ATE366813T1 - Neue peptide - Google Patents

Neue peptide

Info

Publication number
ATE366813T1
ATE366813T1 AT00946453T AT00946453T ATE366813T1 AT E366813 T1 ATE366813 T1 AT E366813T1 AT 00946453 T AT00946453 T AT 00946453T AT 00946453 T AT00946453 T AT 00946453T AT E366813 T1 ATE366813 T1 AT E366813T1
Authority
AT
Austria
Prior art keywords
amino acid
new peptides
compound
activity
replaced
Prior art date
Application number
AT00946453T
Other languages
English (en)
Inventor
Kenji Kangawa
Masayasu Kojima
Hiroshi Hosoda
Hisayuki Matsuo
Yoshiharu Minamitake
Original Assignee
Kenji Kangawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenji Kangawa filed Critical Kenji Kangawa
Application granted granted Critical
Publication of ATE366813T1 publication Critical patent/ATE366813T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT00946453T 1999-07-23 2000-07-24 Neue peptide ATE366813T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21000299 1999-07-23
JP33884199 1999-11-29
JP2000126623 2000-04-26

Publications (1)

Publication Number Publication Date
ATE366813T1 true ATE366813T1 (de) 2007-08-15

Family

ID=27329078

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07006224T ATE449174T1 (de) 1999-07-23 2000-07-24 Neue peptide
AT00946453T ATE366813T1 (de) 1999-07-23 2000-07-24 Neue peptide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07006224T ATE449174T1 (de) 1999-07-23 2000-07-24 Neue peptide

Country Status (16)

