ATE366813T1 - Neue peptide - Google Patents

Neue peptide

Info

Publication number
ATE366813T1
ATE366813T1 AT00946453T AT00946453T ATE366813T1 AT E366813 T1 ATE366813 T1 AT E366813T1 AT 00946453 T AT00946453 T AT 00946453T AT 00946453 T AT00946453 T AT 00946453T AT E366813 T1 ATE366813 T1 AT E366813T1
Authority
AT
Austria
Prior art keywords
amino acid
new peptides
compound
activity
replaced
Prior art date
Application number
AT00946453T
Other languages
German (de)
English (en)
Inventor
Kenji Kangawa
Masayasu Kojima
Hiroshi Hosoda
Hisayuki Matsuo
Yoshiharu Minamitake
Original Assignee
Kenji Kangawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenji Kangawa filed Critical Kenji Kangawa
Application granted granted Critical
Publication of ATE366813T1 publication Critical patent/ATE366813T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT00946453T 1999-07-23 2000-07-24 Neue peptide ATE366813T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21000299 1999-07-23
JP33884199 1999-11-29
JP2000126623 2000-04-26

Publications (1)

Publication Number Publication Date
ATE366813T1 true ATE366813T1 (de) 2007-08-15

Family

ID=27329078

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00946453T ATE366813T1 (de) 1999-07-23 2000-07-24 Neue peptide
AT07006224T ATE449174T1 (de) 1999-07-23 2000-07-24 Neue peptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT07006224T ATE449174T1 (de) 1999-07-23 2000-07-24 Neue peptide

Country Status (16)

