapeutics Inc Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof
US20230055519A1 (en) * 2020-01-16 2023-02-23 The Translational Genomics Research Institute Methods of identifying synthetic molecular binding agents
EP4185608A4 (en) * 2020-07-23 2024-08-21 University of Florida Research Foundation, Inc. INSULIN RECEPTOR-MEDIATED ENHANCEMENT OF GENE TRANSFER

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876242A (en) 1987-09-21 1989-10-24 Merck & Co., Inc. Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast
JPH03501487A (ja) * 1988-06-30 1991-04-04 シティ・オブ・ホープ インシュリン模倣物およびインシュリンリセプター結合部位ペプチド
US5652214A (en) 1989-06-05 1997-07-29 Cephalon, Inc. Treating disorders by application of insulin-like growth factors and analogs
US6310040B1 (en) 1991-11-08 2001-10-30 Cephalon, Inc. Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs
AU4238493A (en) 1992-05-08 1993-12-13 Thomas Jefferson University IGF-1 analogs
DE4432943A1 (de) 1994-09-15 1996-03-21 Radulescu Razvan T Dr Med M D Numerical Mirror Image Strategy (NUMIS)
RU2078769C1 (ru) 1995-08-18 1997-05-10 Научно-исследовательский институт биомедицинской химии РАМН Пептидный фрагмент, обладающий биологической активностью инсулина
US5912160A (en) 1995-08-22 1999-06-15 Thomas Jefferson University Gab1, Grb2 binding protein, and compositions for making and methods of using the same
US6028053A (en) * 1995-10-27 2000-02-22 Mount Sinai Hospital Corporation Peptide inhibitors of a phosphotyrosine-binding domain containing protein
JP2000515726A (ja) 1996-06-07 2000-11-28 ジェネティックス・インスチチュート・インコーポレーテッド 分泌蛋白をコードする成人pbmc由来のポリヌクレオチド
DE69830301T2 (de) * 1997-01-15 2006-02-02 Telik Inc., South San Francisco Modulatoren von insulinrezeptor-aktivität
JP2001525339A (ja) 1997-11-27 2001-12-11 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション Igf受容体に対するアゴニストおよびアンタゴニストの設計方法
CA2356109C (en) 1999-01-06 2008-04-22 Genentech, Inc. Insulin-like growth factor (igf) i mutant variants
EP2368902A3 (en) * 2000-03-29 2011-12-21 DGI Bio Technologies LLC Insulin and IGF-1 receptor agonists and antagonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6010017698, J. Am. Soc. Nephrol. (2000) vol.11, no.11, p.2027−2035 *
JPN6010017699, Biopolymers (2000) vol.55, no.4, p.347−356 *
JPN6010017701, EMBO J. (2000) vol.19, no.7, p.1525−1533 *
JPN6010017704, Gene (1993) vol.128, no.1, p.37−42 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019501664A (ja) * 2015-10-23 2019-01-24 ウニフェルシタイト・トゥヴェンテ インテグリン結合ペプチド及びその使用
JP7174627B2 (ja) 2015-10-23 2022-11-17 ウニフェルシタイト・トゥヴェンテ インテグリン結合ペプチド及びその使用

Also Published As

Publication number Publication date
AU2002366384A8 (en) 2003-09-09
WO2003027246A3 (en) 2003-07-31
JP2005517741A (ja) 2005-06-16
WO2003070747A2 (en) 2003-08-28
AU2002341834A1 (en) 2003-04-07
CA2459999A1 (en) 2003-04-03
AU2002366384A1 (en) 2003-09-09
EP1432433A4 (en) 2006-08-30
WO2003070747A3 (en) 2004-11-11
WO2003027246A2 (en) 2003-04-03
CA2460055A1 (en) 2003-08-28
EP1496935A2 (en) 2005-01-19
EP1496935A4 (en) 2006-06-07
US6875741B2 (en) 2005-04-05
US20030195147A1 (en) 2003-10-16
EP1432433A2 (en) 2004-06-30

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