Country Link
US (5) US7385026B1 (de)
EP (3) EP1197496B8 (de)
JP (2) JP3471780B2 (de)
KR (1) KR100827973B1 (de)
CN (2) CN100506844C (de)
AT (2) ATE449174T1 (de)
AU (2) AU784035B2 (de)
BR (2) BR0012688A (de)
CA (2) CA2696819C (de)
CY (2) CY1107724T1 (de)
DE (2) DE60035502T2 (de)
DK (2) DK1197496T3 (de)
ES (3) ES2335235T3 (de)
IL (2) IL147652A0 (de)
PT (2) PT1795598E (de)
WO (1) WO2001007475A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1197496T3 (da) 1999-07-23 2007-10-22 Kenji Kangawa Hidtil ukendte peptider
CA2392019A1 (en) 1999-11-22 2001-05-31 Zymogenetics, Inc. Method of forming a peptide-receptor complex with zsig33
US6897286B2 (en) 2000-05-11 2005-05-24 Zymogenetics, Inc. Zsig33-like peptides
US7141646B2 (en) 2000-05-12 2006-11-28 Kaneka Corporation Method of purifying vinyl polymer
US6967237B2 (en) 2000-05-30 2005-11-22 Merck & Co., Inc. Ghrelin analogs
US20020187938A1 (en) * 2000-07-24 2002-12-12 Romano Deghenghi Ghrelin antagonists
WO2003084983A1 (fr) * 2002-04-11 2003-10-16 Daiichi Suntory Pharma Co., Ltd. Procede de production d'un peptide modifie
KR20050012224A (ko) * 2002-05-21 2005-01-31 다이이찌 산토리 파마 가부시키가이샤 그렐린 함유 의약 조성물
JP2006504653A (ja) * 2002-07-19 2006-02-09 サイトス バイオテクノロジー アーゲー グレリン−担体複合体
WO2004009616A2 (en) * 2002-07-23 2004-01-29 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Ghrelin analogs
TWI331922B (en) 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
CN1688696A (zh) * 2002-09-18 2005-10-26 蒙特利尔大学医疗中心 Ghrh类似物
EP1407779A1 (de) * 2002-10-10 2004-04-14 Gastrotech A/S Verwendung von Ghrelin zur Behandlung von vermindertem Körpergewicht und Körperfett in Individuen mit Gastrektomie
US10653637B2 (en) 2003-04-30 2020-05-19 Kenji Kangawa Preventives or remedies for hepatopathy
WO2005016951A2 (en) * 2003-06-04 2005-02-24 Eli Lilly And Company Anti-ghrelin fab antibodies
WO2005026211A2 (en) * 2003-09-05 2005-03-24 Eli Lilly And Company Anti-ghrelin antibodies
CN1321131C (zh) * 2003-12-26 2007-06-13 李宁 猪Ghrelin衍生物及其编码基因与应用
JP2007518762A (ja) * 2004-01-20 2007-07-12 サイトス バイオテクノロジー アーゲー グレリン−担体結合体
US7026175B2 (en) 2004-03-29 2006-04-11 Applied Materials, Inc. High throughput measurement of via defects in interconnects
JP2007532495A (ja) * 2004-04-07 2007-11-15 ガストロテック・ファルマ・アクティーゼルスカブ グレリン欠乏を治療するための分泌促進薬の使用
WO2005097830A2 (en) * 2004-04-07 2005-10-20 Aditech Pharma Ab Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds
WO2005097831A2 (en) * 2004-04-07 2005-10-20 Gastrotech Pharma A/S Uses of isolated binding members capable of binding specifically to secretagogues
KR20070050871A (ko) * 2004-05-11 2007-05-16 더 거번먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 레프리젠티드 바이 더 세크러터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 그렐린을 사용하여 전염증성 사이토킨 발현을 억제하는방법
WO2005120484A1 (ja) * 2004-06-09 2005-12-22 Kurume University グレリンの生理学的機能のレギュレーター
WO2006019577A1 (en) * 2004-07-14 2006-02-23 Eli Lilly And Company Anti-ghrelin antibodies
EP1812045A2 (de) * 2004-10-27 2007-08-01 Gastrotech Pharma A/S Verwendung von sekretagoga bei der behandlung von patienten nach einer organtransplantation
EP1812044A2 (de) * 2004-10-27 2007-08-01 Gastrotech Pharma A/S Verwendung von wachstumshormon-sekretagoga bei der behandlung von personen mit nieren- und/oder leberinsuffizienz
US20080300180A1 (en) * 2004-11-30 2008-12-04 Gastrotech Pharma A/S Growth Hormone Secretagogue Receptor 1A Ligands
EP1862173B1 (de) * 2005-02-23 2014-12-17 Kyoto University Promotor der regeneration einer pankreatischen zelle und promotor der insulinproduktion in einer pankreatischen zelle
EP1856154A1 (de) * 2005-02-23 2007-11-21 Eli Lilly And Company Humanisierte antighrelin-antikörper
PT1937262T (pt) 2005-09-29 2019-08-21 Ipsen Pharma Sas Composição para utilização no tratamento de dismotilidade gastrointestinal
CA2630006A1 (en) * 2005-11-21 2007-05-24 Asubio Pharma Co., Ltd. Skin repair accelerating therapeutic agent containing ghrelin and derivatives thereof or substance acting on ghs-r1a as active ingredient