Country Link
US (5) US7385026B1 (enExample)
EP (3) EP1197496B8 (enExample)
JP (2) JP3471780B2 (enExample)
KR (1) KR100827973B1 (enExample)
CN (2) CN100506844C (enExample)
AT (2) ATE366813T1 (enExample)
AU (2) AU784035B2 (enExample)
BR (2) BR0012688A (enExample)
CA (2) CA2380058C (enExample)
CY (2) CY1107724T1 (enExample)
DE (2) DE60043361D1 (enExample)
DK (2) DK1197496T3 (enExample)
ES (3) ES2288151T3 (enExample)
IL (2) IL147652A0 (enExample)
PT (2) PT1197496E (enExample)
WO (1) WO2001007475A1 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1197496E (pt) 1999-07-23 2007-08-29 Kenji Kangawa Novos péptidos
CA2392019A1 (en) 1999-11-22 2001-05-31 Zymogenetics, Inc. Method of forming a peptide-receptor complex with zsig33
US6897286B2 (en) 2000-05-11 2005-05-24 Zymogenetics, Inc. Zsig33-like peptides
EP1288230B1 (en) 2000-05-12 2008-10-01 Kaneka Corporation Method of purifying vinyl polymer
CA2411667A1 (en) * 2000-05-30 2001-12-06 Merck & Co. Inc. Ghrelin analogs
EP1303538A2 (en) * 2000-07-24 2003-04-23 Ardana Bioscience Limited Ghrelin antagonists
AU2003236080B8 (en) * 2002-04-11 2009-07-02 Daiichi Sankyo Company, Limited A method for producing a modified peptide
CN100411683C (zh) 2002-05-21 2008-08-20 阿斯比奥制药株式会社 含有生长素释放肽的药物组合物
KR20050027168A (ko) * 2002-07-19 2005-03-17 사이토스 바이오테크놀로지 아게 그렐린-캐리어 컨쥬게이트
DE60335913D1 (de) 2002-07-23 2011-03-10 Ipsen Pharma Ghrelin-analoga
TWI331922B (en) * 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
CA2496687A1 (en) * 2002-09-18 2004-04-01 Centre Hospitalier De L'universite De Montreal (Chum) Ghrh analogues
EP1407779A1 (en) * 2002-10-10 2004-04-14 Gastrotech A/S Use of ghrelin for treating low body weight and body fat in gastrectomized individuals
KR20060015555A (ko) 2003-04-30 2006-02-17 겐지 간가와 간 질환 예방 치료제
WO2005016951A2 (en) * 2003-06-04 2005-02-24 Eli Lilly And Company Anti-ghrelin fab antibodies
EP1670827A2 (en) * 2003-09-05 2006-06-21 Eli Lilly And Company Anti-ghrelin antibodies
CN1321131C (zh) * 2003-12-26 2007-06-13 李宁 猪Ghrelin衍生物及其编码基因与应用
RU2006130006A (ru) * 2004-01-20 2008-02-27 Цитос Биотехнологи Аг (Ch) Конъюгаты грелин-носитель
US7026175B2 (en) 2004-03-29 2006-04-11 Applied Materials, Inc. High throughput measurement of via defects in interconnects
WO2005097831A2 (en) * 2004-04-07 2005-10-20 Gastrotech Pharma A/S Uses of isolated binding members capable of binding specifically to secretagogues
WO2005097830A2 (en) * 2004-04-07 2005-10-20 Aditech Pharma Ab Uses of isolated binding members capable of reducing the biological activity of secretagogue compounds
US20080171700A1 (en) * 2004-04-07 2008-07-17 Gastrotech Pharma A/S Use Of Secretagogue For The Teatment Of Ghrelin Deficiency
WO2005110463A1 (en) * 2004-05-11 2005-11-24 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health Methods of inhibiting proinflammatory cytokine expression using ghrelin
WO2005120484A1 (ja) * 2004-06-09 2005-12-22 Kurume University グレリンの生理学的機能のレギュレーター
CA2569235A1 (en) * 2004-07-14 2006-02-23 Eli Lilly And Company Anti-ghrelin antibodies
EP1812045A2 (en) * 2004-10-27 2007-08-01 Gastrotech Pharma A/S Uses of secretagogues for treatment of organ transplant patients
EP1812044A2 (en) * 2004-10-27 2007-08-01 Gastrotech Pharma A/S Uses of growth hormone secretagogues in the treatment of individuals suffering from renal and/or liver failure
US20080300180A1 (en) * 2004-11-30 2008-12-04 Gastrotech Pharma A/S Growth Hormone Secretagogue Receptor 1A Ligands
RU2403058C2 (ru) * 2005-02-23 2010-11-10 Киото Юниверсити Стимулятор регенерации панкреатических бета-клеток и продуцирования инсулина в панкреатических бета-клетках
WO2006091381A1 (en) * 2005-02-23 2006-08-31 Eli Lilly And Company Humanized anti-ghrelin antibodies
RU2427587C2 (ru) * 2005-09-28 2011-08-27 Ипсен Фарма С.А.С. Аналоги грелина
CA2625447C (en) 2005-09-29 2015-06-09 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Compositions and methods for stimulating gastrointestinal motility
AU2006316101A1 (en) * 2005-11-21 2007-05-24 Daiichi Sankyo Company, Limited Therapeutic agent for skin or skin repair-promoting agent comprising des-acylghrelin or derivative thereof as active ingredient
RU2420306C2 (ru) * 2005-11-21 2011-06-10 Юниверсити Оф Миязаки ТЕРАПЕВТИЧЕСКОЕ СРЕДСТВО ДЛЯ УСКОРЕННОГО ЗАЖИВЛЕНИЯ КОЖИ, СОДЕРЖАЩЕЕ В КАЧЕСТВЕ АКТИВНОГО ИНГРЕДИЕНТА ГРЕЛИН И ЕГО ПРОИЗВОДНЫЕ ИЛИ ВЕЩЕСТВО, ВОЗДЕЙСТВУЮЩЕЕ НА РЕЦЕПТОР GHS-R1a
