JP2002534996A5 - - Google Patents
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- Publication number
- JP2002534996A5 JP2002534996A5 JP2000596032A JP2000596032A JP2002534996A5 JP 2002534996 A5 JP2002534996 A5 JP 2002534996A5 JP 2000596032 A JP2000596032 A JP 2000596032A JP 2000596032 A JP2000596032 A JP 2000596032A JP 2002534996 A5 JP2002534996 A5 JP 2002534996A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- lys
- tyr
- amino acid
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 aromatic amino acid Chemical class 0.000 description 90
- 150000001413 amino acids Chemical class 0.000 description 70
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 58
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 50
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 50
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 50
- 229960003104 ornithine Drugs 0.000 description 50
- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 description 48
- QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 description 48
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 45
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 44
- 108090000765 processed proteins & peptides Proteins 0.000 description 42
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 39
- 108091058551 α-conotoxin Proteins 0.000 description 38
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 26
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 25
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 17
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 16
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 14
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 13
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 12
- 125000001475 halogen functional group Chemical group 0.000 description 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 8
- 125000003368 amide group Chemical group 0.000 description 7
- 125000000998 L-alanino group Chemical group [H]N([*])[C@](C([H])([H])[H])([H])C(=O)O[H] 0.000 description 5
- PIEXCQIOSMOEOU-UHFFFAOYSA-N 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(Br)C(=O)N(Cl)C1=O PIEXCQIOSMOEOU-UHFFFAOYSA-N 0.000 description 4
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
- UHBYWPGGCSDKFX-VKHMYHEASA-N gamma-carboxy-L-glutamic acid Chemical compound OC(=O)[C@@H](N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-VKHMYHEASA-N 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 description 2
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 2
- 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000024188 Andala Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical group OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 150000001408 amides Chemical group 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11838199P | 1999-01-29 | 1999-01-29 | |
| US60/118,381 | 1999-01-29 | ||
| PCT/US2000/001979 WO2000044776A1 (en) | 1999-01-29 | 2000-01-28 | Alpha-conotoxin peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002534996A JP2002534996A (ja) | 2002-10-22 |
| JP2002534996A5 true JP2002534996A5 (enExample) | 2007-03-29 |
Family
ID=22378229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000596032A Pending JP2002534996A (ja) | 1999-01-29 | 2000-01-28 | アルファ−コノトキシン・ペプチド |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1147130A4 (enExample) |
| JP (1) | JP2002534996A (enExample) |
| AU (1) | AU770076B2 (enExample) |
| CA (2) | CA2743116C (enExample) |
| WO (1) | WO2000044776A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR409401A0 (en) | 2001-03-29 | 2001-04-26 | University Of Melbourne, The | Analgesic compound |
| AU2002245934B2 (en) * | 2001-03-29 | 2008-05-01 | John Down | Alpha conotoxin peptides with analgesic properties |
| WO2008011006A2 (en) | 2006-07-18 | 2008-01-24 | University Of Utah Research Foundation | Methods for treating pain and screening analgesic compounds |
| US9284358B2 (en) | 2006-07-18 | 2016-03-15 | University Of Utah Research Foundation | Conotoxin peptides |
| US20100093643A1 (en) * | 2006-08-17 | 2010-04-15 | Irina Bobrova | Cardioprotective compounds |
| CN103483439B (zh) * | 2012-06-15 | 2015-09-16 | 海南大学 | αO-超家族芋螺毒素肽、其药物组合物及用途 |
| US9469674B2 (en) * | 2012-08-07 | 2016-10-18 | Hainan University | α-conotoxin peptide, pharmaceutical composition and use thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595972A (en) * | 1993-06-29 | 1997-01-21 | University Of Utah Research Foundation | Conotoxin peptides |
| US5432155A (en) * | 1993-06-29 | 1995-07-11 | The Salk Institute For Biological Studies | Conotoxins I |
| US5514774A (en) * | 1993-06-29 | 1996-05-07 | University Of Utah Research Foundation | Conotoxin peptides |
| US5739276A (en) * | 1994-10-07 | 1998-04-14 | University Of Utah Research Foundation | Conotoxin peptides |
| US5719264A (en) * | 1994-10-07 | 1998-02-17 | Univ. Of Utah Research Foundation | Conotoxin peptides |
| US5670622A (en) * | 1996-02-15 | 1997-09-23 | University Of Utah Research Foundation | Conotoxin peptide PIIIA |
| US5672682A (en) * | 1996-03-18 | 1997-09-30 | University Of Utah Research Foundation | Conotoxin peptide PVIIA |
| EP0948346A4 (en) * | 1996-11-18 | 2004-05-12 | Univ Utah Res Found | USE OF THE CONOTOXIN PEPTIDES IMI AND MII AS CARDIOVASCULAR ACTIVE SUBSTANCES |
| US5780433A (en) * | 1996-12-06 | 1998-07-14 | University Of Utah Research Foundation | Use of α-conotoxin MII to treat disorders resulting from nicotine stimulated dopamine release |
| US5889147A (en) * | 1997-01-17 | 1999-03-30 | University Of Utah Research Foundation | Bromo-tryptophan conopeptides |
| US5866682A (en) * | 1997-05-15 | 1999-02-02 | University Of Utah Research Foundation | Conopeptides AuIA, AuIB and AuIC |
| US5969096A (en) * | 1998-06-26 | 1999-10-19 | The Salk Institute For Biological Studies | Conotoxin peptides |
-
2000
- 2000-01-28 CA CA2743116A patent/CA2743116C/en not_active Expired - Fee Related
- 2000-01-28 AU AU29735/00A patent/AU770076B2/en not_active Ceased
- 2000-01-28 EP EP00908382A patent/EP1147130A4/en not_active Withdrawn
- 2000-01-28 WO PCT/US2000/001979 patent/WO2000044776A1/en not_active Ceased
- 2000-01-28 JP JP2000596032A patent/JP2002534996A/ja active Pending
- 2000-01-28 CA CA2361534A patent/CA2361534C/en not_active Expired - Fee Related
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