EP1967201A4 (de) * 2005-11-21 2009-09-30 Univ Miyazaki Therapeutisches mittel für die haut oder die hautreparatur förderndes mittel mit des-acylghrelin oder ein derivat davon als wirkstoff
ES2424970T3 (es) * 2006-03-10 2013-10-10 Ipsen Pharma Uso de un agonista de la grelina para mejorar los efectos catabólicos del tratamiento con glucocorticoides
JP5325092B2 (ja) 2006-03-13 2013-10-23 リアット・ミンツ 悪液質および/または食欲不振症および/または食欲不振症−悪液質および/または栄養失調および/または脂肪異栄養症および/または筋肉消耗および/または食欲−刺激を治療するためのグレリンスプライス変異体の使用
EP2046376B1 (de) * 2006-08-01 2018-08-01 The Scripps Research Institute Impfstoffe und verfahren zur kontrolle von adipositas
WO2008018597A1 (fr) * 2006-08-11 2008-02-14 University Of Miyazaki Agent thérapeutique permettant d'accélérer la réparation des nerfs rachidiens comprenant en tant que matière active de la désacyl ghréline ou un dérivé de celle-ci
WO2008018600A1 (fr) 2006-08-11 2008-02-14 University Of Miyazaki AGENT THÉRAPEUTIQUE PERMETTANT D'ACCÉLÉRER LA RÉPARATION DES NERFS RACHIDIENS COMPRENANT EN TANT QUE MATIÈRE ACTIVE DE LA GHRÉLINE, UN DÉRIVÉ DE CELLE-CI OU UNE SUBSTANCE CAPABLE D'AGIR SUR LE GHS-R1a
CN101541341B (zh) 2006-09-27 2013-06-05 益普生制药两合公司 N末端取代的生长素释放肽类似物
EP2277890B1 (de) * 2008-05-23 2016-01-06 Daiichi Sankyo Company, Limited Zur verlängerung der halbwertzeit eines peptids von interesse in einem plasma geeignetes peptid
CN102348715B (zh) 2009-02-03 2017-12-08 阿穆尼克斯运营公司 延伸重组多肽和包含该延伸重组多肽的组合物
US8883721B2 (en) * 2009-05-12 2014-11-11 Mcgill University Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US9724381B2 (en) 2009-05-12 2017-08-08 The Administrators Of The Tulane Educational Fund Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
ES2599168T3 (es) 2010-01-15 2017-01-31 University Of Miyazaki Grelina para promover la recuperación de un animal en tratamiento médico
AU2011268256B8 (en) * 2010-06-16 2016-12-22 Mcgill University Growth hormone secretatogue receptor antagonists and uses thereof
JP5999712B2 (ja) 2011-03-03 2016-09-28 国立大学法人 宮崎大学 高体温治療剤
JP5560248B2 (ja) * 2011-09-07 2014-07-23 花王株式会社 ジペプチド誘導体及びその製造方法
WO2013130684A1 (en) 2012-02-27 2013-09-06 Amunix Operating Inc. Xten-folate conjugate compositions and methods of making same
KR20220051197A (ko) 2012-05-17 2022-04-26 익스텐드 바이오사이언시즈, 인크. 개선된 약물 전달용 캐리어
US9486503B2 (en) 2012-10-04 2016-11-08 Shionogi & Co., Ltd. Medicinal agent for suppressing malignant tumor metastasis
BR112015009107A2 (pt) * 2012-10-24 2017-11-14 Daiichi Sankyo Co Ltd agente terapêutico para esclerose lateral amiotrófica, uso de um agonista do receptor do secretagogo do hormônio do crescimento ou um sal farmaceuticamente aceitável do mesmo, e, agonista do receptor do secretagogo do hormônio do crescimento ou sal farmaceuticamente aceitável do mesmo
WO2014119753A1 (ja) * 2013-01-31 2014-08-07 学校法人 東京薬科大学 マイオスタチン阻害ペプチド
WO2014156339A1 (ja) * 2013-03-25 2014-10-02 ゼリア新薬工業株式会社 食後期の胃運動亢進剤
US9616109B2 (en) 2014-10-22 2017-04-11 Extend Biosciences, Inc. Insulin vitamin D conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
EP3220961B1 (de) 2014-10-22 2023-07-05 Extend Biosciences, Inc. Therapeutische vitamin-d-konjugate
CN109879935B (zh) * 2019-03-04 2020-11-20 南京工业大学 一种多肽的液相合成方法
EP4058466A1 (de) 2019-11-13 2022-09-21 Amunix Pharmaceuticals, Inc. Strichcodierte xten-polypeptide und zusammensetzungen davon sowie verfahren zu ihrer herstellung und verwendung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
EP0635025B1 (de) * 1992-04-07 2002-11-06 The Scripps Research Institute Verfahren zur herstellung modifizierten proteine
IL118473A0 (en) 1995-06-02 1996-09-12 Suntory Ltd Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof
JP3982866B2 (ja) 1996-03-04 2007-09-26 アスビオファーマ株式会社 分泌型Kex2誘導体の製造方法
CA2198966C (en) 1996-03-04 2011-06-21 Yuji Suzuki Method for cleaving chimeric protein using processing enzyme
WO1998042840A1 (en) * 1997-03-24 1998-10-01 Zymogenetics, Inc. Motilin homologs
IL139686A0 (en) * 1998-06-02 2002-02-10 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6420521B1 (en) * 1999-06-30 2002-07-16 Zymogenetics, Inc. Short gastrointestinal peptides
DK1197496T3 (da) * 1999-07-23 2007-10-22 Kenji Kangawa Hidtil ukendte peptider