ES2424970T3 (es) * 2006-03-10 2013-10-10 Ipsen Pharma Uso de un agonista de la grelina para mejorar los efectos catabólicos del tratamiento con glucocorticoides
KR101201055B1 (ko) 2006-03-13 2012-11-15 리아트 민쯔 악액질 및/또는 식욕감퇴 및/또는 식욕감퇴-악액질 및/또는영양장애 및/또는 지방이영양증 및/또는 근육 쇠약 및/또는 식욕-자극의 치료를 위한 그렐린 스플라이스 변이체의 용도
CA2659264C (en) * 2006-08-01 2016-01-26 The Scripps Research Institute Immunoconjugates of ghrelin for use in vaccines and methods for controlling adiposity
WO2008018597A1 (fr) * 2006-08-11 2008-02-14 University Of Miyazaki Agent thérapeutique permettant d'accélérer la réparation des nerfs rachidiens comprenant en tant que matière active de la désacyl ghréline ou un dérivé de celle-ci
CN101516400A (zh) 2006-08-11 2009-08-26 国立大学法人宫崎大学 以生长素释放肽及其衍生物或作用于GHS-R1a的物质作为有效成分的脊髓神经修复促进治疗剂
JP5134627B2 (ja) * 2006-09-27 2013-01-30 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ Ｎ末端で置換されたグレリン類似体
CA2698582C (en) 2008-05-23 2016-09-13 Asubio Pharma Co., Ltd. Peptide having an extending action for half-life of object peptide in plasma
DK3178835T3 (da) 2009-02-03 2019-06-24 Amunix Pharmaceuticals Inc Forlængede rekombinante polypeptider og sammensætninger omfattende samme
US9724381B2 (en) 2009-05-12 2017-08-08 The Administrators Of The Tulane Educational Fund Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US8883721B2 (en) * 2009-05-12 2014-11-11 Mcgill University Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
JP6057314B2 (ja) 2010-01-15 2017-01-11 国立大学法人 宮崎大学 加療中動物の回復促進治療剤
EP2582715B1 (en) * 2010-06-16 2018-11-28 The Administrators of the Tulane Educational Fund Growth hormone secretatogue receptor antagonists and uses thereof
BR112013021859A2 (pt) 2011-03-03 2016-10-25 Daiichi Sankyo Co Ltd agente hipotérmico para um animal, agente hiportérmico, agente terapêutico para hipertermia em um animal, método para reduzir a temperatura corporal de um animal, método terapêutico para hipertermia em um animal, desacilada ou o seu derivado e uso de gralina desacilada ou o seu derivado
JP5560248B2 (ja) * 2011-09-07 2014-07-23 花王株式会社 ジペプチド誘導体及びその製造方法
MX366864B (es) 2012-02-27 2019-07-26 Amunix Operating Inc Composiciones de conjugados de xten y métodos para realizarlas.
CN104302177B (zh) 2012-05-17 2019-05-28 延伸生物科学股份有限公司 用于改进的药物递送的载体
US9486503B2 (en) 2012-10-04 2016-11-08 Shionogi & Co., Ltd. Medicinal agent for suppressing malignant tumor metastasis
JP6262661B2 (ja) * 2012-10-24 2018-01-17 第一三共株式会社 筋萎縮性側索硬化症治療剤
JP6143270B2 (ja) * 2013-01-31 2017-06-07 学校法人東京薬科大学 マイオスタチン阻害ペプチド
JP6295247B2 (ja) * 2013-03-25 2018-03-14 ゼリア新薬工業株式会社 食後期の胃運動亢進剤
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
CA2964463C (en) 2014-10-22 2024-02-13 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
US9616109B2 (en) 2014-10-22 2017-04-11 Extend Biosciences, Inc. Insulin vitamin D conjugates
CN109879935B (zh) * 2019-03-04 2020-11-20 南京工业大学 一种多肽的液相合成方法
KR20220131221A (ko) 2019-11-13 2022-09-27 아뮤닉스 파마슈티컬스, 인크. 바코드화된 xten 폴리펩티드 및 이의 조성물, 및 이의 제조 방법 및 사용 방법
AU2023353057A1 (en) 2022-09-30 2025-05-01 Extend Biosciences, Inc. Long-acting parathyroid hormone
CN120818010B (zh) * 2025-09-18 2025-12-05 天津科技大学 一种来自植物乳杆菌属细胞外囊泡的短肽及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
IL98910A0 (en) * 1990-07-24 1992-07-15 Polygen Holding Corp Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them
US5663146A (en) * 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
DE69332471T2 (de) * 1992-04-07 2003-08-28 The Scripps Research Institute, La Jolla Verfahren zur herstellung modifizierten proteine
HUP9801337A2 (hu) * 1995-03-31 1998-08-28 American Cyanamid Company Növekedést elősegítő tulajdonsággal rendelkező peptidek
IL118473A0 (en) 1995-06-02 1996-09-12 Suntory Ltd Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof
JP3982866B2 (ja) 1996-03-04 2007-09-26 アスビオファーマ株式会社 分泌型Ｋｅｘ２誘導体の製造方法
CA2198966C (en) 1996-03-04 2011-06-21 Yuji Suzuki Method for cleaving chimeric protein using processing enzyme
KR20010005701A (ko) 1997-03-24 2001-01-15 리스 데브라 케이. 모틸린 상동체
CA2328895A1 (en) 1998-06-02 1999-12-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
CN1120846C (zh) * 1999-02-13 2003-09-10 中国人民解放军军事医学科学院基础医学研究所 生长激素释放肽及其应用
US6420521B1 (en) * 1999-06-30 2002-07-16 Zymogenetics, Inc. Short gastrointestinal peptides
PT1197496E (pt) * 1999-07-23 2007-08-29 Kenji Kangawa Novos péptidos

