RU94046091A - Полипептидные антагонисты бомбезина, фармацевтическая композиция и способ лечения - Google Patents

Полипептидные антагонисты бомбезина, фармацевтическая композиция и способ лечения

Info

Publication number
RU94046091A
RU94046091A RU94046091/04A RU94046091A RU94046091A RU 94046091 A RU94046091 A RU 94046091A RU 94046091/04 A RU94046091/04 A RU 94046091/04A RU 94046091 A RU94046091 A RU 94046091A RU 94046091 A RU94046091 A RU 94046091A
Authority
RU
Russia
Prior art keywords
alkyl
phenyl
hydrogen
group
ais
Prior art date
Application number
RU94046091/04A
Other languages
English (en)
Other versions
RU2114118C1 (ru
Inventor
В.Скэлли Эндрю
Us]
Жи Кэй Рен
Cn]
Original Assignee
Дзе Администрейторс оф дзе Тьюлейн Эдьюкейшионал Фанд (US)
Дзе Администрейторс оф дзе Тьюлейн Эдьюкейшионал Фанд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Администрейторс оф дзе Тьюлейн Эдьюкейшионал Фанд (US), Дзе Администрейторс оф дзе Тьюлейн Эдьюкейшионал Фанд filed Critical Дзе Администрейторс оф дзе Тьюлейн Эдьюкейшионал Фанд (US)
Publication of RU94046091A publication Critical patent/RU94046091A/ru
Application granted granted Critical
Publication of RU2114118C1 publication Critical patent/RU2114118C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Псевдопептиды, включающие в себя пептид формулы, приведенной в описании изобретения, и фармацевтически приемлемые кислоты или соли.

Claims (1)

  1. Псевдопептиды, включающие в себя пептид формулы, приведенной в описании изобретения, и фармацевтически приемлемые кислоты или соли.
RU94046091A 1993-03-15 1994-03-07 Пептиды, или их фармацевтически приемлемые кислоты, или соли, фармацевтическая композиция, обладающая антагонистической активностью по отношению к бомбезину, способ лечения рака у млекопитающих RU2114118C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/031,325 1993-03-15
US08/031,325 US5369094A (en) 1990-11-29 1993-03-15 Polypeptide bombesin antagonists
US08/031325 1993-03-15

Publications (2)

Publication Number Publication Date
RU94046091A true RU94046091A (ru) 1996-09-27
RU2114118C1 RU2114118C1 (ru) 1998-06-27

Family

ID=21858823

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046091A RU2114118C1 (ru) 1993-03-15 1994-03-07 Пептиды, или их фармацевтически приемлемые кислоты, или соли, фармацевтическая композиция, обладающая антагонистической активностью по отношению к бомбезину, способ лечения рака у млекопитающих

Country Status (27)

Country Link
US (1) US5369094A (ru)
EP (1) EP0646127B1 (ru)
JP (1) JP3838656B2 (ru)
KR (1) KR100306506B1 (ru)
AT (1) ATE167874T1 (ru)
AU (1) AU666270B2 (ru)
BR (1) BR9404341A (ru)
CA (1) CA2135787C (ru)
CZ (1) CZ286750B6 (ru)
DE (1) DE69411342T2 (ru)
DK (1) DK0646127T3 (ru)
EE (1) EE03180B1 (ru)
ES (1) ES2120615T3 (ru)
FI (1) FI945378A (ru)
HR (1) HRP940164B1 (ru)
HU (1) HU218288B (ru)
IL (2) IL108851A (ru)
NO (1) NO313418B1 (ru)
NZ (2) NZ299913A (ru)
PL (1) PL180372B1 (ru)
RU (1) RU2114118C1 (ru)
SI (1) SI9420001B (ru)
SK (1) SK282267B6 (ru)
TW (1) TW325478B (ru)
UA (1) UA34456C2 (ru)
WO (1) WO1994021674A1 (ru)
ZA (1) ZA941767B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877277A (en) 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
US5650395A (en) * 1995-03-13 1997-07-22 Hurel; Steven Treatment of pulmonary hypertension
US6989371B1 (en) 1996-08-16 2006-01-24 Dabur Research Foundation Bombesin analogs for treatment of cancer
US6200546B1 (en) 1997-04-22 2001-03-13 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
EP1333829A1 (en) * 2000-11-17 2003-08-13 Warner-Lambert Company LLC Treatment of sexual dysfunction using bombesin antagonists
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US20060239923A1 (en) * 2003-01-13 2006-10-26 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
AU2003303714B2 (en) * 2003-01-13 2009-02-19 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
US8709998B2 (en) 2003-04-22 2014-04-29 Ipsen Pharma S.A.S. Peptide vectors
US7795385B2 (en) * 2004-12-17 2010-09-14 Bexar Global, Inc. Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
EP2100900A1 (en) * 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
EP2198878A1 (en) * 2008-12-18 2010-06-23 University Of Miami Polypeptide bombesin antagonists
EP2485737B1 (en) 2009-10-07 2014-06-25 Merck Sharp & Dohme Corp. Novel trpa1 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162497A (en) * 1987-09-24 1992-11-10 The Administrators Of The Tulane Educational Fund Bradykinin analogs with non-peptide bond
JP2795449B2 (ja) * 1987-09-24 1998-09-10 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ペプチド
US5084555A (en) * 1989-08-21 1992-01-28 The Administrators Of The Tulane Educational Fund An octapeptide bombesin analog
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
GB8813356D0 (en) * 1988-06-06 1988-07-13 Ici Plc Polypeptide compounds
GR1000608B (el) * 1988-07-21 1992-08-31 Erba Carlo Spa Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
DE68928667T2 (de) * 1988-10-14 1998-10-01 Univ Tulane Peptide als arzneimittel
US5217955A (en) * 1989-09-15 1993-06-08 Biomeasure, Inc. Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin
US5244883A (en) * 1990-11-29 1993-09-14 The Administrators Of The Tulane Educational Fund Nonapeptide bombesin antagonists