Also Published As

Publication number Publication date
ATE449174T1 (de) 2009-12-15
CY1109714T1 (el) 2014-08-13
US9573986B2 (en) 2017-02-21
BRPI0012688B8 (pt) 2021-05-25
JP4227857B2 (ja) 2009-02-18
EP2119785B1 (de) 2013-03-13
EP1795598B1 (de) 2009-11-18
AU6023100A (en) 2001-02-13
DE60035502D1 (de) 2007-08-23
AU2006201580B2 (en) 2009-01-08
EP1197496B8 (de) 2007-10-03
ES2335235T3 (es) 2010-03-23
US8524871B2 (en) 2013-09-03
DK1197496T3 (da) 2007-10-22
AU784035B2 (en) 2006-01-19
IL147652A0 (en) 2002-08-14
BRPI0012688B1 (pt) 2018-06-05
CN1362968A (zh) 2002-08-07
JP3471780B2 (ja) 2003-12-02
IL147652A (en) 2010-04-29
BR0012688A (pt) 2002-04-16
CA2380058C (en) 2011-08-09
EP1197496A1 (de) 2002-04-17
US20130172251A1 (en) 2013-07-04
CA2696819C (en) 2015-07-07
CN100506844C (zh) 2009-07-01
US20090170763A1 (en) 2009-07-02
WO2001007475A1 (fr) 2001-02-01
DK1795598T3 (da) 2010-02-01
ES2401939T3 (es) 2013-04-25
PT1197496E (pt) 2007-08-29
PT1795598E (pt) 2010-01-05
EP1197496A4 (de) 2002-11-20
JP2004000251A (ja) 2004-01-08
CA2696819A1 (en) 2001-02-01
KR20020026543A (ko) 2002-04-10
US20100240866A1 (en) 2010-09-23
US9938332B2 (en) 2018-04-10
CN101693736B (zh) 2020-09-11
KR100827973B1 (ko) 2008-05-21
US20110184153A1 (en) 2011-07-28
US8227570B2 (en) 2012-07-24
DE60035502T2 (de) 2008-03-20
EP1197496B1 (de) 2007-07-11
EP1795598A1 (de) 2007-06-13
DE60043361D1 (de) 2009-12-31
CY1107724T1 (el) 2013-04-18
CN101693736A (zh) 2010-04-14
US7385026B1 (en) 2008-06-10
EP2119785A1 (de) 2009-11-18
CA2380058A1 (en) 2001-02-01
AU2006201580A1 (en) 2006-05-18
ES2288151T3 (es) 2008-01-01

Similar Documents

Publication Publication Date Title
DE60043361D1 (de) Neue Peptide
ATE458054T1 (de) Menschliches parathyroidhormon, modifikationen, herstellung und verwendung
MXPA04005906A (es) Cis-2,4,5-trifenil-.imidazolinas y uso de la misma para tratamiento de tumores.
ATE497390T1 (de) Neue therapeutische verwendung von smr-1 peptide
DE69220861D1 (de) Zyklische Peptide und ihre Verwendung
DK1079849T3 (da) Anvendelse af HMG-proteiner til fremstilling af lægemidler med cytotoksisk virkning
EP0270214A3 (de) Vasopressinantagonisten
DE602004023827D1 (de) Ionenkanalaktivität hemmende niedrigmolekulare peptide
BR9712033A (pt) Composição farmacêutica para tratamento de doenças virais.
DE50307025D1 (de) Zubereitungen zur intranasalen applikation ausgewählter, von aminosäuren abgeleiteter cgrp-antagonisten
ATE441713T1 (de) Tumorantigenprotein und dessen verwendung
GB0207644D0 (en) Peptides and their use
EA200300900A1 (ru) Замещенные амины (варианты), способ их получения и их применение в качестве ингибиторов транспорта глицина (варианты), композиция (варианты), промежуточный иодид и способ его получения, способ лечения пациента (варианты)
ATE354646T1 (de) Selektionsmarker
EP1760087A4 (de) Neuer proteinkomplex und anwendungen davon
WO2003022300A1 (fr) Remedes prophylactiques et curatifs contre les maladies des os et des articulations
ATE397753T1 (de) Screening-verfahren für eine prophylaktische und therapeutische substanz für eine nierenerkrankung
GB2361923A (en) Novel protein
ATE417061T1 (de) Scorpionpeptid als blutdrucksenkendes mittel
TH18962A (th) สารผสมที่ทำให้ขนร่วงซึ่งประกอบด้วยสารประกอบซัลฟ์ไฮดริล
TH26711A (th) " สิ่งที่คล้ายกันของปัจจัยหลั่งฮอโมนของการเจริญเติบโต "
EP1308512A4 (de) Neuartige proteine und deren dna
DE69508496D1 (de) Endothelin-antagonisierendes Peptid