Also Published As

Publication number Publication date
CA2380058A1 (en) 2001-02-01
CN100506844C (zh) 2009-07-01
PT1795598E (pt) 2010-01-05
US20090170763A1 (en) 2009-07-02
WO2001007475A1 (en) 2001-02-01
DE60035502D1 (de) 2007-08-23
EP1197496A4 (en) 2002-11-20
CN101693736B (zh) 2020-09-11
CA2696819C (en) 2015-07-07
EP1795598A1 (en) 2007-06-13
CN1362968A (zh) 2002-08-07
EP2119785A1 (en) 2009-11-18
KR20020026543A (ko) 2002-04-10
US20130172251A1 (en) 2013-07-04
EP2119785B1 (en) 2013-03-13
PT1197496E (pt) 2007-08-29
AU6023100A (en) 2001-02-13
CA2696819A1 (en) 2001-02-01
JP4227857B2 (ja) 2009-02-18
AU784035B2 (en) 2006-01-19
US20100240866A1 (en) 2010-09-23
ES2288151T3 (es) 2008-01-01
IL147652A (en) 2010-04-29
BR0012688A (pt) 2002-04-16
ES2335235T3 (es) 2010-03-23
US7385026B1 (en) 2008-06-10
BRPI0012688B1 (pt) 2018-06-05
US9938332B2 (en) 2018-04-10
ATE449174T1 (de) 2009-12-15
AU2006201580B2 (en) 2009-01-08
EP1197496B8 (en) 2007-10-03
CY1109714T1 (el) 2014-08-13
EP1197496B1 (en) 2007-07-11
KR100827973B1 (ko) 2008-05-21
US20110184153A1 (en) 2011-07-28
EP1795598B1 (en) 2009-11-18
CA2380058C (en) 2011-08-09
AU2006201580A1 (en) 2006-05-18
EP1197496A1 (en) 2002-04-17
DE60035502T2 (de) 2008-03-20
CN101693736A (zh) 2010-04-14
CY1107724T1 (el) 2013-04-18
US9573986B2 (en) 2017-02-21
JP3471780B2 (ja) 2003-12-02
US8227570B2 (en) 2012-07-24
JP2004000251A (ja) 2004-01-08
BRPI0012688B8 (pt) 2021-05-25
DK1795598T3 (da) 2010-02-01
IL147652A0 (en) 2002-08-14
DE60043361D1 (de) 2009-12-31
ES2401939T3 (es) 2013-04-25
DK1197496T3 (da) 2007-10-22
US8524871B2 (en) 2013-09-03

Similar Documents

Publication Publication Date Title
ATE449174T1 (de) Neue peptide
ATE458054T1 (de) Menschliches parathyroidhormon, modifikationen, herstellung und verwendung
MXPA04005906A (es) Cis-2,4,5-trifenil-.imidazolinas y uso de la misma para tratamiento de tumores.
ATE497390T1 (de) Neue therapeutische verwendung von smr-1 peptide
DE69220861D1 (de) Zyklische Peptide und ihre Verwendung
RU94046091A (ru) Полипептидные антагонисты бомбезина, фармацевтическая композиция и способ лечения
EP0270214A3 (en) Vasopressin antagonists
DK1079849T3 (da) Anvendelse af HMG-proteiner til fremstilling af lægemidler med cytotoksisk virkning
DE602004023827D1 (de) Ionenkanalaktivität hemmende niedrigmolekulare peptide
ATE441713T1 (de) Tumorantigenprotein und dessen verwendung
DE50307025D1 (de) Zubereitungen zur intranasalen applikation ausgewählter, von aminosäuren abgeleiteter cgrp-antagonisten
GB0207644D0 (en) Peptides and their use
WO2003022300A1 (en) Preventives/remedies for bone/joint diseases
ATE354646T1 (de) Selektionsmarker
AU2003202489A1 (en) Screening method
ATE46173T1 (de) Pharmakologisch aktive peptide.
ATE417061T1 (de) Scorpionpeptid als blutdrucksenkendes mittel
ATE465175T1 (de) Neuer proteinkomplex und anwendungen davon
TH18962A (th) สารผสมที่ทำให้ขนร่วงซึ่งประกอบด้วยสารประกอบซัลฟ์ไฮดริล
TH26711A (th) " สิ่งที่คล้ายกันของปัจจัยหลั่งฮอโมนของการเจริญเติบโต "
AU2001277717A1 (en) Novel proteins and dnas thereof
WO1999060117A3 (fr) Polypeptide prax-1