Also Published As

Publication number Publication date
DE69411342T2 (de) 1998-11-19
IL108851A (en) 2003-05-29
TW325478B (en) 1998-01-21
KR100306506B1 (ko) 2001-12-01
SI9420001B (sl) 1999-08-31
EE03180B1 (et) 1999-04-15
SK136494A3 (en) 1995-08-09
BR9404341A (pt) 1999-08-31
SK282267B6 (sk) 2001-12-03
NO944293L (no) 1995-01-02
ES2120615T3 (es) 1998-11-01
UA34456C2 (ru) 2001-03-15
PL306209A1 (en) 1995-03-06
CZ286750B6 (en) 2000-06-14
JPH07507330A (ja) 1995-08-10
IL154995A0 (en) 2003-10-31
ATE167874T1 (de) 1998-07-15
NZ263668A (en) 1997-06-24
US5369094A (en) 1994-11-29
DE69411342D1 (de) 1998-08-06
RU2114118C1 (ru) 1998-06-27
AU666270B2 (en) 1996-02-01
CA2135787C (en) 2008-08-12
AU6444694A (en) 1994-10-11
IL108851A0 (en) 1994-06-24
EP0646127A1 (en) 1995-04-05
EP0646127B1 (en) 1998-07-01
KR950701646A (ko) 1995-04-28
FI945378A0 (fi) 1994-11-15
CZ280794A3 (en) 1995-07-12
NZ299913A (en) 2000-07-28
CA2135787A1 (en) 1994-09-29
HUT69727A (en) 1995-09-28
JP3838656B2 (ja) 2006-10-25
HRP940164A2 (en) 1996-08-31
PL180372B1 (pl) 2001-01-31
DK0646127T3 (da) 1999-04-12
WO1994021674A1 (en) 1994-09-29
FI945378A (fi) 1994-11-15
HU218288B (en) 2000-07-28
ZA941767B (en) 1994-10-06
NO944293D0 (no) 1994-11-10
HRP940164B1 (en) 2000-02-29
SI9420001A (en) 1995-08-31
NO313418B1 (no) 2002-09-30

Similar Documents

Publication Publication Date Title
RU94046091A (ru) Полипептидные антагонисты бомбезина, фармацевтическая композиция и способ лечения
US5736520A (en) Peptidase inhibitors
KR900008004B1 (ko) 펩티다제 억제물의 제조방법
EP0490667B1 (en) HIV protease inhibitors
PT91926B (pt) Processo para a preparacao de novos inibidores de peptidase
RU96101161A (ru) Новые пептидные производные
US5496927A (en) Peptidase inhibitors
KR910006324A (ko) 펩티다아제 및 아이소머라제 억제제
ID21956A (id) Asam n-(aril dan atau heteroarilasetil) amino ester, komposisi farmasi yang mengandungnya, dan metoda untuk menghambat pelepasan betha-amiloid peptida dan atau sintesanya dengan menggunakan senyawa tersebut
CA2064473A1 (en) Chimeric amino acids and peptides containing these analogues
PT94811A (pt) Processo para a preparacao de novos inibidores de peptidase
RU94035760A (ru) Опиоидные пептиды
AU780100B2 (en) HCV NS3 protease inhibitors
CY1107990T1 (el) Τριπεπτιδια και παραγωγα τριπεπτιδιων για τη θepαπεια νευροεκφυλιστικων ασθενειων
IE62456B1 (en) Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfunctions
GB1491017A (en) Peptides
EP0503044B1 (en) Peptide compounds of laevorotatory amino acids and ring molecules, and therapeutical applications thereof
EP0273893A2 (en) Novel compounds
US5736518A (en) Peptide compounds of (L) amino acids and ring molecules, and therapeutical applications thereof
GB1309728A (en) Hepta-octa-and nona peptides
ES2167464T3 (es) Procedimiento para la preparacion de n-carboxianhidridos de aminoacidos a partir de n-(n'-nitrosocarbamoil)aminoacidos.
GB1346317A (en) Peptide enzyme inhibitor
RU96119245A (ru) Новые пептиды типа опиоидов для обезболивания и их применение
PT87693B (pt) Processo para a preparacao de novos compostos analogos de peptidos com accao inibidora da renina e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20080308